{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:46:23Z","timestamp":1777956383232,"version":"3.51.4"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s43032-026-02060-4","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:08:10Z","timestamp":1773932890000},"page":"564-579","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Model Related to Hypoxia and Endoplasmic Reticulum Stress Predicting Prognosis and Immunotherapy Response in Uterine Corpus Endometrial Cancer"],"prefix":"10.1007","volume":"33","author":[{"given":"Xuenan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7881-1865","authenticated-orcid":false,"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"2060_CR1","doi-asserted-by":"crossref","unstructured":"Baker-Rand H, Kitson SJ. Recent advances in endometrial cancer prevention, early diagnosis and treatment. Cancers (Basel). 2024; 16.","DOI":"10.3390\/cancers16051028"},{"key":"2060_CR2","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1038\/s41467-020-16416-0","volume":"11","author":"Y Suryo Rahmanto","year":"2020","unstructured":"Suryo Rahmanto Y, Shen W, Shi X, Chen X, Yu Y, Yu ZC, et al. Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming. Nat Commun. 2020;11:2717.","journal-title":"Nat Commun"},{"key":"2060_CR3","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.bpobgyn.2021.06.002","volume":"78","author":"HJ Tung","year":"2022","unstructured":"Tung HJ, Huang HJ, Lai CH. Adjuvant and post-surgical treatment in endometrial cancer. Best Pract Res Clin Obstet Gynaecol. 2022;78:52\u201363.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2060_CR4","first-page":"258","volume":"69","author":"RA Brooks","year":"2019","unstructured":"Brooks RA, Fleming GF, Lastra RR, Lee NK, Moroney JW, Son CH, et al. Current recommendations and recent progress in endometrial cancer. CA Cancer J Clin. 2019;69:258\u201379.","journal-title":"CA Cancer J Clin"},{"key":"2060_CR5","doi-asserted-by":"crossref","unstructured":"Sykaras AG, Christofidis K, Politi E, Theocharis S. Exosomes on endometrial cancer: a biomarkers treasure trove? Cancers (Basel). 2022; 14.","DOI":"10.3390\/cancers14071733"},{"key":"2060_CR6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1136\/ijgc-2019-000822","volume":"30","author":"F Di Legge","year":"2020","unstructured":"Legge F, Restaino S, Leone L, Carone V, Ronsini C, Di Fiore GLM, et al. Clinical outcome of recurrent endometrial cancer: analysis of post-relapse survival by pattern of recurrence and secondary treatment. Int J Gynecol Cancer. 2020;30:193\u2013200.","journal-title":"Int J Gynecol Cancer"},{"key":"2060_CR7","doi-asserted-by":"crossref","unstructured":"Lizano M, Carrillo-Garcia A, De La Cruz-Hernandez E, Castro-Munoz LJ, Contreras-Paredes A. Promising predictive molecular biomarkers for cervical cancer (Review). Int J Mol Med. 2024; 53.","DOI":"10.3892\/ijmm.2024.5374"},{"key":"2060_CR8","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/bjc.2015.190","volume":"113","author":"A Talhouk","year":"2015","unstructured":"Talhouk A, McConechy MK, Leung S, Li-Chang HH, Kwon JS, Melnyk N, et al. A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer. 2015;113:299\u2013310.","journal-title":"Br J Cancer"},{"key":"2060_CR9","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1038\/s44321-024-00033-1","volume":"16","author":"W Liu","year":"2024","unstructured":"Liu W, Ma J, Zhang J, Cao J, Hu X, Huang Y, et al. Identification and validation of serum metabolite biomarkers for endometrial cancer diagnosis. EMBO Mol Med. 2024;16:988\u20131003.","journal-title":"EMBO Mol Med"},{"key":"2060_CR10","doi-asserted-by":"publisher","first-page":"116812","DOI":"10.1016\/j.biopha.2024.116812","volume":"175","author":"L Guan","year":"2024","unstructured":"Guan L, Ge R, Ma S. Newsights of endoplasmic reticulum in hypoxia. Biomed Pharmacother. 2024;175:116812.","journal-title":"Biomed Pharmacother"},{"key":"2060_CR11","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/onc.2016.225","volume":"36","author":"S Chouaib","year":"2017","unstructured":"Chouaib S, Noman MZ, Kosmatopoulos K, Curran MA. Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer. Oncogene. 2017;36:439\u201345.","journal-title":"Oncogene"},{"key":"2060_CR12","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.immuni.2014.09.008","volume":"41","author":"A Palazon","year":"2014","unstructured":"Palazon A, Goldrath AW, Nizet V, Johnson RS. HIF transcription factors, inflammation, and immunity. Immunity. 2014;41:518\u201328.","journal-title":"Immunity"},{"key":"2060_CR13","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrc.2017.51","volume":"17","author":"M De Palma","year":"2017","unstructured":"De Palma M, Biziato D, Petrova TV. Microenvironmental regulation of tumour angiogenesis. Nat Rev Cancer. 2017;17:457\u201374.","journal-title":"Nat Rev Cancer"},{"key":"2060_CR14","doi-asserted-by":"publisher","first-page":"1075431","DOI":"10.3389\/fendo.2022.1075431","volume":"13","author":"J Chen","year":"2022","unstructured":"Chen J, Wang G, Zhang D, Luo X, Zhang D, Zhang Y. Construction of novel hypoxia-related gene model for prognosis and tumor microenvironment in endometrial carcinoma. Front Endocrinol (Lausanne). 2022;13:1075431.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2060_CR15","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s00262-017-2019-6","volume":"66","author":"E Mohamed","year":"2017","unstructured":"Mohamed E, Cao Y, Rodriguez PC. Endoplasmic reticulum stress regulates tumor growth and anti-tumor immunity: a promising opportunity for cancer immunotherapy. Cancer Immunol Immunother. 2017;66:1069\u201378.","journal-title":"Cancer Immunol Immunother"},{"key":"2060_CR16","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1002\/jcp.24578","volume":"229","author":"G Cali","year":"2014","unstructured":"Cali G, Insabato L, Conza D, Bifulco G, Parrillo L, Mirra P, et al. GRP78 mediates cell growth and invasiveness in endometrial cancer. J Cell Physiol. 2014;229:1417\u201326.","journal-title":"J Cell Physiol"},{"key":"2060_CR17","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.ygyno.2012.11.024","volume":"128","author":"K Matsuo","year":"2013","unstructured":"Matsuo K, Gray MJ, Yang DY, Srivastava SA, Tripathi PB, Sonoda LA, et al. The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival. Gynecol Oncol. 2013;128:552\u20139.","journal-title":"Gynecol Oncol"},{"key":"2060_CR18","doi-asserted-by":"publisher","first-page":"1362891","DOI":"10.3389\/fonc.2024.1362891","volume":"14","author":"S Lin","year":"2024","unstructured":"Lin S, Wei C, Wei Y, Fan J. Construction and verification of an endoplasmic reticulum stress-related prognostic model for endometrial cancer based on WGCNA and machine learning algorithms. Front Oncol. 2024;14:1362891.","journal-title":"Front Oncol"},{"key":"2060_CR19","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.3389\/fimmu.2019.02951","volume":"10","author":"P Diaz-Bulnes","year":"2019","unstructured":"Diaz-Bulnes P, Saiz ML, Lopez-Larrea C, Rodriguez RM. Crosstalk between hypoxia and ER stress response: a key regulator of macrophage polarization. Front Immunol. 2019;10:2951.","journal-title":"Front Immunol"},{"key":"2060_CR20","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1172\/JCI84426","volume":"126","author":"N Lin","year":"2016","unstructured":"Lin N, Simon MC. Hypoxia-inducible factors: key regulators of myeloid cells during inflammation. J Clin Invest. 2016;126:3661\u201371.","journal-title":"J Clin Invest"},{"key":"2060_CR21","doi-asserted-by":"publisher","first-page":"1250684","DOI":"10.1126\/science.1250684","volume":"345","author":"SC Cheng","year":"2014","unstructured":"Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, et al. mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014;345:1250684.","journal-title":"Science"},{"key":"2060_CR22","first-page":"857516","volume":"2012","author":"AH Schonthal","year":"2012","unstructured":"Schonthal AH. Endoplasmic reticulum stress: its role in disease and novel prospects for therapy. Scientifica (Cairo). 2012;2012:857516.","journal-title":"Scientifica (Cairo)"},{"key":"2060_CR23","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41576-021-00431-y","volume":"23","author":"I Cortes-Ciriano","year":"2022","unstructured":"Cortes-Ciriano I, Gulhan DC, Lee JJ, Melloni GEM, Park PJ. Computational analysis of cancer genome sequencing data. Nat Rev Genet. 2022;23:298\u2013314.","journal-title":"Nat Rev Genet"},{"key":"2060_CR24","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41568-022-00502-0","volume":"22","author":"P Jiang","year":"2022","unstructured":"Jiang P, Sinha S, Aldape K, Hannenhalli S, Sahinalp C, Ruppin E. Big data in basic and translational cancer research. Nat Rev Cancer. 2022;22:625\u201339.","journal-title":"Nat Rev Cancer"},{"key":"2060_CR25","doi-asserted-by":"publisher","first-page":"147052","DOI":"10.1016\/j.gene.2022.147052","volume":"852","author":"J Chen","year":"2023","unstructured":"Chen J, Luo X, Wang G, Zhang J, Zhang Y. Analysis of m(6)A methylation patterns and tumor microenvironment in endometrial cancer. Gene. 2023;852:147052.","journal-title":"Gene"},{"key":"2060_CR26","doi-asserted-by":"publisher","first-page":"1001374","DOI":"10.3389\/fgene.2022.1001374","volume":"13","author":"J Chen","year":"2022","unstructured":"Chen J, Wang G, Luo X, Zhang J, Zhang Y. Cuproptosis patterns and tumor microenvironment in endometrial cancer. Front Genet. 2022;13:1001374.","journal-title":"Front Genet"},{"key":"2060_CR27","unstructured":"National Cancer Institute. Genomic data commons data portal. Available from: https:\/\/portal.gdc.cancer.gov\/"},{"key":"2060_CR28","doi-asserted-by":"publisher","first-page":"998140","DOI":"10.3389\/fimmu.2022.998140","volume":"13","author":"J Li","year":"2022","unstructured":"Li J, Qiao H, Wu F, Sun S, Feng C, Li C, et al. A novel hypoxia- and lactate metabolism-related signature to predict prognosis and immunotherapy responses for breast cancer by integrating machine learning and bioinformatic analyses. Front Immunol. 2022;13:998140.","journal-title":"Front Immunol"},{"key":"2060_CR29","doi-asserted-by":"publisher","first-page":"3870","DOI":"10.1111\/jcmm.16321","volume":"25","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Guan G, Cheng P, Cheng W, Yang L, Wu A. Characterization of an endoplasmic reticulum stress-related signature to evaluate immune features and predict prognosis in glioma. J Cell Mol Med. 2021;25:3870\u201384.","journal-title":"J Cell Mol Med"},{"key":"2060_CR30","unstructured":"STRING Consortium. STRING. Protein-protein interaction networks functional enrichment analysis. Available from: https:\/\/cn.string-db.org\/"},{"key":"2060_CR31","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102:15545\u201350.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2060_CR32","unstructured":"National Cancer Institute Center for Cancer Research. CellMiner (NCI-60). Available from: https:\/\/discover.nci.nih.gov\/cellminer"},{"key":"2060_CR33","unstructured":"Innsbruck Medical University Institute of Bioinformatics. The cancer immunome atlas. Available from: https:\/\/tcia.at\/home"},{"key":"2060_CR34","doi-asserted-by":"publisher","first-page":"106223","DOI":"10.1016\/j.bspc.2024.106223","volume":"93","author":"L Feng","year":"2024","unstructured":"Feng L, Chen C, Wang L, Zhang J, Li Y, Yang T, et al. ECMS-NET: A multi-task model for early endometrial cancer MRI sequences classification and segmentation of key tumor structures. Biomed Signal Process Control. 2024;93:106223.","journal-title":"Biomed Signal Process Control"},{"key":"2060_CR35","doi-asserted-by":"publisher","first-page":"110069","DOI":"10.1016\/j.biopha.2020.110069","volume":"127","author":"S Chen","year":"2020","unstructured":"Chen S, Chen J, Hua X, Sun Y, Cui R, Sha J, et al. The emerging role of XBP1 in cancer. Biomed Pharmacother. 2020;127:110069.","journal-title":"Biomed Pharmacother"},{"key":"2060_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-016-2779-x","volume":"421","author":"A Tankiewicz-Kwedlo","year":"2016","unstructured":"Tankiewicz-Kwedlo A, Hermanowicz J, Surazynski A, Rozkiewicz D, Pryczynicz A, Domaniewski T, et al. Erythropoietin accelerates tumor growth through increase of erythropoietin receptor (EpoR) as well as by the stimulation of angiogenesis in DLD-1 and Ht-29 xenografts. Mol Cell Biochem. 2016;421:1\u201318.","journal-title":"Mol Cell Biochem"},{"key":"2060_CR37","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.ccell.2018.03.014","volume":"33","author":"AC Berger","year":"2018","unstructured":"Berger AC, Korkut A, Kanchi RS, Hegde AM, Lenoir W, Liu W, et al. A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers. Cancer Cell. 2018;33:690\u2013e7059.","journal-title":"Cancer Cell"},{"key":"2060_CR38","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1515\/HMBCI.2010.025","volume":"2","author":"S Sengupta","year":"2010","unstructured":"Sengupta S, Sharma CG, Jordan VC. Estrogen regulation of X-box binding protein-1 and its role in estrogen induced growth of breast and endometrial cancer cells. Horm Mol Biol Clin Investig. 2010;2:235\u201343.","journal-title":"Horm Mol Biol Clin Investig"},{"key":"2060_CR39","doi-asserted-by":"publisher","first-page":"9946","DOI":"10.1073\/pnas.1334037100","volume":"100","author":"AH Lee","year":"2003","unstructured":"Lee AH, Iwakoshi NN, Anderson KC, Glimcher LH. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A. 2003;100:9946\u201351.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2060_CR40","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1093\/carcin\/23.11.1797","volume":"23","author":"Y Yasuda","year":"2002","unstructured":"Yasuda Y, Fujita Y, Masuda S, Musha T, Ueda K, Tanaka H, et al. Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs. Carcinogenesis. 2002;23:1797\u2013805.","journal-title":"Carcinogenesis"},{"key":"2060_CR41","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1002\/cncr.20244","volume":"100","author":"G Acs","year":"2004","unstructured":"Acs G, Xu X, Chu C, Acs P, Verma A. Prognostic significance of erythropoietin expression in human endometrial carcinoma. Cancer. 2004;100:2376\u201386.","journal-title":"Cancer"},{"key":"2060_CR42","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/modpathol.2015.147","volume":"29","author":"IC Van Gool","year":"2016","unstructured":"Van Gool IC, Stelloo E, Nout RA, Nijman HW, Edmondson RJ, Church DN, et al. Prognostic significance of L1CAM expression and its association with mutant p53 expression in high-risk endometrial cancer. Mod Pathol. 2016;29:174\u201381.","journal-title":"Mod Pathol"},{"key":"2060_CR43","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ygyno.2016.02.003","volume":"141","author":"TH Dellinger","year":"2016","unstructured":"Dellinger TH, Smith DD, Ouyang C, Warden CD, Williams JC, Han ES. L1CAM is an independent predictor of poor survival in endometrial cancer - An analysis of The Cancer Genome Atlas (TCGA). Gynecol Oncol. 2016;141:336\u201340.","journal-title":"Gynecol Oncol"},{"key":"2060_CR44","doi-asserted-by":"publisher","first-page":"421","DOI":"10.21873\/anticanres.13128","volume":"39","author":"J Klat","year":"2019","unstructured":"Klat J, Mladenka A, Dvorackova J, Bajsova S, Simetka O. L1CAM as a negative prognostic factor in endometrioid endometrial adenocarcinoma FIGO stage IA-IB. Anticancer Res. 2019;39:421\u20134.","journal-title":"Anticancer Res"},{"key":"2060_CR45","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1002\/cncr.33567","volume":"127","author":"ME Urick","year":"2021","unstructured":"Urick ME, Yu EJ, Bell DW. High-risk endometrial cancer proteomic profiling reveals that FBXW7 mutation alters L1CAM and TGM2 protein levels. Cancer. 2021;127:2905\u201315.","journal-title":"Cancer"},{"key":"2060_CR46","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1002\/cncr.33782","volume":"127","author":"S Lehrer","year":"2021","unstructured":"Lehrer S, Rheinstein PH. FBXW7, L1CAM, and TGM2 in endometrial cancer. Cancer. 2021;127:4103\u20134.","journal-title":"Cancer"},{"key":"2060_CR47","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1002\/1097-0142(20001115)89:10<2059::AID-CNCR5>3.0.CO;2-3","volume":"89","author":"N Takai","year":"2000","unstructured":"Takai N, Miyazaki T, Fujisawa K, Nasu K, Miyakawa I. Expression of c-Ets1 is associated with malignant potential in endometrial carcinoma. Cancer. 2000;89:2059\u201367.","journal-title":"Cancer"},{"key":"2060_CR48","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1097\/IGC.0b013e31822c271f","volume":"21","author":"W Yamagami","year":"2011","unstructured":"Yamagami W, Susumu N, Tanaka H, Hirasawa A, Banno K, Suzuki N, et al. Immunofluorescence-detected infiltration of CD4\u2009+\u2009FOXP3+ regulatory T cells is relevant to the prognosis of patients with endometrial cancer. Int J Gynecol Cancer. 2011;21:1628\u201334.","journal-title":"Int J Gynecol Cancer"},{"key":"2060_CR49","doi-asserted-by":"crossref","unstructured":"Reiser J, Banerjee A. Effector. Memory, and dysfunctional CD8(+) T cell fates in the antitumor immune response. J Immunol Res. 2016; 2016:8941260.","DOI":"10.1155\/2016\/8941260"},{"key":"2060_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.csbj.2018.11.004","volume":"17","author":"NR Maimela","year":"2019","unstructured":"Maimela NR, Liu S, Zhang Y. Fates of CD8\u2009+\u2009T cells in tumor microenvironment. Comput Struct Biotechnol J. 2019;17:1\u201313.","journal-title":"Comput Struct Biotechnol J"},{"key":"2060_CR51","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ygyno.2009.03.022","volume":"114","author":"RA de Jong","year":"2009","unstructured":"de Jong RA, Leffers N, Boezen HM, ten Hoor KA, van der Zee AG, Hollema H, et al. Presence of tumor-infiltrating lymphocytes is an independent prognostic factor in type I and II endometrial cancer. Gynecol Oncol. 2009;114:105\u201310.","journal-title":"Gynecol Oncol"},{"key":"2060_CR52","doi-asserted-by":"publisher","first-page":"e27879","DOI":"10.1016\/j.heliyon.2024.e27879","volume":"10","author":"J Liu","year":"2024","unstructured":"Liu J, Qu Y, Li YY, Xu YL, Yan YF, Qin H. Exploring prognostic microbiota markers in patients with endometrial carcinoma: Intratumoral insights. Heliyon. 2024;10:e27879.","journal-title":"Heliyon"},{"key":"2060_CR53","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1182\/blood-2018-11-844548","volume":"133","author":"MA Giese","year":"2019","unstructured":"Giese MA, Hind LE, Huttenlocher A. Neutrophil plasticity in the tumor microenvironment. Blood. 2019;133:2159\u201367.","journal-title":"Blood"},{"key":"2060_CR54","doi-asserted-by":"crossref","unstructured":"Canel M, Taggart D, Sims AH, Lonergan DW, Waizenegger IC, Serrels A. T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity. Elife. 2020; 9.","DOI":"10.7554\/eLife.48092"},{"key":"2060_CR55","doi-asserted-by":"crossref","unstructured":"Chen Q, Wang C, Lei X, Huang T, Zhou R, Lu Y. Immune cytolytic activity for comprehensive insights of the immune landscape in endometrial carcinoma. J Oncol. 2022; 2022:9060243.","DOI":"10.1155\/2022\/9060243"},{"key":"2060_CR56","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1530\/ERC-11-0045","volume":"18","author":"GL Gravina","year":"2011","unstructured":"Gravina GL, Marampon F, Petini F, Biordi L, Sherris D, Jannini EA, et al. The TORC1\/TORC2 inhibitor, Palomid 529, reduces tumor growth and sensitizes to docetaxel and cisplatin in aggressive and hormone-refractory prostate cancer cells. Endocr Relat Cancer. 2011;18:385\u2013400.","journal-title":"Endocr Relat Cancer"},{"key":"2060_CR57","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1038\/onc.2010.603","volume":"30","author":"T Xiang","year":"2011","unstructured":"Xiang T, Jia Y, Sherris D, Li S, Wang H, Lu D, et al. Targeting the Akt\/mTOR pathway in Brca1-deficient cancers. Oncogene. 2011;30:2443\u201350.","journal-title":"Oncogene"},{"key":"2060_CR58","unstructured":"Joseph JD, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E et al. The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer. Elife 2016; 5."},{"key":"2060_CR59","doi-asserted-by":"publisher","first-page":"726794","DOI":"10.3389\/fonc.2021.726794","volume":"11","author":"F Gao","year":"2021","unstructured":"Gao F, Wang Z, Gu J, Zhang X, Wang H. A hypoxia-associated prognostic gene signature risk model and prognosis predictors in gliomas. Front Oncol. 2021;11:726794.","journal-title":"Front Oncol"},{"key":"2060_CR60","doi-asserted-by":"publisher","first-page":"619396","DOI":"10.3389\/fcell.2021.619396","volume":"9","author":"R Huang","year":"2021","unstructured":"Huang R, Li G, Wang K, Wang Z, Zeng F, Hu H, et al. Comprehensive analysis of the clinical and biological significances of endoplasmic reticulum stress in diffuse gliomas. Front Cell Dev Biol. 2021;9:619396.","journal-title":"Front Cell Dev Biol"},{"key":"2060_CR61","doi-asserted-by":"publisher","first-page":"641487","DOI":"10.3389\/fonc.2021.641487","volume":"11","author":"P Liu","year":"2021","unstructured":"Liu P, Wei J, Mao F, Xin Z, Duan H, Du Y, et al. Establishment of a prognostic model for hepatocellular carcinoma based on endoplasmic reticulum stress-related gene analysis. Front Oncol. 2021;11:641487.","journal-title":"Front Oncol"},{"key":"2060_CR62","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2174\/1574892817666220623154831","volume":"18","author":"L Xie","year":"2022","unstructured":"Xie L, Pan M, Zhang Z, Jiang X, Chen Y, Liu G, et al. Development and validation of a hypoxia-related prognostic model for ovarian cancer. Recent Pat Anticancer Drug Discov. 2022;18:161\u201373.","journal-title":"Recent Pat Anticancer Drug Discov"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-026-02060-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-026-02060-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-026-02060-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:02:56Z","timestamp":1777946576000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-026-02060-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["2060"],"URL":"https:\/\/doi.org\/10.1007\/s43032-026-02060-4","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study protocol was reviewed and the need for approval was waived by Affiliated Hospital of Yan\u2019an University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare that they have no conflicts of interest with the contents of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}