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MSCs were isolated from healthy donors, cultured, characterized by flow cytometry, and labeled with BrdU. At the third week, 2\u2009\u00d7\u200910\u2076 cells in PBS were injected into the ovaries via the endometrial canal. At the sixth week, rats were sacrificed, and ovarian tissues were analyzed histopathologically and immunohistochemically. The results showed that streptozotocin-induced diabetes mellitus led to structural alterations in ovarian follicles. Notably, bone marrow- and ovary-derived MSCs were effective in ameliorating these changes, while endometrium-derived MSCs showed moderate effects. These findings suggest that MSCs have therapeutic potential to mitigate ovarian dysfunction caused by pancreatic \u03b2-cell injury and hyperglycemia, highlighting their possible role as a cellular therapy in models of STZ-induced ovarian impairment.<\/jats:p>","DOI":"10.1007\/s43032-026-02063-1","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:33:32Z","timestamp":1772735612000},"page":"786-800","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Potential of Bone Marrow- and Ovarian\/Endometrium-Derived Mesenchymal Stem Cells in Regulating Ovarian Function in a Streptozotocin-Induced Diabetes Mellitus Rat Model"],"prefix":"10.1007","volume":"33","author":[{"given":"Eda","family":"Tun\u00e7","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7366-1569","authenticated-orcid":false,"given":"Naz","family":"Dizeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferda Alpaslan","family":"P\u0131narl\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"issue":"2","key":"2063_CR1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s10517-021-05191-7","volume":"171","author":"MA Darenskaya","year":"2021","unstructured":"Darenskaya MA, Kolesnikova LI, Kolesnikov SI. 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