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After inducing experimental diabetes in the DM\u2009+\u2009HT group, 5 mg\/kg\/day Hydroxytyrosol was administered. The HT group received 5 mg\/kg\/day Hydroxytyrosol. After all treatments were completed, the experiment was terminated and testicular tissues were taken for analyses. Experimental DM model caused oxidative stress, histopathological changes, increase in pro-inflammatory cytokines, decrease in OTULIN levels and increase in apoptotic germ cells in testicular tissues. In contrast, HT supplementation to rats with experimental DM was found to modulate these adverse effects to a great extent. In conclusion, HT may have anti-inflammatory, anti-oxidant and anti-diabetic effects against DM and related damage in testicular tissues by regulating OTULIN levels.<\/jats:p>","DOI":"10.1007\/s43032-026-02085-9","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:28:08Z","timestamp":1773930488000},"page":"593-603","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Hydroxytyrosol on OTULIN Levels in Test\u0131cular T\u0131ssue in Exper\u0131mental D\u0131abetes Model Induced w\u0131th Streptozotocin"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-9832","authenticated-orcid":false,"given":"Tuba","family":"Yal\u00e7\u0131n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9014-2448","authenticated-orcid":false,"given":"Sercan","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"2085_CR1","doi-asserted-by":"publisher","first-page":"122149","DOI":"10.1016\/j.saa.2022.122149","volume":"288","author":"FK Baloglu","year":"2023","unstructured":"Baloglu FK, Tas DG, Yilmaz O, Severcan F. 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