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HDACs play a key role in the epigenetic control of fertility in both sexes. Understanding their isoform-specific functions could help create more focused treatments for infertility and increase the success of reproduction. This review elucidates the mechanisms by which HDACs contribute to infertility and explores their potential as therapeutic targets in reproductive medicine.<\/jats:p>","DOI":"10.1007\/s43032-026-02104-9","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:13:48Z","timestamp":1777043628000},"page":"1119-1134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decoding Infertility: the Epigenetic Influence of HDACs on Reproductive Function"],"prefix":"10.1007","volume":"33","author":[{"given":"Annanya","family":"Kapur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashaswini","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda","family":"Rajagopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruthi","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil Viren","family":"D\u2019Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipshita","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-9353","authenticated-orcid":false,"given":"Babitha Kampa","family":"Sundara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"2104_CR1","unstructured":"American Society for Reproductive Medicine (ASRM). 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