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Sci."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometriosis is a complex chronic inflammatory disease with an unclear etiology and limited treatment options, severely affecting the reproductive health and quality of life of many women. Histone deacetylases (HDACs), as key epigenetic regulatory molecules, play a significant role in the pathogenesis and progression of endometriosis. This article reviews the abnormal expression of HDACs in endometriosis and their molecular mechanisms in driving the disease by regulating processes such as cell proliferation, apoptosis, inflammation, and epithelial-mesenchymal transition (EMT). It also summarizes the therapeutic potential of histone deacetylase inhibitors (HDACis) such as Vorinostat, Romidepsin, and Butyrate demonstrated in preclinical studies, and analyzes the main challenges currently faced in clinical translation. 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This manuscript is a review article and does not involve human participants or animals.","order":1,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors consent to publication of this manuscript.","order":3,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This manuscript is a narrative review based exclusively on previously published studies. 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