{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:56:18Z","timestamp":1791212178475,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"DOI":"10.1007\/s43032-026-02223-3","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:38:42Z","timestamp":1791211122000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Therapeutic Effects of Cytokine-Rich Serum and Platelet-Rich Plasma in a Rat Model of Ovarian Ischemia-Reperfusion Injury"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6050-6765","authenticated-orcid":false,"given":"Erol","family":"Karaka\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanifi","family":"Erol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ermi\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Ak\u00e7akavak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevzat Emre","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zhan","family":"Karata\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"4","key":"2223_CR1","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.ejogrb.2014.01.017","volume":"37","author":"P \u00d6zcan","year":"2020","unstructured":"Parlakgumus HA, Aka Bolat F, Bulgan Kilicdag E, Simsek E, Parlakgumus A. Atorvastatin for ovarian torsion: effects on follicle counts, AMH, and VEGF expression. Eur J Obstet Gynecol Reprod Biol. 2014;175:186\u2013190. https:\/\/doi.org\/10.1016\/j.ejogrb.2014.01.017.","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"2223_CR2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.18502\/ijrm.v23i11.20544","volume":"43","author":"H Gen\u00e7","year":"2021","unstructured":"Bagheri RB, Mohammadian S. Unveiling the molecular nexus: long non-coding RNAs, RNA-binding proteins, and DNA damage in ovarian ischemia-reperfusion injury: A narrative review. Int J Reprod Biomed. 2026;23(11):881\u201396. https:\/\/doi.org\/10.18502\/ijrm.v23i11.20544.","journal-title":"Cukurova Med J"},{"issue":"3","key":"2223_CR3","doi-asserted-by":"publisher","first-page":"R114","DOI":"10.1186\/ar3050","volume":"12","author":"M Rutgers","year":"2010","unstructured":"Rutgers M, Saris DB, Dhert WJ, Creemers LB. Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection. Arthritis Res Ther. 2010;12(3):R114. https:\/\/doi.org\/10.1186\/ar3050.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"2223_CR4","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1186\/s12884-023-06140-0","volume":"23","author":"NM Shalma","year":"2023","unstructured":"Shalma NM, Salamah HM, Alsawareah A, Shaarawy AS, Mohamed MR, Manirambona E, Abd-ElGawad M. The efficacy of intrauterine infusion of platelet-rich plasma in women undergoing assisted reproduction: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2023;23(1):843. https:\/\/doi.org\/10.1186\/s12884-023-06140-0.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"24","key":"2223_CR5","doi-asserted-by":"publisher","first-page":"15942","DOI":"10.3390\/ijms232415942","volume":"23","author":"A Rodr\u00edguez-Eguren","year":"2022","unstructured":"Rodr\u00edguez-Eguren A, G\u00f3mez-\u00c1lvarez M, Franc\u00e9s-Herrero E, Romeu M, Ferrero H, Seli E, Cervell\u00f3 I. Human umbilical cord-based therapeutics: stem cells and blood derivatives for female reproductive medicine. Int J Mol Sci. 2022;23(24):15942. https:\/\/doi.org\/10.3390\/ijms232415942.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2223_CR6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000440617","volume":"81","author":"M Bakacak","year":"2016","unstructured":"Bakacak M, Bostanci MS, \u0130nanc F, Yaylali A, Serin S, Attar R, Yildirim G, Yildirim OK. Protective effect of platelet-rich plasma on experimental ischemia\/reperfusion injury in rat ovary. Gynecol Obstet Invest. 2016;81(3):225\u201331. 10.1159\/000440617. https:\/\/doi.org\/10.1159\/000440617.","journal-title":"Gynecol Obstet Invest"},{"issue":"2","key":"2223_CR7","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1080\/08977194.2021.2012467","volume":"44","author":"\u00d6 Budak","year":"2022","unstructured":"Shakouri SK, Dolati S, Santhakumar J, Thakor AS, Yarani R. Autologous conditioned serum for degenerative diseases and prospects. Growth Factors (Chur, Switzerland), 2021;39(1-6):59\u201370. https:\/\/doi.org\/10.1080\/08977194.2021.2012467.","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"6","key":"2223_CR8","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1111\/jog.15232","volume":"48","author":"MS Bostanc\u0131","year":"2022","unstructured":"Bostanc\u0131 MS, Budak \u00d6, \u00c7akiro\u011flu H, G\u00f6k K, K\u00f6se O, \u00c7okluk E. The protective effect of platelet-rich plasma against experimental ischemia\/reperfusion injury in the rat ovary on in vitro fertilization outcomes. J Obstet Gynaecol Res. 2022;48(6):1390\u20138. https:\/\/doi.org\/10.1111\/jog.15232.","journal-title":"J Obstet Gynaecol Res"},{"issue":"11","key":"2223_CR9","doi-asserted-by":"publisher","first-page":"10211","DOI":"10.18632\/aging.103403","volume":"12","author":"Y Cakiroglu","year":"2020","unstructured":"Cakiroglu Y, Saltik A, Yuceturk A, Karaosmanoglu O, Kopuk SY, Scott RT, Tiras B, Seli E. Effects of intraovarian injection of autologous platelet-rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency. Aging. 2020;12(11):10211\u201322. https:\/\/doi.org\/10.18632\/aging.103403.","journal-title":"Aging"},{"key":"2223_CR10","doi-asserted-by":"publisher","first-page":"100028","DOI":"10.4103\/cjp.cjp_3_22","volume":"2","author":"J Wang","year":"2021","unstructured":"Allam EA, Abdel Moniem RA, Soliman GY. Functional and structural assessment of the possible protective effect of platelet-rich plasma against ischemia\/reperfusion-induced ovarian injury in adult rats. Chin J Physiol. 2022;65(2);64\u201371. https:\/\/doi.org\/10.4103\/cjp.cjp_3_22.","journal-title":"Curr Res Pharmacol Drug Discov"},{"key":"2223_CR11","doi-asserted-by":"publisher","first-page":"102459","DOI":"10.1016\/j.tice.2024.102459","volume":"89","author":"F Kazak","year":"2024","unstructured":"Kazak F, Akcakavak G, Alakus I, Alakus H, Kirgiz O, Karatas O, Deveci MZY, Coskun P. Proanthocyanidin alleviates testicular torsion\/detorsion-induced ischemia\/reperfusion injury in rats. Tissue Cell. 2024;89:102459. https:\/\/doi.org\/10.1016\/j.tice.2024.102459.","journal-title":"Tissue Cell"},{"issue":"4","key":"2223_CR12","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1080\/15376516.2023.2297234","volume":"34","author":"G Akcakavak","year":"2024","unstructured":"Akcakavak G, Kazak F, Karatas O, Alakus H, Alakus I, Kirgiz O, Celik Z, Yilmaz Deveci MZ, Ozdemir O, Tuzcu M. Eucalyptol regulates Nrf2 and NF-\u03baB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis. Toxicol Mech Methods. 2024;34(4):413\u201322. https:\/\/doi.org\/10.1080\/15376516.2023.2297234.","journal-title":"Toxicol Mech Methods"},{"issue":"6","key":"2223_CR13","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1007\/s12011-023-03871-1","volume":"202","author":"E Karaman","year":"2024","unstructured":"Karaman E, Onder GO, Goktepe O, Karakas E, Mat OC, Bolat D, Koseoglu E, Tur K, Baran M, Ermis M, Balcioglu E, Yay A. Protective effects of boric acid taken in different ways on experimental ovarian ischemia and reperfusion. Biol Trace Elem Res. 2024;202(6):2730\u201343. https:\/\/doi.org\/10.1007\/s12011-023-03871-1.","journal-title":"Biol Trace Elem Res"},{"key":"2223_CR14","doi-asserted-by":"publisher","first-page":"12123","DOI":"10.18632\/aging.206099","volume":"16","author":"M Cozzolino","year":"2024","unstructured":"Cozzolino M, Ergun Y, Seli DA, Herraiz S. Intraovarian PRP injection improves oocyte quality and early embryo development in mouse models of chemotherapy-induced diminished ovarian reserve. Aging. 2024;16:12123\u201337. https:\/\/doi.org\/10.18632\/aging.206099.","journal-title":"Aging"},{"issue":"9","key":"2223_CR15","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1080\/09513590.2018.1450378","volume":"34","author":"C Nayki","year":"2018","unstructured":"Nayki C, et al. The effect of rutin on ovarian ischemia-reperfusion injury in a rat model. Gynecol Endocrinol. 2018;34(9):809\u201314. https:\/\/doi.org\/10.1080\/09513590.2018.1450378.","journal-title":"Gynecol Endocrinol"},{"issue":"10","key":"2223_CR16","doi-asserted-by":"publisher","first-page":"300060520964661","DOI":"10.1177\/0300060520964661","volume":"48","author":"H Ren","year":"2020","unstructured":"Ren H, Zhang S, Wang X, Li Z, Guo W. Role of platelet-rich plasma in the treatment of osteoarthritis: a meta-analysis. J Int Med Res. 2020;48(10):300060520964661. https:\/\/doi.org\/10.1177\/0300060520964661.","journal-title":"J Int Med Res"},{"issue":"1","key":"2223_CR17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/agm2.12196","volume":"5","author":"ES Sills","year":"2022","unstructured":"Sills ES. Ovarian recovery via autologous platelet-rich plasma: new benchmarks for condensed cytokine applications to reverse reproductive aging. Aging Med (Milton). 2022;5(1):63\u20137. https:\/\/doi.org\/10.1002\/agm2.12196.","journal-title":"Aging Med (Milton)"},{"issue":"10","key":"2223_CR18","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1177\/1933719118816839","volume":"26","author":"I Hortu","year":"2019","unstructured":"Hortu I, Ozceltik G, Sahin C, Akman L, Yildirim N, Erbas O. Granulocyte colony-stimulating factor prevents ischemia\/reperfusion-induced ovarian injury in rats: evaluation of histological and biochemical parameters. Reprod Sci. 2019;26(10):1389\u201394. https:\/\/doi.org\/10.1177\/1933719118816839.","journal-title":"Reprod Sci"},{"issue":"6","key":"2223_CR19","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.3390\/ijms241713299","volume":"58","author":"HY Jang","year":"2017","unstructured":"Tognoloni A, Bartolini D, Pepe M, Di Meo A, Porcellato I, Guidoni K, Galli F, Chiaradia E. Platelets rich plasma increases antioxidant defenses of tenocytes via Nrf2 signal pathway. Int J Mol Sci. 2023;24(17):13299. https:\/\/doi.org\/10.3390\/ijms241713299.","journal-title":"Yonsei Med J"},{"issue":"9","key":"2223_CR20","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1080\/15376516.2018.1491662","volume":"28","author":"F Dehghani","year":"2018","unstructured":"Dehghani F, Aboutalebi H, Esmaeilpour T, Panjehshahin MR, Bordbar H. Effect of platelet-rich plasma (PRP) on ovarian structures in cyclophosphamide-induced ovarian failure in female rats: a stereological study. Toxicol Mech Methods. 2018;28(9):653\u20139. https:\/\/doi.org\/10.1080\/15376516.2018.1491662.","journal-title":"Toxicol Mech Methods"},{"issue":"3","key":"2223_CR21","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.rbmo.2021.06.019","volume":"43","author":"L Cacciottola","year":"2021","unstructured":"Cacciottola L, Donnez J, Dolmans MM. Ovarian tissue damage after grafting: systematic review of strategies to improve follicle outcomes. Reprod Biomed Online. 2021;43(3):351\u201369. https:\/\/doi.org\/10.1016\/j.rbmo.2021.06.019.","journal-title":"Reprod Biomed Online"},{"issue":"8","key":"2223_CR22","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1080\/01443615.2019.1701639","volume":"40","author":"I Hortu","year":"2020","unstructured":"Hortu I, Ilgen O, Sahin C, Akdemir A, Yigitturk G, Erbas O. Losartan ameliorates ovarian ischaemia\/reperfusion injury in rats: an experimental study. J Obstet Gynaecol. 2020;40(8):1148\u201354.","journal-title":"J Obstet Gynaecol"},{"issue":"5","key":"2223_CR23","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1128\/MCB.19.10.7203","volume":"62","author":"M Ingec","year":"2011","unstructured":"Peruzzi F, Prisco M, Dews M, Salomoni P, Grassilli E, Romano G, Calabretta B, Baserga R. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol. 1999;19(10):7203\u201315. https:\/\/doi.org\/10.1128\/MCB.19.10.7203.","journal-title":"J Physiol Pharmacol"},{"issue":"1","key":"2223_CR24","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/humrep\/det391","volume":"29","author":"F Li","year":"2014","unstructured":"Li F, Turan V, Lierman S, Cuvelier C, De Sutter P, Oktay K. Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death. Hum Reprod. 2014;29(1):107\u201313. https:\/\/doi.org\/10.1093\/humrep\/det391.","journal-title":"Hum Reprod"},{"issue":"3","key":"2223_CR25","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/humrep\/17.3.605","volume":"17","author":"J Van der Liu","year":"2002","unstructured":"Liu J, Van der Elst J, Van den Broecke R, Dhont M. Early massive follicle loss and apoptosis in heterotopically grafted newborn mouse ovaries. Hum Reprod. 2002;17(3):605\u201311. https:\/\/doi.org\/10.1093\/humrep\/17.3.605.","journal-title":"Hum Reprod"},{"key":"2223_CR26","doi-asserted-by":"publisher","first-page":"1292168","DOI":"10.3389\/fendo.2023.1292168","volume":"14","author":"X Li","year":"2023","unstructured":"Li X, Liu H, Lin G, Xu L. The effect of ovarian injection of autologous platelet-rich plasma in patients with poor ovarian responder: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023;14:1292168. https:\/\/doi.org\/10.3389\/fendo.2023.1292168.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"2223_CR27","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1080\/15376516.2022.2057264","volume":"32","author":"H Aboutalebi","year":"2022","unstructured":"Aboutalebi H, Alipour F, Ebrahimzadeh-Bideskan A. The protective effect of co-administration of platelet-rich plasma (PRP) and pentoxifylline (PTX) on cyclophosphamide-induced premature ovarian failure in mature and immature rats. Toxicol Mech Methods. 2022;32(8):588\u201396. https:\/\/doi.org\/10.1080\/15376516.2022.2057264.","journal-title":"Toxicol Mech Methods"},{"issue":"2","key":"2223_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.4274\/anajog.galenos.2024.29392","volume":"1","author":"H G\u00f6z\u00fcyukar\u0131","year":"2024","unstructured":"G\u00f6z\u00fcyukar\u0131 H, K\u0131l\u0131\u00e7 SH. Thrombocyte-rich plasma in gynecology: a review. Anatol J Obstet Gynecol Res. 2024;1(2):41\u20137. https:\/\/doi.org\/10.4274\/anajog.galenos.2024.29392.","journal-title":"Anatol J Obstet Gynecol Res"},{"key":"2223_CR29","doi-asserted-by":"publisher","unstructured":"Wang Z, Wang Y, Yang T, Li J, Yang X. Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice. Stem Cell Res Ther. 2017;8(1):11. https:\/\/doi.org\/10.1186\/s13287-016-0458-1. Erratum in: Stem Cell Res Ther. 2017;8(1):49.\u00a0https:\/\/doi.org\/10.1186\/s13287-017-0526-1.","DOI":"10.1186\/s13287-016-0458-1"},{"issue":"2","key":"2223_CR30","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/bcpt.13696","volume":"130","author":"S Zheng","year":"2022","unstructured":"Zheng S, Ma M, Chen Y, Li M. Effects of quercetin on ovarian function and regulation of the ovarian PI3K\/Akt\/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure. Basic Clin Pharmacol Toxicol. 2022;130(2):240\u201353. https:\/\/doi.org\/10.1111\/bcpt.13696.","journal-title":"Basic Clin Pharmacol Toxicol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-026-02223-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-026-02223-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-026-02223-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:38:43Z","timestamp":1791211123000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-026-02223-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":30,"alternative-id":["2223"],"URL":"https:\/\/doi.org\/10.1007\/s43032-026-02223-3","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"assertion":[{"value":"24 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experimental procedures were approved by the Erciyes University Animal Experiments Local Ethics Committee (HADYEK), under Decision No: 24\/026. All animals were obtained from the Experimental Research and Application Center (DEKAM), Erciyes University. Since no privately-owned animals were used, informed consent was not required. All procedures were conducted in accordance with institutional and international guidelines for the care and use of laboratory animals.","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":2,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The subjects in this trial have not concomitantly been involved in other randomized trials. Data regarding any of the subjects in the study has not been previously published unless specified. Data will be made available to the editors of the journal for review or query upon request.","order":3,"name":"Ethics","label":"Attestation Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"ACRS and PRP attenuate ovarian I\/R injury in rats, with ACRS being associated with more pronounced improvements in histological integrity, follicular preservation, and angiogenesis.","order":5,"name":"Ethics","label":"Capsule","group":{"name":"EthicsHeading","label":"Declarations"}}]}}