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Sci."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) plays an important role in placental function. Its bioavailability depends on the balance between enzymatic synthesis by cystathionine \u03b2-synthase (CBS), cystathionine \u03b3-lyase (CSE\/\n                    <jats:italic>CTH)<\/jats:italic>\n                    and 3-mercaptopyruvate sulfurtransferase (3-MST\/\n                    <jats:italic>MPST<\/jats:italic>\n                    ), and mitochondrial oxidation through sulfide:quinone oxidoreductase (SQOR), persulfide dioxygenase (ETHE1) and thiosulfate sulfurtransferase (TST). However, the extent to which H\n                    <jats:sub>2<\/jats:sub>\n                    S synthesis, oxidation and experimental modulation have been investigated in placental systems remains unclear. This scoping review mapped the placental H\n                    <jats:sub>2<\/jats:sub>\n                    S literature to identify where evidence is concentrated and where gaps remain. Following JBI methodology and PRISMA-ScR reporting, Scopus, Embase, MEDLINE and Web of Science were searched for primary studies involving placental or trophoblast H\u2082S biology. Sixty-four studies were included. Pre-eclampsia dominated the literature (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200927), while most other pregnancy conditions were sparsely represented. CBS and CSE\/\n                    <jats:italic>CTH<\/jats:italic>\n                    were investigated in 34 and 29 studies respectively, while 3-MST\/\n                    <jats:italic>MPST<\/jats:italic>\n                    was investigated in only seven studies. None of the included studies assessed the principal mitochondrial sulfide-oxidation enzymes SQOR, ETHE1 or TST. Sulfide concentrations, relative assay signals or H\n                    <jats:sub>2<\/jats:sub>\n                    S production were reported in 23 studies across six analytical approaches. Sulfide measurement was highly heterogeneous across studies, making direct comparison between studies limited. H\n                    <jats:sub>2<\/jats:sub>\n                    S was experimentally modulated in 85 intervention applications but measured in only 23. Overall, placental H\n                    <jats:sub>2<\/jats:sub>\n                    S research is concentrated on biosynthetic enzyme expression and pre-eclampsia, while sulfide clearance, early gestation and standardised measurement remain major gaps. These gaps limit interpretation of changes in placental H\n                    <jats:sub>2<\/jats:sub>\n                    S bioavailability and the evaluation of donor-based therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1007\/s43032-026-02236-y","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:00:33Z","timestamp":1791925233000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping Hydrogen Sulfide Biosynthesis and Oxidation Pathways in Placental Health and Disease: a Scoping Review"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1592-7776","authenticated-orcid":false,"given":"Anord","family":"Nkuba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Bushell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leni R.","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Aston-Mourney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik Q.","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-2925","authenticated-orcid":false,"given":"Bryony A.","family":"McNeill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"2236_CR1","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1152\/physrev.00017.2011","volume":"92","author":"R Wang","year":"2012","unstructured":"Wang R. 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