{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:41:54Z","timestamp":1792680114133,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Zhejiang Medical and Health Science and Technology Program","award":["2025KY270, 2025KY1413"],"award-info":[{"award-number":["2025KY270, 2025KY1413"]}]},{"name":"Ningbo Municipal Key Laboratory of Major Gynecological Diseases and Reproductive Health","award":["Ningbo Municipal Key Laboratory of Major Gynecological Diseases and Reproductive Health"],"award-info":[{"award-number":["Ningbo Municipal Key Laboratory of Major Gynecological Diseases and Reproductive Health"]}]},{"name":"Ningbo Top Medical and Health Research Program","award":["2024021020"],"award-info":[{"award-number":["2024021020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"DOI":"10.1007\/s43032-026-02241-1","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:02:16Z","timestamp":1792677736000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["STAT3\/MTND4 Mediates Obesity-Related Seminal Vesicle Injury and Impaired Sperm Motility Via Reactive Oxygen Species \/Mitochondrial Dysfunction"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1207-8331","authenticated-orcid":false,"given":"Haiyue","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanya","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangxu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhao","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"issue":"10271","key":"2241_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/s0140-6736(20)32667-2","volume":"397","author":"A Agarwal","year":"2021","unstructured":"Agarwal A, Baskaran S, Parekh N, Cho CL, Henkel R, Vij S, et al. Male infertility. Lancet. 2021;397(10271):319\u201333. https:\/\/doi.org\/10.1016\/s0140-6736(20)32667-2.","journal-title":"Lancet"},{"issue":"3","key":"2241_CR2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/rmb2.12282","volume":"18","author":"T Noda","year":"2019","unstructured":"Noda T, Ikawa M. Physiological function of seminal vesicle secretions on male fecundity. Reprod Med Biol. 2019;18(3):241\u20136. https:\/\/doi.org\/10.1002\/rmb2.12282.","journal-title":"Reprod Med Biol"},{"key":"2241_CR3","doi-asserted-by":"publisher","first-page":"102393","DOI":"10.1016\/j.bpobgyn.2023.102393","volume":"90","author":"D Ameratunga","year":"2023","unstructured":"Ameratunga D, Gebeh A, Amoako A. Obesity and male infertility. Best Pract Res Clin Obstet Gynaecol. 2023;90:102393. https:\/\/doi.org\/10.1016\/j.bpobgyn.2023.102393.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"5","key":"2241_CR4","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1002\/oby.24269","volume":"33","author":"JM Mucinski","year":"2025","unstructured":"Mucinski JM, Kelley DE, Winters SJ, Goodpaster BH. Effects of weight loss on testosterone, sex hormone-binding globulin, adiposity, and insulin sensitivity in women and men. Obes (Silver Spring). 2025;33(5):962\u201373. https:\/\/doi.org\/10.1002\/oby.24269.","journal-title":"Obes (Silver Spring)"},{"issue":"4","key":"2241_CR5","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s10815-020-01707-8","volume":"37","author":"T Pini","year":"2020","unstructured":"Pini T, Parks J, Russ J, Dzieciatkowska M, Hansen KC, Schoolcraft WB, et al. Obesity significantly alters the human sperm proteome, with potential implications for fertility. J Assist Reprod Genet. 2020;37(4):777\u201387. https:\/\/doi.org\/10.1007\/s10815-020-01707-8.","journal-title":"J Assist Reprod Genet"},{"issue":"7","key":"2241_CR6","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1007\/s11695-019-03798-4","volume":"29","author":"B Calder\u00f3n","year":"2019","unstructured":"Calder\u00f3n B, Huerta L, Galindo J, Gonz\u00e1lez Casbas JM, Escobar-Morreale HF, Mart\u00edn-Hidalgo A, et al. Lack of improvement of sperm characteristics in obese males after obesity surgery despite the beneficial changes observed in reproductive hormones. Obes Surg. 2019;29(7):2045\u201350. https:\/\/doi.org\/10.1007\/s11695-019-03798-4.","journal-title":"Obes Surg"},{"issue":"8","key":"2241_CR7","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1007\/s10815-021-02199-w","volume":"38","author":"FW Dahadhah","year":"2021","unstructured":"Dahadhah FW, Jaweesh MS, Al Zoubi MS, Alarjah MIA, Hammadeh ME, Amor H. Mitochondrial nicotinamide adenine dinucleotide hydride dehydrogenase (NADH) subunit 4 (MTND4) polymorphisms and their association with male infertility. J Assist Reprod Genet. 2021;38(8):2021\u20139. https:\/\/doi.org\/10.1007\/s10815-021-02199-w.","journal-title":"J Assist Reprod Genet"},{"issue":"9","key":"2241_CR8","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1007\/s00417-020-04993-1","volume":"259","author":"S Sundaramurthy","year":"2021","unstructured":"Sundaramurthy S, SelvaKumar A, Ching J, Dharani V, Sarangapani S, Yu-Wai-Man P. Leber hereditary optic neuropathy-new insights and old challenges. Graefes Arch Clin Exp Ophthalmol. 2021;259(9):2461\u201372. https:\/\/doi.org\/10.1007\/s00417-020-04993-1.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"4","key":"2241_CR9","doi-asserted-by":"publisher","first-page":"100746","DOI":"10.1016\/j.mcpro.2024.100746","volume":"23","author":"S Dagar","year":"2024","unstructured":"Dagar S, Sharma M, Tsaprailis G, Tapia CS, Crynen G, Joshi PS, et al. Ribosome profiling and mass spectrometry reveal widespread mitochondrial translation defects in a striatal cell model of huntington disease. Mol Cell Proteom. 2024;23(4):100746. https:\/\/doi.org\/10.1016\/j.mcpro.2024.100746.","journal-title":"Mol Cell Proteom"},{"issue":"1","key":"2241_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12863-022-01032-2","volume":"23","author":"GC Cavalcante","year":"2022","unstructured":"Cavalcante GC, Ribeiro-Dos-Santos \u00c2, de Ara\u00fajo GS. Mitochondria in tumour progression: a network of mtDNA variants in different types of cancer. BMC Genom Data. 2022;23(1):16. https:\/\/doi.org\/10.1186\/s12863-022-01032-2.","journal-title":"BMC Genom Data"},{"key":"2241_CR11","unstructured":"JASPAR. Available from. https:\/\/jaspar.elixir.no\/"},{"key":"2241_CR12","doi-asserted-by":"crossref","unstructured":"St\u00e1rka L, Du\u0161kov\u00e1 M, Hill M. [Hypogonadismus ob\u00e9zn\u00edch mu\u017e\u016f]. Vnitr Lek.2020;66(8):24\u2009\u2013\u20097.","DOI":"10.36290\/vnl.2020.154"},{"key":"2241_CR13","doi-asserted-by":"publisher","first-page":"1520835","DOI":"10.3389\/fendo.2025.1520835","volume":"16","author":"Y Wang","year":"2025","unstructured":"Wang Y, Fu X, Li H. Mechanisms of oxidative stress-induced sperm dysfunction. Front Endocrinol (Lausanne). 2025;16:1520835. https:\/\/doi.org\/10.3389\/fendo.2025.1520835.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2241_CR14","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jes.2024.03.015","volume":"151","author":"SH Park","year":"2025","unstructured":"Park SH, Gye MC. Dibutyl phthalate disrupts [Ca(2+)](i), reactive oxygen species, [pH](i), protein kinases and mitochondrial activity, impairing sperm function. J Environ Sci (China). 2025;151:68\u201378. https:\/\/doi.org\/10.1016\/j.jes.2024.03.015.","journal-title":"J Environ Sci (China)"},{"key":"2241_CR15","doi-asserted-by":"publisher","unstructured":"Mercola J. Reductive stress and mitochondrial dysfunction: The hidden link in chronic disease. Free Radic Biol Med. 2025;233. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.03.029. :118\u2009\u2013\u200931.","DOI":"10.1016\/j.freeradbiomed.2025.03.029"},{"issue":"1","key":"2241_CR16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12964-020-0527-z","volume":"18","author":"JH Ma","year":"2020","unstructured":"Ma JH, Qin L, Li X. Role of STAT3 signaling pathway in breast cancer. Cell Commun Signal. 2020;18(1):33. https:\/\/doi.org\/10.1186\/s12964-020-0527-z.","journal-title":"Cell Commun Signal"},{"issue":"1","key":"2241_CR17","doi-asserted-by":"publisher","first-page":"18529","DOI":"10.1038\/s41598-025-03231-0","volume":"15","author":"MA Senousy","year":"2025","unstructured":"Senousy MA, Shaker OG, Gamal A, Aboraia NM, Ayeldeen G. Serum expression signature of TUG1, MALAT1, miR-483, and miR-141 and their targets TGF-\u03b21 and STAT3 in severe male factor infertility. Sci Rep. 2025;15(1):18529. https:\/\/doi.org\/10.1038\/s41598-025-03231-0.","journal-title":"Sci Rep"},{"issue":"1","key":"2241_CR18","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s00395-021-00898-0","volume":"116","author":"S Comita","year":"2021","unstructured":"Comita S, Femmino S, Thairi C, Alloatti G, Boengler K, Pagliaro P, et al. Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function. Basic Res Cardiol. 2021;116(1):56. https:\/\/doi.org\/10.1007\/s00395-021-00898-0.","journal-title":"Basic Res Cardiol"},{"key":"2241_CR19","doi-asserted-by":"publisher","first-page":"115151","DOI":"10.1016\/j.taap.2020.115151","volume":"404","author":"G Fu","year":"2020","unstructured":"Fu G, Dai J, Li Z, Chen F, Liu L, Yi L, et al. The role of STAT3\/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat. Toxicol Appl Pharmacol. 2020;404:115151. https:\/\/doi.org\/10.1016\/j.taap.2020.115151.","journal-title":"Toxicol Appl Pharmacol"},{"key":"2241_CR20","doi-asserted-by":"publisher","unstructured":"Peron M, Dinarello A, Meneghetti G, Martorano L, Betto RM, Facchinello N, et al. Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation. Development. 2021;148(17). https:\/\/doi.org\/10.1242\/dev.199477.","DOI":"10.1242\/dev.199477"},{"key":"2241_CR21","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.biocel.2015.05.017","volume":"65","author":"G Leman","year":"2015","unstructured":"Leman G, Gueguen N, Desquiret-Dumas V, Kane MS, Wettervald C, Chupin S, et al. Assembly defects induce oxidative stress in inherited mitochondrial complex I deficiency. Int J Biochem Cell Biol. 2015;65:91\u2013103. https:\/\/doi.org\/10.1016\/j.biocel.2015.05.017.","journal-title":"Int J Biochem Cell Biol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-026-02241-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-026-02241-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-026-02241-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:02:19Z","timestamp":1792677739000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-026-02241-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":21,"alternative-id":["2241"],"URL":"https:\/\/doi.org\/10.1007\/s43032-026-02241-1","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"29 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animal experiments were undertaken under the approval of the Animal Ethics Committee of Zhejiang Luoxi Medical Technology Co., Ltd., Hangzhou, China (Approval No.: LX4825040102).","order":1,"name":"Ethics","label":"Ethical statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no potential conflicts of interest","order":2,"name":"Ethics","label":"Conflict interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}