{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:18:59Z","timestamp":1791811139071,"version":"4.3.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spine Deform"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s43390-020-00107-3","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T17:03:18Z","timestamp":1586192598000},"page":"1093-1097","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Skip constructs in spinal muscular atrophy: outcomes of a novel approach for posterior spinal instrumentation and fusion"],"prefix":"10.1007","volume":"8","author":[{"given":"Matthew W.","family":"Konigsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob R.","family":"Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Roye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"issue":"9","key":"107_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1046\/j.1440-1754.2003.00266.x","volume":"39","author":"SY Chng","year":"2003","unstructured":"Chng SY, Wong YQ, Hui JH et al (2003) Pulmonary function and scoliosis in children with spinal muscular atrophy types II and III. J Paediatr Child Health 39(9):673\u2013676","journal-title":"J Paediatr Child Health"},{"issue":"2","key":"107_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/(SICI)1099-0496(200002)29:2<141::AID-PPUL9>3.0.CO;2-Y","volume":"29","author":"D Gozal","year":"2000","unstructured":"Gozal D (2000) Pulmonary manifestations of neuromuscular disease with special reference to Duchenne muscular dystrophy and spinal muscular atrophy. Pediatr Pulmonol 29(2):141\u2013150","journal-title":"Pediatr Pulmonol"},{"issue":"3","key":"107_CR3","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1177\/088307389400900321","volume":"9","author":"FJ Samaha","year":"1994","unstructured":"Samaha FJ, Buncher CR, Russman BS et al (1994) Pulmonary function in spinal muscular atrophy. J Child Neurol 9(3):326\u2013329","journal-title":"J Child Neurol"},{"issue":"4","key":"107_CR4","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/j.1469-8749.1989.tb04029.x","volume":"31","author":"L Merlini","year":"1989","unstructured":"Merlini L, Granata C, Bonfiglioli S et al (1989) Scoliosis in spinal muscular atrophy: natural history and management. Dev Med Child Neurol 31(4):501\u2013508","journal-title":"Dev Med Child Neurol"},{"issue":"suppl 1","key":"107_CR5","doi-asserted-by":"publisher","first-page":"148","DOI":"10.2106\/JBJS.F.00293","volume":"89","author":"DJ Sucato","year":"2007","unstructured":"Sucato DJ (2007) Spine deformity in spinal muscular atrophy. J Bone Joint Surg Am 89(suppl 1):148\u2013154","journal-title":"J Bone Joint Surg Am"},{"key":"107_CR6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2106\/00004623-197658010-00003","volume":"58","author":"RN Hensinger","year":"1976","unstructured":"Hensinger RN, MacEwen GD (1976) Spinal deformity associated with heritable neurological conditions: spinal muscular atrophy, Friedreich\u2019s ataxia, familial dysautonomia, and Charcot\u2013Marie\u2013Tooth disease. J Bone Joint Surg Am 58:13\u201324","journal-title":"J Bone Joint Surg Am"},{"key":"107_CR7","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/j.1469-8749.1974.tb04188.x","volume":"16","author":"V Dubowitz","year":"1974","unstructured":"Dubowitz V (1974) Benign infantile spinal muscular atrophy. Dev Med Child Neurol 16:672\u2013675","journal-title":"Dev Med Child Neurol"},{"issue":"7","key":"107_CR8","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1177\/0883073815627882","volume":"31","author":"M Hach\u00e9","year":"2016","unstructured":"Hach\u00e9 M, Swoboda KJ, Sethna N et al (2016) Intrathecal injections in children with spinal muscular atrophy: nusinersen clinical trial experience. J Child Neurol 31(7):899\u2013906","journal-title":"J Child Neurol"},{"key":"107_CR9","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1101\/gad.1941310","volume":"24","author":"Y Hua","year":"2010","unstructured":"Hua Y, Sahashi K, Hung G et al (2010) Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model. Genes Dev 24:1634\u20131644","journal-title":"Genes Dev"},{"key":"107_CR10","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.ajhg.2008.01.014","volume":"82","author":"Y Hua","year":"2008","unstructured":"Hua Y, Vickers TA, Okunola HL et al (2008) Antisense masking of an hnRNP A1\/A2 intronic splicing silencer corrects Ital splicing in transgenic mice. Am J Hum Genet 82:834\u2013848","journal-title":"Am J Hum Genet"},{"key":"107_CR11","unstructured":"U.S. National Library of Medicine. Genetics home reference: SMN1 gene. https:\/\/ghr.nlm.nih.gov\/gene\/SMN1. Accessed 27 June 2017"},{"key":"107_CR12","unstructured":"Clinical Trials, A Service of the U.S. National Institutes of Health. A study to assess the efficacy and safety of nusinersen (ISIS 396443) in participants with later-onset spinal muscular atrophy (SMA) (CHERISH).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02292537. Accessed 22 June 2017"},{"issue":"4","key":"107_CR13","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S1090-3798(03)00060-6","volume":"7","author":"M Main","year":"2003","unstructured":"Main M, Kairon H, Mercuri E et al (2003) The Hammersmith functional motor scale for children with spinal muscular atrophy: a scale to test ability and monitor progress in children with limited ambulation. Eur J Paediatr Neurol 7(4):155\u2013159","journal-title":"Eur J Paediatr Neurol"},{"key":"107_CR14","unstructured":"Mercuri E. Efficacy and safety of nusinersen in children with later-onset spinal muscular atrophy (SMA): end of study results from the phase 3 CHERISH study. American Academy of Neurology. American Academy of Neurology. 22 Apr 2017; Boston, MA. http:\/\/phx.corporate-ir.net\/External.File?t\u2009=\u20091&item\u2009=\u2009VHlwZT0yfFBhcmVudElEPTUyNTE0NTV8Q2hpbGRJRD02Njc0MzY\u2009=\u2009Accessed 20 June 2017"},{"issue":"3","key":"107_CR15","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s00247-017-4031-6","volume":"48","author":"JJ Weaver","year":"2018","unstructured":"Weaver JJ, Natarajan N, Dhaw DWW et al (2018) Transforaminal intrathecal delivery of nusinersen using cone-beam computed tomography for children with spinal muscular atrophy and extensive surgical instrumentation: early results of technical success and safety. Pediatr Radiol 48(3):392\u2013397. https:\/\/doi.org\/10.1007\/s00247-017-4031-6(Epub 2017 Nov 13)","journal-title":"Pediatr Radiol"},{"issue":"1","key":"107_CR16","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00415-018-9124-0","volume":"266","author":"CD Wurster","year":"2019","unstructured":"Wurster CD, Winter B, Wollinsky K et al (2019) Intrathecal administration of nusinersen in adolescent and adult SMA type 2 and 3 patients. J Neurol 266(1):183\u2013194. https:\/\/doi.org\/10.1007\/s00415-018-9124-0(Epub 2018 Nov 20)","journal-title":"J Neurol"},{"issue":"12","key":"107_CR17","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1007\/s00247-018-4206-9","volume":"48","author":"MA Mousa","year":"2018","unstructured":"Mousa MA, Aria DJ, Schaefer CM et al (2018) A comprehensive institutional overview of intrathecal nusinersen injections for spinal muscular atrophy. Pediatr Radiol 48(12):1797\u20131805. https:\/\/doi.org\/10.1007\/s00247-018-4206-9 (Epub 2018 Jul 18)","journal-title":"Pediatr Radiol"},{"issue":"16","key":"107_CR18","doi-asserted-by":"publisher","first-page":"E968","DOI":"10.1097\/BRS.0000000000002588","volume":"43","author":"L Miladi","year":"2018","unstructured":"Miladi L, Gaume M, Khouri N et al (2018) Minimally invasive surgery for neuromuscular scoliosis. Spine 43(16):E968\u2013E975","journal-title":"Spine"}],"container-title":["Spine Deformity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43390-020-00107-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s43390-020-00107-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43390-020-00107-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T23:24:10Z","timestamp":1617665050000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s43390-020-00107-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,6]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["107"],"URL":"https:\/\/doi.org\/10.1007\/s43390-020-00107-3","relation":{},"ISSN":["2212-134X","2212-1358"],"issn-type":[{"value":"2212-134X","type":"print"},{"value":"2212-1358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,6]]},"assertion":[{"value":"11 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This work is approved by the Institutional Review Board at Columbia University (Protocol AAAS0358).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"IRB approval\/research ethics committee"}}]}}