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The extreme long-term outcomes of nonoperative treatment are underreported. This study aimed to investigate the long-term outcome of nonoperative-treated AIS patients. Comparison between a bracing and an observation approach were performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a retrospective cohort study, 20 nonoperatively treated AIS patients were observed concerning patient-related outcome measures (PROM) (visual analog scale (VAS), Short Form Health Survey 36 item (SF 36), Scoliosis Research Society (SRS 24), Oswestry Low Back Pain Disability Index (ODI), Psychological General Well-Being Index (PGWBI)), radiological curve progression and health-related quality of life (HRQoL). Baseline characteristics and radiological imaging were collected. At follow-up, anteroposterior and lateral X-rays as well as questionnaires were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twenty patients (16 females, mean age: 14.6\u2009\u00b1\u20093.2\u00a0years) with a follow-up time of 42\u2009\u00b1\u20099\u00a0years were included. Nine patients (initial Cobb 35\u00b0\u2009\u00b1\u200919\u00b0) were treated with bracing for a mean time of 26\u2009\u00b1\u20099\u00a0months, while the other 11 patients (initial Cobb 29\u00b0\u2009\u00b1\u200911\u00b0) were observed. The primary curve progressed from 32\u00b0\u2009\u00b1\u200915\u00b0 to 52\u00b0\u2009\u00b1\u200925\u00b0 in average with no significant difference between the cohorts (<jats:italic>p<\/jats:italic>\u2009=\u20090.371). At final follow-up, a mean ODI score of 7\u2009\u00b1\u20097.9 points with no difference depending on the treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.668) was seen. No significant differences were observed for PROMs. Curve magnitude correlated neither at diagnosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.617) nor at follow-up (<jats:italic>p<\/jats:italic>\u2009=\u20090.535) with the ODI score at final follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>After a mean of 42\u00a0years, patients with nonoperative treatment of moderate AIS demonstrated a good clinical outcome despite progression of the deformity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Level of evidence<\/jats:title>\n                <jats:p>Level IV, therapeutic study.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s43390-022-00541-5","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T07:04:32Z","timestamp":1657609472000},"page":"1331-1338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Long-term outcome of patients with adolescent idiopathic scoliosis seeking nonoperative treatment after a mean follow-up of 42\u00a0years"],"prefix":"10.1007","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7190-1127","authenticated-orcid":false,"given":"Mazda","family":"Farshad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"G\u00f6tschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"B\u00f6ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J.","family":"Laux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Method","family":"Kabelitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"541_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1748-7161-1-2","volume":"1","author":"MA Asher","year":"2006","unstructured":"Asher MA, Burton DC (2006) Adolescent idiopathic scoliosis: natural history and long term treatment effects. 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