{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:52:45Z","timestamp":1784692365844,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010975","name":"Pediatric Orthopaedic Society of North America","doi-asserted-by":"publisher","award":["920442"],"award-info":[{"award-number":["920442"]}],"id":[{"id":"10.13039\/100010975","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spine Deform"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>There is variability in clinical outcomes with vertebral body tethering (VBT) partly due to a limited understanding of the growth modulation (GM) response. We used the largest sample of patients with 3D spine reconstructions to characterize the vertebra and disc morphologic changes that accompany growth modulation during the first two years following VBT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A multicenter registry was used to identify idiopathic scoliosis patients who underwent VBT with 2\u00a0years of follow-up. Calibrated biplanar X-rays obtained at longitudinal timepoints underwent 3D reconstruction to obtain precision morphological measurements. GM was defined as change in instrumented coronal angulation from post-op to 2-years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fifty patients (mean age: 12.5\u2009\u00b1\u20091.3yrs) were analyzed over a mean of 27.7\u00a0months. GM was positively correlated with concave vertebra height growth (<jats:italic>r<\/jats:italic>\u2009=\u20090.57, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), 3D spine length growth (<jats:italic>r<\/jats:italic>\u2009=\u20090.36, <jats:italic>p<\/jats:italic>\u2009=\u20090.008), and decreased convex disc height (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u00a00.42, p\u2009=\u20090.002). High modulators (patients experiencing GM\u2009&gt;\u200910\u00b0) experienced an additional 1.6\u00a0mm (229% increase) of mean concave vertebra growth during study period compared to the Poor Modulators (GM\u2009&lt;\u2009\u2212\u00a010\u00b0) group, (2.3 vs. 0.7\u00a0mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.039), while convex vertebra height growth was similar (1.3 vs. 1.4\u00a0mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.91).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>When successful, VBT enables asymmetric vertebra body growth, leading to continued postoperative coronal angulation correction (GM). A strong GM response is correlated with concave vertebral body height growth and overall instrumented spine growth. A poor GM response is associated with an increase in convex disc height (suspected tether rupture). Future studies will investigate the patient and technique-specific factors that influence increased growth remodeling.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s43390-024-00909-9","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T17:01:54Z","timestamp":1717520514000},"page":"1689-1698","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Growth modulation response in vertebral body tethering depends primarily on magnitude of concave vertebral body growth"],"prefix":"10.1007","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-4502","authenticated-orcid":false,"suffix":"Jr","given":"Craig R.","family":"Louer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidyadhar V.","family":"Upasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Hurry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Nian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L.","family":"Farnsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter O.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Parent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"El-Hawary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Pediatric Spine Study Group (PSSG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"909_CR1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.20.01533","author":"AF Buyuk","year":"2021","unstructured":"Buyuk AF, Milbrandt TA, Mathew SE, Larson AN (2021) Measurable thoracic motion remains at 1 year following anterior vertebral body tethering, with sagittal motion greater than coronal motion. 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Louer, Jr.:DePuy, A Johnson & Johnson Company: Paid consultant. National. Scoliosis Clinics, Inc.: IP royalties. Nuvasive: Other financial or material support. Vidyadhar V. Upasani: Daedalus Medical Solutions, Inc.: Employee. DePuy, A Johnson & Johnson Company: Paid consultant. Imagen: Stock or stock Options. nView: Research support. OrthoPediatrics: IP royalties; Paid consultant; Research support. Pacira: Paid consultant. Pediatric Orthopaedic Society of North America: Board or committee member. Scoliosis Research Society: Board or committee member. Spine: Editorial or governing board. Stryker: Paid consultant. Wolters Kluwer Health\u2014Lippincott Williams & Wilkins: Publishing royalties, financial or material support. ZimVie: Research support. Peter O. Newton: DePuy Synthes Spine via Setting Scoliosis Straight Foundation: Research support. DePuy Synthes Spine, A Johnson & Johnson Company: IP royalties. EOS Imaging via Setting Scoliosis Straight Foundation: Research support. Globus Medical: Paid consultant. Medtronic via Setting Scoliosis Straight: Research support. Nuvasive via Setting Scoliosis Straight Foundation: Research support. Pacira: Paid consultant; Paid presenter or speaker. Stryker K2M: IP royalties; Paid consultant. Stryker K2M via Setting Scoliosis. Straight Foundation: Research support. Theime Publishing: Publishing royalties, financial or material support. ZimVie via Setting Scoliosis Straight Foundation: Research support. Stefan Parent: Canadian Spine Society: Board or committee member. DePuy, A Johnson & Johnson Company: Paid consultant; Paid presenter or speaker; Research support. EOS-Imaging: IP royalties; Paid consultant; Research support. Pediatric Orthopaedic Society of North America: Board or committee member. Rodin 4D: IP royalties. Scoliosis Research. Society: Board or committee member. Setting scoliosis straight foundation: Research support. Spinologics: Employee; Stock or stock Options. Ron El-Hawary: (a,b) DePuy Synthes; (a,b) Medtronic, (a,b,c,e) Orthopediatrics, (a) ZimVie (e) Scoliosis Research Society, (e) Pediatric Spine Foundation a. Grants\/research support b. Consultant c. Stock\/shareholder (self-managed) d. Speaker\u2019s bureau e. Advisory board or panel f. Employee, salary (commercial interest) g. Other financial or material support (royalties, patents, etc.).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This work is approved by the IRB at Vanderbilt University Medical Center (#151924).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}