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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Jennifer Urquhart, Parham Rasoulinejad, and Firoz Miyanji. All authors contributed to interpretation of the data. The first draft of the manuscript was written by Jennifer Urquhart and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was reviewed and approved by the Research Ethics Board of each participating clinical site. Consent to participate: Informed consent was obtained from all individual participants, and legal guardians where appropriate, included in the study. 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