{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T01:34:31Z","timestamp":1767144871668,"version":"build-2238731810"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacol. Rep"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Due to co-occurrence of seizures and cardiovascular disorders, nebivolol, a widely used selective \u03b2\n                      <jats:sub>1<\/jats:sub>\n                      -blocker with vasodilatory properties, may be co-administered with antiepileptic drugs. Therefore, we wanted to assess interactions between nebivolol and four conventional antiepileptic drugs: carbamazepine, valproate, phenytoin and phenobarbital in the screening model of tonic\u2013clonic convulsions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seizure experiments were conducted in the electroconvulsive threshold and maximal electroshock tests in mice. The chimney test served as a method of assessing motor coordination, whereas long-term memory was evaluated in the computerized step-through passive-avoidance task. To exclude or confirm pharmacokinetic interactions, we measured brain concentrations of antiepileptic drugs using the fluorescence polarization immunoassay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>It was shown that nebivolol applied at doses 0.5\u201315\u00a0mg\/kg did not raise the threshold for electroconvulsions. However, nebivolol at the dose of 15\u00a0mg\/kg reduced the anti-electroshock properties of carbamazepine. The effect of valproate, phenytoin, and phenobarbital remained unchanged by combination with the \u03b2-blocker. Nebivolol significantly decreased the brain concentration of valproate, but did not affect concentrations of remaining antiepileptic drugs. Therefore, contribution of pharmacokinetic interactions to the final effect of the nebivolol\/carbamazepine combination seems not probable. Nebivolol alone and in combinations with antiepileptic drugs did not impair motor performance in mice. Nebivolol alone did not affect long-term memory of animals, and did not potentiate memory impairment induced by valproate and carbamazepine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study indicates that nebivolol attenuated effectiveness of some antiepileptic drugs. In case the results are confirmed in clinical settings, this \u03b2-blocker should be used with caution in epileptic patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s43440-019-00029-6","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T08:03:26Z","timestamp":1580717006000},"page":"80-86","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nebivolol attenuates the anticonvulsant action of carbamazepine and phenobarbital against the maximal electroshock-induced seizures in mice"],"prefix":"10.1007","volume":"72","author":[{"given":"Kinga K.","family":"Borowicz-Reutt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Banach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Rudkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"29_CR1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.pharep.2014.03.009","volume":"66","author":"KK Borowicz","year":"2014","unstructured":"Borowicz KK, Banach M. Antiarrhythmic drugs and epilepsy. Pharmacol Rep. 2014;66:545\u201351.","journal-title":"Pharmacol Rep"},{"issue":"8","key":"29_CR2","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/j.1528-1167.2012.03518.x","volume":"53","author":"A Ponnusamy","year":"2012","unstructured":"Ponnusamy A, Marques JLB, Reuber M. Comparison of heart rate variability parameters during complex partial seizures and psychogenic nonepileptic seizures. Epilepsia. 2012;53(8):1314\u201321.","journal-title":"Epilepsia"},{"issue":"5","key":"29_CR3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrneurol.2014.64","volume":"10","author":"CA Massey","year":"2014","unstructured":"Massey CA, Sowers LP, Dlouhy BJ, Richerson GB. Mechanisms of sudden unexpected death in epilepsy: the pathway to prevention. Nat Rev Neurol. 2014;10(5):271\u201382.","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"29_CR4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.eplepsyres.2011.12.003","volume":"99","author":"JG Little","year":"2012","unstructured":"Little JG, Bealer SL. \u03b2 Adrenergic blockade prevents cardiac dysfunction following status epilepticus in rats. Epilepsy Res. 2012;99(3):233\u20139.","journal-title":"Epilepsy Res"},{"issue":"4","key":"29_CR5","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.0013-9580.2004.05503.x","volume":"45","author":"M Nei","year":"2004","unstructured":"Nei M, Ho RT, Abou-Khalil BW, Drislane FW, Liporace J, Romeo A, et al. EEG and ECG in sudden unexplained death in epilepsy. Epilepsia. 2004;45(4):338\u201345.","journal-title":"Epilepsia"},{"issue":"28","key":"29_CR6","doi-asserted-by":"crossref","first-page":"10281","DOI":"10.1523\/JNEUROSCI.0888-15.2015","volume":"35","author":"BJ Dlouhy","year":"2015","unstructured":"Dlouhy BJ, Gehlbach BK, Kreple CJ, Kawasaki H, Oya H, Buzza C, et al. Breathing inhibited when seizures spread to the amygdala and upon amygdala stimulation. J Neurosci. 2015;35(28):10281\u20139.","journal-title":"J Neurosci"},{"key":"29_CR7","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1528-1157.1996.tb00644.x","volume":"37","author":"DC Hesdorffer","year":"1996","unstructured":"Hesdorffer DC, Hause WA, Annegers JF, Rocca WA. Severe, uncontrolled hypertension and adult\u2014onset seizures: a case-control study in Rochester, Minnesota. Epilepsia. 1996;37:736\u201341.","journal-title":"Epilepsia"},{"key":"29_CR8","doi-asserted-by":"crossref","first-page":"30554","DOI":"10.1074\/jbc.271.48.30554","volume":"271","author":"I Herrero","year":"1996","unstructured":"Herrero I, Sanchez-Prieto J. c-AMP-dependent facilitation of glutamate release by \u03b2-adrenergic receptors in cerebrocortical nerve terminals. J Biol Chem. 1996;271:30554\u201360.","journal-title":"J Biol Chem"},{"key":"29_CR9","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1212\/WNL.36.8.1067","volume":"36","author":"GA Reznikoff","year":"1986","unstructured":"Reznikoff GA, Manaker S, Rhodes CH, Winokur A, Rainbow TC. Localization and quantification of b-adrenergic receptors in human brain. Neurology. 1986;36:1067\u201373.","journal-title":"Neurology"},{"issue":"12","key":"29_CR10","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s40265-015-0435-5","volume":"75","author":"J Fongemie","year":"2015","unstructured":"Fongemie J, Felix-Getzik E. A review of nebivolol pharmacology and clinical evidence. Drugs. 2015;75(12):1349\u201371.","journal-title":"Drugs"},{"key":"29_CR11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/00005344-200401000-00022","volume":"43","author":"AA Groot","year":"2004","unstructured":"Groot AA, Mathy MJ, Pieter A, Stephan LM. Antioxidant activity of NBV in the rat aorta. J Cardiovasc Pharmacol. 2004;43:148\u201353.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"5","key":"29_CR12","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.cjca.2013.12.001","volume":"30","author":"L Poirier","year":"2014","unstructured":"Poirier L, Tobe SW. Contemporary use of \u03b2-blockers: clinical relevance of subclassification. Can J Cardiol. 2014;30(5):S9\u201315.","journal-title":"Can J Cardiol"},{"issue":"1","key":"29_CR13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/0253-7613.48890","volume":"41","author":"R Goel","year":"2009","unstructured":"Goel R, Goel A, Manocha A, Pillai KK, Srivastava RS. Influence of nebivolol on anticonvulsant effect of lamotrigine. Indian J Pharmacol. 2009;41(1):41\u20136.","journal-title":"Indian J Pharmacol"},{"issue":"2","key":"29_CR14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00213-007-0878-9","volume":"195","author":"KK Borowicz","year":"2007","unstructured":"Borowicz KK, Banach M, Zarczuk R, Lukasik D, Luszczki JJ, Czuczwar SJ. Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model. Psychopharmacology. 2007;195(2):167\u201374.","journal-title":"Psychopharmacology"},{"issue":"2","key":"29_CR15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1358\/mf.2009.31.2.1338414","volume":"31","author":"MM Castel-Branco","year":"2009","unstructured":"Castel-Branco MM, Alvez GL, Figueiredo IV, Falc\u00e3o AC, Caramona MM. The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic drug. Methods Find Exp Clin Pharmacol. 2009;31(2):101\u20136.","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"29_CR16","first-page":"99","volume":"96","author":"JT Litchfield","year":"1949","unstructured":"Litchfield JT, Wilcoxon F. A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther. 1949;96:99\u2013113.","journal-title":"J Pharmacol Exp Ther"},{"key":"29_CR17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000134913","volume":"3","author":"JR Boissier","year":"1960","unstructured":"Boissier JR, Tardy J, Diverres JC. Une nouvelle methode simple pour explorer l\u2019action tranquilisante: le test de la cheminee. Med Exp (Basel). 1960;3:81\u20134.","journal-title":"Med Exp (Basel)"},{"issue":"1","key":"29_CR18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/1056-8719(95)00115-8","volume":"35","author":"Y Kitano","year":"1996","unstructured":"Kitano Y, Usui C, Takasuna K, Hirohashi M, Nomura M. Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice. Pharmacol Toxicol Methods. 1996;35(1):25\u20139.","journal-title":"Pharmacol Toxicol Methods"},{"issue":"3","key":"29_CR19","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2007","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 2007;22(3):659\u201362.","journal-title":"FASEB J"},{"issue":"2","key":"29_CR20","first-page":"128","volume":"27","author":"N Khanna","year":"1989","unstructured":"Khanna N, Ray A, Alkondon M, Sen P. Effect of beta-adrenoceptor antagonists and some related drugs on maximal electroshock seizures in mice. Indian J Exp Biol. 1989;27(2):128\u201330.","journal-title":"Indian J Exp Biol"},{"issue":"1\u20132","key":"29_CR21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0091-3057(01)00654-2","volume":"71","author":"E Luchowska","year":"2002","unstructured":"Luchowska E, Luchowski P, Wielosz M, Kleinrok Z, Czuczwar SJ, Urba\u0144ska EM. Propranolol and metoprolol enhance the anticonvulsant action of valproate and diazepam against maximal electroshock. Pharmacol Biochem Behav. 2002;71(1\u20132):223\u201331.","journal-title":"Pharmacol Biochem Behav"},{"issue":"5","key":"29_CR22","first-page":"429","volume":"46","author":"EI Tkatchenko","year":"1987","unstructured":"Tkatchenko EI, Lossev NA, K\u00e4stner I, Seidel J. Influence of beta adrenergic blockers and their combinations with anticholinergic drugs on epileptiform activity in rabbit hippocampus. Biomed Biochim Acta. 1987;46(5):429\u201332.","journal-title":"Biomed Biochim Acta"},{"issue":"2","key":"29_CR23","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/01616412.2015.1136779","volume":"38","author":"H Shafaroodi","year":"2016","unstructured":"Shafaroodi H, Khosravani E, Fakhrzad A, Moezi L. The interaction between morphine and propranolol in chemical and electrical seizure models in mice. Neurol Res. 2016;38(2):166\u201376.","journal-title":"Neurol Res"},{"issue":"5","key":"29_CR24","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1213\/ane.0b013e31816ba49d","volume":"106","author":"T Nakamura","year":"2008","unstructured":"Nakamura T, Oda Y, Takahashi R, Tanaka K, Hase I, Asada A. Propranolol increases the threshold for lidocaine-induced convulsions in awake rats: a direct effect on the brain. Anesth Analg. 2008;106(5):1450\u20135.","journal-title":"Anesth Analg"},{"issue":"4","key":"29_CR25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0278-5846(94)90082-5","volume":"18","author":"G Amabeoku","year":"1994","unstructured":"Amabeoku G, Chandomba R. Strychnine-induced seizures in mice: the role of noradrenaline. Prog Neuropsychopharmacol Biol Psychiatry. 1994;18(4):753\u201363.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"3","key":"29_CR26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0091-3057(00)00385-3","volume":"67","author":"D Peri\u010di\u0107","year":"2000","unstructured":"Peri\u010di\u0107 D, Jazvinscak M, Svob D, Mirkovic K. Beta-1 adrenoceptor antagonists potentiate the anticonvulsive effect of swim stress in mice. Pharmacol Biochem Behav. 2000;67(3):507\u201310.","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"29_CR27","first-page":"175","volume":"33","author":"V Paul","year":"1989","unstructured":"Paul V, Krishnamoorthy MS. The effect of beta-adrenoceptor antagonists alone and in combination with a GABA-elevating agent on isoniazid-induced convulsions in rats. Indian J Physiol Pharmacol. 1989;33(3):175\u20138.","journal-title":"Indian J Physiol Pharmacol"},{"issue":"5","key":"29_CR28","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0091-3057(85)90518-0","volume":"22","author":"CE Lints","year":"1985","unstructured":"Lints CE, Nyquist-Battie C. A possible role for beta-adrenergic receptors in the expression of audiogenic seizures. Pharmacol Biochem Behav. 1985;22(5):711\u20136.","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"29_CR29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0014-2999(02)01536-4","volume":"442","author":"G De Sarro","year":"2002","unstructured":"De Sarro G, Di Paola ED, Ferreri G, De Sarro A, Fischer W. Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA\/2 mice. Eur J Pharmacol. 2002;442(3):205\u201313.","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"29_CR30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0920-1211(89)90057-0","volume":"4","author":"CM Lathers","year":"1989","unstructured":"Lathers CM, Stauffer AZ, Tumer N, Kraras CM, Goldman BD. Anticonvulsant and antiarrhythmic actions of the beta blocking agent timolol. Epilepsy Res. 1989;4(1):42\u201354.","journal-title":"Epilepsy Res"},{"issue":"6","key":"29_CR31","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.pharep.2017.05.005","volume":"69","author":"M Banach","year":"2017","unstructured":"Banach M, Pop\u0142awska M, Borowicz-Reutt KK. Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model. Pharmacol Rep. 2017;69(6):1173\u20137.","journal-title":"Pharmacol Rep"},{"issue":"4","key":"29_CR32","first-page":"296","volume":"111","author":"R Goel","year":"2011","unstructured":"Goel R, Goel A, Kumar Y. Influence of carvedilol on anticonvulsant effect of gabapentin. Acta Neurol Belg. 2011;111(4):296\u2013305.","journal-title":"Acta Neurol Belg"},{"issue":"1","key":"29_CR33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0014-2999(91)90650-F","volume":"199","author":"Y Chugh","year":"1991","unstructured":"Chugh Y, Chakrabarti A, Sharma PL. Diazepam-atenolol combination antagonizes aminophylline-induced convulsions and lethality in mice. Eur J Pharmacol. 1991;199(1):135\u20137.","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"29_CR34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00045391-199406000-00007","volume":"1","author":"GG de Oliveira","year":"1994","unstructured":"de Oliveira GG, Borges MA. Propranolol action in chronically unstable generalized epilepsy. Am J Ther. 1994;1(1):38\u201341.","journal-title":"Am J Ther"},{"issue":"3","key":"29_CR35","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/jnnp.58.3.382","volume":"58","author":"T Mayer","year":"1995","unstructured":"Mayer T, Specht U. Propranolol in startle induced epileptic seizures. J Neurol Neurosurg Psychiatry. 1995;58(3):382\u20133.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"29_CR36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(99)00321-3","volume":"267","author":"Y Wada","year":"1999","unstructured":"Wada Y, Hirao N, Shiraishi J, Nakamura M, Koshino Y. Pindolol potentiates the effect of fluoxetine on hippocampal seizures in rats. Neurosci Lett. 1999;267(1):61\u20134.","journal-title":"Neurosci Lett"},{"issue":"6","key":"29_CR37","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1006\/phrs.1998.0390","volume":"38","author":"SS Raju","year":"1998","unstructured":"Raju SS, Gopalakrishna HN, Venkatadri N. Effect of propranolol and nifedipine on maximal electroshock-induced seizures in mice: individually and in combination. Pharmacol Res. 1998;38(6):449\u201352.","journal-title":"Pharmacol Res"},{"key":"29_CR38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-2999(01)01452-2","volume":"431","author":"E Luchowska","year":"2001","unstructured":"Luchowska E, Luchowski P, Wielosz M, Kleinrok Z, Urbanska EM. \u03b2-adrenoceptor blockade enhances the anticonvulsant effect of glutamate receptor antagonists against maximal electroshock. Eur J Pharmacol. 2001;431:209\u201314.","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"29_CR39","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/FJC.0b013e3182a0b5ff","volume":"62","author":"MU Khan","year":"2013","unstructured":"Khan MU, Zhao W, Zhao T, Al Darazi F, Ahokas RA, Sun Y, et al. Nebivolol: a multifaceted antioxidant and cardioprotectant in hypertensive heart disease. J Cardiovasc Pharmacol. 2013;62(5):445\u201351.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"29_CR40","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3390\/ijms14011455","volume":"14","author":"N Cardenas-Rodriguez","year":"2013","unstructured":"Cardenas-Rodriguez N, Huerta-Gertrudis B, Rivera-Espinosa L, Montesinos-Correa H, Bandala C, Carmona-Aparicio L, et al. Role of oxidative stress in refractory epilepsy: evidence in patients and experimental models. Int J Mol Sci. 2013;14(1):1455\u201376.","journal-title":"Int J Mol Sci"},{"issue":"7","key":"29_CR41","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1037\/neu0000465","volume":"32","author":"S Barton","year":"2018","unstructured":"Barton S, Nadebaum C, Anderson VA, Vajda F, Reutens DC, Wood AG. Memory dysfunction in school-aged children exposed prenatally to antiepileptic drugs. Neuropsychology. 2018;32(7):784\u201396.","journal-title":"Neuropsychology"},{"issue":"Suppl 3","key":"29_CR42","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1111\/j.1528-1157.1987.tb05776.x","volume":"28","author":"MR Trimble","year":"1987","unstructured":"Trimble MR. Anticonvulsant drugs and cognitive function: a review of the literature. Epilepsia. 1987;28(Suppl 3):S37\u201345.","journal-title":"Epilepsia"},{"issue":"2","key":"29_CR43","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1111\/j.1528-1157.1987.tb05767.x","volume":"28","author":"EP Vining","year":"1987","unstructured":"Vining EP. Cognitive dysfunction associated with antiepileptic drug therapy. Epilepsia. 1987;28(2):S18\u201322.","journal-title":"Epilepsia"},{"issue":"3","key":"29_CR44","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.yebeh.2004.12.012","volume":"6","author":"H Jokeit","year":"2005","unstructured":"Jokeit H, Kr\u00e4mer G, Ebner A. Do antiepileptic drugs accelerate forgetting. Epilepsy Behav. 2005;6(3):430\u20132.","journal-title":"Epilepsy Behav"}],"updated-by":[{"DOI":"10.1007\/s43440-021-00275-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000}}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-019-00029-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43440-019-00029-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-019-00029-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T18:10:22Z","timestamp":1627668622000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43440-019-00029-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["29"],"URL":"https:\/\/doi.org\/10.1007\/s43440-019-00029-6","relation":{},"ISSN":["1734-1140","2299-5684"],"issn-type":[{"value":"1734-1140","type":"print"},{"value":"2299-5684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,20]]},"assertion":[{"value":"26 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2021","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s43440-021-00275-7","URL":"https:\/\/doi.org\/10.1007\/s43440-021-00275-7","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}]}}