{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T16:30:46Z","timestamp":1744821046099},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacol. Rep"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s43440-019-00051-8","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T08:03:06Z","timestamp":1579766586000},"page":"890-902","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Itaconimides derivatives induce relaxation in mesenteric artery and negative inotropism by inhibition of CA2+ influx"],"prefix":"10.1007","volume":"72","author":[{"given":"Raiana dos Anjos","family":"Moraes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quiara Lovatti","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Barbosa","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Fiama de Azevedo","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson de Melo","family":"Jesus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane Rodrigues Santana","family":"da Hora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorimar Serafim","family":"Stiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdir","family":"Cechinel-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darizy Fl\u00e1via","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"51_CR1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/ajh\/hpu151","volume":"28","author":"D Achelrod","year":"2015","unstructured":"Achelrod D, Wenzel U, Frey S. Systematic review and meta-analysis of the prevalence of resistant hypertension in treated hypertensive populations. Am J Hypertens. 2015;28:355\u201361. https:\/\/doi.org\/10.1093\/ajh\/hpu151.","journal-title":"Am J Hypertens"},{"key":"51_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1161\/CIRCULATIONAHA.117.032582","volume":"137","author":"P Muntner","year":"2018","unstructured":"Muntner P, Carey RM, Gidding S, Jones DW, Taler SJ, Wright JT, et al. Potential US population impact of the 2017 ACC\/AHA high blood pressure guideline. Circulation. 2018;137:109\u201318. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.032582.","journal-title":"Circulation"},{"key":"51_CR3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.phrs.2017.10.003","volume":"128","author":"C Cuspidi","year":"2018","unstructured":"Cuspidi C, Tadic M, Grassi G, Mancia G. Treatment of hypertension: the ESH\/ESC guidelines recommendations. Pharmacol Res. 2018;128:315\u201321. https:\/\/doi.org\/10.1016\/j.phrs.2017.10.003.","journal-title":"Pharmacol Res"},{"key":"51_CR4","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1161\/CIRCRESAHA.116.303603","volume":"116","author":"S Oparil","year":"2015","unstructured":"Oparil S, Schmieder RE. New approaches in the treatment of hypertension. Circ Res. 2015;116:1074\u201395. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.303603.","journal-title":"Circ Res"},{"key":"51_CR5","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1161\/HYPERTENSIONAHA.110.168948","volume":"57","author":"SAD La","year":"2011","unstructured":"La SAD, Segura J, Banegas JR, Gorostidi M, La CJJD, Armario P, et al. Clinical features of 8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring. Hypertension. 2011;57:898\u2013902. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.110.168948.","journal-title":"Hypertension"},{"key":"51_CR6","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1161\/HYPERTENSIONAHA.111.180497","volume":"58","author":"MR Hanselin","year":"2011","unstructured":"Hanselin MR, Saseen JJ, Allen RR, Marrs JC, Nair KV. Description of antihypertensive use in patients with resistant hypertension prescribed four or more agents. Hypertension. 2011;58:1008\u2013133. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.111.180497.","journal-title":"Hypertension"},{"key":"51_CR7","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cjca.2015.06.033","volume":"32","author":"M Siddiqui","year":"2016","unstructured":"Siddiqui M, Dudenbostel T, Calhoun DA. Resistant and refractory hypertension: antihypertensive treatment resistance vs treatment failure. Can J Cardiol. 2016;32:603\u20136. https:\/\/doi.org\/10.1016\/j.cjca.2015.06.033.","journal-title":"Can J Cardiol"},{"key":"51_CR8","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S1875-5364(15)30072-8","volume":"13","author":"R-R Bai","year":"2015","unstructured":"Bai R-R, Wu X, Xu J. Current natural products with antihypertensive activity. Chin J Nat Med. 2015;13:721\u20139. https:\/\/doi.org\/10.1016\/S1875-5364(15)30072-8.","journal-title":"Chin J Nat Med"},{"key":"51_CR9","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1021\/np50057a036","volume":"51","author":"MS Tempesta","year":"1988","unstructured":"Tempesta MS, Corley DG, Beutler JA, Metral CJ, Yunes RA, Giacomozzi CA, et al. Phyllanthimide, a new alkaloid from Phyllanthus sellowianus. J Nat Prod. 1988;51:617\u20138. https:\/\/doi.org\/10.1021\/np50057a036.","journal-title":"J Nat Prod"},{"key":"51_CR10","first-page":"313","volume":"17","author":"JB Calixto","year":"1984","unstructured":"Calixto JB, Yunes RA, Neto AS, Valle RM, Rae G. Antispasmodic effects of an alkaloid extracted from Phyllanthus sellowianus: a comparative study with papaverine. Braz J Med Biol Res. 1984;17:313\u201321.","journal-title":"Braz J Med Biol Res"},{"key":"51_CR11","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/j.2042-7158.1995.tb00450.x","volume":"1","author":"V Cechinel Filho","year":"1995","unstructured":"Cechinel Filho V, Nunes RJ, Calixto JB, Yunes RA. Inhibition of guinea-pig ileum contraction by Phyllanthimide analogues: structure-activity relationships. Pharm Sci. 1995;1:399\u2013401. https:\/\/doi.org\/10.1111\/j.2042-7158.1995.tb00450.x.","journal-title":"Pharm Sci"},{"key":"51_CR12","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-93322007000200014","author":"ZBVS Pontes","year":"2007","unstructured":"Pontes ZBVS, Lima EDO, Cechinel Filho V. Profile of susceptibility in vitro of Trichosporon asahii and Trichosporon inkin strains against cyclic imides. Rev Bras Ci\u00eancias Farm. 2007. https:\/\/doi.org\/10.1590\/S1516-93322007000200014.","journal-title":"Rev Bras Ci\u00eancias Farm"},{"key":"51_CR13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1590\/S0100-40421998000100015","volume":"21","author":"V Cechinel Filho","year":"1998","unstructured":"Cechinel Filho V, Yunes RA. Estrat\u00e9gias para a Obten\u00e7\u00e3o de Compostos Farmacologicamente Ativos a partir de Plantas Medicinais. Conceitos sobre Modifica\u00e7\u00e3o Estrutural para Otimiza\u00e7\u00e3o da Atividade. Quim Nova. 1998;21:99\u2013105. https:\/\/doi.org\/10.1590\/S0100-40421998000100015.","journal-title":"Quim Nova"},{"key":"51_CR14","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1515\/znc-2004-9-1010","volume":"59","author":"SRT Prado","year":"2004","unstructured":"Prado SRT, Cechinel-Filho V, Campos-Buzzi F, Corr\u00eaa R, Cadena SMCS, De Oliveira MBM. Biological evaluation of some selected cyclic imides: mitochondrial effects and in vitro cytotoxicity. Zeitschrift Fur Naturforsch - Sect C J Biosci. 2004;59:663\u201372. https:\/\/doi.org\/10.1515\/znc-2004-9-1010.","journal-title":"Zeitschrift Fur Naturforsch - Sect C J Biosci"},{"key":"51_CR15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ejphar.2010.06.035","volume":"644","author":"SW Seto","year":"2010","unstructured":"Seto SW, Bexis S, McCormick PA, Docherty JR. Actions of thalidomide in producing vascular relaxations. Eur J Pharmacol. 2010;644:113\u20139. https:\/\/doi.org\/10.1016\/j.ejphar.2010.06.035.","journal-title":"Eur J Pharmacol"},{"key":"51_CR16","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1515\/znc-2010-7-806","volume":"65 C","author":"\u00caAN Ribeiro","year":"2010","unstructured":"Ribeiro \u00caAN, Furtado FF, Noldin VF, Corr\u00eaa R, Cechinel-Filho V, de Medeiros IA. Vasorelaxant action of N-p-nitrophenylmaleimide in the isolated rat mesenteric artery. Zeitschrift Fur Naturforsch - Sect C J Biosci. 2010;65 C:451\u20137. https:\/\/doi.org\/10.1515\/znc-2010-7-806.","journal-title":"Zeitschrift Fur Naturforsch - Sect C J Biosci"},{"key":"51_CR17","doi-asserted-by":"publisher","first-page":"647","DOI":"10.2174\/1573406412666160229150833","volume":"12","author":"D Stiz","year":"2016","unstructured":"Stiz D, Corr\u00eaa R, D\u2019Auria FD, Simonetti G, Cechinel-Filho V. Synthesis of cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) and evaluation of their antifungal potential. Med Chem (Los Angel). 2016;12:647\u201354. https:\/\/doi.org\/10.2174\/1573406412666160229150833.","journal-title":"Med Chem (Los Angel)"},{"key":"51_CR18","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/j.1742-7843.2011.00749.x","volume":"109","author":"DF Silva","year":"2011","unstructured":"Silva DF, Ara\u00fajo IGA, Albuquerque JGF, Porto DL, Dias KLG, Cavalcante KVM, et al. Rotundifolone-induced relaxation is mediated by BKCa channel activation and Cav channel inactivation. Basic Clin Pharmacol Toxicol. 2011;109:465\u201375. https:\/\/doi.org\/10.1111\/j.1742-7843.2011.00749.x.","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"51_CR19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.vph.2015.02.016","volume":"67","author":"BPV Dantas","year":"2015","unstructured":"Dantas BPV, Alves QL, de Assis KS, Ribeiro TP, de Almeida M\u00d4M, de Vasconcelos AP, et al. Participation of the TRP channel in the cardiovascular effects induced by carvacrol in normotensive rat. Vascu Pharmacol. 2015;67:48\u201358. https:\/\/doi.org\/10.1016\/j.vph.2015.02.016.","journal-title":"Vascu Pharmacol"},{"key":"51_CR20","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1161\/ATVBAHA.117.309813","volume":"37","author":"S Godo","year":"2017","unstructured":"Godo S, Shimokawa H. Endothelial functions. Arterioscler Thromb Vasc Biol. 2017;37:e108\u2013e114114. https:\/\/doi.org\/10.1161\/ATVBAHA.117.309813.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"51_CR21","doi-asserted-by":"publisher","first-page":"141","DOI":"10.5487\/TR.2014.30.3.141","volume":"30","author":"KT Kang","year":"2014","unstructured":"Kang KT. Endothelium-derived relaxing factors of small resistance arteries in hypertension. Toxicol Res. 2014;30:141\u20138. https:\/\/doi.org\/10.5487\/TR.2014.30.3.141.","journal-title":"Toxicol Res"},{"key":"51_CR22","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1113\/jphysiol.1991.sp018505","volume":"435","author":"VY Ganitkevich","year":"1991","unstructured":"Ganitkevich VY, Isenberg G. Depolarization-mediated intracellular calcium transients in isolated smooth muscle cells of guinea-pig urinary bladder. J Physiol. 1991;435:187\u2013205. https:\/\/doi.org\/10.1113\/jphysiol.1991.sp018505.","journal-title":"J Physiol"},{"key":"51_CR23","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s10974-015-9416-2","volume":"36","author":"RD Mills","year":"2015","unstructured":"Mills RD, Mita M, Walsh MP. A role for the Ca2+-dependent tyrosine kinase Pyk2 in tonic depolarization-induced vascular smooth muscle contraction. J Muscle Res Cell Motil. 2015;36:479\u201389. https:\/\/doi.org\/10.1007\/s10974-015-9416-2.","journal-title":"J Muscle Res Cell Motil"},{"key":"51_CR24","doi-asserted-by":"crossref","first-page":"15709","DOI":"10.1016\/S0021-9258(18)66775-4","volume":"261","author":"S Kobayashi","year":"1986","unstructured":"Kobayashi S, Kanaide H, Nakamura M. Complete overlap of caffeine- and K+ depolarization-sensitive intracellular calcium storage site in cultured rat arterial smooth muscle cells. J Biol Chem. 1986;261:15709\u201313.","journal-title":"J Biol Chem"},{"key":"51_CR25","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/0006-291X(85)91973-4","volume":"129","author":"S Kobayashi","year":"1985","unstructured":"Kobayashi S, Kanaide H, Nakamura M. K+-depolarization induces a direct release of Ca2+ from intracellular storage sites in cultured vascular smooth muscle cells from rat aorta. Biochem Biophys Res Commun. 1985;129:877\u201384.","journal-title":"Biochem Biophys Res Commun"},{"key":"51_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1139\/Y10-013","volume":"88","author":"N Ziolkowski","year":"2010","unstructured":"Ziolkowski N, Grover AK. Functional linkage as a direction for studies in oxidative stress: \u03b1-adrenergic receptors. Can J Physiol Pharmacol. 2010;88:220\u201332. https:\/\/doi.org\/10.1139\/Y10-013.","journal-title":"Can J Physiol Pharmacol"},{"key":"51_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1161\/01.HYP.35.1.173","volume":"35","author":"WF Jackson","year":"2000","unstructured":"Jackson WF. Ion channels and vascular tone. Hypertension. 2000;35:173\u20138. https:\/\/doi.org\/10.1161\/01.HYP.35.1.173.","journal-title":"Hypertension"},{"key":"51_CR28","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/sj.mn.7800140","volume":"9","author":"RH Cox","year":"2002","unstructured":"Cox RH, Rusch NJ. New expression profiles of voltage-gated ion channels in arteries exposed to high blood pressure. Microcirculation. 2002;9:243\u201357. https:\/\/doi.org\/10.1038\/sj.mn.7800140.","journal-title":"Microcirculation"},{"key":"51_CR29","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.phrs.2013.01.008","volume":"70","author":"BK Joseph","year":"2013","unstructured":"Joseph BK, Thakali KM, Moore CL, Rhee SW. Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches. Pharmacol Res. 2013;70:126\u201338. https:\/\/doi.org\/10.1016\/j.phrs.2013.01.008.","journal-title":"Pharmacol Res"},{"key":"51_CR30","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1038\/sj.bjp.0701066","volume":"120","author":"AI McCulloch","year":"1997","unstructured":"McCulloch AI, Bottrill FE, Randall MD, Hiley CR. Characterization and modulation of EDHF-mediated relaxations in the rat isolated superior mesenteric arterial bed. Br J Pharmacol. 1997;120:1431\u20138. https:\/\/doi.org\/10.1038\/sj.bjp.0701066.","journal-title":"Br J Pharmacol"},{"key":"51_CR31","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jash.2008.09.002","volume":"3","author":"BM Wynne","year":"2009","unstructured":"Wynne BM, Chiao C-W, Webb RC. Vascular smooth muscle cell signaling mechanisms for contraction to angiotensin II and endothelin-1. J Am Soc Hypertens. 2009;3:84\u201395. https:\/\/doi.org\/10.1016\/j.jash.2008.09.002.","journal-title":"J Am Soc Hypertens"},{"key":"51_CR32","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/(SICI)1098-1128(199807)18:4%3c225::AID-MED2%3e3.0.CO;2-X","volume":"18","author":"JB Calixto","year":"1998","unstructured":"Calixto JB, Santos ARS, Cechinel Filho V, Yunes RA. A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential. Med Res Rev. 1998;18:225\u201358. https:\/\/doi.org\/10.1002\/(SICI)1098-1128(199807)18:4%3c225:AID-MED2%3e3.0.CO;2-X.","journal-title":"Med Res Rev"},{"key":"51_CR33","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/sj.bjp.0707455","volume":"153","author":"FP Leung","year":"2008","unstructured":"Leung FP, Yung LM, Yao X, Laher I, Huang Y. Store-operated calcium entry in vascular smooth muscle. Br J Pharmacol. 2008;153:846\u201357. https:\/\/doi.org\/10.1038\/sj.bjp.0707455.","journal-title":"Br J Pharmacol"},{"key":"51_CR34","doi-asserted-by":"publisher","first-page":"e33","DOI":"10.1161\/HYPERTENSIONAHA.113.02444","volume":"63","author":"S Goulopoulou","year":"2014","unstructured":"Goulopoulou S, Webb RC. Symphony of vascular contraction: how smooth muscle cells lose harmony to signal increased vascular resistance in hypertension. Hypertension. 2014;63:e33\u2013e39. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.113.02444.","journal-title":"Hypertension"},{"key":"51_CR35","doi-asserted-by":"publisher","first-page":"19678","DOI":"10.3390\/molecules191219678","volume":"19","author":"CL Mac\u00eado","year":"2014","unstructured":"Mac\u00eado CL, Vasconcelos LHC, De C Correia AC, Martins IRR, De Lira DP, De O Santos BV, De A Cavalcante F, Da Silva BA. Mechanisms underlying vasorelaxation induced in rat aorta by galetin 3,6-dimethyl ether, a flavonoid from piptadenia stipulacea (benth.) ducke. Molecules. 2014;19:19678\u201395. https:\/\/doi.org\/10.3390\/molecules191219678.","journal-title":"Molecules"},{"key":"51_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/951497","volume":"2012","author":"RA Fernandez","year":"2012","unstructured":"Fernandez RA, Sundivakkam P, Smith KA, Zeifman AS, Drennan AR, Yuan JX-J. Pathogenic role of store-operated and receptor-operated channels in pulmonary arterial hypertension. J Signal Transduct. 2012;2012:1\u201316. https:\/\/doi.org\/10.1155\/2012\/951497.","journal-title":"J Signal Transduct"},{"key":"51_CR37","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1161\/01.RES.0000231255.32630.df","volume":"98","author":"S Earley","year":"2006","unstructured":"Earley S. Molecular diversity of receptor operated channels in vascular smooth muscle: a role for heteromultimeric TRP channels? Circ Res. 2006;98:1462\u20134. https:\/\/doi.org\/10.1161\/01.RES.0000231255.32630.df.","journal-title":"Circ Res"},{"key":"51_CR38","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/0016-5085(91)90802-R","volume":"100","author":"J Yu","year":"1991","unstructured":"Yu J, Bose R. Calcium channels in smooth muscle. Gastroenterology. 1991;100:1448\u2013600. https:\/\/doi.org\/10.1016\/0016-5085(91)90802-R.","journal-title":"Gastroenterology"},{"key":"51_CR39","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.vph.2016.05.001","volume":"82","author":"DCG Garcia","year":"2016","unstructured":"Garcia DCG, Pereira AC, Gutierrez SJC, Barbosa-Filho JM, Lemos VS, C\u00f4rtes SF. Structure-related blockage of calcium channels by vasodilator alkamides in mice mesenteric artery. Vascul Pharmacol. 2016;82:60\u20135. https:\/\/doi.org\/10.1016\/j.vph.2016.05.001.","journal-title":"Vascul Pharmacol"},{"key":"51_CR40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1291\/hypres.21.33","volume":"21","author":"T Kubo","year":"1998","unstructured":"Kubo T, Taguchi K, Ueda M. L-type calcium channels in vascular smooth muscle cells from spontaneously hypertensive rats: effects of calcium agonist and antagonist. Hypertens Res Off J Jpn Soc Hypertens. 1998;21:33\u20137. https:\/\/doi.org\/10.1291\/hypres.21.33.","journal-title":"Hypertens Res Off J Jpn Soc Hypertens"},{"key":"51_CR41","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1093\/bja\/81.4.578","volume":"81","author":"S Hirata","year":"1998","unstructured":"Hirata S, Enoki T, Kitamura R, Vinh VH, Nakamura K, Mori K. Effects of isoflurane on receptor-operated Ca2+ channels in rat aortic smooth muscle. Br J Anaesth. 1998;81:578\u201383. https:\/\/doi.org\/10.1093\/bja\/81.4.578.","journal-title":"Br J Anaesth"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-019-00051-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s43440-019-00051-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-019-00051-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:39:43Z","timestamp":1611275983000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s43440-019-00051-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["51"],"URL":"https:\/\/doi.org\/10.1007\/s43440-019-00051-8","relation":{},"ISSN":["1734-1140","2299-5684"],"issn-type":[{"value":"1734-1140","type":"print"},{"value":"2299-5684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,23]]},"assertion":[{"value":"9 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there are no conflicts of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}