{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:21:51Z","timestamp":1759638111137},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacol. Rep"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s43440-019-00053-6","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T12:09:15Z","timestamp":1578658155000},"page":"96-103","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["\u03b12-Adrenoceptor agonist induces peripheral antinociception via the endocannabinoid system"],"prefix":"10.1007","volume":"72","author":[{"given":"Thiago Roberto Lima","family":"Romero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Gomes","family":"Miranda e Castor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosimo","family":"Parrella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Piscitelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Di Marzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Dimitri Gama","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"53_CR1","unstructured":"Willian WMIII, John AEH, Roman TS, Richard MB. F\u00e1rmacos usados na medica\u00e7\u00e3o pr\u00e9-anest\u00e9sica. In: Willian WMIII Manual de anestesia veterin\u00e1ria. Proc Artmed, 3\u00aa ed, Porto Alegre; 2001. pp. 31\u201344."},{"key":"53_CR2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/BF00539619","volume":"256","author":"G Kroneberg","year":"1967","unstructured":"Kroneberg G, Oberdorf A, Hoffmeiter F, Wirth W. On the pharmacology of 2-(2,6-dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine (Bayer 1470), a substance inhibitory for adrenergic and cholinergic neurons. Naunyn Schmiedebergs Arch Pharmacol Exp Pathol. 1967;256:257\u201380.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol Exp Pathol"},{"key":"53_CR3","first-page":"188","volume":"218","author":"WH Hsu","year":"1981","unstructured":"Hsu WH. Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents. J Pharmacol Exp Ther. 1981;218:188\u201392.","journal-title":"J Pharmacol Exp Ther"},{"key":"53_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0361-9230(98)00159-2","volume":"48","author":"S F\u00fcrst","year":"1999","unstructured":"F\u00fcrst S. Transmitters involved in antinociception in the spinal cord. Brain Res Bull. 1999;48:129\u201341.","journal-title":"Brain Res Bull"},{"key":"53_CR5","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/sj.bjp.0706045","volume":"144","author":"SM Tham","year":"2005","unstructured":"Tham SM, Angus JA, Tudor EM, Wright CE. Synergistic and additive interactions of the cannabinoid agonist CP55,940 with mu opioid receptor and alpha2-adrenoceptor agonists in acute pain models in mice. Br J Pharmacol. 2005;144:875\u201384.","journal-title":"Br J Pharmacol"},{"key":"53_CR6","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1097\/00000542-200309000-00027","volume":"99","author":"MH Yoon","year":"2003","unstructured":"Yoon MH, Choi JI. Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test. Anesthesiology. 2003;99:701\u20137.","journal-title":"Anesthesiology"},{"key":"53_CR7","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/0091-3057(85)90537-4","volume":"22","author":"TL Yaksh","year":"1985","unstructured":"Yaksh TL. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol Biochem Behav. 1985;22:845\u201358.","journal-title":"Pharmacol Biochem Behav"},{"key":"53_CR8","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.lfs.2011.01.017","volume":"88","author":"GM Reis","year":"2001","unstructured":"Reis GM, Ramos MA, Pacheco DF, Klein A, Perez AC, Duarte ID. Endogenous cannabinoid receptor agonist anandamide induces peripheral antinociception by activation of ATP-sensitive K+ channels. Life Sci. 2001;88:653\u20137.","journal-title":"Life Sci"},{"key":"53_CR9","doi-asserted-by":"crossref","unstructured":"Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, et al. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 2002;54:161\u2013202.","DOI":"10.1124\/pr.54.2.161"},{"key":"53_CR10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1177\/0269881105056996","volume":"20","author":"MJ Khodayar","year":"2006","unstructured":"Khodayar MJ, Shafaghi B, Naderi N, Zarrindast MR. Antinociceptive effect of spinally administered cannabinergic and 2-adrenoceptor drugs on the formalin test in rat: possible interactions. J Psychopharmacol. 2006;20:67\u201374.","journal-title":"J Psychopharmacol"},{"key":"53_CR11","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.jpain.2017.12.002","volume":"19","author":"RCM Ferreira","year":"2018","unstructured":"Ferreira RCM, Castor MGM, Piscitelli F, Di Marzo V, Duarte IDG. Romero TRL the involvement of the endocannabinoid system in the peripheral antinociceptive action of ketamine. J Pain. 2018;19:487\u201395.","journal-title":"J Pain"},{"key":"53_CR12","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","volume":"16","author":"M Zimmermann","year":"1983","unstructured":"Zimmermann M. Ethical guidelines for investigation of experimental pain in conscious animals. Pain. 1983;16:109\u201310.","journal-title":"Pain"},{"key":"53_CR13","first-page":"409","volume":"111","author":"LO Randall","year":"1957","unstructured":"Randall LO, Sellito JJ. A method for measurement of analgesic activity on inflamed tissues. Arch Int Pharmacodyn Ther. 1957;111:409\u201319.","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"53_CR14","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1074\/jbc.272.6.3315","volume":"272","author":"T Bisogno","year":"1997","unstructured":"Bisogno T, Maurelli S, Melck D, De Petrocellis L, Di Marzo V. Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes. J Biol Chem. 1997;272:3315\u201323.","journal-title":"J Biol Chem"},{"key":"53_CR15","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1126\/science.1088208","volume":"302","author":"G Marsicano","year":"2003","unstructured":"Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science. 2003;302:84\u20138.","journal-title":"Science"},{"key":"53_CR16","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1440-1681.1977.tb02678.x","volume":"4","author":"GA Bentley","year":"1977","unstructured":"Bentley GA, Copeland IW, Starr J. The actions of some alpha-adrenoceptor agonists and antagonists in an antinociceptive test in mice. Clin Exp Pharmacol Physiol. 1977;4:405.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"53_CR17","first-page":"1009","volume":"22","author":"LA Naves","year":"1989","unstructured":"Naves LA, Freire AC. Xylazine antinociception in mice: evidence for mediation by postsynaptic adrenoceptors. Braz J Med Biol Res. 1989;22:1009\u2013100.","journal-title":"Braz J Med Biol Res"},{"key":"53_CR18","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1093\/bja\/76.4.544","volume":"76","author":"CS Goodchild","year":"1996","unstructured":"Goodchild CS, Guo Z, Davies A, Gent JP. Antinociceptive actions of intratecal xylazine: interations with spinal cord opioid pathways. Br J Anaesth. 1996;76:544\u201351.","journal-title":"Br J Anaesth"},{"key":"53_CR19","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/0028-3908(74)90112-9","volume":"13","author":"H Schmitt","year":"1974","unstructured":"Schmitt H, Le Douarec JC, Petillot N. The antinociceptive effect of some alpha-sympathomimetic agents. Neuropharmacology. 1974;13:289\u201394.","journal-title":"Neuropharmacology"},{"key":"53_CR20","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0304-3959(96)03218-6","volume":"69","author":"MS Gold","year":"1997","unstructured":"Gold MS, Dastmalchi S, Levine JD. \u03b12-Adrenergic receptor subtypes in rat dorsal root and superior cervical ganglion neurons. Pain. 1997;69:179\u201390.","journal-title":"Pain"},{"key":"53_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ejphar.2009.02.019","volume":"608","author":"TRL Romero","year":"2009","unstructured":"Romero TRL, Perez AC, Francischi JN, Duarte IDG. Probable involvement of \u03b12C-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by Xylazine. Eur J Pharmacol. 2009;608:23\u20137.","journal-title":"Eur J Pharmacol"},{"key":"53_CR22","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/newbio240200a0","volume":"240","author":"SH Ferreira","year":"1972","unstructured":"Ferreira SH. Prostaglandins, aspirin like drugs and analgesia. Nature (New Biol). 1972;240:200\u20133.","journal-title":"Nature (New Biol)"},{"key":"53_CR23","unstructured":"Bevan S. Nociceptive peripheral neurons: cellular properties. In: Melzack R, Wall D 4 Eds.), Textbook of pain, Churchill Livingstone 4\u00aa ed, London; 1999. pp. 85\u2013103."},{"key":"53_CR24","first-page":"118","volume":"46","author":"R Vinegar","year":"1987","unstructured":"Vinegar R, Truax JF, Selph JL, Johnston PR, Venable AL, McKenzie KK. Pathway to carrageenan-induced inflammation in the hind limb of the rat. Fed Proc. 1987;46:118\u201326.","journal-title":"Fed Proc"},{"key":"53_CR25","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0014-2999(00)00355-1","volume":"400","author":"AC Soares","year":"2000","unstructured":"Soares AC, Leite R, Tatsuo MA, Duarte ID. Activation of ATP-sensitive K(+) channels: mechanism of peripheral antinociceptive action of the nitric oxide donor, sodium nitroprusside. Eur J Pharmacol. 2000;400:67\u201371.","journal-title":"Eur J Pharmacol"},{"key":"53_CR26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0014-2999(88)90296-8","volume":"146","author":"M Nakamura","year":"1988","unstructured":"Nakamura M, Ferreira SH. Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin-like substances. Eur J Pharmacol. 1988;146:223\u20138.","journal-title":"Eur J Pharmacol"},{"key":"53_CR27","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/0306-4522(94)00562-J","volume":"66","author":"SG Khasar","year":"1995","unstructured":"Khasar SG, Green PG, Chou B, Levine DJ. Peripheral nociceptive effects of \u03b12-adrenergic receptor agonist in the rat. Neuroscience. 1995;66:427\u201332.","journal-title":"Neuroscience"},{"key":"53_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1476-5381.1983.tb10504.x","volume":"79","author":"GA Bentley","year":"1983","unstructured":"Bentley GA, Newton SH, Jennifer S. Studies on the antinociceptive action of \u03b1-agonist drugs and their interactions with opioid mechanisms. Br J Pharmacol. 1983;79:125\u201334.","journal-title":"Br J Pharmacol"},{"key":"53_CR29","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neuropharm.2004.07.030","volume":"1","author":"AC Howlett","year":"2004","unstructured":"Howlett AC, Breivogel CS, Childers SR, Deadwyler SA, Hampson SE, Porrino LJ. Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology. 2004;1:345\u201358.","journal-title":"Neuropharmacology"},{"key":"53_CR30","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/365061a0","volume":"365","author":"S Munro","year":"1993","unstructured":"Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 1993;365:61\u20135.","journal-title":"Nature"},{"key":"53_CR31","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0304-3959(01)00321-9","volume":"93","author":"TP Malan","year":"2001","unstructured":"Malan TP, Ibrahim MM, Deng H, Liu Q, Mata HP, Vanderah T. CB2 cannabinoid receptor-mediated peripheral antinociception. Pain. 2001;93:239\u201345.","journal-title":"Pain"},{"key":"53_CR32","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0304-3959(01)00454-7","volume":"96","author":"N Clayton","year":"2002","unstructured":"Clayton N, Marshall FH, Bountra C, O'Shaughnessy CT. CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain. 2002;96:253\u201360.","journal-title":"Pain"},{"key":"53_CR33","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1097\/00000542-200310000-00031","volume":"99","author":"A Quartilho","year":"2003","unstructured":"Quartilho A, Mata HP, Ibrahim MM, Vanderah TW, Porreca F, Makriyannis A, et al. Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology. 2003;99:955\u201360.","journal-title":"Anesthesiology"},{"key":"53_CR34","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.1073\/pnas.0409888102","volume":"102","author":"MM Ibrahim","year":"2005","unstructured":"Ibrahim MM, Porreca F, Lai J, Albrecht PJ, Rice FL, Khodorova A, et al. CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci USA. 2005;102:3093\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"53_CR35","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1213\/ANE.0b013e3182707859","volume":"116","author":"TRL Romero","year":"2013","unstructured":"Romero TRL, Resende LC, Guzzo LS, Duarte ID. CB1 and CB2 cannabinoid receptor agonists induce peripheral antinociception by activation of the endogenous noradrenergic system. Anesth Analg. 2013;116:463\u201372.","journal-title":"Anesth Analg"},{"key":"53_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/112_0505","volume":"160","author":"V Di Marzo","year":"2006","unstructured":"Di Marzo V. Endocannabinoids: synthesis and degradation. Rev Physiol Biochem Pharmacol. 2006;160:1\u201324.","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"53_CR37","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/nrd2553","volume":"7","author":"V Di Marzo","year":"2008","unstructured":"Di Marzo V. Targeting the endocannabinoid system: to enhance or reduce? Nat Rev Drug Discov. 2008;7:438\u201355.","journal-title":"Nat Rev Drug Discov"},{"key":"53_CR38","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1126\/science.277.5329.1094","volume":"277","author":"M Beltramo","year":"1997","unstructured":"Beltramo M, Stella N, Calignano A, Lin SY, Makriyannis A, Piomelli D. Functional role of highaffinity anandamide transport, as revealed by selective inhibition. Science. 1997;277:1094\u20137.","journal-title":"Science"},{"key":"53_CR39","doi-asserted-by":"publisher","first-page":"5298","DOI":"10.1074\/jbc.M306642200","volume":"279","author":"Y Okamoto","year":"2004","unstructured":"Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N. Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem. 2004;279:5298\u2013305.","journal-title":"J Biol Chem"},{"key":"53_CR40","first-page":"1182","volume":"22","author":"J Kim","year":"2002","unstructured":"Kim J, Isokawa M, Ledent C, Alger BE. Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus. J Neurosci. 2002;22:1182\u201391.","journal-title":"J Neurosci"},{"key":"53_CR41","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1600-0625.1996.tb00088.x","volume":"5","author":"KU Schallreuter","year":"1996","unstructured":"Schallreuter KU, K\u00f6rner C, Pittelkow MR, Swanson NN, Gardner ML. The induction of the alpha-1-adrenoceptor signal transduction system on human melanocytes. Exp Dermatol. 1996;5:20\u20133.","journal-title":"Exp Dermatol"},{"key":"53_CR42","doi-asserted-by":"publisher","first-page":"7670","DOI":"10.1073\/pnas.78.12.7670","volume":"78","author":"JD McSwigan","year":"1981","unstructured":"McSwigan JD, Hanson DR, Lubiniecki A, Heston LL, Sheppard JR. Down syndrome fibroblasts are hyperresponsive to beta-adrenergic stimulation. Proc Natl Acad Sci USA. 1981;78:7670\u20133.","journal-title":"Proc Natl Acad Sci USA"},{"key":"53_CR43","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/j.0022-202X.2004.23210.x","volume":"123","author":"JM Gillbro","year":"2004","unstructured":"Gillbro JM, Marles LK, Hibberts NA, Schallreuter KU. Autocrine catecholamine biosynthesis and the beta-adrenoceptor signal promote pigmentation in human epidermal melanocytes. J Invest Dermatol. 2004;123:346\u201353.","journal-title":"J Invest Dermatol"},{"key":"53_CR44","first-page":"57","volume":"2","author":"M Johnson","year":"2001","unstructured":"Johnson M. Beta2-adrenoceptors: mechanisms of action of beta2-agonists. Paediatr Respir Rev. 2001;2:57\u201362.","journal-title":"Paediatr Respir Rev"},{"key":"53_CR45","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1177\/0022034510388034","volume":"90","author":"P Steenhuis","year":"2011","unstructured":"Steenhuis P, Huntley RE, Gurenko Z, Yin L, Dale BA, Fazel N, et al. Adrenergic signaling in human oral keratinocytes and wound repair. J Dent Res. 2011;90:86\u2013192.","journal-title":"J Dent Res"},{"key":"53_CR46","doi-asserted-by":"crossref","unstructured":"Maccarrone M, Di Rienzo M, Battista N, Gasperi V, Guerrieri P, Rossi A, et al. The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase. J Biol Chem 2003;278:3896\u2013903.","DOI":"10.1074\/jbc.M303994200"},{"key":"53_CR47","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1038\/bjp.2008.175","volume":"154","author":"DF Pacheco","year":"2008","unstructured":"Pacheco DF, Klein A, Perez AC, Pacheco FCM, Francischi JN, Duarte ID. The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors. Br J Pharmacol. 2008;154:1143\u20139.","journal-title":"Br J Pharmacol."},{"key":"53_CR48","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/j.1460-9568.2004.03459.x","volume":"20","author":"W Binder","year":"2004","unstructured":"Binder W, Mousa SA, Sitte NA, Kaiser M, Stein C, Sch\u00e4fer M. Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue. Eur J Neurosci. 2004;20:92\u2013100.","journal-title":"Eur J Neurosci"},{"key":"53_CR49","doi-asserted-by":"crossref","unstructured":"Maisel AS, Knowlton KU, Fowler P, Rearden A, Ziegler MG, Motulsky HJ,\u00a0et al. Adrenergic\u00a0control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. J Clin Invest 1990;85:462\u20137.","DOI":"10.1172\/JCI114460"},{"key":"53_CR50","first-page":"487","volume":"53","author":"AP Kohm","year":"2001","unstructured":"Kohm AP, Sanders VM. Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo. Pharmacol Rev. 2001;53:487\u2013525.","journal-title":"Pharmacol Rev"},{"key":"53_CR51","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1006\/brbi.2001.0639","volume":"16","author":"VM Sanders","year":"2007","unstructured":"Sanders VM, Straub RH. Norepinephrine, the beta-adrenergic receptor, and immunity. Brain Behav Immun. 2007;16:290\u2013332.","journal-title":"Brain Behav Immun"},{"key":"53_CR52","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0005-2760(98)00110-6","volume":"1394","author":"VK Pestonjamasp","year":"1998","unstructured":"Pestonjamasp VK, Burstein SH. Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system. Biochim Biophys Acta. 1998;1394:249\u201360.","journal-title":"Biochim Biophys Acta"},{"key":"53_CR53","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1124\/jpet.109.163998","volume":"333","author":"SJ Mnich","year":"2010","unstructured":"Mnich SJ, Hiebsch RR, Huff RM, Muthian S. Anti-inflammatory properties of CB1-receptor antagonist involves beta2 adrenoceptors. J Pharmacol Exp Ther. 2010;333:445\u201353.","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-019-00053-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s43440-019-00053-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-019-00053-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T03:27:08Z","timestamp":1610162828000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s43440-019-00053-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,10]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["53"],"URL":"https:\/\/doi.org\/10.1007\/s43440-019-00053-6","relation":{},"ISSN":["1734-1140","2299-5684"],"issn-type":[{"value":"1734-1140","type":"print"},{"value":"2299-5684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,10]]},"assertion":[{"value":"17 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors inform non conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}