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The selective antagonists of the 5-HT<jats:sub>2A<\/jats:sub>, 5-HT<jats:sub>2C<\/jats:sub> and 5-HT<jats:sub>1A<\/jats:sub> serotonin receptor subtypes: M100907, SB242084 and WAY100635, respectively were applied through a microdialysis probe.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The WDS response to 25I-NBOMe (1 and 3\u00a0mg\/kg) was significantly reduced by local administration of M100907 and SB242084 (100\u00a0nM). The 25I-NBOMe-induced increase in glutamate, DA and 5-HT release was inhibited by M100907 and SB242084. WAY100635 had no effect on 25I-NBOMe-induced WDS and glutamate release, while it decreased DA and 5-HT release from cortical neuronal terminals.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The obtained results suggest that 5-HT<jats:sub>2A<\/jats:sub> and 5-HT<jats:sub>2C<\/jats:sub> receptors play a role in 25I-NBOMe-induced hallucinogenic activity and in glutamate, DA and 5-HT release in the rat frontal cortex as their respective antagonists attenuated the effect of this hallucinogen. The disinhibition of GABA cells by the 5-HT<jats:sub>1A<\/jats:sub> receptor antagonist seems to underlie the mechanism of decreased DA and 5-HT release from neuronal terminals in the frontal cortex.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s43440-020-00181-4","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T13:02:54Z","timestamp":1605013374000},"page":"1593-1603","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Contribution of serotonin receptor subtypes to hallucinogenic activity of 25I-NBOMe and to its effect on neurotransmission"],"prefix":"10.1007","volume":"72","author":[{"given":"Monika","family":"Herian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Wojtas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata Katarzyna","family":"Soboci\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Skawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gonz\u00e1lez-Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-1394","authenticated-orcid":false,"given":"Krystyna","family":"Go\u0142embiowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"181_CR1","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.neuropharm.2015.08.034","volume":"99","author":"A Rickli","year":"2015","unstructured":"Rickli A, Luethi D, Reinisch J, Buchy D, Hoener MC, Liechti ME. 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