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To understand the mechanism of susceptibility to this disease, one should consider the significant role of the interaction between immune and nervous systems. Their joint development from the moment of conception is a matrix of later predispositions, both associated with the mobilization of the proinflammatory pathways (TNF\u03b1, IL-1\u03b2, IL-6) and associated with psychological coping with stress. Such an early development period is associated with epigenetic processes that are strongly marked in prenatal development up to 1\u00a0year of age and determinate the characteristic phenotype for various forms of pathology, including depression. Regarding the inflammatory hypothesis of depression, interleukin 17 (IL-17), among other proinflammatory cytokines, might play an important role in the development of depressive disorders. It is secreted by Th17 cells, crossed the placental barrier and acts on the brain structures of the fetus by increasing IL-17 receptor levels and affecting the intensity of its signaling in the brain.<\/jats:p>","DOI":"10.1007\/s43440-020-00202-2","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T23:23:16Z","timestamp":1609456996000},"page":"346-356","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Update on the neurodevelopmental theory of depression: is there any \u2018unconscious code\u2019?"],"prefix":"10.1007","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-5255","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Ga\u0142ecka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Bli\u017aniewska-Kowalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Pin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ga\u0142ecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"202_CR1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/da.22607","volume":"34","author":"AR Docherty","year":"2017","unstructured":"Docherty AR, Edwards AC, Yang F, et al. 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