{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:20:03Z","timestamp":1771237203739,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100010728","name":"ICAR-Indian Veterinary Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010728","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacol. Rep"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s43440-022-00399-4","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T04:02:24Z","timestamp":1659931344000},"page":"1054-1068","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Luteolin alleviates vascular dysfunctions in CLP-induced polymicrobial sepsis in mice"],"prefix":"10.1007","volume":"74","author":[{"given":"Soya","family":"Rungsung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6800-8437","authenticated-orcid":false,"given":"Thakur Uttam","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirthika","family":"Perumalraja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Mahobiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meemansha","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhu Cholenahalli","family":"Lingaraju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhashree","family":"Parida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monalisa","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"399_CR1","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.jcrc.2016.11.036","volume":"38","author":"A Moskowitz","year":"2017","unstructured":"Moskowitz A, Omar Y, Chase M, Lokhandwala S, Patel P, Andersen LW, et al. Reasons for death in patients with sepsis and septic shock. J Crit Care. 2017;38:284\u20138.","journal-title":"J Crit Care"},{"key":"399_CR2","doi-asserted-by":"publisher","first-page":"720313","DOI":"10.3389\/fgene.2021.720313","volume":"12","author":"J Sun","year":"2021","unstructured":"Sun J, Zhang H, Liu D, Cui L, Wang Q, Gan L, et al. A functional variant of CXCL16 is associated with predisposition to sepsis and MODS in trauma patients. Front Genet. 2021;12:720313.","journal-title":"Front Genet"},{"key":"399_CR3","first-page":"629","volume":"92","author":"C Caraballo","year":"2019","unstructured":"Caraballo C, Jaimes F. Organ dysfunction in sepsis: an ominous trajectory from infection to death. Yale J Biol Med. 2019;92:629\u201340.","journal-title":"Yale J Biol Med"},{"key":"399_CR4","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1097\/PCC.0000000000000254","volume":"15","author":"A Ruth","year":"2014","unstructured":"Ruth A, McCracken CE, Fortenberry JD, Hall M, Simon HK, Hebbar KB. Pediatric severe sepsis: current trends and outcomes from the Pediatric Health Information Systems database. Pediatr Crit Care Med. 2014;15:828\u201338.","journal-title":"Pediatr Crit Care Med"},{"key":"399_CR5","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1097\/01.CCM.0000261890.41311.E9","volume":"35","author":"VY Dombrovskiy","year":"2007","unstructured":"Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 2007;35:1244\u201350.","journal-title":"Crit Care Med"},{"key":"399_CR6","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1097\/CCM.0b013e31827c09f8","volume":"41","author":"DF Gaieski","year":"2013","unstructured":"Gaieski DF, Edwards JM, Kallan MJ, Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med. 2013;41:1167\u201374.","journal-title":"Crit Care Med"},{"issue":"2","key":"399_CR7","doi-asserted-by":"publisher","first-page":"e88501","DOI":"10.1371\/journal.pone.0088501","volume":"9","author":"SE Gill","year":"2014","unstructured":"Gill SE, Taneja R, Rohan M, Wang L, Mehta S. Pulmonary microvascular albumin leak is associated with endothelial cell death in murine sepsis-induced lung injury in vivo. PLoS ONE. 2014;9(2):e88501.","journal-title":"PLoS ONE"},{"key":"399_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153567","volume":"86","author":"A Karimi","year":"2021","unstructured":"Karimi A, Naeini F, Azar VA, Hasanzadeh M, Ostadrahimia A, Niazkare HR, et al. A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis. Phytomedicine. 2021;86: 153567.","journal-title":"Phytomedicine"},{"key":"399_CR9","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/1541-4337.12047","volume":"13","author":"SF Nabavi","year":"2014","unstructured":"Nabavi SF, Daglia M, Moghaddam AH, Habtemariam S, Nabavi SM. Curcumin and liver disease: from chemistry to medicine. Compr Rev Food Sci Food Saf. 2014;13:62\u201377.","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"8","key":"399_CR10","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1292\/jvms.16-0196","volume":"78","author":"K Kanai","year":"2016","unstructured":"Kanai K, Nagata S, Hatta T, Sugiura Y, Sato K, Yamashita Y, et al. Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats. J Vet Med Sci. 2016;78(8):1381\u20134.","journal-title":"J Vet Med Sci"},{"issue":"5","key":"399_CR11","first-page":"1477","volume":"45","author":"B Wu","year":"2020","unstructured":"Wu B, Song H, Fan M, You F, Zhang L, Luo J, et al. Luteolin attenuates sepsis-induced myocardial injury by enhancing autophagy in mice. Int J Mol Med. 2020;45(5):1477\u201387.","journal-title":"Int J Mol Med"},{"issue":"8","key":"399_CR12","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1080\/09168451.2015.1116928","volume":"80","author":"Y Zang","year":"2016","unstructured":"Zang Y, Igarashi K, Li Y. Anti-diabetic effects of luteolin and luteolin-7-O-glucoside on KK-A(y) mice. Biosci Biotechnol Biochem. 2016;80(8):1580\u20136.","journal-title":"Biosci Biotechnol Biochem"},{"issue":"1","key":"399_CR13","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3892\/ijmm.2016.2809","volume":"39","author":"J Xiong","year":"2017","unstructured":"Xiong J, Wang K, Yuan C, Xing R, Ni J, Hu G, et al. Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects. Int J Mol Med. 2017;39(1):113\u201325.","journal-title":"Int J Mol Med"},{"issue":"6","key":"399_CR14","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1164\/rccm.202006-2301ED","volume":"202","author":"F Uhel","year":"2020","unstructured":"Uhel F, Poll T. Norepinephrine in septic shock: a mixed blessing. Am J Respir Crit Care Med. 2020;202(6):788\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"399_CR15","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1093\/bja\/aeh171","volume":"93","author":"JD Young","year":"2004","unstructured":"Young JD. The heart and circulation in severe sepsis. Br J Anaesth. 2004;93:114\u201320.","journal-title":"Br J Anaesth"},{"issue":"4","key":"399_CR16","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1177\/0300060517743836","volume":"46","author":"AM Burgdorff","year":"2018","unstructured":"Burgdorff AM, Bucher M, Schumann J. Vasoplegia in patients with sepsis and septic shock: pathways and mechanisms. J Int Med Res. 2018;46(4):1303\u201310.","journal-title":"J Int Med Res"},{"key":"399_CR17","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1097\/00005344-200309000-00003","volume":"42","author":"A Bermejo","year":"2003","unstructured":"Bermejo A, Zarzuelo A, Duarte J. In vivo vascular effects of genistein on a rat model of septic shock induced by lipopolysaccharide. J Cardiovasc Pharmacol. 2003;42:329\u201338.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"399_CR18","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1164\/rccm.201910-1911TR","volume":"202","author":"J Joffre","year":"2020","unstructured":"Joffre J, Hellman J, Ince C, Ait-Oufella H. Endothelial Responses in Sepsis. Am J Respir Crit Care Med. 2020;202(3):361\u201370.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3\u20134","key":"399_CR19","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.lfs.2008.05.010","volume":"83","author":"X Ma","year":"2008","unstructured":"Ma X, Li YF, Gao Q, Ye ZG, Lu XJ, Wang HP, et al. Inhibition of superoxide anion-mediated impairment of endothelium by treatment with luteolin and apigenin in rat mesenteric artery. Life Sci. 2008;83(3\u20134):110\u20137.","journal-title":"Life Sci"},{"issue":"4","key":"399_CR20","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.phrs.2009.10.004","volume":"61","author":"LB Qian","year":"2010","unstructured":"Qian LB, Wang HP, Chen Y, Chen FX, Ma YY, Bruce IC, et al. Luteolin reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress. Pharmacol Res. 2010;61(4):281\u20137.","journal-title":"Pharmacol Res"},{"issue":"11","key":"399_CR21","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1002\/ptr.4917","volume":"27","author":"HM El-Bassossy","year":"2011","unstructured":"El-Bassossy HM, Abo-Warda SM, Fahmy A. Chrysin and luteolin attenuate diabetes-induced impairment in endothelial-dependent relaxation: effect on lipid profile, AGEs and NO generation. Phytother Res. 2011;27(11):1678\u201384.","journal-title":"Phytother Res"},{"key":"399_CR22","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.3389\/fphar.2018.01094","volume":"9","author":"D Gentile","year":"2018","unstructured":"Gentile D, Fornai M, Pellegrini C, Colucci R, Benvenuti L, Duranti E, et al. Luteolin prevents cardiometabolic alterations and vascular dysfunction in mice with HFD-induced obesity. Front Pharmacol. 2018;9:1094.","journal-title":"Front Pharmacol"},{"key":"399_CR23","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1164\/ajrccm.165.6.2101049","volume":"165","author":"A Kotanidou","year":"2002","unstructured":"Kotanidou A, Xagorari A, Bagli E, Kitsanta P, Fotsis T, Papapetropoulos A, et al. Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Am J Respir Crit Care Med. 2002;165:818\u201323.","journal-title":"Am J Respir Crit Care Med"},{"key":"399_CR24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-4804(80)90037-2","volume":"29","author":"KA Wichterman","year":"1980","unstructured":"Wichterman KA, Baue AE, Chaudry IH. Sepsis and septic shock-a review of laboratory models and a proposal. J Surg Res. 1980;29:189\u2013201.","journal-title":"J Surg Res"},{"issue":"4","key":"399_CR25","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCT method. Methods. 2001;25(4):402\u20138.","journal-title":"Methods"},{"key":"399_CR26","doi-asserted-by":"publisher","first-page":"8352727","DOI":"10.1155\/2018\/8352727","volume":"2018","author":"X Zhai","year":"2018","unstructured":"Zhai X, Yang Z, Zheng G, Yu T, Wang P, Liu X, et al. Lactate as a potential biomarker of sepsis in a rat cecal ligation and puncture model. Mediators Inflamm. 2018;2018:8352727.","journal-title":"Mediators Inflamm"},{"issue":"7","key":"399_CR27","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.21037\/jtd.2016.05.55","volume":"8","author":"SM Lee","year":"2016","unstructured":"Lee SM, An WS. New clinical criteria for septic shock: serum lactate level as new emerging vital sign. J Thorac Dis. 2016;8(7):1388\u201390.","journal-title":"J Thorac Dis"},{"issue":"10","key":"399_CR28","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.nut.2009.02.010","volume":"25","author":"H Shapiro","year":"2009","unstructured":"Shapiro H, Lev S, Cohen J, Singer P. Polyphenols in the prevention and treatment of sepsis syndromes: rationale and pre-clinical evidence. Nutrition. 2009;25(10):981\u201397.","journal-title":"Nutrition"},{"issue":"4","key":"399_CR29","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1186\/cc3748","volume":"9","author":"JL Vincent","year":"2005","unstructured":"Vincent JL, Backer D. Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. Crit Care. 2005;9(4):S9\u201312.","journal-title":"Crit Care"},{"issue":"1","key":"399_CR30","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1124\/jpet.302.1.66","volume":"302","author":"F Perez-Viscaine","year":"2002","unstructured":"Perez-Viscaine F, Ibarra M, Cogolludo AL, Duarte J, Zaragoza Arnaez F, Moreno L, et al. Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. J Pharmacol Exp Ther. 2002;302(1):66\u201372.","journal-title":"J Pharmacol Exp Ther"},{"key":"399_CR31","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.3390\/molecules24122243","volume":"24","author":"N Kamkaew","year":"2019","unstructured":"Kamkaew N, Paracha TU, Ingkaninan K, Waranuch N, Chootip K. Vasodilatory effects and mechanisms of action of bacopa monnieri active compounds on rat mesenteric arteries. Molecules. 2019;24:2243.","journal-title":"Molecules"},{"issue":"18","key":"399_CR32","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.3390\/molecules25184320","volume":"25","author":"L Ciumarnean","year":"2020","unstructured":"Ciumarnean L, Milaciu MV, Runcan O, Vesa SC, Rachisan AL, Negrean V, et al. The effects of flavonoids in cardiovascular diseases. Molecules. 2020;25(18):4320.","journal-title":"Molecules"},{"key":"399_CR33","doi-asserted-by":"publisher","first-page":"H1695","DOI":"10.1152\/ajpheart.00564.2008","volume":"295","author":"HI Cohn","year":"2008","unstructured":"Cohn HI, Harris DM, Pesant S, Pfeiffer M, Zhou RH, Koch WJ, et al. Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances 1D-adrenergic receptor constriction. AJP Heart Circ Physiol. 2008;295:H1695\u2013704.","journal-title":"AJP Heart Circ Physiol"},{"issue":"3","key":"399_CR34","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/sj.bjp.0706325","volume":"146","author":"C Hosoda","year":"2005","unstructured":"Hosoda C, Tanoue A, Shibano M, Tanaka Y, Hiroyama M, Koshimizu TA, et al. Correlation between vasoconstrictor roles and mRNA expression of alpha1-adrenoceptor subtypes in blood vessels of genetically engineered mice. Br J Pharmacol. 2005;146(3):456\u201366.","journal-title":"Br J Pharmacol"},{"key":"399_CR35","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/SHK.0b013e31821a4002","volume":"36","author":"K Kandasamy","year":"2011","unstructured":"Kandasamy K, Prawez S, Choudhury S, More AS, Ahanger AA, Singh TU, et al. Atorvastatin prevents vascular hyporeactivity to norepinephrine in sepsis: role of nitric oxide and \u03b11-adrenoceptor mRNA expression. Shock. 2011;36:76\u201382.","journal-title":"Shock"},{"key":"399_CR36","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/SHK.0000000000000138","volume":"41","author":"R Thangamalai","year":"2014","unstructured":"Thangamalai R, Kandasamy K, Sukumarn SV, Reddy N, Singh V, Choudhury S, et al. Atorvastatin prevents sepsis-induced downregulation of myocardial \u03b21-adrenoceptors and decreased cAMP response in mice. Shock. 2014;41:406\u201312.","journal-title":"Shock"},{"key":"399_CR37","first-page":"36","volume":"1535","author":"P Wang","year":"2000","unstructured":"Wang P, Tait SM, Chaudry IH. Sustained elevation of norepinephrine depresses hepatocellular function. Biochem Biophys Acta. 2000;1535:36\u201344.","journal-title":"Biochem Biophys Acta"},{"issue":"1","key":"399_CR38","first-page":"H149","volume":"313","author":"D Secco","year":"2010","unstructured":"Secco D, Olivon V, Corr\u00eaa T, Celes M, Abreu M, Rossi M, et al. Cardiovascular hyporesponsiveness in sepsis is associated with G-protein receptor kinase expression via a nitric oxide-dependent mechanism. Crit Care. 2010;313(1):H149\u201363.","journal-title":"Crit Care"},{"issue":"Suppl 1","key":"399_CR39","doi-asserted-by":"publisher","first-page":"S379","DOI":"10.1038\/sj.bjp.0707604","volume":"153","author":"E Kelly","year":"2008","unstructured":"Kelly E, Bailey CP, Henderson G. Agonist-selective mechanisms of GPCR desensitization. Br J Pharmacol. 2008;153(Suppl 1):S379\u201388.","journal-title":"Br J Pharmacol"},{"issue":"10","key":"399_CR40","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1073\/pnas.1701529114","volume":"114","author":"TJ Cahill III","year":"2017","unstructured":"Cahill TJ III, Thomsen ARB, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, et al. Distinct conformations of GPCR\u2013\u03b2-arrestin complexes mediate desensitization, signaling, and endocytosis. Proc Natl Acad Sci USA. 2017;114(10):2562\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"key":"399_CR41","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S1499-3872(13)60047-8","volume":"12","author":"W Chen","year":"2013","unstructured":"Chen W, Sang JY, Liu DJ, Qin J, Huo YM, Xu J, et al. Desensitization of G-protein-coupled receptors induces vascular hypocontractility in response to norepinephrine in the mesenteric arteries of cirrhotic patients and rats. Hepatobiliary Pancreat Dis Int. 2013;12:295\u2013304.","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"399_CR42","doi-asserted-by":"publisher","first-page":"E18","DOI":"10.1161\/01.RES.87.7.e18","volume":"87","author":"WA Boyle","year":"2000","unstructured":"Boyle WA, Parvathaneni LS, Bourlier V, Sauter C, Laubach VE, Cobb JP. iNOS gene expression modulates microvascular responsiveness in endotoxin-challenged mice. Circ Res. 2000;87:E18-24.","journal-title":"Circ Res"},{"key":"399_CR43","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s40635-019-0274-x","volume":"7","author":"S Lambden","year":"2019","unstructured":"Lambden S. Bench to bedside review: therapeutic modulation of nitric oxide in sepsis-an update. Intensive Care Med Exp. 2019;7:64.","journal-title":"Intensive Care Med Exp"},{"issue":"4","key":"399_CR44","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1373\/jalm.2018.026377","volume":"3","author":"RJ Webber","year":"2019","unstructured":"Webber RJ, Sweet RM, Webber DS. Inducible nitric oxide synthase in circulating microvesicles: discovery, evolution, and evidence as a novel biomarker and the probable causative agent for sepsis. J Appl Lab Med. 2019;3(4):698\u2013711.","journal-title":"J Appl Lab Med"},{"key":"399_CR45","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/SHK.0b013e3181bea334","volume":"33","author":"SJ Chen","year":"2010","unstructured":"Chen SJ, Li SY, Shih CC, Liao MH, Wu CC. NO contributes to abnormal vascular calcium regulation and reactivity induced by peritonitis-associated septic shock in rats. Shock. 2010;33:473\u20138.","journal-title":"Shock"},{"issue":"4","key":"399_CR46","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1097\/00003246-200204000-00030","volume":"30","author":"K Takakura","year":"2002","unstructured":"Takakura K, Taniguchi T, Muramatsu I, Takeuchi K, Fukuda S. Modification of alpha1-adrenoceptors by peroxynitrite as a possible mechanism of systemic hypotension in sepsis. Crit Care Med. 2002;30(4):894\u20139.","journal-title":"Crit Care Med"},{"key":"399_CR47","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1164\/rccm.2011144","volume":"165","author":"JA Scott","year":"2002","unstructured":"Scott JA, Mehta S, Duggan M, Bihari A, McCormack DG. Functional inhibition of constitutive nitric oxide synthase in a rat model of sepsis. Am J Respir Crit Care Med. 2002;165:1426\u201332.","journal-title":"Am J Respir Crit Care Med"},{"key":"399_CR48","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1097\/FJC.0b013e3181bfafd6","volume":"54","author":"J Subramani","year":"2009","unstructured":"Subramani J, Kathirvel K, Leo MD, Kuntamallappanavar G, Singh TU, Mishra SK. Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. J Cardiovasc Pharmacol. 2009;54:526\u201334.","journal-title":"J Cardiovasc Pharmacol"},{"key":"399_CR49","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00394-013-0525-7","volume":"53","author":"H Si","year":"2014","unstructured":"Si H, Wyeth RP, Liu D. The flavonoid luteolin induces nitric oxide production and arterial relaxation. Eur J Nutr. 2014;53:269\u201375.","journal-title":"Eur J Nutr"},{"key":"399_CR50","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S0008-6363(00)00049-3","volume":"46","author":"SK Mishra","year":"2000","unstructured":"Mishra SK, Abbot SE, Choudhury Z, Cheng M, Khatab N, Maycock NJ, et al. Endothelium-dependent relaxation of rat aorta and main pulmonary artery by the phytoestrogens genistein and daidzein. Cardiovasc Res. 2000;46:539\u201346.","journal-title":"Cardiovasc Res"},{"key":"399_CR51","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jare.2020.01.002","volume":"24","author":"HM Abdallah","year":"2020","unstructured":"Abdallah HM, Hassan NA, El-Halawany AM, Mohamed GA, Safo MK, El-Bassossy HM. Major flavonoids from Psiadia punctulata produce vasodilaion via activation of endothelial dependent NO signaling. J Adv Res. 2020;24:273\u20139.","journal-title":"J Adv Res"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-022-00399-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43440-022-00399-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-022-00399-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T20:02:07Z","timestamp":1666382527000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43440-022-00399-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["399"],"URL":"https:\/\/doi.org\/10.1007\/s43440-022-00399-4","relation":{},"ISSN":["1734-1140","2299-5684"],"issn-type":[{"value":"1734-1140","type":"print"},{"value":"2299-5684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"assertion":[{"value":"29 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}