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Rep"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Perioperative anesthetic and\/or analgesic demand present considerable variation, and part of that variation appears to be genetic in origin. Here we investigate the impact of common polymorphisms in <jats:italic>OPRM1, COMT, SLC6A4, ABCB1,<\/jats:italic> and <jats:italic>CYP2B6<\/jats:italic> genes, on the intra-operative consumption of remifentanil and propofol, as well as the postoperative analgesic needs, in patients subjected to thyroidectomy surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a prospective cohort study with 90 patients scheduled to undergo elective thyroidectomy, under total intravenous anesthesia achieved by target control infusion (TCI) of propofol and remifentanil. Postoperative analgesics were administered by protocol and on-demand by the individual patient. Genotyping was established by PCR\u2013RFLP methods. Genotyping data, intra-operative hemodynamics, and total consumption of remifentanil and propofol, as well as postoperative analgesic needs and pain perception, were recorded for each individual.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients with the <jats:italic>ABCB1<\/jats:italic> 3435TT genotype appeared to experience significantly less pain within one hour post-operatively, compared to C carriers [mean VAS (SD)\u2009=\u20090.86 (1.22) vs. 2.42 (1.75); <jats:italic>p<\/jats:italic>\u2009=\u20090.017], a finding limited to those seeking rescue analgesic treatment. Intra-operatively, homozygotes patients for the minor allele of <jats:italic>OPRM1<\/jats:italic> A118G and <jats:italic>CYP2B6<\/jats:italic> G516T appeared to consume less remifentanil [mean (SD)\u2009=\u20099.12 (1.01) vs. 13.53 (5.15), for <jats:italic>OPRM1<\/jats:italic> 118GG and A carriers] and propofol [median (range)\u2009=\u200914.95 (11.53, 1359.5) vs. 121.4 (1.43, 2349.4), for <jats:italic>CYP2B6<\/jats:italic> 516TT and G carriers, respectively] but the difference was not statistically significant in our sample.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The <jats:italic>ABCB1<\/jats:italic> C3435T polymorphism appears to affect the postoperative perception of surgical pain among patients with low pain threshold. The small number of minor allele homozygotes for the <jats:italic>OPRM1<\/jats:italic> A118G and <jats:italic>CYP2B6<\/jats:italic> G516T polymorphisms precludes a definitive conclusion regarding the inclusion of the latter in a TCI-programming algorithm, based on the results of this study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical trial registration number<\/jats:title>\n                <jats:p>ACTRN12616001598471.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s43440-023-00455-7","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T17:17:23Z","timestamp":1675790243000},"page":"386-396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of common OPRM1, COMT, SLC6A4, ABCB1, and CYP2B6 polymorphisms on perioperative analgesic and propofol demands on patients subjected to thyroidectomy surgery"],"prefix":"10.1007","volume":"75","clinical-trial-number":[{"clinical-trial-number":"actrn12616001598471","registry":"10.18810\/anzctr"}],"author":[{"given":"Ioanna","family":"Soultati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charikleia","family":"Ntenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Tsaousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3781-9680","authenticated-orcid":false,"given":"Chryssa","family":"Pourzitaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Gkinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evanthia","family":"Thomaidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiros","family":"Alexandrakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodosios","family":"Papavramidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis","family":"Goulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"455_CR1","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S0952-8180(96)00179-1","volume":"8","author":"LG Michelsen","year":"1996","unstructured":"Michelsen LG, Hug CC. 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