{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:44:06Z","timestamp":1789055046027,"version":"build-2803163510"},"reference-count":301,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacol. Rep"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s43440-023-00554-5","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:02:13Z","timestamp":1700755333000},"page":"25-50","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis"],"prefix":"10.1007","volume":"76","author":[{"given":"Azam","family":"Hosseinzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Pourhanifeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Amiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sheibani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Irilouzadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-2330","authenticated-orcid":false,"given":"Saeed","family":"Mehrzadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"554_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2019.02.001","volume":"65","author":"M Parola","year":"2019","unstructured":"Parola M, Pinzani M. Pathophysiology of organ and tissue fibrosis. Mol Aspects Med. 2019;65:1.","journal-title":"Mol Aspects Med"},{"issue":"1","key":"554_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1172\/JCI93563","volume":"128","author":"J-I Jun","year":"2018","unstructured":"Jun J-I, Lau LF. Resolution of organ fibrosis. J Clin lnvest. 2018;128(1):97\u2013107.","journal-title":"J Clin lnvest"},{"key":"554_CR3","doi-asserted-by":"crossref","unstructured":"Liu L, Sun Q, Davis F, Mao J, Zhao H, Ma D. Epithelial\u2013mesenchymal transition in organ fibrosis development: current understanding and treatment strategies. Burns Trauma. 2022;10:tkac011.","DOI":"10.1093\/burnst\/tkac011"},{"issue":"2","key":"554_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/jpi.12302","volume":"60","author":"W Hu","year":"2016","unstructured":"Hu W, Ma Z, Jiang S, Fan C, Deng C, Yan X, et al. Melatonin: the dawning of a treatment for fibrosis? J Pineal Res. 2016;60(2):121\u201331.","journal-title":"J Pineal Res"},{"issue":"10","key":"554_CR5","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1007\/s00198-023-06836-1","volume":"34","author":"A Bagherifard","year":"2023","unstructured":"Bagherifard A, Hosseinzadeh A, Koosha F, Sheibani M, Karimi-Behnagh A, Reiter RJ, et al. Melatonin and bone-related diseases: an updated mechanistic overview of current evidence and future prospects. Osteoporos Int. 2023;34(10):1677\u2013701.","journal-title":"Osteoporos Int"},{"issue":"7","key":"554_CR6","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.nrleng.2018.08.004","volume":"37","author":"JJ Poza","year":"2022","unstructured":"Poza JJ, Pujol M, Ortega-Alb\u00e1s JJ, Romero O. Melatonin in sleep disorders. Neurolog\u00eda (English Edition). 2022;37(7):575\u201385.","journal-title":"Neurolog\u00eda (English Edition)"},{"issue":"9","key":"554_CR7","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.3390\/cells12091237","volume":"12","author":"G Anderson","year":"2023","unstructured":"Anderson G, Almulla AF, Reiter RJ, Maes M. Redefining autoimmune disorders\u2019 pathoetiology: implications for mood and psychotic disorders\u2019 association with neurodegenerative and classical autoimmune disorders. Cells. 2023;12(9):1237.","journal-title":"Cells"},{"key":"554_CR8","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1007\/BF01923947","volume":"49","author":"RJ Reiter","year":"1993","unstructured":"Reiter RJ. The melatonin rhythm: both a clock and a calendar. Experientia. 1993;49:654\u201364.","journal-title":"Experientia"},{"issue":"6","key":"554_CR9","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1080\/01616412.2017.1315864","volume":"39","author":"Z Xie","year":"2017","unstructured":"Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, et al. A review of sleep disorders and melatonin. Neurol Res. 2017;39(6):559\u201365.","journal-title":"Neurol Res"},{"issue":"2","key":"554_CR10","first-page":"1174","volume":"1","author":"S Masahiro","year":"2023","unstructured":"Masahiro S, Fukunaga K, Kawahata I. Use of melatonin for the treatment of dementia: Addressing core symptoms and behavioral challenges. J Clin Bas Psycho. 2023;1(2):1174.","journal-title":"J Clin Bas Psycho."},{"issue":"4","key":"554_CR11","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3390\/brainsci10040219","volume":"10","author":"B Rzepka-Migut","year":"2020","unstructured":"Rzepka-Migut B, Paprocka J. Efficacy and safety of melatonin treatment in children with Autism Spectrum Disorder and Attention-Deficit\/Hyperactivity Disorder\u2014a review of the literature. Brain Sci. 2020;10(4):219.","journal-title":"Brain Sci"},{"issue":"5","key":"554_CR12","doi-asserted-by":"publisher","first-page":"837","DOI":"10.3390\/antiox11050837","volume":"11","author":"A Arjunan","year":"2022","unstructured":"Arjunan A, Sah DK, Jung YD, Song J. Hepatic encephalopathy and melatonin. Antioxidants. 2022;11(5):837.","journal-title":"Antioxidants"},{"issue":"12","key":"554_CR13","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1080\/14728222.2018.1541318","volume":"22","author":"A Hosseinzadeh","year":"2018","unstructured":"Hosseinzadeh A, Javad-Moosavi SA, Reiter RJ, Yarahmadi R, Ghaznavi H, Mehrzadi S. Oxidative\/nitrosative stress, autophagy and apoptosis as therapeutic targets of melatonin in idiopathic pulmonary fibrosis. Expert Opin Ther Targets. 2018;22(12):1049\u201361.","journal-title":"Expert Opin Ther Targets"},{"key":"554_CR14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.lfs.2018.03.032","volume":"201","author":"A Hosseinzadeh","year":"2018","unstructured":"Hosseinzadeh A, Javad-Moosavi SA, Reiter RJ, Hemati K, Ghaznavi H, Mehrzadi S. Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin. Life Sci. 2018;201:17\u201329.","journal-title":"Life Sci"},{"issue":"3","key":"554_CR15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s40211-021-00395-9","volume":"35","author":"C Popow","year":"2021","unstructured":"Popow C, Ohmann S, Plener P. Practitioner\u2019s review: Medication for children and adolescents with autism spectrum disorder (ASD) and comorbid conditions. Neuropsychiatrie. 2021;35(3):113\u201334.","journal-title":"Neuropsychiatrie"},{"issue":"3","key":"554_CR16","doi-asserted-by":"publisher","first-page":"239","DOI":"10.5409\/wjcp.v11.i3.239","volume":"11","author":"MO Ogundele","year":"2022","unstructured":"Ogundele MO, Yemula C. Management of sleep disorders among children and adolescents with neurodevelopmental disorders: a practical guide for clinicians. World J Clin Pediatr. 2022;11(3):239.","journal-title":"World J Clin Pediatr"},{"issue":"3","key":"554_CR17","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.3390\/ijms22031490","volume":"22","author":"S Lalanne","year":"2021","unstructured":"Lalanne S, Fougerou-Leurent C, Anderson GM, Schroder CM, Nir T, Chokron S, et al. Melatonin: from pharmacokinetics to clinical use in autism spectrum disorder. Int J Mol Sci. 2021;22(3):1490.","journal-title":"Int J Mol Sci"},{"key":"554_CR18","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s40263-019-00680-w","volume":"33","author":"FM Besag","year":"2019","unstructured":"Besag FM, Vasey MJ, Lao KS, Wong IC. Adverse events associated with melatonin for the treatment of primary or secondary sleep disorders: a systematic review. CNS Drugs. 2019;33:1167\u201386.","journal-title":"CNS Drugs"},{"key":"554_CR19","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s40501-020-00233-9","volume":"7","author":"LB Gerlach","year":"2020","unstructured":"Gerlach LB, Kales HC. Pharmacological management of neuropsychiatric symptoms of dementia. Curr Treat Options Psychiatry. 2020;7:489\u2013507.","journal-title":"Curr Treat Options Psychiatry"},{"issue":"1","key":"554_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41983-022-00524-3","volume":"58","author":"I Adnyana","year":"2022","unstructured":"Adnyana I, Tertia C, Widyadharma I, Mahadewi NPAP. Melatonin as a treatment for migraine sufferers: a systematic review. Egypt J Neurol Psychiatry Neurosurg. 2022;58(1):1\u201310.","journal-title":"Egypt J Neurol Psychiatry Neurosurg"},{"key":"554_CR21","doi-asserted-by":"crossref","unstructured":"Nussbaumer\u2010Streit B, Greenblatt A, Kaminski\u2010Hartenthaler A, Van Noord MG, Forneris CA, Morgan LC, et al. Melatonin and agomelatine for preventing seasonal affective disorder. Cochrane Database Syst Rev. 2019; 6:CD011271.","DOI":"10.1002\/14651858.CD011271.pub3"},{"issue":"4","key":"554_CR22","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s00018-023-04736-5","volume":"80","author":"RJ Reiter","year":"2023","unstructured":"Reiter RJ, Sharma R, Cucielo MS, Tan DX, Rosales-Corral S, Gancitano G, et al. Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm. Cell Mol Life Sci. 2023;80(4):88.","journal-title":"Cell Mol Life Sci"},{"key":"554_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/17474124.2023.2267439","volume":"17","author":"S Mehrzadi","year":"2023","unstructured":"Mehrzadi S, Sheibani M, Koosha F, Alinaghian N, Pourhanifeh MH, Tabaeian SAP, et al. Protective and therapeutic potential of melatonin against intestinal diseases: updated review of current data based on molecular mechanisms. Expert Rev Gastroenterol Hepatol. 2023;17:1\u201319.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"554_CR24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2147\/CIA.S361519","volume":"18","author":"C Tuft","year":"2023","unstructured":"Tuft C, Matar E, Menczel Schrire Z, Grunstein RR, Yee BJ, Hoyos CM. Current insights into the risks of using melatonin as a treatment for sleep disorders in older adults. Clin Interv Aging. 2023;18:49\u201359.","journal-title":"Clin Interv Aging"},{"issue":"12","key":"554_CR25","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s40263-019-00680-w","volume":"33","author":"FMC Besag","year":"2019","unstructured":"Besag FMC, Vasey MJ, Lao KSJ, Wong ICK. Adverse events associated with melatonin for the treatment of primary or secondary sleep disorders: a systematic review. CNS Drugs. 2019;33(12):1167\u201386.","journal-title":"CNS Drugs"},{"issue":"1","key":"554_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1507\/endocrj.EJ12-0263","volume":"60","author":"H Tamura","year":"2013","unstructured":"Tamura H, Takasaki A, Taketani T, Tanabe M, Kizuka F, Lee L, et al. Melatonin as a free radical scavenger in the ovarian follicle. Endocr J. 2013;60(1):1\u201313.","journal-title":"Endocr J"},{"key":"554_CR27","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.theriogenology.2023.04.006","volume":"205","author":"NM Hashem","year":"2023","unstructured":"Hashem NM, El-Hawy AS, El-Bassiony MF, Saber A, Radwan MA, Ghanem N. Melatonin administration during the first half of pregnancy improves the reproductive performance of rabbits: Emphasis on ovarian and placental functions. Theriogenology. 2023;205:40\u20139.","journal-title":"Theriogenology"},{"issue":"12","key":"554_CR28","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1056\/NEJMra1300575","volume":"372","author":"DC Rockey","year":"2015","unstructured":"Rockey DC, Bell PD, Hill JA. Fibrosis\u2014a common pathway to organ injury and failure. NEJM. 2015;372(12):1138\u201349.","journal-title":"NEJM"},{"issue":"12","key":"554_CR29","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.prp.2014.08.006","volume":"210","author":"\u0130 G\u00fcrses","year":"2014","unstructured":"G\u00fcrses \u0130, \u00d6zeren M, Serin M, Y\u00fccel N, Erkal H\u015e. Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model. Pathol Res Pract. 2014;210(12):863\u201371.","journal-title":"Pathol Res Pract"},{"issue":"3","key":"554_CR30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/cbf.1136","volume":"23","author":"I Kus","year":"2005","unstructured":"Kus I, Ogeturk M, Oner H, Sahin S, Yekeler H, Sarsilmaz M. Protective effects of melatonin against carbon tetrachloride-induced hepatotoxicity in rats: a light microscopic and biochemical study. Cell Biochem Funct. 2005;23(3):169\u201374.","journal-title":"Cell Biochem Funct"},{"issue":"4","key":"554_CR31","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1177\/0748233708093725","volume":"24","author":"M Ogeturk","year":"2008","unstructured":"Ogeturk M, Kus I, Pekmez H, Yekeler H, Sahin S, Sarsilmaz M. Inhibition of carbon tetrachloride\u2013mediated apoptosis and oxidative stress by melatonin in experimental liver fibrosis. Toxicol Ind Health. 2008;24(4):201\u20138.","journal-title":"Toxicol Ind Health"},{"issue":"2","key":"554_CR32","first-page":"118","volume":"71","author":"A Sezer","year":"2010","unstructured":"Sezer A, Hatipoglu AR, Usta U, Altun G, Sut N. Effects of intraperitoneal melatonin on caustic sclerosing cholangitis due to scolicidal solution in a rat model. CTR. 2010;71(2):118\u201328.","journal-title":"CTR"},{"issue":"5","key":"554_CR33","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1177\/0748233710389853","volume":"27","author":"U Tas","year":"2011","unstructured":"Tas U, Ogeturk M, Meydan S, Kus I, Kuloglu T, Ilhan N, et al. Hepatotoxic activity of toluene inhalation and protective role of melatonin. Toxicol Ind Health. 2011;27(5):465\u201373.","journal-title":"Toxicol Ind Health"},{"issue":"2","key":"554_CR34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/01913120252959254","volume":"26","author":"A Stacchiotti","year":"2002","unstructured":"Stacchiotti A, Lavazza A, Rezzani R, Bianchi R. Cyclosporine A-induced kidney alterations are limited by melatonin in rats: an electron microscope study. Ultrastruct Pathol. 2002;26(2):81\u20137.","journal-title":"Ultrastruct Pathol"},{"issue":"2","key":"554_CR35","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/jpi.12199","volume":"58","author":"CK Sun","year":"2015","unstructured":"Sun CK, Lee FY, Kao YH, Chiang HJ, Sung PH, Tsai TH, et al. Systemic combined melatonin\u2013mitochondria treatment improves acute respiratory distress syndrome in the rat. J Pineal Res. 2015;58(2):137\u201350.","journal-title":"J Pineal Res"},{"issue":"1\u20133","key":"554_CR36","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejphar.2009.06.044","volume":"616","author":"S Hu","year":"2009","unstructured":"Hu S, Yin S, Jiang X, Huang D, Shen G. Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis. Eur J Pharmacol. 2009;616(1\u20133):287\u201392.","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"554_CR37","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1600-079X.2009.00676.x","volume":"46","author":"V Tahan","year":"2009","unstructured":"Tahan V, Atug O, Akin H, Eren F, Tahan G, Tarcin O, et al. Melatonin ameliorates methionine-and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. J Pineal Res. 2009;46(4):401\u20137.","journal-title":"J Pineal Res"},{"issue":"13","key":"554_CR38","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.3748\/wjg.v11.i13.1951","volume":"11","author":"M Esrefoglu","year":"2005","unstructured":"Esrefoglu M, G\u00fcl M, Emre MH, Polat A, Selimoglu MA. Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats. World J Gastroenterol. 2005;11(13):1951.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"554_CR39","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/j.1600-079X.2005.00275.x","volume":"40","author":"E Marquez","year":"2006","unstructured":"Marquez E, S\u00e1nchez-Fidalgo S, Calvo JR, Lastra CAld, Motilva V. Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis. J Pineal Res. 2006;40(1):48\u201355.","journal-title":"J Pineal Res"},{"issue":"3","key":"554_CR40","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.trsl.2015.04.002","volume":"166","author":"H-S Choi","year":"2015","unstructured":"Choi H-S, Kang J-W, Lee S-M. Melatonin attenuates carbon tetrachloride\u2013induced liver fibrosis via inhibition of necroptosis. Transl Res. 2015;166(3):292\u2013303.","journal-title":"Transl Res"},{"issue":"3","key":"554_CR41","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1080\/09553000601129093","volume":"83","author":"M Serin","year":"2007","unstructured":"Serin M, G\u00fclba\u015f H, G\u00fcrses \u0130, Erkal H\u015e, Y\u00fccel N. The histopathological evaluation of the effectiveness of melatonin as a protectant against acute lung injury induced by radiation therapy in a rat model. Int J Radiat Biol. 2007;83(3):187\u201393.","journal-title":"Int J Radiat Biol"},{"issue":"2","key":"554_CR42","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3109\/01902148.2013.866181","volume":"40","author":"E Taslidere","year":"2014","unstructured":"Taslidere E, Esrefoglu M, Elbe H, Cetin A, Ates B. Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats. Exp Lung Res. 2014;40(2):59\u201365.","journal-title":"Exp Lung Res"},{"issue":"9","key":"554_CR43","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1177\/0748233712464811","volume":"30","author":"C Aktas","year":"2014","unstructured":"Aktas C, Kanter M, Erboga M, Mete R, Oran M. Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats. Toxicol Ind Health. 2014;30(9):835\u201344.","journal-title":"Toxicol Ind Health"},{"issue":"2","key":"554_CR44","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.trsl.2014.10.003","volume":"165","author":"I Crespo","year":"2015","unstructured":"Crespo I, San-Miguel B, Fern\u00e1ndez A, De Urbina JO, Gonz\u00e1lez-Gallego J, Tu\u00f1\u00f3n MJ. Melatonin limits the expression of profibrogenic genes and ameliorates the progression of hepatic fibrosis in mice. Transl Res. 2015;165(2):346\u201357.","journal-title":"Transl Res"},{"issue":"5","key":"554_CR45","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1358\/mf.2010.32.5.1423893","volume":"32","author":"K Atalik","year":"2010","unstructured":"Atalik K, Keles B, Uyar Y, Dundar M, Oz M, Esen H. Response to vasoconstrictor agents by detrusor smooth muscles from cisplatin-treated rats and antioxidant treatment. Methods Find Exp Clin Pharmacol. 2010;32(5):305\u201310.","journal-title":"Methods Find Exp Clin Pharmacol"},{"issue":"7","key":"554_CR46","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1089\/end.2009.0035","volume":"23","author":"E Ozbek","year":"2009","unstructured":"Ozbek E, Ilbey YO, Ozbek M, Simsek A, Cekmen M, Somay A. Melatonin attenuates unilateral ureteral obstruction\u2013induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression. J Endourol. 2009;23(7):1165\u201373.","journal-title":"J Endourol"},{"issue":"5","key":"554_CR47","first-page":"313","volume":"53","author":"G Tahan","year":"2010","unstructured":"Tahan G, Akin H, Aydogan F, Ramadan SS, Yapicier O, Tarcin O, et al. Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats. Can J Surg. 2010;53(5):313.","journal-title":"Can J Surg"},{"issue":"19\u201320","key":"554_CR48","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s10354-008-0599-7","volume":"158","author":"S Aust","year":"2008","unstructured":"Aust S, J\u00e4ger W, Kirschner H, Klimpfinger M, Thalhammer T. Pancreatic stellate\/myofibroblast cells express G-protein-coupled melatonin receptor 1. Wien Med Wochensch. 2008;158(19\u201320):575\u20138.","journal-title":"Wien Med Wochensch"},{"issue":"5","key":"554_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097266","volume":"9","author":"H Zhao","year":"2014","unstructured":"Zhao H, Wu Q-Q, Cao L-F, Qing H-Y, Zhang C, Chen Y-H, et al. Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomycin-induced pulmonary fibrosis in mice. PLoS ONE. 2014;9(5): e97266.","journal-title":"PLoS ONE"},{"key":"554_CR50","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00424-012-1139-2","volume":"464","author":"I Ben Soussia","year":"2012","unstructured":"Ben Soussia I, Mies F, Naeije R, Shlyonsky V. Melatonin down-regulates volume-sensitive chloride channels in fibroblasts. Pflug Arch Eur J. 2012;464:273\u201385.","journal-title":"Pflug Arch Eur J"},{"issue":"2","key":"554_CR51","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1600-079X.2005.00227.x","volume":"39","author":"A Cruz","year":"2005","unstructured":"Cruz A, Padillo FJ, Torres E, Navarrete CM, Mu\u00f1oz-Casta\u00f1eda JR, Caballero FJ, et al. Melatonin prevents experimental liver cirrhosis induced by thioacetamide in rats. J Pineal Res. 2005;39(2):143\u201350.","journal-title":"J Pineal Res"},{"issue":"3","key":"554_CR52","first-page":"203","volume":"26","author":"J-C Zhang","year":"2010","unstructured":"Zhang J-C, Xie Y-F, Liu S-J, Dai L-B, Li J-P. The expression of melatonin receptor in human hypertrophic scar. Zhonghua wai ke za zhi [Chinese J Surgery]. 2010;26(3):203\u20137.","journal-title":"Zhonghua wai ke za zhi [Chinese J Surgery]"},{"issue":"6","key":"554_CR53","first-page":"422","volume":"27","author":"Y Xie","year":"2011","unstructured":"Xie Y, Zhang J, Liu S, Dai L, Du G. Effect of melatonin on proliferation and apoptosis of fibroblasts in human hypertrophic scar. Zhonghua wai ke za zhi [Chinese J Burns]. 2011;27(6):422\u20136.","journal-title":"Zhonghua wai ke za zhi [Chinese J Burns]"},{"issue":"12","key":"554_CR54","first-page":"1491","volume":"11","author":"IC Lawrance","year":"2017","unstructured":"Lawrance IC, Rogler G, Bamias G, Breynaert C, Florholmen J, Pellino G, et al. Cellular and molecular mediators of intestinal fibrosis. J Crohns Colitis. 2017;11(12):1491\u2013503.","journal-title":"J Crohns Colitis"},{"key":"554_CR55","doi-asserted-by":"publisher","first-page":"764641","DOI":"10.1155\/2015\/764641","volume":"2015","author":"E Sziksz","year":"2015","unstructured":"Sziksz E, Pap D, Lippai R, B\u00e9res NJ, Fekete A, Szab\u00f3 AJ, et al. Fibrosis related inflammatory mediators: role of the IL-10 cytokine family. Mediators Inflamm. 2015;2015:764641.","journal-title":"Mediators Inflamm."},{"issue":"1","key":"554_CR56","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1600-065X.2012.01099.x","volume":"246","author":"JA DiDonato","year":"2012","unstructured":"DiDonato JA, Mercurio F, Karin M. NF-\u03baB and the link between inflammation and cancer. Immunol Rev. 2012;246(1):379\u2013400.","journal-title":"Immunol Rev"},{"issue":"2","key":"554_CR57","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1172\/JCI11914","volume":"107","author":"Y Yamamoto","year":"2001","unstructured":"Yamamoto Y, Gaynor RB. Therapeutic potential of inhibition of the NF-\u03baB pathway in the treatment of inflammation and cancer. J Clin Invest. 2001;107(2):135\u201342.","journal-title":"J Clin Invest"},{"issue":"9","key":"554_CR58","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1136\/gut.2007.130112","volume":"58","author":"J Dambacher","year":"2009","unstructured":"Dambacher J, Beigel F, Zitzmann K, De Toni E, G\u00f6ke B, Diepolder HM, et al. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. Gut. 2009;58(9):1207\u201317.","journal-title":"Gut"},{"issue":"10","key":"554_CR59","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.it.2008.07.004","volume":"29","author":"M-S Kim","year":"2008","unstructured":"Kim M-S, R\u00e5dinger M, Gilfillan AM. The multiple roles of phosphoinositide 3-kinase in mast cell biology. Trends Immunol. 2008;29(10):493\u2013501.","journal-title":"Trends Immunol"},{"issue":"10","key":"554_CR60","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/intimm\/dxs056","volume":"24","author":"Y Liu","year":"2012","unstructured":"Liu Y, Zhu H, Su Z, Sun C, Yin J, Yuan H, et al. IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKC\u03b2\/Erk1\/2\/NF-\u03baB-dependent signaling pathway. Int Immunol. 2012;24(10):605\u201312.","journal-title":"Int Immunol"},{"issue":"1","key":"554_CR61","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/cr.2008.302","volume":"19","author":"X Guo","year":"2009","unstructured":"Guo X, Wang X-F. Signaling cross-talk between TGF-\u03b2\/BMP and other pathways. Cell Res. 2009;19(1):71\u201388.","journal-title":"Cell Res"},{"issue":"2","key":"554_CR62","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1600-079X.2009.00735.x","volume":"48","author":"L Rodella","year":"2010","unstructured":"Rodella L, Filippini F, Bonomini F, Bresciani R, Reiter R, Rezzani R. Beneficial effects of melatonin on nicotine-induced vasculopathy. J Pineal Res. 2010;48(2):126\u201332.","journal-title":"J Pineal Res"},{"issue":"12","key":"554_CR63","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/ijo.2014.37","volume":"38","author":"E Mart\u00ednez-Mart\u00ednez","year":"2014","unstructured":"Mart\u00ednez-Mart\u00ednez E, Miana M, Jurado-L\u00f3pez R, Bartolom\u00e9 M, Souza Neto F, Salaices M, et al. The potential role of leptin in the vascular remodeling associated with obesity. Int J Obes. 2014;38(12):1565\u201372.","journal-title":"Int J Obes"},{"issue":"7","key":"554_CR64","doi-asserted-by":"publisher","first-page":"e45870","DOI":"10.1371\/journal.pone.0045870","volume":"10","author":"CJ Oh","year":"2012","unstructured":"Oh CJ, Kim J-Y, Choi Y-K, Kim H-J, Jeong J-Y, Bae K-H, et al. Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-\u03b2\/Smad signaling. PLoS One. 2012;10(7):e45870.","journal-title":"PLoS One."},{"issue":"3","key":"554_CR65","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.freeradbiomed.2011.11.012","volume":"52","author":"CJ Oh","year":"2012","unstructured":"Oh CJ, Kim J-Y, Min A-K, Park K-G, Harris RA, Kim H-J, et al. Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-\u03b2\/Smad signaling. Free Radic Biol Med. 2012;52(3):671\u201382.","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"554_CR66","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrm3434","volume":"13","author":"J Massagu\u00e9","year":"2012","unstructured":"Massagu\u00e9 J. TGF\u03b2 signalling in context. Nat Rev Mol Cell Biol. 2012;13(10):616\u201330.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"554_CR67","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.actatropica.2013.09.014","volume":"128","author":"LGR Oliveira","year":"2013","unstructured":"Oliveira LGR, Kuehn CC, dos Santos CD, Miranda MA, da Costa CMB, Mendon\u00e7a VJ, et al. Protective actions of melatonin against heart damage during chronic Chagas disease. Acta Trop. 2013;128(3):652\u20138.","journal-title":"Acta Trop"},{"issue":"1","key":"554_CR68","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/jpi.12190","volume":"58","author":"HM Yeung","year":"2015","unstructured":"Yeung HM, Hung MW, Lau CF, Fung ML. Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats. J Pineal Res. 2015;58(1):12\u201325.","journal-title":"J Pineal Res"},{"issue":"4","key":"554_CR69","first-page":"567","volume":"66","author":"G Czechowska","year":"2015","unstructured":"Czechowska G, Celinski K, Korolczuk A, Wojcicka G, Dudka J, Bojarska A, et al. Protective effects of melatonin against thioacetamide-induced liver fibrosis in rats. J Physiol Pharmacol. 2015;66(4):567\u201379.","journal-title":"J Physiol Pharmacol"},{"issue":"15","key":"554_CR70","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1016\/j.lfs.2005.04.013","volume":"77","author":"H Wang","year":"2005","unstructured":"Wang H, Wei W, Wang N-P, Gui S-Y, Wu L, Sun W-Y, et al. Melatonin ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress. Life Sci. 2005;77(15):1902\u201315.","journal-title":"Life Sci"},{"issue":"3","key":"554_CR71","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/j.1600-079X.2011.00950.x","volume":"52","author":"GD Kim","year":"2012","unstructured":"Kim GD, Lee SE, Kim TH, Jin YH, Park YS, Park CS. Melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts. J Pineal Res. 2012;52(3):356\u201364.","journal-title":"J Pineal Res"},{"issue":"12","key":"554_CR72","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1016\/j.bcp.2013.10.009","volume":"86","author":"M G\u00f3mez-Florit","year":"2013","unstructured":"G\u00f3mez-Florit M, Ramis JM, Monjo M. Anti-fibrotic and anti-inflammatory properties of melatonin on human gingival fibroblasts in vitro. Biochem Pharmacol. 2013;86(12):1784\u201390.","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"554_CR73","first-page":"50","volume":"20","author":"FS Erol","year":"2010","unstructured":"Erol FS, Kavakli A, Ilhan N, Ozercan IH, Sarsilmaz M. Efects of melatonin and octreotide on peridural fibrosis in an animal model of laminectomy. Turk Neurosurg. 2010;20(1):50-6.","journal-title":"Turk Neurosurg."},{"issue":"5","key":"554_CR74","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1097\/HJH.0000000000000149","volume":"32","author":"E Mart\u00ednez-Mart\u00ednez","year":"2014","unstructured":"Mart\u00ednez-Mart\u00ednez E, Jurado-L\u00f3pez R, Valero-Mu\u00f1oz M, Bartolom\u00e9 MV, Ballesteros S, Luaces M, et al. Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress: potential role in obesity. J Hypertens. 2014;32(5):1104\u201314.","journal-title":"J Hypertens"},{"issue":"12","key":"554_CR75","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","volume":"15","author":"C Bonnans","year":"2014","unstructured":"Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol. 2014;15(12):786\u2013801.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"554_CR76","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1172\/JCI93557","volume":"128","author":"J Herrera","year":"2018","unstructured":"Herrera J, Henke CA, Bitterman PB. Extracellular matrix as a driver of progressive fibrosis. J Clin Invest. 2018;128(1):45\u201353.","journal-title":"J Clin Invest"},{"issue":"12","key":"554_CR77","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrm3902","volume":"15","author":"JK Mouw","year":"2014","unstructured":"Mouw JK, Ou G, Weaver VM. Extracellular matrix assembly: a multiscale deconstruction. Nat Rev Mol Cell Biol. 2014;15(12):771\u201385.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"554_CR78","first-page":"29","volume":"62","author":"J Drobnik","year":"2011","unstructured":"Drobnik J, Slotwinska D, Olczak S, Tosik D, Pieniazek A, Matczak K, et al. Pharmacological doses of melatonin reduce the glycosaminoglycan level within the infarcted heart scar. J Physiol Pharmacol. 2011;62(1):29.","journal-title":"J Physiol Pharmacol"},{"key":"554_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.110066","volume":"85","author":"MP Czubryt","year":"2021","unstructured":"Czubryt MP, Hale TM. Cardiac fibrosis: pathobiology and therapeutic targets. Cell Signal. 2021;85: 110066.","journal-title":"Cell Signal"},{"key":"554_CR80","doi-asserted-by":"publisher","first-page":"4045","DOI":"10.1007\/s11010-021-04219-w","volume":"476","author":"W Qin","year":"2021","unstructured":"Qin W, Cao L, Massey IY. Role of PI3K\/Akt signaling pathway in cardiac fibrosis. Mol Cell Biochem. 2021;476:4045\u201359.","journal-title":"Mol Cell Biochem"},{"issue":"7","key":"554_CR81","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.3390\/molecules23071819","volume":"23","author":"F Nduhirabandi","year":"2018","unstructured":"Nduhirabandi F, Maarman GJ. Melatonin in heart failure: a promising therapeutic strategy? Molecules. 2018;23(7):1819.","journal-title":"Molecules"},{"issue":"1","key":"554_CR82","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12514","volume":"65","author":"A Galano","year":"2018","unstructured":"Galano A, Reiter RJ. Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection. J Pineal Res. 2018;65(1): e12514.","journal-title":"J Pineal Res"},{"issue":"11","key":"554_CR83","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1517\/13543784.2012.714771","volume":"21","author":"L Paulis","year":"2012","unstructured":"Paulis L, Simko F, Laudon M. Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs. 2012;21(11):1661\u201378.","journal-title":"Expert Opin Investig Drugs"},{"issue":"2","key":"554_CR84","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1748-1716.2012.02410.x","volume":"205","author":"F Nduhirabandi","year":"2012","unstructured":"Nduhirabandi F, du Toit EF, Lochner A. Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities? Acta Physiol. 2012;205(2):209\u201323.","journal-title":"Acta Physiol"},{"issue":"10","key":"554_CR85","doi-asserted-by":"publisher","first-page":"17920","DOI":"10.3390\/ijms151017920","volume":"15","author":"O Pechanova","year":"2014","unstructured":"Pechanova O, Paulis L, Simko F. Peripheral and central effects of melatonin on blood pressure regulation. Int J Mol Sci. 2014;15(10):17920\u201337.","journal-title":"Int J Mol Sci"},{"key":"554_CR86","first-page":"79","volume":"23","author":"E Sewerynek","year":"2002","unstructured":"Sewerynek E. Melatonin and the cardiovascular system. Neuro Endocrinol Lett. 2002;23:79\u201383.","journal-title":"Neuro Endocrinol Lett"},{"issue":"1","key":"554_CR87","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.acthis.2003.10.003","volume":"106","author":"B M\u0131zrak","year":"2004","unstructured":"M\u0131zrak B, Parlakpinar H, Acet A, Turkoz Y. Effects of pinealectomy and exogenous melatonin on rat hearts. Acta Histochemi. 2004;106(1):29\u201336.","journal-title":"Acta Histochemi"},{"issue":"6","key":"554_CR88","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1097\/01.hjh.0000358830.95439.e8","volume":"27","author":"F Simko","year":"2009","unstructured":"Simko F, Pechanova O, Pelouch V, Krajcirovicova K, Mullerova M, Bednarova K, et al. Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats. J Hypertens Suppl. 2009;27(6):S5-10.","journal-title":"J Hypertens Suppl"},{"issue":"3","key":"554_CR89","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/jpi.12263","volume":"59","author":"G Maarman","year":"2015","unstructured":"Maarman G, Blackhurst D, Thienemann F, Blauwet L, Butrous G, Davies N, et al. Melatonin as a preventive and curative therapy against pulmonary hypertension. J Pineal Res. 2015;59(3):343\u201353.","journal-title":"J Pineal Res"},{"key":"554_CR90","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1097\/01.hjh.0000388489.28213.08","volume":"28","author":"F Simko","year":"2010","unstructured":"Simko F, Pechanova O, Pelouch V, Krajcirovicova K, Celec P, Palffy R, et al. Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril. J Hypertens. 2010;28:S13\u20138.","journal-title":"J Hypertens"},{"key":"554_CR91","doi-asserted-by":"publisher","first-page":"703175","DOI":"10.1155\/2014\/703175","volume":"2014","author":"F Simko","year":"2014","unstructured":"Simko F, Pechanova O, Repova Bednarova K, Krajcirovicova K, Celec P, Kamodyova N, et al. Hypertension and cardiovascular remodelling in rats exposed to continuous light: protection by ACE-inhibition and melatonin. Mediators Inflamm. 2014;2014:703175.","journal-title":"Mediators Inflamm."},{"key":"554_CR92","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1097\/01.hjh.0000358831.33558.97","volume":"27","author":"L Paulis","year":"2009","unstructured":"Paulis L, Pechanova O, Zicha J, Krajcirovicova K, Barta A, Pelouch V, et al. Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats. J Hypertens. 2009;27:S11\u20136.","journal-title":"J Hypertens"},{"key":"554_CR93","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.freeradbiomed.2016.06.015","volume":"97","author":"H Pei","year":"2016","unstructured":"Pei H, Du J, Song X, He L, Zhang Y, Li X, et al. Melatonin prevents adverse myocardial infarction remodeling via Notch1\/Mfn2 pathway. Free Radic Biol Med. 2016;97:408\u201317.","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"554_CR94","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165848","volume":"1866","author":"C-N Xu","year":"2020","unstructured":"Xu C-N, Kong L-H, Ding P, Liu Y, Fan Z-G, Gao E-H, et al. Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt\/mTOR pathway. Biochim Biophys Acta Mol Basis Dis. 2020;1866(10): 165848.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"3","key":"554_CR95","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12433","volume":"63","author":"M Zhai","year":"2017","unstructured":"Zhai M, Liu Z, Zhang B, Jing L, Li B, Li K, et al. Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1\u03b2: In vivo and in vitro studies. J Pineal Res. 2017;63(3): e12433.","journal-title":"J Pineal Res"},{"issue":"7","key":"554_CR96","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.3390\/jcm11071909","volume":"11","author":"A Dom\u00ednguez-Rodr\u00edguez","year":"2022","unstructured":"Dom\u00ednguez-Rodr\u00edguez A, Hern\u00e1ndez-Vaquero D, Abreu-Gonz\u00e1lez P, B\u00e1ez-Ferrer N, D\u00edaz R, Avanzas P, et al. Early treatment of acute myocardial infarction with melatonin: effects on MMP-9 and adverse cardiac events. J Clin Med. 2022;11(7):1909.","journal-title":"J Clin Med"},{"issue":"1","key":"554_CR97","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12686","volume":"70","author":"J Jiang","year":"2021","unstructured":"Jiang J, Liang S, Zhang J, Du Z, Xu Q, Duan J, et al. Melatonin ameliorates PM2.5-induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis. J Pineal Res. 2021;70(1): e12686.","journal-title":"J Pineal Res"},{"issue":"4","key":"554_CR98","doi-asserted-by":"publisher","first-page":"5282","DOI":"10.1096\/fj.201902692R","volume":"34","author":"H Che","year":"2020","unstructured":"Che H, Wang Y, Li H, Li Y, Sahil A, Lv J, et al. Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1\/miR-141-mediated NLRP3 inflammasome and TGF-\u03b21\/Smads signaling in diabetic cardiomyopathy. FASEB J. 2020;34(4):5282\u201398.","journal-title":"FASEB J"},{"issue":"14","key":"554_CR99","doi-asserted-by":"publisher","first-page":"47","DOI":"10.14715\/cmb\/2018.64.14.8","volume":"64","author":"Y Behram Kandemir","year":"2018","unstructured":"Behram Kandemir Y, Guntekin \u00dc, Tosun V, Korucuk N, Bozdemir MN. Melatonin protects against streptozotocin-induced diabetic cardiomyopathy by the phosphorylation of vascular endothelial growth factor-A (VEGF-A). Cell Mol Biol (Noisy-le-grand). 2018;64(14):47\u201352.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"issue":"9","key":"554_CR100","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.17219\/acem\/103799","volume":"28","author":"YB Kandemir","year":"2019","unstructured":"Kandemir YB, Tosun V, G\u00fcntekin \u00dc. Melatonin protects against streptozotocin-induced diabetic cardiomyopathy through the mammalian target of rapamycin (mTOR) signaling pathway. Adv Clin Exp Med. 2019;28(9):1171\u20137.","journal-title":"Adv Clin Exp Med"},{"issue":"10","key":"554_CR101","doi-asserted-by":"publisher","first-page":"5132","DOI":"10.1111\/jcmm.13802","volume":"22","author":"S Wang","year":"2018","unstructured":"Wang S, Zhao Z, Feng X, Cheng Z, Xiong Z, Wang T, et al. Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition. J Cell Mol Med. 2018;22(10):5132\u201344.","journal-title":"J Cell Mol Med"},{"key":"554_CR102","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cellsig.2018.03.012","volume":"47","author":"H Zhou","year":"2018","unstructured":"Zhou H, Yue Y, Wang J, Ma Q, Chen Y. Melatonin therapy for diabetic cardiomyopathy: a mechanism involving Syk-mitochondrial complex I-SERCA pathway. Cell signal. 2018;47:88\u2013100.","journal-title":"Cell signal"},{"issue":"1","key":"554_CR103","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s12192-017-0827-4","volume":"23","author":"H Zhu","year":"2018","unstructured":"Zhu H, Jin Q, Li Y, Ma Q, Wang J, Li D, et al. Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via sup Cell death & disease.ression of IP3R-[Ca(2+)]c\/VDAC-[Ca(2+)]m axis by activation of MAPK\/ERK signaling pathway. Cell Stress Chaperones. 2018;23(1):101\u201313.","journal-title":"Cell Stress Chaperones"},{"issue":"1","key":"554_CR104","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.904","volume":"10","author":"K Huang","year":"2022","unstructured":"Huang K, Luo X, Zhong Y, Deng L, Feng J. New insights into the role of melatonin in diabetic cardiomyopathy. Pharmacol Res Perspect. 2022;10(1): e00904.","journal-title":"Pharmacol Res Perspect"},{"issue":"17","key":"554_CR105","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1002\/1873-3468.12315","volume":"590","author":"G Zhao","year":"2016","unstructured":"Zhao G, Su Z, Song D, Mao Y, Mao X. The long noncoding RNA MALAT 1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-\u03baB. FEBS Lett. 2016;590(17):2884\u201395.","journal-title":"FEBS Lett"},{"key":"554_CR106","doi-asserted-by":"publisher","first-page":"1535201","DOI":"10.1155\/2020\/1535201","volume":"2020","author":"L Lu","year":"2020","unstructured":"Lu L, Ma J, Sun M, Wang X, Gao E, Lu L, et al. Melatonin ameliorates MI-induced cardiac remodeling and apoptosis through a JNK\/p53-dependent mechanism in diabetes mellitus. Oxid Med Cell Longev. 2020;:2020:1535201.","journal-title":"Oxid Med Cell Longev."},{"issue":"11","key":"554_CR107","doi-asserted-by":"publisher","first-page":"4843","DOI":"10.1172\/JCI95945","volume":"128","author":"DM Abraham","year":"2018","unstructured":"Abraham DM, Lee TE, Watson LJ, Mao L, Chandok G, Wang H-G, et al. The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction. J clin invest. 2018;128(11):4843\u201355.","journal-title":"J clin invest"},{"issue":"4","key":"554_CR108","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.cardiores.2005.11.015","volume":"69","author":"S Kyoi","year":"2006","unstructured":"Kyoi S, Otani H, Matsuhisa S, Akita Y, Tatsumi K, Enoki C, et al. Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster. Cardiovasc Res. 2006;69(4):888\u201398.","journal-title":"Cardiovasc Res"},{"issue":"15","key":"554_CR109","doi-asserted-by":"publisher","first-page":"15330","DOI":"10.1074\/jbc.M314142200","volume":"279","author":"BG Petrich","year":"2004","unstructured":"Petrich BG, Eloff BC, Lerner DL, Kovacs A, Saffitz JE, Rosenbaum DS, et al. Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects*[boxs]. J Biol Chem. 2004;279(15):15330\u20138.","journal-title":"J Biol Chem"},{"issue":"2","key":"554_CR110","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.5","volume":"3","author":"A Chaanine","year":"2012","unstructured":"Chaanine A, Jeong D, Liang L, Chemaly E, Fish K, Gordon R, et al. JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure. Cell Death Dis. 2012;3(2): e265-e.","journal-title":"Cell Death Dis"},{"issue":"8","key":"554_CR111","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1038\/cdd.2014.46","volume":"21","author":"C Huang","year":"2014","unstructured":"Huang C, Kuo W, Yeh Y, Ho T, Lin J, Lin D, et al. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. Cell Death Differ. 2014;21(8):1262\u201374.","journal-title":"Cell Death Differ"},{"key":"554_CR112","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.yjmcc.2018.08.006","volume":"122","author":"C-Y Huang","year":"2018","unstructured":"Huang C-Y, Lai C-H, Kuo C-H, Chiang S-F, Pai P-Y, Lin J-Y, et al. Inhibition of ERK-Drp1 signaling and mitochondria fragmentation alleviates IGF-IIR-induced mitochondria dysfunction during heart failure. J Mol Cell Cardiol. 2018;122:58\u201368.","journal-title":"J Mol Cell Cardiol"},{"issue":"21","key":"554_CR113","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012575","volume":"8","author":"W Xu","year":"2019","unstructured":"Xu W, Zhang L, Zhang Y, Zhang K, Wu Y, Jin D. TRAF 1 exacerbates myocardial ischemia reperfusion injury via ASK 1\u2013JNK\/p38 signaling. J Am Heart Assoc. 2019;8(21): e012575.","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"554_CR114","doi-asserted-by":"publisher","first-page":"607","DOI":"10.4196\/kjpp.2018.22.6.607","volume":"22","author":"Y Wu","year":"2018","unstructured":"Wu Y, Si F, Luo L, Jing F, Jiang K, Zhou J, et al. The effect of melatonin on cardio fibrosis in juvenile rats with pressure overload and deregulation of HDACs. Korean J Physiol Pharmacol. 2018;22(6):607\u201316.","journal-title":"Korean J Physiol Pharmacol"},{"issue":"3","key":"554_CR115","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1093\/cvr\/cvn215","volume":"80","author":"P Gallo","year":"2008","unstructured":"Gallo P, Latronico MV, Gallo P, Grimaldi S, Borgia F, Todaro M, et al. Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure. Cardiovasc Res. 2008;80(3):416\u201324.","journal-title":"Cardiovasc Res"},{"issue":"5","key":"554_CR116","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1124\/mol.114.096974","volume":"87","author":"SH Kang","year":"2015","unstructured":"Kang SH, Seok YM, Song MJ, Lee HA, Kurz T, Kim I. Histone deacetylase inhibition attenuates cardiac hypertrophy and fibrosis through acetylation of mineralocorticoid receptor in spontaneously hypertensive rats. Mol Pharmacol. 2015;87(5):782\u201391.","journal-title":"Mol Pharmacol"},{"issue":"7","key":"554_CR117","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.tcm.2011.11.006","volume":"20","author":"Y Li","year":"2010","unstructured":"Li Y, Hiroi Y, Liao JK. Notch signaling as an important mediator of cardiac repair and regeneration after myocardial infarction. Trends Cardiovasc Med. 2010;20(7):228\u201331.","journal-title":"Trends Cardiovasc Med"},{"issue":"3","key":"554_CR118","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1161\/CIRCRESAHA.110.218487","volume":"107","author":"K Urbanek","year":"2010","unstructured":"Urbanek K, Cabral-da-Silva MC, Ide-Iwata N, Maestroni S, Delucchi F, Zheng H, et al. Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart. Circ Res. 2010;107(3):429\u201341.","journal-title":"Circ Res"},{"issue":"32","key":"554_CR119","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1093\/eurheartj\/ehs269","volume":"35","author":"M Nemir","year":"2014","unstructured":"Nemir M, Metrich M, Plaisance I, Lepore M, Cruchet S, Berthonneche C, et al. The Notch pathway controls fibrotic and regenerative repair in the adult heart. Eur Heart J. 2014;35(32):2174\u201385.","journal-title":"Eur Heart J"},{"issue":"4","key":"554_CR120","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/jpi.12272","volume":"59","author":"L Yu","year":"2015","unstructured":"Yu L, Liang H, Lu Z, Zhao G, Zhai M, Yang Y, et al. Membrane receptor-dependent N otch1\/H es1 activation by melatonin protects against myocardial ischemia\u2013reperfusion injury: in vivo and in vitro studies. J Pineal Res. 2015;59(4):420\u201333.","journal-title":"J Pineal Res"},{"issue":"1","key":"554_CR121","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2741\/E617","volume":"5","author":"A Lochner","year":"2013","unstructured":"Lochner A, Huisamen B, Nduhirabandi F. Cardioprotective effect of melatonin against ischaemia\/reperfusion damage. Front Biosci (Elite Ed). 2013;5(1):305\u201315.","journal-title":"Front Biosci (Elite Ed)"},{"issue":"23","key":"554_CR122","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.3760\/cma.j.issn.0366-6999.20130721","volume":"126","author":"X-l Zhou","year":"2013","unstructured":"Zhou X-l, Wan L, Liu J-c. Activated Notch1 reduces myocardial ischemia reperfusion injury in vitro during ischemic postconditioning by crosstalk with the RISK signaling pathway. Chin Med J. 2013;126(23):4545\u201351.","journal-title":"Chin Med J"},{"key":"554_CR123","first-page":"257","volume-title":"Vitam Horm. 101","author":"JA Neyra","year":"2016","unstructured":"Neyra JA, Hu MC. Chapter eleven-\u03b1Klotho and chronic kidney disease. In: Litwack G, editor. Vitam Horm. 101. Academic Press: Berlin; 2016. p. 257\u2013310."},{"key":"554_CR124","doi-asserted-by":"crossref","unstructured":"Geng X, Zhong D, Su L, Lin Z, Yang B. Chapter Nine - Preventive and therapeutic effect of Ganoderma lucidum on kidney injuries and diseases. In: Du G, editor. Adv Pharmacol. 87: Academic Press; 2020. p. 257\u201376.","DOI":"10.1016\/bs.apha.2019.10.003"},{"key":"554_CR125","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/B978-0-323-90546-6.00007-1","volume-title":"Wound healing, fibrosis, and the myofibroblast","author":"G Gabbiani","year":"2022","unstructured":"Gabbiani G, Coen M, Zampieri F. Chapter 3\u2014fibrotic diseases. In: Gabbiani G, Coen M, Zampieri F, editors. Wound healing, fibrosis, and the myofibroblast. Academic Press; 2022. p. 27\u201385."},{"issue":"2","key":"554_CR126","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/sj.ki.5000054","volume":"69","author":"Y Liu","year":"2006","unstructured":"Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int. 2006;69(2):213\u20137.","journal-title":"Kidney Int"},{"issue":"1","key":"554_CR127","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S1357-2725(96)00119-7","volume":"29","author":"AM el Nahas","year":"1997","unstructured":"el Nahas AM, Muchaneta-Kubara EC, Essawy M, Soylemezoglu O. Renal fibrosis: insights into pathogenesis and treatment. Int J Biochem Cell Biol. 1997;29(1):55\u201362.","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"554_CR128","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21873\/invivo.11019","volume":"31","author":"A Nogueira","year":"2017","unstructured":"Nogueira A, Pires MJ, Oliveira PA. Pathophysiological mechanisms of renal fibrosis: a review of animal models and therapeutic strategies. In Vivo. 2017;31(1):1\u201322.","journal-title":"In Vivo"},{"issue":"2","key":"554_CR129","doi-asserted-by":"publisher","first-page":"192","DOI":"10.4103\/2230-8210.93735","volume":"16","author":"S Kalra","year":"2012","unstructured":"Kalra S, Agrawal S, Sahay M. The reno-pineal axis: a novel role for melatonin. Indian J Endocrinol Metab. 2012;16(2):192\u20134.","journal-title":"Indian J Endocrinol Metab"},{"issue":"7","key":"554_CR130","doi-asserted-by":"publisher","first-page":"936","DOI":"10.2174\/1381612820666140929092929","volume":"21","author":"J Hrenak","year":"2015","unstructured":"Hrenak J, Paulis L, Repova K, Aziriova S, Nagtegaal EJ, Reiter RJ, et al. Melatonin and renal protection: novel perspectives from animal experiments and human studies (review). Curr Pharm Des. 2015;21(7):936\u201349.","journal-title":"Curr Pharm Des"},{"issue":"3","key":"554_CR131","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1097\/HJH.0b013e3283340c16","volume":"28","author":"JP Forman","year":"2010","unstructured":"Forman JP, Curhan GC, Schernhammer ES. Urinary melatonin and risk of incident hypertension among young women. J Hypertens. 2010;28(3):446\u201351.","journal-title":"J Hypertens"},{"issue":"2","key":"554_CR132","first-page":"137","volume":"8","author":"H Molaee Govarchin Ghalae","year":"2011","unstructured":"Molaee Govarchin Ghalae H, Zare S, Choopanloo M, Rahimian R. The lunar cycle: effects of full moon on renal colic. Urol J. 2011;8(2):137\u201340.","journal-title":"Urol J"},{"issue":"11","key":"554_CR133","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/s41419-018-1157-x","volume":"9","author":"R Qi","year":"2018","unstructured":"Qi R, Yang C. Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury. Cell Death Dis. 2018;9(11):1126.","journal-title":"Cell Death Dis"},{"issue":"7","key":"554_CR134","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/iub.1174","volume":"65","author":"Q Wei","year":"2013","unstructured":"Wei Q, Mi QS, Dong Z. The regulation and function of microRNAs in kidney diseases. IUBMB Life. 2013;65(7):602\u201314.","journal-title":"IUBMB Life"},{"issue":"10","key":"554_CR135","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.3390\/ijms19102898","volume":"19","author":"YM Yoon","year":"2018","unstructured":"Yoon YM, Han YS, Yun CW, Lee JH, Kim R, Lee SH. Pioglitazone protects mesenchymal stem cells against P-cresol-induced mitochondrial dysfunction via up-regulation of PINK-1. Int J Mol Sci. 2018;19(10):2898.","journal-title":"Int J Mol Sci"},{"issue":"15","key":"554_CR136","doi-asserted-by":"publisher","first-page":"5323","DOI":"10.3390\/ijms21155323","volume":"21","author":"YM Yoon","year":"2020","unstructured":"Yoon YM, Go G, Yun CW, Lim JH, Lee JH, Lee SH. Melatonin suppresses renal cortical fibrosis by inhibiting cytoskeleton reorganization and mitochondrial dysfunction through regulation of miR-4516. Int J Mol Sci. 2020;21(15):5323.","journal-title":"Int J Mol Sci"},{"issue":"16","key":"554_CR137","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1038\/s41388-018-0601-9","volume":"38","author":"T Cui","year":"2019","unstructured":"Cui T, Bell EH, McElroy J, Becker AP, Gulati PM, Geurts M, et al. miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma. Oncogene. 2019;38(16):2923\u201336.","journal-title":"Oncogene"},{"issue":"12","key":"554_CR138","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1016\/j.bbadis.2017.08.014","volume":"1863","author":"S Chowdhari","year":"2017","unstructured":"Chowdhari S, Sardana K, Saini N. miR-4516, a microRNA downregulated in psoriasis inhibits keratinocyte motility by targeting fibronectin\/integrin \u03b19 signaling. Biochim Biophys Acta Mol Basis Dis. 2017;1863(12):3142\u201352.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"554_CR139","doi-asserted-by":"publisher","first-page":"C2","DOI":"10.1152\/ajpcell.00060.2014","volume":"307","author":"PS Tsou","year":"2014","unstructured":"Tsou PS, Haak AJ, Khanna D, Neubig RR. Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription. Am J Physiol Cell Physiol. 2014;307(1):C2-13.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"554_CR140","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12632","volume":"68","author":"YM Yoon","year":"2020","unstructured":"Yoon YM, Lee JH, Song KH, Noh H, Lee SH. Melatonin-stimulated exosomes enhance the regenerative potential of chronic kidney disease-derived mesenchymal stem\/stromal cells via cellular prion proteins. J Pineal Res. 2020;68(3): e12632.","journal-title":"J Pineal Res"},{"key":"554_CR141","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.978337","volume":"13","author":"K Repova","year":"2022","unstructured":"Repova K, Stanko P, Baka T, Krajcirovicova K, Aziriova S, Hrenak J, et al. Lactacystin-induced kidney fibrosis: protection by melatonin and captopril. Front Pharmacol. 2022;13: 978337.","journal-title":"Front Pharmacol"},{"key":"554_CR142","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jtbi.2011.10.018","volume":"293","author":"R Sopakayang","year":"2012","unstructured":"Sopakayang R, De Vita R, Kwansa A, Freeman JW. Elastic and viscoelastic properties of a type I collagen fiber. J Theor Biol. 2012;293:197\u2013205.","journal-title":"J Theor Biol"},{"issue":"3","key":"554_CR143","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1615\/CritRevBiomedEng.v29.i3.10","volume":"29","author":"FH Silver","year":"2001","unstructured":"Silver FH, Horvath I, Foran DJ. Viscoelasticity of the vessel wall: the role of collagen and elastic fibers. Crit Rev Biomed Eng. 2001;29(3):279\u2013301.","journal-title":"Crit Rev Biomed Eng"},{"issue":"20","key":"554_CR144","doi-asserted-by":"publisher","first-page":"13437","DOI":"10.1074\/jbc.272.20.13437","volume":"272","author":"A Craiu","year":"1997","unstructured":"Craiu A, Gaczynska M, Akopian T, Gramm CF, Fenteany G, Goldberg AL, et al. Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J Biol Chem. 1997;272(20):13437\u201345.","journal-title":"J Biol Chem"},{"issue":"8","key":"554_CR145","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.3390\/ijms18081612","volume":"18","author":"F Simko","year":"2017","unstructured":"Simko F, Pechanova O, Repova K, Aziriova S, Krajcirovicova K, Celec P, et al. Lactacystin-Induced Model of Hypertension in Rats: Effects of Melatonin and Captopril. Int J Mol Sci. 2017;18(8):1612.","journal-title":"Int J Mol Sci"},{"issue":"7","key":"554_CR146","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/ki.2008.351","volume":"74","author":"DO Schlondorff","year":"2008","unstructured":"Schlondorff DO. Overview of factors contributing to the pathophysiology of progressive renal disease. Kidney Int. 2008;74(7):860\u20136.","journal-title":"Kidney Int"},{"issue":"1","key":"554_CR147","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1186\/s13287-020-01906-1","volume":"11","author":"JH Yea","year":"2020","unstructured":"Yea JH, Park JK, Kim IJ, Sym G, Bae TS, Jo CH. Regeneration of a full-thickness defect of rotator cuff tendon with freshly thawed umbilical cord-derived mesenchymal stem cells in a rat model. Stem Cell Res Ther. 2020;11(1):387.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"554_CR148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep24120","volume":"6","author":"M Di Trapani","year":"2016","unstructured":"Di Trapani M, Bassi G, Midolo M, Gatti A, Takam Kamga P, Cassaro A, et al. Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions. Sci Rep. 2016;6(1):1\u201313.","journal-title":"Sci Rep"},{"key":"554_CR149","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.actbio.2020.07.020","volume":"114","author":"JH Yea","year":"2020","unstructured":"Yea JH, Bae TS, Kim BJ, Cho YW, Jo CH. Regeneration of the rotator cuff tendon-to-bone interface using umbilical cord-derived mesenchymal stem cells and gradient extracellular matrix scaffolds from adipose tissue in a rat model. Acta Biomater. 2020;114:104\u201316.","journal-title":"Acta Biomater"},{"issue":"1","key":"554_CR150","doi-asserted-by":"publisher","first-page":"9889","DOI":"10.1038\/s41598-018-28151-0","volume":"8","author":"L Bai","year":"2018","unstructured":"Bai L, Shao H, Wang H, Zhang Z, Su C, Dong L, et al. Author correction: effects of mesenchymal stem cell-derived exosomes on experimental autoimmune uveitis. Sci Rep. 2018;8(1):9889.","journal-title":"Sci Rep"},{"key":"554_CR151","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.copbio.2019.01.005","volume":"60","author":"CY Kao","year":"2019","unstructured":"Kao CY, Papoutsakis ET. Extracellular vesicles: exosomes, microparticles, their parts, and their targets to enable their biomanufacturing and clinical applications. Curr Opin Biotechnol. 2019;60:89\u201398.","journal-title":"Curr Opin Biotechnol"},{"issue":"2","key":"554_CR152","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.ymthe.2016.11.019","volume":"25","author":"Y Yan","year":"2017","unstructured":"Yan Y, Jiang W, Tan Y, Zou S, Zhang H, Mao F, et al. hucMSC exosome-derived GPX1 is required for the recovery of hepatic oxidant injury. Mol Ther. 2017;25(2):465\u201379.","journal-title":"Mol Ther"},{"key":"554_CR153","doi-asserted-by":"publisher","first-page":"204173142110596","DOI":"10.1177\/20417314211059624","volume":"12","author":"JH Yea","year":"2021","unstructured":"Yea JH, Yoon YM, Lee JH, Yun CW, Lee SH. Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model. J Tissue Eng. 2021;12:20417314211059624.","journal-title":"J Tissue Eng"},{"key":"554_CR154","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.redox.2018.07.011","volume":"18","author":"R Li","year":"2018","unstructured":"Li R, Xin T, Li D, Wang C, Zhu H, Zhou H. Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy. Redox Biol. 2018;18:229\u201343.","journal-title":"Redox Biol"},{"key":"554_CR155","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cellsig.2018.01.020","volume":"45","author":"H Zhou","year":"2018","unstructured":"Zhou H, Wang J, Zhu P, Hu S, Ren J. Ripk3 regulates cardiac microvascular reperfusion injury: the role of IP3R-dependent calcium overload, XO-mediated oxidative stress and F-action\/filopodia-based cellular migration. Cell Signal. 2018;45:12\u201322.","journal-title":"Cell Signal"},{"key":"554_CR156","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.freeradbiomed.2016.03.035","volume":"95","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Zhou H, Wu W, Shi C, Hu S, Yin T, et al. Liraglutide protects cardiac microvascular endothelial cells against hypoxia\/reoxygenation injury through the suppression of the SR-Ca(2+)-XO-ROS axis via activation of the GLP-1R\/PI3K\/Akt\/survivin pathways. Free Radic Biol Med. 2016;95:278\u201392.","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"554_CR157","first-page":"1318","volume":"19","author":"J Li","year":"2019","unstructured":"Li J, Li N, Yan S, Lu Y, Miao X, Gu Z, et al. Melatonin attenuates renal fibrosis in diabetic mice by activating the AMPK\/PGC1\u03b1 signaling pathway and rescuing mitochondrial function. Mol Med Rep. 2019;19(2):1318\u201330.","journal-title":"Mol Med Rep"},{"issue":"2","key":"554_CR158","doi-asserted-by":"publisher","first-page":"113","DOI":"10.7555\/JBR.31.20160028","volume":"33","author":"TK Motawi","year":"2019","unstructured":"Motawi TK, Ahmed SA, Hamed MA, El-Maraghy SA, Aziz WM. Melatonin and\/or rowatinex attenuate streptozotocin-induced diabetic renal injury in rats. J Biomed Res. 2019;33(2):113\u201321.","journal-title":"J Biomed Res"},{"key":"554_CR159","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellsig.2017.05.012","volume":"37","author":"O Torres-Quesada","year":"2017","unstructured":"Torres-Quesada O, Mayrhofer JE, Stefan E. The many faces of compartmentalized PKA signalosomes. Cell Signal. 2017;37:1\u201311.","journal-title":"Cell Signal"},{"issue":"3","key":"554_CR160","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s10456-017-9542-0","volume":"20","author":"AF Alghanem","year":"2017","unstructured":"Alghanem AF, Wilkinson EL, Emmett MS, Aljasir MA, Holmes K, Rothermel BA, et al. RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. Angiogenesis. 2017;20(3):341\u201358.","journal-title":"Angiogenesis"},{"issue":"6","key":"554_CR161","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1038\/s41418-018-0086-7","volume":"25","author":"H Zhou","year":"2018","unstructured":"Zhou H, Zhu P, Wang J, Zhu H, Ren J, Chen Y. Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2\u03b1-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy. Cell Death Differ. 2018;25(6):1080\u201393.","journal-title":"Cell Death Differ"},{"issue":"2","key":"554_CR162","doi-asserted-by":"publisher","first-page":"e12379","DOI":"10.1111\/jpi.12379","volume":"62","author":"HY Lee","year":"2017","unstructured":"Lee HY, Back K. Melatonin is required for H(2) O(2) - and NO-mediated defense signaling through MAPKKK3 and OXI1 in Arabidopsis thaliana. J Pineal Res. 2017;62(2):e12379.","journal-title":"J Pineal Res."},{"issue":"3","key":"554_CR163","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/cdd.2016.150","volume":"24","author":"F Dufour","year":"2017","unstructured":"Dufour F, Rattier T, Shirley S, Picarda G, Constantinescu AA, Morl\u00e9 A, et al. N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death. Cell Death Differ. 2017;24(3):500\u201310.","journal-title":"Cell Death Differ"},{"issue":"2","key":"554_CR164","doi-asserted-by":"publisher","first-page":"e12391","DOI":"10.1111\/jpi.12391","volume":"62","author":"JC Mayo","year":"2017","unstructured":"Mayo JC, Sainz RM, Gonz\u00e1lez Men\u00e9ndez P, Cepas V, Tan DX, Reiter RJ. Melatonin and sirtuins: A \"not-so unexpected\" relationship. J Pineal Res. 2017;62(2):e12391.","journal-title":"J Pineal Res."},{"issue":"4","key":"554_CR165","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/path.2721","volume":"221","author":"F Yang","year":"2010","unstructured":"Yang F, Huang XR, Chung AC, Hou CC, Lai KN, Lan HY. Essential role for Smad3 in angiotensin II-induced tubular epithelial-mesenchymal transition. J Pathol. 2010;221(4):390\u2013401.","journal-title":"J Pathol"},{"key":"554_CR166","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fphys.2015.00082","volume":"6","author":"XM Meng","year":"2015","unstructured":"Meng XM, Tang PM, Li J, Lan HY. TGF-\u03b2\/Smad signaling in renal fibrosis. Front Physiol. 2015;6:82.","journal-title":"Front Physiol"},{"key":"554_CR167","doi-asserted-by":"publisher","first-page":"6424","DOI":"10.1038\/srep06424","volume":"4","author":"Y Morishita","year":"2014","unstructured":"Morishita Y, Yoshizawa H, Watanabe M, Ishibashi K, Muto S, Kusano E, et al. siRNAs targeted to Smad4 prevent renal fibrosis in vivo. Sci Rep. 2014;4:6424.","journal-title":"Sci Rep"},{"issue":"6","key":"554_CR168","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1681\/ASN.2015040449","volume":"27","author":"L Xiao","year":"2016","unstructured":"Xiao L, Zhou D, Tan RJ, Fu H, Zhou L, Hou FF, et al. Sustained Activation of Wnt\/\u03b2-Catenin Signaling Drives AKI to CKD Progression. J Am Soc Nephrol. 2016;27(6):1727\u201340.","journal-title":"J Am Soc Nephrol"},{"key":"554_CR169","doi-asserted-by":"publisher","first-page":"204062231986911","DOI":"10.1177\/2040622319869116","volume":"10","author":"DQ Chen","year":"2019","unstructured":"Chen DQ, Cao G, Zhao H, Chen L, Yang T, Wang M, et al. Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and \u03b2-catenin pathway in AKI-to-CKD continuum. Ther Adv Chronic Dis. 2019;10:2040622319869116.","journal-title":"Ther Adv Chronic Dis"},{"issue":"Pt 1","key":"554_CR170","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1242\/jcs.103036","volume":"126","author":"X Tian","year":"2013","unstructured":"Tian X, Zhang J, Tan TK, Lyons JG, Zhao H, Niu B, et al. Association of \u03b2-catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF-\u03b21. J Cell Sci. 2013;126(Pt 1):67\u201376.","journal-title":"J Cell Sci"},{"issue":"6","key":"554_CR171","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.arcmed.2020.05.008","volume":"51","author":"Z Fan","year":"2020","unstructured":"Fan Z, Qi X, Yang W, Xia L, Wu Y. Melatonin ameliorates renal fibrosis through the inhibition of NF-\u03baB and TGF-\u03b21\/Smad3 pathways in db\/db diabetic mice. Arch Med Res. 2020;51(6):524\u201334.","journal-title":"Arch Med Res"},{"issue":"3","key":"554_CR172","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.semnephrol.2010.03.007","volume":"30","author":"GH Tesch","year":"2010","unstructured":"Tesch GH. Macrophages and Diabetic Nephropathy. Semin Nephrol. 2010;30(3):290\u2013301.","journal-title":"Semin Nephrol"},{"issue":"3","key":"554_CR173","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1142\/S0192415X12500401","volume":"40","author":"K Wang","year":"2012","unstructured":"Wang K, Wu YG, Su J, Zhang JJ, Zhang P, Qi XM. Total glucosides of paeony regulates JAK2\/STAT3 activation and macrophage proliferation in diabetic rat kidneys. Am J Chin Med. 2012;40(3):521\u201336.","journal-title":"Am J Chin Med"},{"key":"554_CR174","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3389\/fphar.2017.00461","volume":"8","author":"KL Walton","year":"2017","unstructured":"Walton KL, Johnson KE, Harrison CA. Targeting TGF-\u03b2 mediated SMAD signaling for the prevention of fibrosis. Front Pharmacol. 2017;8:461.","journal-title":"Front Pharmacol"},{"issue":"6","key":"554_CR175","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1046\/j.1523-1755.2003.00016.x","volume":"63","author":"JH Li","year":"2003","unstructured":"Li JH, Huang XR, Zhu HJ, Johnson R, Lan HY. Role of TGF-beta signaling in extracellular matrix production under high glucose conditions. Kidney Int. 2003;63(6):2010\u20139.","journal-title":"Kidney Int"},{"issue":"9","key":"554_CR176","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.7150\/ijms.42603","volume":"17","author":"YS Han","year":"2020","unstructured":"Han YS, Yoon YM, Go G, Lee JH, Lee SH. Melatonin protects human renal proximal tubule epithelial cells against high glucose-mediated fibrosis via the cellular prion protein-TGF-\u03b2-Smad signaling axis. Int J Med Sci. 2020;17(9):1235\u201345.","journal-title":"Int J Med Sci"},{"issue":"10","key":"554_CR177","doi-asserted-by":"publisher","first-page":"5615","DOI":"10.1111\/jcmm.15221","volume":"24","author":"N Li","year":"2020","unstructured":"Li N, Wang Z, Gao F, Lei Y, Li Z. Melatonin ameliorates renal fibroblast-myofibroblast transdifferentiation and renal fibrosis through miR-21-5p regulation. J Cell Mol Med. 2020;24(10):5615\u201328.","journal-title":"J Cell Mol Med"},{"issue":"5","key":"554_CR178","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/j.1398-9995.2009.02305.x","volume":"65","author":"S Harari","year":"2010","unstructured":"Harari S, Caminati A. IPF: new insight on pathogenesis and treatment. Allergy. 2010;65(5):537\u201353.","journal-title":"Allergy"},{"issue":"2","key":"554_CR179","first-page":"327","volume":"29","author":"M Karimfar","year":"2015","unstructured":"Karimfar M, Rostami S, Haghani K, Bakhtiyari S, Noori-Zadeh A. Melatonin alleviates bleomycin-induced pulmonary fibrosis in mice. J Biol Regul Homeost Agents. 2015;29(2):327\u201334.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"1","key":"554_CR180","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1034\/j.1600-079x.2002.10796.x","volume":"32","author":"SO Arslan","year":"2002","unstructured":"Arslan SO, Zerin M, Vural H, Coskun A. The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats. J Pineal Res. 2002;32(1):21\u20135.","journal-title":"J Pineal Res"},{"issue":"1","key":"554_CR181","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1600-079X.2005.00272.x","volume":"40","author":"Z Yildirim","year":"2006","unstructured":"Yildirim Z, Kotuk M, Erdogan H, Iraz M, Yagmurca M, Kuku I, et al. Preventive effect of melatonin on bleomycin-induced lung fibrosis in rats. J Pineal Res. 2006;40(1):27\u201333.","journal-title":"J Pineal Res"},{"key":"554_CR182","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2021.104737","volume":"124","author":"H Yousefi-Manesh","year":"2022","unstructured":"Yousefi-Manesh H, Noori T, Asgardoon MH, Derakhshan MH, Tavangar SM, Sheibani M, et al. Protective effect of dapsone against bleomycin-induced lung fibrosis in rat. Exp Mol Pathol. 2022;124: 104737.","journal-title":"Exp Mol Pathol"},{"issue":"56","key":"554_CR183","doi-asserted-by":"publisher","first-page":"95692","DOI":"10.18632\/oncotarget.21680","volume":"8","author":"N-R Shin","year":"2017","unstructured":"Shin N-R, Park J-W, Lee I-C, Ko J-W, Park S-H, Kim J-S, et al. Melatonin suppresses fibrotic responses induced by cigarette smoke via downregulation of TGF-\u03b21. Oncotarget. 2017;8(56):95692.","journal-title":"Oncotarget"},{"issue":"2","key":"554_CR184","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1600-079X.2005.00229.x","volume":"39","author":"T Genovese","year":"2005","unstructured":"Genovese T, Paola RD, Mazzon E, Mui\u00e0 C, Caputi AP, Cuzzocrea S. Melatonin limits lung injury in bleomycin treated mice. J Pineal Res. 2005;39(2):105\u201312.","journal-title":"J Pineal Res"},{"issue":"9","key":"554_CR185","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1136\/thx.48.9.931","volume":"48","author":"J Gauldie","year":"1993","unstructured":"Gauldie J, Jordana M, Cox G. Cytokines and pulmonary fibrosis. Thorax. 1993;48(9):931\u20135.","journal-title":"Thorax"},{"issue":"2","key":"554_CR186","doi-asserted-by":"publisher","first-page":"136","DOI":"10.7326\/0003-4819-134-2-200101160-00015","volume":"134","author":"M Selman","year":"2001","unstructured":"Selman M, King TE Jr, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med. 2001;134(2):136\u201351.","journal-title":"Ann Intern Med"},{"issue":"7","key":"554_CR187","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1084\/jem.20110551","volume":"208","author":"TA Wynn","year":"2011","unstructured":"Wynn TA. Integrating mechanisms of pulmonary fibrosis. J Exp Med. 2011;208(7):1339\u201350.","journal-title":"J Exp Med"},{"issue":"3","key":"554_CR188","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1084\/jem.20092121","volume":"207","author":"MS Wilson","year":"2010","unstructured":"Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, et al. Bleomycin and IL-1\u03b2\u2013mediated pulmonary fibrosis is IL-17A dependent. J Exp Med. 2010;207(3):535\u201352.","journal-title":"J Exp Med"},{"issue":"6","key":"554_CR189","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.4049\/jimmunol.1004081","volume":"187","author":"S Mi","year":"2011","unstructured":"Mi S, Li Z, Yang H-Z, Liu H, Wang J-P, Ma Y-G, et al. Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-\u03b21\u2013dependent and\u2013independent mechanisms. J Immunol. 2011;187(6):3003\u201314.","journal-title":"J Immunol"},{"issue":"4","key":"554_CR190","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3892\/etm.2022.11197","volume":"23","author":"L Li","year":"2022","unstructured":"Li L, Gang X, Wang J, Gong X. Role of melatonin in respiratory diseases (Review). Exp Ther Med. 2022;23(4):271.","journal-title":"Exp Ther Med"},{"issue":"2","key":"554_CR191","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1172\/JCI20729","volume":"113","author":"HA Chapman","year":"2004","unstructured":"Chapman HA. Disorders of lung matrix remodeling. J Clinical Invest. 2004;113(2):148\u201357.","journal-title":"J Clinical Invest"},{"issue":"1","key":"554_CR192","doi-asserted-by":"publisher","first-page":"G116","DOI":"10.1152\/ajpgi.00051.2005","volume":"289","author":"BA Vallance","year":"2005","unstructured":"Vallance BA, Gunawan MI, Hewlett B, Bercik P, Van Kampen C, Galeazzi F, et al. TGF-\u03b21 gene transfer to the mouse colon leads to intestinal fibrosis. Am J Physiol Gastrointest Liver Physiol. 2005;289(1):G116\u201328.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"554_CR193","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1513\/pats.201203-023AW","volume":"9","author":"IE Fernandez","year":"2012","unstructured":"Fernandez IE, Eickelberg O. The impact of TGF-\u03b2 on lung fibrosis: from targeting to biomarkers. Proc Am Thorac Soc. 2012;9(3):111\u20136.","journal-title":"Proc Am Thorac Soc"},{"key":"554_CR194","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-015-0319-y","volume":"17","author":"C Dong","year":"2016","unstructured":"Dong C, Gongora R, Sosulski ML, Luo F, Sanchez CG. Regulation of transforming growth factor-beta1 (TGF-\u03b21)-induced pro-fibrotic activities by circadian clock gene BMAL1. Resp Res. 2016;17:1\u201317.","journal-title":"Resp Res"},{"issue":"4","key":"554_CR195","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/1534735409353332","volume":"8","author":"SM Hill","year":"2009","unstructured":"Hill SM, Frasch T, Xiang S, Yuan L, Duplessis T, Mao L. Molecular mechanisms of melatonin anticancer effects. Integr Cancer Ther. 2009;8(4):337\u201346.","journal-title":"Integr Cancer Ther"},{"issue":"1","key":"554_CR196","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1600-079X.2009.00729.x","volume":"48","author":"B Jung-Hynes","year":"2010","unstructured":"Jung-Hynes B, Reiter RJ, Ahmad N. Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J Pineal Res. 2010;48(1):9\u201319.","journal-title":"J Pineal Res"},{"issue":"1","key":"554_CR197","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/annrheumdis-2014-205740","volume":"75","author":"P Zerr","year":"2016","unstructured":"Zerr P, Palumbo-Zerr K, Huang J, Tomcik M, Sumova B, Distler O, et al. Sirt1 regulates canonical TGF-\u03b2 signalling to control fibroblast activation and tissue fibrosis. Ann Rheum Dis. 2016;75(1):226\u201333.","journal-title":"Ann Rheum Dis"},{"issue":"22","key":"554_CR198","doi-asserted-by":"publisher","first-page":"10431","DOI":"10.1158\/0008-5472.CAN-05-1522","volume":"65","author":"MC Wilkes","year":"2005","unstructured":"Wilkes MC, Mitchell H, Penheiter SG, Dor\u00e9 JJ, Suzuki K, Edens M, et al. Transforming growth factor-\u03b2 activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. Cancer Res. 2005;65(22):10431\u201340.","journal-title":"Cancer Res"},{"issue":"34","key":"554_CR199","doi-asserted-by":"publisher","first-page":"12747","DOI":"10.1073\/pnas.0605333103","volume":"103","author":"RR Gomis","year":"2006","unstructured":"Gomis RR, Alarc\u00f3n C, He W, Wang Q, Seoane J, Lash A, et al. A FoxO\u2013Smad synexpression group in human keratinocytes. Proc Natl Acad Sci. 2006;103(34):12747\u201352.","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"554_CR200","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0092-8674(04)00298-3","volume":"117","author":"J Seoane","year":"2004","unstructured":"Seoane J, Le H-V, Shen L, Anderson SA, Massagu\u00e9 J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell. 2004;117(2):211\u201323.","journal-title":"Cell"},{"issue":"1","key":"554_CR201","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/cr.2008.328","volume":"19","author":"YE Zhang","year":"2009","unstructured":"Zhang YE. Non-Smad pathways in TGF-\u03b2 signaling. Cell Res. 2009;19(1):128\u201339.","journal-title":"Cell Res"},{"key":"554_CR202","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110827","volume":"132","author":"Z Ding","year":"2020","unstructured":"Ding Z, Wu X, Wang Y, Ji S, Zhang W, Kang J, et al. Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3\u03b2\/Nrf2 pathway. Biomed Pharmacother. 2020;132: 110827.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"554_CR203","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jss.2006.07.026","volume":"138","author":"E Bowley","year":"2007","unstructured":"Bowley E, O\u2019Gorman DB, Gan BS. \u03b2-catenin signaling in fibroproliferative disease. J Surg Res. 2007;138(1):141\u201350.","journal-title":"J Surg Res"},{"issue":"1","key":"554_CR204","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1165\/rcmb.2012-0524OC","volume":"49","author":"V Aumiller","year":"2013","unstructured":"Aumiller V, Balsara N, Wilhelm J, G\u00fcnther A, K\u00f6nigshoff M. WNT\/\u03b2-catenin signaling induces IL-1\u03b2 expression by alveolar epithelial cells in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2013;49(1):96\u2013104.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"554_CR205","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/S0002-9440(10)64282-4","volume":"162","author":"M Chilosi","year":"2003","unstructured":"Chilosi M, Poletti V, Zam\u00f2 A, Lestani M, Montagna L, Piccoli P, et al. Aberrant Wnt\/\u03b2-catenin pathway activation in idiopathic pulmonary fibrosis. The Am J Pathol. 2003;162(5):1495\u2013502.","journal-title":"The Am J Pathol"},{"issue":"5","key":"554_CR206","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002142","volume":"3","author":"M K\u00f6nigshoff","year":"2008","unstructured":"K\u00f6nigshoff M, Balsara N, Pfaff E-M, Kramer M, Chrobak I, Seeger W, et al. Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS ONE. 2008;3(5): e2142.","journal-title":"PLoS ONE"},{"issue":"3","key":"554_CR207","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050062","volume":"5","author":"M Selman","year":"2008","unstructured":"Selman M, Pardo A, Kaminski N. Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? PLoS Med. 2008;5(3): e62.","journal-title":"PLoS Med"},{"issue":"4","key":"554_CR208","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.phrs.2008.02.001","volume":"57","author":"F Caraci","year":"2008","unstructured":"Caraci F, Gili E, Calafiore M, Failla M, La Rosa C, Crimi N, et al. TGF-\u03b21 targets the GSK-3\u03b2\/\u03b2-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts. Pharmacol Res. 2008;57(4):274\u201382.","journal-title":"Pharmacol Res"},{"issue":"11","key":"554_CR209","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1210\/me.2012-1071","volume":"26","author":"L Mao","year":"2012","unstructured":"Mao L, Dauchy RT, Blask DE, Slakey LM, Xiang S, Yuan L, et al. Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3\u03b2. Mol Endocrinol. 2012;26(11):1808\u201320.","journal-title":"Mol Endocrinol"},{"issue":"6","key":"554_CR210","doi-asserted-by":"publisher","first-page":"5567","DOI":"10.3892\/mmr.2016.5950","volume":"14","author":"N Yu","year":"2016","unstructured":"Yu N, Sun YT, Su XM, He M, Dai B, Kang J. Melatonin attenuates TGF\u03b21-induced epithelial-mesenchymal transition in lung alveolar epithelial cells. Mol Med Rep. 2016;14(6):5567\u201372.","journal-title":"Mol Med Rep"},{"issue":"5","key":"554_CR211","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1164\/rccm.201106-0965OC","volume":"185","author":"AC MacKinnon","year":"2012","unstructured":"MacKinnon AC, Gibbons MA, Farnworth SL, Leffler H, Nilsson UJ, Delaine T, et al. Regulation of transforming growth factor-\u03b21\u2013driven lung fibrosis by galectin-3. Am J Respir Crit Care Med. 2012;185(5):537\u201346.","journal-title":"Am J Respir Crit Care Med"},{"issue":"18","key":"554_CR212","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1002\/cbic.201600285","volume":"17","author":"T Delaine","year":"2016","unstructured":"Delaine T, Collins P, MacKinnon A, Sharma G, Stegmayr J, Rajput VK, et al. Galectin-3-binding glycomimetics that strongly reduce bleomycin-induced lung fibrosis and modulate intracellular glycan recognition. ChemBioChem. 2016;17(18):1759\u201370.","journal-title":"ChemBioChem"},{"issue":"4","key":"554_CR213","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41419-021-03603-0","volume":"12","author":"W Jia","year":"2021","unstructured":"Jia W, Wang Z, Gao C, Wu J, Wu Q. Trajectory modeling of endothelial-to-mesenchymal transition reveals galectin-3 as a mediator in pulmonary fibrosis. Cell Death Dis. 2021;12(4):327.","journal-title":"Cell Death Dis"},{"key":"554_CR214","first-page":"1","volume":"44","author":"YJ Lan","year":"2022","unstructured":"Lan YJ, Cheng MH, Ji HM, Bi YQ, Han YY, Yang CY, et al. Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression. Acta Pharmacol Sin. 2022;44(5):1\u20139.","journal-title":"Acta Pharmacol Sin"},{"issue":"5","key":"554_CR215","doi-asserted-by":"publisher","first-page":"L887","DOI":"10.1152\/ajplung.00432.2005","volume":"291","author":"X Li","year":"2006","unstructured":"Li X, Molina-Molina M, Abdul-Hafez A, Ramirez J, Serrano-Mollar A, Xaubet A, et al. Extravascular sources of lung angiotensin peptide synthesis in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2006;291(5):L887\u201395.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"12","key":"554_CR216","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.2174\/138161207780618885","volume":"13","author":"BD Uhal","year":"2007","unstructured":"Uhal BD, Kyong Kim J, Li X, Molina-Molina M. Angiotensin-TGF-\u03b21 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myofibroblasts and macrophages. Curr Pharm Des. 2007;13(12):1247\u201356.","journal-title":"Curr Pharm Des"},{"issue":"05","key":"554_CR217","doi-asserted-by":"publisher","first-page":"P06","DOI":"10.1055\/s-0033-1345044","volume":"67","author":"J Eschenbrenner","year":"2013","unstructured":"Eschenbrenner J, Janssen W, Kojonazarov B, Murmann K, Ghofrani A, Weissmann N, et al. Role of JAK-STAT pathway in pulmonary fibrosis. Pneumologie. 2013;67(05):P06.","journal-title":"Pneumologie"},{"issue":"1","key":"554_CR218","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3892\/mmr.2016.5313","volume":"14","author":"ZZ Ji","year":"2016","unstructured":"Ji ZZ, Xu YC. Melatonin protects podocytes from angiotensin II-induced injury in an in vitro diabetic nephropathy model. Mol Med Rep. 2016;14(1):920\u20136.","journal-title":"Mol Med Rep"},{"key":"554_CR219","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/bs.ctdb.2016.12.001","volume":"123","author":"CM Pfleger","year":"2017","unstructured":"Pfleger CM. The Hippo pathway: a master regulatory network important in development and dysregulated in disease. Curr Top Dev Biol. 2017;123:181\u2013228.","journal-title":"Curr Top Dev Biol"},{"key":"554_CR220","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceb.2017.03.006","volume":"48","author":"HE Richardson","year":"2017","unstructured":"Richardson HE, Portela M. Tissue growth and tumorigenesis in Drosophila: cell polarity and the Hippo pathway. Curr Opin Cell Biol. 2017;48:1\u20139.","journal-title":"Curr Opin Cell Biol"},{"issue":"4","key":"554_CR221","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.3390\/ijms19041118","volume":"19","author":"X Zhao","year":"2018","unstructured":"Zhao X, Sun J, Su W, Shan H, Zhang B, Wang Y, et al. Melatonin protects against lung fibrosis by regulating the Hippo\/YAP pathway. Int J Mol Sci. 2018;19(4):1118.","journal-title":"Int J Mol Sci"},{"issue":"11","key":"554_CR222","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1164\/rccm.200308-1111OC","volume":"169","author":"M Ebina","year":"2004","unstructured":"Ebina M, Shimizukawa M, Shibata N, Kimura Y, Suzuki T, Endo M, et al. Heterogeneous increase in CD34-positive alveolar capillaries in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2004;169(11):1203\u20138.","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"554_CR223","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1002\/jcb.25192","volume":"116","author":"AKV Iyer","year":"2015","unstructured":"Iyer AKV, Ramesh V, Castro CA, Kaushik V, Kulkarni YM, Wright CA, et al. Nitric oxide mediates bleomycin-induced angiogenesis and pulmonary fibrosis via regulation of VEGF. J Cell Biochem. 2015;116(11):2484\u201393.","journal-title":"J Cell Biochem"},{"issue":"5","key":"554_CR224","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1183\/09031936.00152106","volume":"29","author":"N Chaudhary","year":"2007","unstructured":"Chaudhary N, Roth G, Hilberg F, M\u00fcller-Quernheim J, Prasse A, Zissel G, et al. Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis. Eur Respir. 2007;29(5):976\u201385.","journal-title":"Eur Respir"},{"issue":"2","key":"554_CR225","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.4049\/jimmunol.175.2.1224","volume":"175","author":"N Hamada","year":"2005","unstructured":"Hamada N, Kuwano K, Yamada M, Hagimoto N, Hiasa K, Egashira K, et al. Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice. J Immun. 2005;175(2):1224\u201331.","journal-title":"J Immun"},{"issue":"1","key":"554_CR226","doi-asserted-by":"publisher","first-page":"G143","DOI":"10.1152\/ajpgi.00186.2004","volume":"288","author":"Y Motomura","year":"2005","unstructured":"Motomura Y, Kanbayashi H, Khan W, Deng Y, Blennerhassett P, Margetts P, et al. The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-\u03b2 type II receptor gene transfer. Am J Physiol Gastrointest Liver Physiol. 2005;288(1):G143\u201350.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"554_CR227","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.mvr.2013.02.008","volume":"87","author":"V Alvarez-Garc\u00eda","year":"2013","unstructured":"Alvarez-Garc\u00eda V, Gonz\u00e1lez A, Alonso-Gonz\u00e1lez C, Mart\u00ednez-Campa C, Cos S. Antiangiogenic effects of melatonin in endothelial cell cultures. Microvasc Res. 2013;87:25\u201333.","journal-title":"Microvasc Res"},{"issue":"4","key":"554_CR228","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/jpi.12007","volume":"54","author":"V Alvarez-Garc\u00eda","year":"2013","unstructured":"Alvarez-Garc\u00eda V, Gonz\u00e1lez A, Alonso-Gonz\u00e1lez C, Mart\u00ednez-Campa C, Cos S. Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells. J Pineal Res. 2013;54(4):373\u201380.","journal-title":"J Pineal Res"},{"key":"554_CR229","doi-asserted-by":"publisher","first-page":"639531","DOI":"10.1155\/2014\/639531","volume":"2014","author":"J Song","year":"2014","unstructured":"Song J, Kang SM, Lee WT, Park KA, Lee KM, Lee JE. The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion-induced injury. Oxid Med Cell Longev. 2014;2014:639531.","journal-title":"Oxid Med Cell Longev."},{"issue":"1","key":"554_CR230","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1515\/acph-2017-0010","volume":"67","author":"NM Al-Rasheed","year":"2017","unstructured":"Al-Rasheed NM, Fadda L, Attia HA, Sharaf IA, Mohamed AM, Al-Rasheed NM. Pulmonary prophylactic impact of melatonin and\/or quercetin: a novel therapy for inflammatory hypoxic stress in rats. Acta Pharm. 2017;67(1):125\u201335.","journal-title":"Acta Pharm"},{"issue":"4","key":"554_CR231","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/jpi.12184","volume":"57","author":"H Jin","year":"2014","unstructured":"Jin H, Wang Y, Zhou L, Liu L, Zhang P, Deng W, et al. Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells. J Pineal Res. 2014;57(4):442\u201350.","journal-title":"J Pineal Res"},{"issue":"13","key":"554_CR232","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1084\/jem.20061536","volume":"203","author":"XM Wang","year":"2006","unstructured":"Wang XM, Zhang Y, Kim HP, Zhou Z, Feghali-Bostwick CA, Liu F, et al. Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. The J Exp Med. 2006;203(13):2895\u2013906.","journal-title":"The J Exp Med"},{"issue":"8","key":"554_CR233","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.21037\/jtd.2017.07.01","volume":"9","author":"Y Xing","year":"2017","unstructured":"Xing Y, Wang L, Wang H, Kong X, Zhan L. Dynamic expression of transformating growth factor-\u03b21 and caveolin-1 in the lung of Bleomycin-induced interstitial lung disease. J Thorac Dis. 2017;9(8):2360.","journal-title":"J Thorac Dis"},{"issue":"7","key":"554_CR234","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1091\/mbc.01-11-0529","volume":"13","author":"D Volonte","year":"2002","unstructured":"Volonte D, Zhang K, Lisanti MP, Galbiati F. Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Mol Biol Cell. 2002;13(7):2502\u201317.","journal-title":"Mol Biol Cell"},{"issue":"30","key":"554_CR235","doi-asserted-by":"publisher","first-page":"23368","DOI":"10.1074\/jbc.M002020200","volume":"275","author":"F Galbiati","year":"2000","unstructured":"Galbiati F, Brown AM, Weinstein DE, Ben-Ze\u2019ev A, Pestell RG, Lisanti MP. Caveolin-1 expression inhibits Wnt\/\u03b2-catenin\/Lef-1 signaling by recruiting \u03b2-catenin to caveolae membrane domains. J Biol Chem. 2000;275(30):23368\u201377.","journal-title":"J Biol Chem"},{"key":"554_CR236","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1755-1536-7-13","volume":"7","author":"P Cipriani","year":"2014","unstructured":"Cipriani P, Di Benedetto P, Capece D, Zazzeroni F, Liakouli V, Ruscitti P, et al. Impaired Cav-1 expression in SSc mesenchymal cells upregulates VEGF signaling: a link between vascular involvement and fibrosis. Fibrogen Tissue Repair. 2014;7:13.","journal-title":"Fibrogen Tissue Repair"},{"key":"554_CR237","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s10549-008-0220-1","volume":"118","author":"L Lai","year":"2009","unstructured":"Lai L, Yuan L, Cheng Q, Dong C, Mao L, Hill SM. Alteration of the MT1 melatonin receptor gene and its expression in primary human breast tumors and breast cancer cell lines. Breast Cancer Res Treat. 2009;118:293\u2013305.","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"554_CR238","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122654","volume":"10","author":"A Mougeolle","year":"2015","unstructured":"Mougeolle A, Poussard S, Decossas M, Lamaze C, Lambert O, Dargelos E. Oxidative stress induces caveolin 1 degradation and impairs caveolae functions in skeletal muscle cells. PLoS ONE. 2015;10(3): e0122654.","journal-title":"PLoS ONE"},{"issue":"4","key":"554_CR239","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1111\/j.1471-4159.2005.03589.x","volume":"96","author":"J Shen","year":"2006","unstructured":"Shen J, Ma S, Chan P, Lee W, Fung PC, Cheung RT, et al. Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury. J Neurochem. 2006;96(4):1078\u201389.","journal-title":"J Neurochem"},{"issue":"11","key":"554_CR240","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014003","volume":"5","author":"M Bocchino","year":"2010","unstructured":"Bocchino M, Agnese S, Fagone E, Svegliati S, Grieco D, Vancheri C, et al. Reactive oxygen species are required for maintenance and differentiation of primary lung fibroblasts in idiopathic pulmonary fibrosis. PLoS ONE. 2010;5(11): e14003.","journal-title":"PLoS ONE"},{"issue":"5","key":"554_CR241","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.freeradbiomed.2006.11.031","volume":"42","author":"Y-C Hsu","year":"2007","unstructured":"Hsu Y-C, Wang L-F, Chien YW. Nitric oxide in the pathogenesis of diffuse pulmonary fibrosis. Free Radic Biol Med. 2007;42(5):599\u2013607.","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"554_CR242","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1600-079X.2012.00972.x","volume":"53","author":"JW Kang","year":"2012","unstructured":"Kang JW, Lee SM. Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia\/reperfusion. J Pineal Res. 2012;53(1):67\u201376.","journal-title":"J Pineal Res"},{"issue":"26","key":"554_CR243","doi-asserted-by":"publisher","first-page":"10562","DOI":"10.1073\/pnas.1107559108","volume":"108","author":"WE Lawson","year":"2011","unstructured":"Lawson WE, Cheng D-S, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, et al. Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc Natl Acad Sci. 2011;108(26):10562\u20137.","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"554_CR244","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/sj.cdd.4401840","volume":"13","author":"J Wu","year":"2006","unstructured":"Wu J, Kaufman R. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Dis. 2006;13(3):374\u201384.","journal-title":"Cell Death Dis"},{"issue":"12","key":"554_CR245","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1089\/ars.2007.1819","volume":"9","author":"K Kohno","year":"2007","unstructured":"Kohno K. How transmembrane proteins sense endoplasmic reticulum stress. Antioxid Redox Signal. 2007;9(12):2295\u2013304.","journal-title":"Antioxid Redox Signal"},{"issue":"7","key":"554_CR246","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrm2199","volume":"8","author":"D Ron","year":"2007","unstructured":"Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007;8(7):519\u201329.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"Suppl 1","key":"554_CR247","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1016\/S0168-8278(02)00429-4","volume":"38","author":"SL Friedman","year":"2003","unstructured":"Friedman SL. Liver fibrosis\u2014from bench to bedside. J Hepatol. 2003;38(Suppl 1):S38-53.","journal-title":"J Hepatol"},{"issue":"16","key":"554_CR248","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1056\/NEJMra035021","volume":"350","author":"P Gin\u00e8s","year":"2004","unstructured":"Gin\u00e8s P, C\u00e1rdenas A, Arroyo V, Rod\u00e9s J. Management of cirrhosis and ascites. NEJM. 2004;350(16):1646\u201354.","journal-title":"NEJM"},{"key":"554_CR249","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.730176","volume":"9","author":"Z Tan","year":"2021","unstructured":"Tan Z, Sun H, Xue T, Gan C, Liu H, Xie Y, et al. Liver fibrosis: therapeutic targets and advances in drug therapy. Front Cell Dev Biol. 2021;9: 730176.","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"554_CR250","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/JCI24282","volume":"115","author":"R Bataller","year":"2005","unstructured":"Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005;115(2):209\u201318.","journal-title":"J Clin Invest"},{"issue":"3","key":"554_CR251","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/FJC.0000000000000872","volume":"76","author":"M Sheibani","year":"2020","unstructured":"Sheibani M, Nezamoleslami S, Mousavi SE, Faghir-Ghanesefat H, Yousefi-Manesh H, Rezayat SM, et al. Protective effects of spermidine against cirrhotic cardiomyopathy in bile duct-ligated rats. J Cardiovasc Pharmacol. 2020;76(3):286\u201395.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"12","key":"554_CR252","doi-asserted-by":"publisher","first-page":"3348","DOI":"10.1007\/s10620-006-9717-9","volume":"52","author":"G Tahan","year":"2007","unstructured":"Tahan G, Tarcin O, Tahan V, Eren F, Gedik N, Sahan E, et al. The effects of N-acetylcysteine on bile duct ligation-induced liver fibrosis in rats. Dig Dis Sci. 2007;52(12):3348\u201354.","journal-title":"Dig Dis Sci"},{"issue":"4","key":"554_CR253","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1046\/j.1440-1746.2003.03004.x","volume":"18","author":"O Tar\u00e7in","year":"2003","unstructured":"Tar\u00e7in O, Av\u015far K, Demirt\u00fcrk L, G\u00fcltepe M, Oktar BK, Ozdo\u011fan OC, et al. In vivo inefficiency of pentoxifylline and interferon-alpha on hepatic fibrosis in biliary-obstructed rats: assessment by tissue collagen content and prolidase activity. J Gastroenterol Hepatol. 2003;18(4):437\u201344.","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"554_CR254","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1600-079X.2004.00137.x","volume":"37","author":"V Tahan","year":"2004","unstructured":"Tahan V, Ozaras R, Canbakan B, Uzun H, Aydin S, Yildirim B, et al. Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats. J Pineal Res. 2004;37(2):78\u201384.","journal-title":"J Pineal Res"},{"issue":"3","key":"554_CR255","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/hep.510270313","volume":"27","author":"G Svegliati Baroni","year":"1998","unstructured":"Svegliati Baroni G, D\u2019Ambrosio L, Ferretti G, Casini A, Di Sario A, Salzano R, et al. Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology. 1998;27(3):720\u20136.","journal-title":"Hepatology"},{"issue":"5","key":"554_CR256","first-page":"1262","volume":"19","author":"P Bedossa","year":"1994","unstructured":"Bedossa P, Houglum K, Trautwein C, Holstege A, Chojkier M. Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Hepatology. 1994;19(5):1262\u201371.","journal-title":"Hepatology"},{"issue":"1","key":"554_CR257","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S1665-2681(19)31810-1","volume":"8","author":"E-S Sahar","year":"2009","unstructured":"Sahar E-S, Hassanen SI. Basic studiesImprovement of hepatic fibrosis by leukotriene inhibition in cholestatic rats. Ann Hepatol. 2009;8(1):41\u20139.","journal-title":"Ann Hepatol"},{"issue":"12","key":"554_CR258","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.3748\/wjg.15.1452","volume":"15","author":"RT Hong","year":"2009","unstructured":"Hong RT, Xu JM, Mei Q. Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol. 2009;15(12):1452\u20138.","journal-title":"World J Gastroenterol"},{"issue":"2","key":"554_CR259","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1139\/cjpp-2015-0266","volume":"94","author":"K Mortezaee","year":"2016","unstructured":"Mortezaee K, Sabbaghziarani F, Omidi A, Dehpour AR, Omidi N, Ghasemi S, et al. Therapeutic value of melatonin post-treatment on CCl4-induced fibrotic rat liver. Can J Physiol Pharmacol. 2016;94(2):119\u201330.","journal-title":"Can J Physiol Pharmacol"},{"key":"554_CR260","doi-asserted-by":"publisher","first-page":"556","DOI":"10.3389\/fphar.2018.00556","volume":"9","author":"B Gonz\u00e1lez-Fern\u00e1ndez","year":"2018","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez B, S\u00e1nchez DI, Crespo I, San-Miguel B, de Urbina JO, Gonz\u00e1lez-Gallego J, et al. Melatonin attenuates dysregulation of the circadian clock pathway in mice with ccl4-induced fibrosis and human hepatic stellate cells. Front Pharmacol. 2018;9:556.","journal-title":"Front Pharmacol."},{"issue":"9","key":"554_CR261","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1111\/j.1440-1746.2006.04447.x","volume":"21","author":"H Kaneda","year":"2006","unstructured":"Kaneda H, Hashimoto E, Yatsuji S, Tokushige K, Shiratori K. Hyaluronic acid levels can predict severe fibrosis and platelet counts can predict cirrhosis in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2006;21(9):1459\u201365.","journal-title":"J Gastroenterol Hepatol"},{"issue":"4","key":"554_CR262","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3748\/wjg.v13.i4.557","volume":"13","author":"SS Dang","year":"2007","unstructured":"Dang SS, Wang BF, Cheng YA, Song P, Liu ZG, Li ZF. Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats. World J Gastroenterol. 2007;13(4):557\u201363.","journal-title":"World J Gastroenterol"},{"issue":"4","key":"554_CR263","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1159\/000007493","volume":"59","author":"A Hayasaka","year":"1998","unstructured":"Hayasaka A, Saisho H. Serum markers as tools to monitor liver fibrosis. Digestion. 1998;59(4):381\u20134.","journal-title":"Digestion"},{"issue":"8","key":"554_CR264","doi-asserted-by":"publisher","first-page":"8625","DOI":"10.18632\/oncotarget.7065","volume":"7","author":"D Zhou","year":"2016","unstructured":"Zhou D, Wang Y, Chen L, Jia L, Yuan J, Sun M, et al. Evolving roles of circadian rhythms in liver homeostasis and pathology. Oncotarget. 2016;7(8):8625.","journal-title":"Oncotarget"},{"issue":"27","key":"554_CR265","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.2174\/09298673113209990136","volume":"20","author":"ME Zardi","year":"2013","unstructured":"Zardi ME, Navarini L, Sambataro G, Piccinni P, Sambataro MF, Spina C, et al. Hepatic PPARs: their role in liver physiology, fibrosis and treatment. Curr Med Chem. 2013;20(27):3370\u201396.","journal-title":"Curr Med Chem"},{"issue":"5","key":"554_CR266","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1002\/hep.26200","volume":"57","author":"S Roychowdhury","year":"2013","unstructured":"Roychowdhury S, McMullen MR, Pisano SG, Liu X, Nagy LE. Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. Hepatology. 2013;57(5):1773\u201383.","journal-title":"Hepatology"},{"issue":"8","key":"554_CR267","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.15252\/emmm.201403856","volume":"6","author":"J Gautheron","year":"2014","unstructured":"Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, Koppe C, et al. A positive feedback loop between RIP 3 and JNK controls non-alcoholic steatohepatitis. EMBO Mol Med. 2014;6(8):1062\u201374.","journal-title":"EMBO Mol Med"},{"issue":"2","key":"554_CR268","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.ceb.2009.12.003","volume":"22","author":"DE Christofferson","year":"2010","unstructured":"Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol. 2010;22(2):263\u20138.","journal-title":"Curr Opin Cell Biol"},{"issue":"2","key":"554_CR269","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.trsl.2014.10.003","volume":"165","author":"I Crespo","year":"2015","unstructured":"Crespo I, San-Miguel B, Fern\u00e1ndez A, Ortiz de Urbina J, Gonz\u00e1lez-Gallego J, Tu\u00f1\u00f3n MJ. Melatonin limits the expression of profibrogenic genes and ameliorates the progression of hepatic fibrosis in mice. Transl Res. 2015;165(2):346\u201357.","journal-title":"Transl Res"},{"issue":"3","key":"554_CR270","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s11596-022-2530-7","volume":"42","author":"L Jie","year":"2022","unstructured":"Jie L, Hong R-T, Zhang Y-J, Sha L-L, Chen W, Ren X-F. Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy. Curr Med Sci. 2022;42(3):498\u2013504.","journal-title":"Curr Med Sci."},{"issue":"4","key":"554_CR271","first-page":"333","volume":"30","author":"B \u00dcst\u00fcnda\u011f","year":"2000","unstructured":"\u00dcst\u00fcnda\u011f B, \u00c7inkilin\u00e7 N, Halifeo\u011flu \u0130, Canatan H, \u00d6zercan \u0130H. Effect of melatonin on hepatic fibrogenesis, vitamin c and hydroxyproline levels in liver of ethanol-fed rats. Turk J Med Sci. 2000;30(4):333\u201340.","journal-title":"Turk J Med Sci."},{"issue":"7","key":"554_CR272","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","volume":"24","author":"SL Friedman","year":"2018","unstructured":"Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ. Mechanisms of NAFLD development and therapeutic strategies. Nat Med. 2018;24(7):908\u201322.","journal-title":"Nat Med"},{"issue":"1","key":"554_CR273","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12929-016-0303-y","volume":"23","author":"K Rehman","year":"2016","unstructured":"Rehman K, Akash MS. Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked? J Biomed Sci. 2016;23(1):87.","journal-title":"J Biomed Sci"},{"issue":"2","key":"554_CR274","doi-asserted-by":"publisher","first-page":"109","DOI":"10.34172\/mejdd.2021.213","volume":"13","author":"M Sohrabi","year":"2021","unstructured":"Sohrabi M, Gholami A, Taheri M, Fekri S, Amirkalali B, Hatami S, et al. Melatonin levels in patients with nonalcoholic fatty liver disease compared with healthy individuals according to fibrosis level. Middle East J Dig Dis. 2021;13(2):109\u201314.","journal-title":"Middle East J Dig Dis"},{"issue":"3","key":"554_CR275","first-page":"229","volume":"14","author":"M Sohrabi","year":"2021","unstructured":"Sohrabi M, Gholami A, Amirkalali B, Taherizadeh M, Kolahdoz M, SafarnezhadTameshkel F, et al. Is melatonin associated with pro-inflammatory cytokine activity and liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients? Gastroenterol Hepatol Bed Bench. 2021;14(3):229\u201336.","journal-title":"Gastroenterol Hepatol Bed Bench"},{"issue":"6","key":"554_CR276","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","volume":"134","author":"SL Friedman","year":"2008","unstructured":"Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008;134(6):1655\u201369.","journal-title":"Gastroenterology"},{"issue":"4","key":"554_CR277","first-page":"207","volume":"20","author":"K Mortezaee","year":"2016","unstructured":"Mortezaee K, Pasbakhsh P, Ragerdi Kashani I, Sabbaghziarani F, Omidi A, Zendedel A, et al. Melatonin pretreatment enhances the homing of bone marrow-derived mesenchymal stem cells following transplantation in a rat model of liver fibrosis. Iran Biomed J. 2016;20(4):207\u201316.","journal-title":"Iran Biomed J"},{"key":"554_CR278","doi-asserted-by":"publisher","first-page":"1535201","DOI":"10.1155\/2020\/1535201","volume":"2020","author":"L Lu","year":"2020","unstructured":"Lu L, Ma J, Sun M, Wang X, Gao E, Lu L, et al. Melatonin ameliorates mi-induced cardiac remodeling and apoptosis through a JNK\/p53-dependent mechanism in diabetes mellitus. Oxid Med Cell Longev. 2020;2020:1535201.","journal-title":"Oxid Med Cell Longev"},{"key":"554_CR279","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.2147\/IJN.S235518","volume":"15","author":"X Zhao","year":"2020","unstructured":"Zhao X, Wang X, Wang J, Yuan J, Zhang J, Zhu X, et al. A peptide-functionalized magnetic nanoplatform-loaded melatonin for targeted amelioration of fibrosis in pressure overload-induced cardiac hypertrophy. Int J Nanomedicine. 2020;15:1321\u201333.","journal-title":"Int J Nanomedicine"},{"issue":"3","key":"554_CR280","doi-asserted-by":"publisher","first-page":"e12433","DOI":"10.1111\/jpi.12433","volume":"63","author":"M Zhai","year":"2017","unstructured":"Zhai M, Liu Z, Zhang B, Jing L, Li B, Li K, et al. Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1\u03b2: in vivo and in vitro studies. J Pineal Res. 2017;63(3):e12433.","journal-title":"J Pineal Res."},{"issue":"7","key":"554_CR281","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.3390\/cells10071682","volume":"10","author":"YM Yoon","year":"2021","unstructured":"Yoon YM, Go G, Yoon S, Lim JH, Lee G, Lee JH, et al. Melatonin treatment improves renal fibrosis via miR-4516\/SIAH3\/PINK1 axis. Cells. 2021;10(7):1682.","journal-title":"Cells"},{"issue":"5","key":"554_CR282","first-page":"1584","volume":"12","author":"J Wei","year":"2020","unstructured":"Wei J, Wang Y, Qi X, Fan Z, Wu Y. Melatonin ameliorates hyperglycaemia-induced renal inflammation by inhibiting the activation of TLR4 and TGF-\u03b21\/Smad3 signalling pathway. Am J Transl Res. 2020;12(5):1584\u201399.","journal-title":"Am J Transl Res"},{"issue":"1","key":"554_CR283","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3390\/antiox9010039","volume":"9","author":"JY Kim","year":"2020","unstructured":"Kim JY, Park JH, Jeon EJ, Leem J, Park KK. Melatonin prevents transforming growth factor-\u03b21-stimulated transdifferentiation of renal interstitial fibroblasts to myofibroblasts by suppressing reactive oxygen species-dependent mechanisms. Antioxidants (Basel). 2020;9(1):39.","journal-title":"Antioxidants (Basel)."},{"key":"554_CR284","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.freeradbiomed.2019.01.046","volume":"134","author":"DQ Chen","year":"2019","unstructured":"Chen DQ, Feng YL, Chen L, Liu JR, Wang M, Vaziri ND, et al. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6\/AxlNF\u03baB\/Nrf2 axis. Free Radic Biol Med. 2019;134:484\u201397.","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"554_CR285","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1089\/end.2009.0035","volume":"23","author":"E Ozbek","year":"2009","unstructured":"Ozbek E, Ilbey YO, Ozbek M, Simsek A, Cekmen M, Somay A. Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression. J Endourol. 2009;23(7):1165\u201373.","journal-title":"J Endourol"},{"key":"554_CR286","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113238","volume":"232","author":"X Li","year":"2022","unstructured":"Li X, Zhang T, Lv W, Wang H, Chen H, Xu Q, et al. Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt\/\u03b2-catenin signaling pathway in mice. Ecotoxicol Environ Saf. 2022;232:113238.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"2","key":"554_CR287","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00441-017-2604-1","volume":"369","author":"K Mortezaee","year":"2017","unstructured":"Mortezaee K, Khanlarkhani N, Sabbaghziarani F, Nekoonam S, Majidpoor J, Hosseini A, et al. Preconditioning with melatonin improves therapeutic outcomes of bone marrow-derived mesenchymal stem cells in targeting liver fibrosis induced by CCl4. Cell Tissue Res. 2017;369(2):303\u201312.","journal-title":"Cell Tissue Res"},{"key":"554_CR288","doi-asserted-by":"crossref","unstructured":"Das N, Mandala A, Naaz S, Giri S, Jain M, Bandyopadhyay D, et al. Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice. J Pineal Res. 2017;62(4).","DOI":"10.1111\/jpi.12404"},{"issue":"2","key":"554_CR289","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/biof.1342","volume":"43","author":"B Gonz\u00e1lez-Fern\u00e1ndez","year":"2017","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez B, S\u00e1nchez DI, Crespo I, San-Miguel B, \u00c1lvarez M, Tu\u00f1\u00f3n MJ, et al. Inhibition of the SphK1\/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. BioFactors. 2017;43(2):272\u201382.","journal-title":"BioFactors"},{"issue":"6","key":"554_CR290","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s10517-016-3526-8","volume":"161","author":"DS Nalobin","year":"2016","unstructured":"Nalobin DS, Suprunenko EA, Golichenkov VA. Effects of melatonin on differentiation potential of ito cells in mice with induced fibrosis of the liver. Bull Exp Biol Med. 2016;161(6):845\u20139.","journal-title":"Bull Exp Biol Med"},{"issue":"4","key":"554_CR291","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/jpi.12319","volume":"60","author":"JW Kang","year":"2016","unstructured":"Kang JW, Hong JM, Lee SM. Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis. J Pineal Res. 2016;60(4):383\u201393.","journal-title":"J Pineal Res"},{"issue":"2","key":"554_CR292","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/jpi.12247","volume":"59","author":"B San-Miguel","year":"2015","unstructured":"San-Miguel B, Crespo I, S\u00e1nchez DI, Gonz\u00e1lez-Fern\u00e1ndez B, Ortiz de Urbina JJ, Tu\u00f1\u00f3n MJ, et al. Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis. J Pineal Res. 2015;59(2):151\u201362.","journal-title":"J Pineal Res"},{"issue":"3","key":"554_CR293","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.trsl.2015.04.002","volume":"166","author":"HS Choi","year":"2015","unstructured":"Choi HS, Kang JW, Lee SM. Melatonin attenuates carbon tetrachloride-induced liver fibrosis via inhibition of necroptosis. Transl Res. 2015;166(3):292\u2013303.","journal-title":"Transl Res"},{"issue":"2","key":"554_CR294","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1002\/jcb.26331","volume":"119","author":"K Mortezaee","year":"2018","unstructured":"Mortezaee K, Majidpoor J, Daneshi E, Abouzaripour M, Abdi M. Post-treatment of melatonin with CCl(4) better reduces fibrogenic and oxidative changes in liver than melatonin co-treatment. J Cell Biochem. 2018;119(2):1716\u201325.","journal-title":"J Cell Biochem"},{"key":"554_CR295","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.lfs.2017.11.036","volume":"192","author":"MA Lebda","year":"2018","unstructured":"Lebda MA, Sadek KM, Abouzed TK, Tohamy HG, El-Sayed YS. Melatonin mitigates thioacetamide-induced hepatic fibrosis via antioxidant activity and modulation of proinflammatory cytokines and fibrogenic genes. Life Sci. 2018;192:136\u201343.","journal-title":"Life Sci"},{"key":"554_CR296","doi-asserted-by":"publisher","first-page":"556","DOI":"10.3389\/fphar.2018.00556","volume":"9","author":"B Gonz\u00e1lez-Fern\u00e1ndez","year":"2018","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez B, S\u00e1nchez DI, Crespo I, San-Miguel B, de Urbina JO, Gonz\u00e1lez-Gallego J, et al. Melatonin attenuates dysregulation of the circadian clock pathway in mice with CCl(4)-induced fibrosis and human hepatic stellate cells. Front Pharmacol. 2018;9:556.","journal-title":"Front Pharmacol"},{"issue":"4","key":"554_CR297","first-page":"117","volume":"2","author":"S Bona","year":"2018","unstructured":"Bona S, Rodrigues G, Moreira AJ, Di Naso FC, Dias AS, Da Silveira TR, et al. Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride. J Gastroenterol Hepatol. 2018;2(4):117\u201323.","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"554_CR298","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s11596-018-1871-8","volume":"38","author":"YR Wang","year":"2018","unstructured":"Wang YR, Hong RT, Xie YY, Xu JM. Melatonin ameliorates liver fibrosis induced by carbon tetrachloride in rats via inhibiting TGF-\u03b21\/Smad signaling pathway. Curr Med Sci. 2018;38(2):236\u201344.","journal-title":"Curr Med Sci"},{"key":"554_CR299","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120622","volume":"301","author":"Q Liu","year":"2022","unstructured":"Liu Q, Sun Y, Zhu Y, Qiao S, Cai J, Zhang Z. Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1\/NF-kB\/NLRP3 and PERK\/TGF-\u03b21 axis activation. Life Sci. 2022;301: 120622.","journal-title":"Life Sci"},{"issue":"3","key":"554_CR300","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s11596-022-2530-7","volume":"42","author":"L Jie","year":"2022","unstructured":"Jie L, Hong RT, Zhang YJ, Sha LL, Chen W, Ren XF. Melatonin alleviates liver fibrosis by inhibiting autophagy. Curr Med Sci. 2022;42(3):498\u2013504.","journal-title":"Curr Med Sci"},{"key":"554_CR301","doi-asserted-by":"publisher","DOI":"10.1590\/1519-6984.253061","volume":"84","author":"H Rafiq","year":"2022","unstructured":"Rafiq H, Ayaz M, Khan HA, Iqbal M, Quraish S, Afridi SG, et al. Therapeutic potential of stem cell and melatonin on the reduction of CCl4-induced liver fibrosis in experimental mice model. Braz J Biol. 2022;84: e253061.","journal-title":"Braz J Biol"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-023-00554-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43440-023-00554-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-023-00554-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T02:35:28Z","timestamp":1706754928000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43440-023-00554-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":301,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["554"],"URL":"https:\/\/doi.org\/10.1007\/s43440-023-00554-5","relation":{},"ISSN":["1734-1140","2299-5684"],"issn-type":[{"value":"1734-1140","type":"print"},{"value":"2299-5684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]},"assertion":[{"value":"16 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}