{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:31:37Z","timestamp":1774989097380,"version":"3.50.1"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD091994"],"award-info":[{"award-number":["R01HD091994"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM142520"],"award-info":[{"award-number":["T32GM142520"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacol. Rep"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s43440-024-00628-y","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T04:01:26Z","timestamp":1721361686000},"page":"1055-1066","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Padsevonil suppresses seizures without inducing cell death in neonatal rats"],"prefix":"10.1007","volume":"76","author":[{"given":"Sean","family":"Quinlan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Witherspoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1763-060X","authenticated-orcid":false,"given":"Patrick A.","family":"Forcelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"628_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.pediatrneurol.2011.11.006","volume":"46","author":"HC Glass","year":"2012","unstructured":"Glass HC, Kan J, Bonifacio SL, Ferriero DM. Neonatal seizures: treatment practices among term and preterm infants. Pediatr Neurol. 2012;46:111\u20135. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2011.11.006.","journal-title":"Pediatr Neurol"},{"key":"628_CR2","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1111\/epi.14537","volume":"59","author":"F Pisani","year":"2018","unstructured":"Pisani F, Facini C, Bianchi E, Giussani G, Piccolo B, Beghi E. Incidence of neonatal seizures, perinatal risk factors for epilepsy and mortality after neonatal seizures in the province of Parma. Italy Epilepsia. 2018;59:1764\u201373. https:\/\/doi.org\/10.1111\/epi.14537.","journal-title":"Italy Epilepsia"},{"key":"628_CR3","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1055\/s-0040-1702943","volume":"40","author":"J Ziobro","year":"2020","unstructured":"Ziobro J, Shellhaas RA. Neonatal seizures: diagnosis, etiologies, and management. Semin Neurol. 2020;40:246\u201356. https:\/\/doi.org\/10.1055\/s-0040-1702943.","journal-title":"Semin Neurol"},{"key":"628_CR4","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1056\/NEJM199908123410704","volume":"341","author":"MJ Painter","year":"1999","unstructured":"Painter MJ, Scher MS, Stein AD, Armatti S, Wang Z, Gardiner JC, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med. 1999;341:485\u20139. https:\/\/doi.org\/10.1056\/NEJM199908123410704.","journal-title":"N Engl J Med"},{"key":"628_CR5","doi-asserted-by":"publisher","first-page":"e20193182","DOI":"10.1542\/peds.2019-3182","volume":"145","author":"C Sharpe","year":"2020","unstructured":"Sharpe C, Reiner GE, Davis SL, Nespeca M, Gold JJ, Rasmussen M, et al. Levetiracetam Versus Phenobarbital for neonatal seizures: a Randomized Controlled Trial. Pediatrics. 2020;145:e20193182. https:\/\/doi.org\/10.1542\/peds.2019-3182.","journal-title":"Pediatrics"},{"key":"628_CR6","first-page":"161","volume":"79","author":"EF Sperber","year":"1999","unstructured":"Sperber EF, Vel\u00edskov\u00e1 J, Germano IM, Friedman LK, Mosh\u00e9 SL. Age-dependent vulnerability to seizures. Adv Neurol. 1999;79:161\u20139.","journal-title":"Adv Neurol"},{"key":"628_CR7","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nrn3956","volume":"16","author":"Y Ben-Ari","year":"2015","unstructured":"Ben-Ari Y. Is birth a critical period in the pathogenesis of autism spectrum disorders? Nat Rev Neurosci. 2015;16:498\u2013505. https:\/\/doi.org\/10.1038\/nrn3956.","journal-title":"Nat Rev Neurosci"},{"key":"628_CR8","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1523\/JNEUROSCI.22-08-03005.2002","volume":"22","author":"SS Kumar","year":"2002","unstructured":"Kumar SS, Bacci A, Kharazia V, Huguenard JR. A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons. J Neurosci. 2002;22:3005\u201315. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-08-03005.2002.","journal-title":"J Neurosci"},{"key":"628_CR9","doi-asserted-by":"publisher","first-page":"15089","DOI":"10.1073\/pnas.222550499","volume":"99","author":"P Bittigau","year":"2002","unstructured":"Bittigau P, Sifringer M, Genz K, Reith E, Pospischil D, Govindarajalu S, et al. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci U S A. 2002;99:15089\u201394.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"628_CR10","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/epi.13335","volume":"57","author":"L Brown","year":"2016","unstructured":"Brown L, Gutherz S, Kulick C, Soper C, Kondratyev A, Forcelli PA. Profile of retigabine-induced neuronal apoptosis in the developing rat brain. Epilepsia. 2016;57:660\u201370. https:\/\/doi.org\/10.1111\/epi.13335.","journal-title":"Epilepsia"},{"key":"628_CR11","doi-asserted-by":"publisher","first-page":"e207","DOI":"10.1111\/j.1528-1167.2011.03297.x","volume":"52","author":"PA Forcelli","year":"2011","unstructured":"Forcelli PA, Kim J, Kondratyev A, Gale K. Pattern of antiepileptic drug-induced cell death in limbic regions of the neonatal rat brain. Epilepsia. 2011;52:e207\u2013211. https:\/\/doi.org\/10.1111\/j.1528-1167.2011.03297.x.","journal-title":"Epilepsia"},{"key":"628_CR12","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1124\/jpet.107.123133","volume":"322","author":"I Katz","year":"2007","unstructured":"Katz I, Kim J, Gale K, Kondratyev A. Effects of lamotrigine alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain. J Pharmacol Exp Ther. 2007;322:494\u2013500. https:\/\/doi.org\/10.1124\/jpet.107.123133.","journal-title":"J Pharmacol Exp Ther"},{"key":"628_CR13","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1111\/epi.13365","volume":"57","author":"S Kaushal","year":"2016","unstructured":"Kaushal S, Tamer Z, Opoku F, Forcelli PA. Anticonvulsant drug-induced cell death in the developing white matter of the rodent brain. Epilepsia. 2016;57:727\u201334. https:\/\/doi.org\/10.1111\/epi.13365.","journal-title":"Epilepsia"},{"key":"628_CR14","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1124\/jpet.107.126250","volume":"323","author":"J Kim","year":"2007","unstructured":"Kim J, Kondratyev A, Gale K. Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy. J Pharmacol Exp Ther. 2007;323:165\u201373. https:\/\/doi.org\/10.1124\/jpet.107.126250.","journal-title":"J Pharmacol Exp Ther"},{"key":"628_CR15","doi-asserted-by":"publisher","first-page":"105245","DOI":"10.1016\/j.nbd.2020.105245","volume":"149","author":"KK Noguchi","year":"2021","unstructured":"Noguchi KK, Fuhler NA, Wang SH, Capuano S, Brunner KR, Larson S, et al. Brain pathology caused in the neonatal macaque by short and prolonged exposures to anticonvulsant drugs. Neurobiol Dis. 2021;149:105245. https:\/\/doi.org\/10.1016\/j.nbd.2020.105245.","journal-title":"Neurobiol Dis"},{"key":"628_CR16","doi-asserted-by":"publisher","unstructured":"Boylan GB, Rennie JM, Pressler RM, Wilson G, Morton M, Binnie CD. Phenobarbitone, neonatal seizures, and video-EEG. Arch Dis Child - Fetal Neonatal Ed. 2002;86. https:\/\/doi.org\/10.1136\/fn.86.3.F165.:165F\u2013 170.","DOI":"10.1136\/fn.86.3.F165"},{"key":"628_CR17","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/epi.13990","volume":"59","author":"N Al-Muhtasib","year":"2018","unstructured":"Al-Muhtasib N, Sepulveda-Rodriguez A, Vicini S, Forcelli PA. Neonatal phenobarbital exposure disrupts GABAergic synaptic maturation in rat CA1 neurons. Epilepsia. 2018;59:333\u201344. https:\/\/doi.org\/10.1111\/epi.13990.","journal-title":"Epilepsia"},{"key":"628_CR18","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/ana.23600","volume":"72","author":"PA Forcelli","year":"2012","unstructured":"Forcelli PA, Janssen MJ, Vicini S, Gale K. Neonatal exposure to antiepileptic drugs disrupts striatal synaptic development. Ann Neurol. 2012;72:363\u201372. https:\/\/doi.org\/10.1002\/ana.23600.","journal-title":"Ann Neurol"},{"issue":"Suppl 3","key":"628_CR19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1528-1167.2010.02603.x","volume":"51","author":"PA Forcelli","year":"2010","unstructured":"Forcelli PA, Janssen MJ, Stamps LA, Sweeney C, Vicini S, Gale K. Therapeutic strategies to avoid long-term adverse outcomes of neonatal antiepileptic drug exposure. Epilepsia. 2010;51(Suppl 3):18\u201323.","journal-title":"Epilepsia"},{"key":"628_CR20","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1111\/j.1528-1167.2010.02971.x","volume":"52","author":"PA Forcelli","year":"2011","unstructured":"Forcelli PA, Gale K, Kondratyev A. Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood. Epilepsia. 2011;52:e20\u201322. https:\/\/doi.org\/10.1111\/j.1528-1167.2010.02971.x.","journal-title":"Epilepsia"},{"key":"628_CR21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.yebeh.2016.01.018","volume":"57","author":"S Frankel","year":"2016","unstructured":"Frankel S, Medvedeva N, Gutherz S, Kulick C, Kondratyev A, Forcelli PA. Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats. Epilepsy Behav EB. 2016;57:34\u201340. https:\/\/doi.org\/10.1016\/j.yebeh.2016.01.018.","journal-title":"Epilepsy Behav EB"},{"key":"628_CR22","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.yebeh.2014.07.010","volume":"37","author":"SB Gutherz","year":"2014","unstructured":"Gutherz SB, Kulick CV, Soper C, Kondratyev A, Gale K, Forcelli PA. Brief postnatal exposure to phenobarbital impairs passive avoidance learning and sensorimotor gating in rats. Epilepsy Behav. 2014;37:265\u20139. https:\/\/doi.org\/10.1016\/j.yebeh.2014.07.010.","journal-title":"Epilepsy Behav"},{"key":"628_CR23","doi-asserted-by":"publisher","first-page":"9986","DOI":"10.1038\/s41598-018-28044-2","volume":"8","author":"SMM Quinlan","year":"2018","unstructured":"Quinlan SMM, Rodriguez-Alvarez N, Molloy EJ, Madden SF, Boylan GB, Henshall DC, et al. Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures. Sci Rep. 2018;8:9986. https:\/\/doi.org\/10.1038\/s41598-018-28044-2.","journal-title":"Sci Rep"},{"key":"628_CR24","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1007\/s13760-020-01366-7","volume":"121","author":"S Kanmaz","year":"2021","unstructured":"Kanmaz S, Altun K\u00f6ro\u011flu \u00d6, Terek D, Serin HM, Simsek E, Dokurel Cetin \u0130, et al. Efficacy of levetiracetam as first-line therapy for neonatal clinical seizures and neurodevelopmental outcome at 12 months of age. Acta Neurol Belg. 2021;121:1495\u2013503. https:\/\/doi.org\/10.1007\/s13760-020-01366-7.","journal-title":"Acta Neurol Belg"},{"key":"628_CR25","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1177\/08830738221086107","volume":"37","author":"C Verwoerd","year":"2022","unstructured":"Verwoerd C, Limjoco J, Rajamanickam V, Knox A. Efficacy of Levetiracetam and Phenobarbital as First-Line treatment for neonatal seizures. J Child Neurol. 2022;37:401\u20139. https:\/\/doi.org\/10.1177\/08830738221086107.","journal-title":"J Child Neurol"},{"key":"628_CR26","doi-asserted-by":"publisher","first-page":"747745","DOI":"10.3389\/fneur.2021.747745","volume":"12","author":"M-Y Qiao","year":"2021","unstructured":"Qiao M-Y, Cui H-T, Zhao L-Z, Miao J-K, Chen Q-X. Efficacy and Safety of Levetiracetam vs. Phenobarbital for neonatal seizures: a systematic review and Meta-analysis. Front Neurol. 2021;12:747745. https:\/\/doi.org\/10.3389\/fneur.2021.747745.","journal-title":"Front Neurol"},{"key":"628_CR27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1124\/jpet.119.261222","volume":"372","author":"K Leclercq","year":"2020","unstructured":"Leclercq K, Matagne A, Provins L, Klitgaard H, Kaminski RM. Pharmacological Profile of the Novel antiepileptic drug candidate padsevonil: characterization in Rodent Seizure and Epilepsy models. J Pharmacol Exp Ther. 2020;372:11\u201320. https:\/\/doi.org\/10.1124\/jpet.119.261222.","journal-title":"J Pharmacol Exp Ther"},{"key":"628_CR28","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","volume":"20","author":"W L\u00f6scher","year":"2011","unstructured":"L\u00f6scher W. Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Seizure. 2011;20:359\u201368. https:\/\/doi.org\/10.1016\/j.seizure.2011.01.003.","journal-title":"Seizure"},{"key":"628_CR29","first-page":"256","volume":"288","author":"L Vel\u00edsek","year":"1987","unstructured":"Vel\u00edsek L, Mares P. Influence of clonazepam on electrocorticographic changes induced by metrazol in rats during ontogenesis. Arch Int Pharmacodyn Ther. 1987;288:256\u201369.","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"628_CR30","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1139\/y89-216","volume":"67","author":"L Vel\u00edsek","year":"1989","unstructured":"Vel\u00edsek L, Kulh\u00e1nkov\u00e1 I, Roztocilov\u00e1 L, Mares P, Vel\u00edskov\u00e1 J, Mirvaldov\u00e1 H. Ethosuximide affects both pentylenetetrazole- and kainate-induced clonic seizures but differentiates between tonic-clonic seizures. Can J Physiol Pharmacol. 1989;67:1357\u201361.","journal-title":"Can J Physiol Pharmacol"},{"key":"628_CR31","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/0091-3057(89)90170-6","volume":"32","author":"L Vel\u00edsek","year":"1989","unstructured":"Vel\u00edsek L, Mikol\u00e1sov\u00e1 R, Blankov\u00e1-Vankov\u00e1 S, Mares P. Effects of ketamine on metrazol-induced seizures during ontogenesis in rats. Pharmacol Biochem Behav. 1989;32:405\u201310.","journal-title":"Pharmacol Biochem Behav"},{"key":"628_CR32","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/0024-3205(90)90334-N","volume":"46","author":"L Vel\u00edsek","year":"1990","unstructured":"Vel\u00edsek L, Kus\u00e1 R, Kulovan\u00e1 M, Mares P. Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate. Life Sci. 1990;46:1349\u201357.","journal-title":"Life Sci"},{"key":"628_CR33","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/BF02245658","volume":"104","author":"L Vel\u00edsek","year":"1991","unstructured":"Vel\u00edsek L, Veresov\u00e1 S, P\u00f4bisov\u00e1 H, Mares P. Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. II. The effects of MK-801. Psychopharmacology. 1991;104:510\u20134.","journal-title":"Psychopharmacology"},{"key":"628_CR34","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0091-3057(96)00245-6","volume":"56","author":"L Vel\u00edsek","year":"1997","unstructured":"Vel\u00edsek L, Vachov\u00e1 D, Mares P. Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. IV. Effects of CGP 39551. Pharmacol Biochem Behav. 1997;56:493\u20138.","journal-title":"Pharmacol Biochem Behav"},{"key":"628_CR35","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/0920-1211(91)90007-3","volume":"10","author":"H Kubova","year":"1991","unstructured":"Kubova H, Mares P. Anticonvulsant effects of phenobarbital and primidone during ontogenesis in rats. Epilepsy Res. 1991;10:148\u201355.","journal-title":"Epilepsy Res"},{"key":"628_CR36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0920-1211(92)90003-C","volume":"13","author":"L Stankov\u00e1","year":"1992","unstructured":"Stankov\u00e1 L, Kubov\u00e1 H, Mares P. Anticonvulsant action of lamotrigine during ontogenesis in rats. Epilepsy Res. 1992;13:17\u201322.","journal-title":"Epilepsy Res"},{"key":"628_CR37","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/j.1528-1157.1993.tb02397.x","volume":"34","author":"H Kubov\u00e1","year":"1993","unstructured":"Kubov\u00e1 H, Mares P. Anticonvulsant action of oxcarbazepine, hydroxycarbamazepine, and carbamazepine against metrazol-induced motor seizures in developing rats. Epilepsia. 1993;34:188\u201392.","journal-title":"Epilepsia"},{"key":"628_CR38","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1111\/j.1528-1157.1993.tb02145.x","volume":"34","author":"H Kubov\u00e1","year":"1993","unstructured":"Kubov\u00e1 H, Rathousk\u00e1 J, Mares P. Anticonvulsant effects of bretazenil (Ro 16-6028) during ontogenesis. Epilepsia. 1993;34:1130\u20134.","journal-title":"Epilepsia"},{"key":"628_CR39","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/0091-3057(93)90170-X","volume":"44","author":"J Rathousk\u00e1","year":"1993","unstructured":"Rathousk\u00e1 J, Kubov\u00e1 H, Mares P, Vorl\u00edcek J. Anticonvulsant activity of flumazenil in rats during ontogenetic development. Pharmacol Biochem Behav. 1993;44:581\u20136.","journal-title":"Pharmacol Biochem Behav"},{"key":"628_CR40","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0091-3057(94)00329-H","volume":"51","author":"L Vel\u00edsek","year":"1995","unstructured":"Vel\u00edsek L, Kubov\u00e1 H, Mares P, Vachov\u00e1 D. Kainate\/AMPA receptor antagonists are anticonvulsant against the tonic hindlimb component of pentylenetetrazol-induced seizures in developing rats. Pharmacol Biochem Behav. 1995;51:153\u20138.","journal-title":"Pharmacol Biochem Behav"},{"key":"628_CR41","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/0361-9230(95)02019-3","volume":"38","author":"L Vel\u00edsek","year":"1995","unstructured":"Vel\u00edsek L, Roztocilov\u00e1 L, Kus\u00e1 R, Mares P. Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester. Brain Res Bull. 1995;38:525\u20139.","journal-title":"Brain Res Bull"},{"key":"628_CR42","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1111\/j.1528-1157.1996.tb00641.x","volume":"37","author":"J Vel\u00edskov\u00e1","year":"1996","unstructured":"Vel\u00edskov\u00e1 J, Vel\u00edsek L, Mosh\u00e9 SL. Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. Epilepsia. 1996;37:718\u201322.","journal-title":"Epilepsia"},{"key":"628_CR43","first-page":"501","volume":"48","author":"R Haugvicov\u00e1","year":"1999","unstructured":"Haugvicov\u00e1 R, Kubov\u00e1 H, Mares P. Antipentylenetetrazol action of clobazam in developing rats. Physiol Res. 1999;48:501\u20137.","journal-title":"Physiol Res"},{"key":"628_CR44","doi-asserted-by":"publisher","first-page":"363","DOI":"10.33549\/physiolres.930209","volume":"51","author":"R Haugvicov\u00e1","year":"2002","unstructured":"Haugvicov\u00e1 R, Kubov\u00e1 H, Mares P. Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats? Physiol Res. 2002;51:363\u201370.","journal-title":"Physiol Res"},{"key":"628_CR45","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1111\/j.1528-1157.2000.tb04600.x","volume":"41","author":"R Haugvicov\u00e1","year":"2000","unstructured":"Haugvicov\u00e1 R, Kubov\u00e1 H, Skutov\u00e1 M, Mares P. Anticonvulsant action of topiramate against motor seizures in developing rats. Epilepsia. 2000;41:1235\u201340.","journal-title":"Epilepsia"},{"key":"628_CR46","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1111\/j.1528-1157.2000.tb00112.x","volume":"41","author":"R Haugvicov\u00e1","year":"2000","unstructured":"Haugvicov\u00e1 R, Skutov\u00e1 M, Kubov\u00e1 H, Suchomelov\u00e1 L, Mares P. Two different anticonvulsant actions of tiagabine in developing rats. Epilepsia. 2000;41:1375\u201381.","journal-title":"Epilepsia"},{"key":"628_CR47","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.seizure.2009.04.002","volume":"18","author":"J Tchekalarova","year":"2009","unstructured":"Tchekalarova J, Kubov\u00e1 H, Mares P. Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats. Seizure. 2009;18:463\u20139. https:\/\/doi.org\/10.1016\/j.seizure.2009.04.002.","journal-title":"Seizure"},{"key":"628_CR48","doi-asserted-by":"publisher","first-page":"305","DOI":"10.33549\/physiolres.931754","volume":"59","author":"P Mares","year":"2010","unstructured":"Mares P, Kubov\u00e1 H, Kasal A. Anticonvulsant action of a new analogue of allopregnanolone in immature rats. Physiol Res. 2010;59:305\u20138.","journal-title":"Physiol Res"},{"key":"628_CR49","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.eplepsyres.2012.03.006","volume":"101","author":"PA Forcelli","year":"2012","unstructured":"Forcelli PA, Soper C, Lakhkar A, Gale K, Kondratyev A. Anticonvulsant effect of retigabine during postnatal development in rats. Epilepsy Res. 2012;101:135\u201340. https:\/\/doi.org\/10.1016\/j.eplepsyres.2012.03.006.","journal-title":"Epilepsy Res"},{"key":"628_CR50","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.eplepsyres.2013.09.013","volume":"107","author":"PA Forcelli","year":"2013","unstructured":"Forcelli PA, Soper C, Duckles A, Gale K, Kondratyev A. Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats. Epilepsy Res. 2013;107:217\u201323. https:\/\/doi.org\/10.1016\/j.eplepsyres.2013.09.013.","journal-title":"Epilepsy Res"},{"key":"628_CR51","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.eplepsyres.2013.06.001","volume":"106","author":"P Mare\u0161","year":"2013","unstructured":"Mare\u0161 P, Kubov\u00e1 H, Hen N, Yagen B, Bialer M. Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats. Epilepsy Res. 2013;106:64\u201373. https:\/\/doi.org\/10.1016\/j.eplepsyres.2013.06.001.","journal-title":"Epilepsy Res"},{"key":"628_CR52","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1111\/epi.13842","volume":"58","author":"MN Huizenga","year":"2017","unstructured":"Huizenga MN, Wicker E, Beck VC, Forcelli PA. Anticonvulsant effect of cannabinoid receptor agonists in models of seizures in developing rats. Epilepsia. 2017;58:1593\u2013602. https:\/\/doi.org\/10.1111\/epi.13842.","journal-title":"Epilepsia"},{"key":"628_CR53","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.neuropharm.2019.01.002","volume":"148","author":"MN Huizenga","year":"2019","unstructured":"Huizenga MN, Sepulveda-Rodriguez A, Forcelli PA. Preclinical safety and efficacy of cannabidivarin for early life seizures. Neuropharmacology. 2019;148:189\u201398. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.01.002.","journal-title":"Neuropharmacology"},{"key":"628_CR54","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1007\/s43440-022-00413-9","volume":"74","author":"E Witherspoon","year":"2022","unstructured":"Witherspoon E, Quinlan S, Forcelli PA. Preclinical efficacy of cannabidiol for the treatment of early-life seizures. Pharmacol Rep. 2022;74:1092\u20138. https:\/\/doi.org\/10.1007\/s43440-022-00413-9.","journal-title":"Pharmacol Rep"},{"key":"628_CR55","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1007\/BF00169017","volume":"346","author":"L Velisek","year":"1992","unstructured":"Velisek L, Kubova H, Pohl M, Stankova L, Mares P, Schickerova R. Pentylenetetrazol-induced seizures in rats: an ontogenetic study. Naunyn Schmiedebergs Arch Pharmacol. 1992;346:588\u201391.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"628_CR56","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/ana.24967","volume":"82","author":"D Torolira","year":"2017","unstructured":"Torolira D, Suchomelova L, Wasterlain CG, Niquet J. Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury. Ann Neurol. 2017;82:115\u201320. https:\/\/doi.org\/10.1002\/ana.24967.","journal-title":"Ann Neurol"},{"key":"628_CR57","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1179\/1743132813Y.0000000289","volume":"36","author":"R Shimada","year":"2014","unstructured":"Shimada R, Abe K, Furutani R, Kibayashi K. Changes in dopamine transporter expression in the midbrain following traumatic brain injury: an immunohistochemical and in situ hybridization study in a mouse model. Neurol Res. 2014;36:239\u201346. https:\/\/doi.org\/10.1179\/1743132813Y.0000000289.","journal-title":"Neurol Res"},{"issue":"1","key":"628_CR58","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s12640-018-9944-9","volume":"35","author":"MN Huizenga","year":"2019","unstructured":"Huizenga MN, Forcelli PA. Neuroprotective action of the CB1\/2 receptor agonist, WIN 55,212-2, against DMSO but not Phenobarbital-Induced neurotoxicity in immature rats. Neurotox Res. 2019;35(1):173\u201382. https:\/\/doi.org\/10.1007\/s12640-018-9944-9.","journal-title":"Neurotox Res"},{"key":"628_CR59","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/j.1749-6632.2003.tb07517.x","volume":"993","author":"P Bittigau","year":"2003","unstructured":"Bittigau P, Sifringer M, Ikonomidou C. Antiepileptic drugs and apoptosis in the developing brain. Ann N Y Acad Sci. 2003;993:103\u201314. discussion 123\u2013124.","journal-title":"Ann N Y Acad Sci"},{"key":"628_CR60","volume-title":"A stereotaxic atlas of the developing rat brain","author":"N Sherwood","year":"1970","unstructured":"Sherwood N, Timiras P. A stereotaxic atlas of the developing rat brain. Berkeley, CA: University of California Press; 1970."},{"key":"628_CR61","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0014-2999(93)90768-D","volume":"232","author":"W L\u00f6scher","year":"1993","unstructured":"L\u00f6scher W, H\u00f6nack D. Profile of Ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats. Eur J Pharmacol. 1993;232:147\u201358. https:\/\/doi.org\/10.1016\/0014-2999(93)90768-D.","journal-title":"Eur J Pharmacol"},{"key":"628_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/jpet.119.261149","volume":"372","author":"M Wood","year":"2020","unstructured":"Wood M, Daniels V, Provins L, Wolff C, Kaminski RM, Gillard M. Pharmacological Profile of the Novel antiepileptic drug candidate padsevonil: interactions with synaptic vesicle 2 proteins and the GABAA receptor. J Pharmacol Exp Ther. 2020;372:1\u201310. https:\/\/doi.org\/10.1124\/jpet.119.261149.","journal-title":"J Pharmacol Exp Ther"},{"key":"628_CR63","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1111\/epi.16497","volume":"61","author":"I Niespodziany","year":"2020","unstructured":"Niespodziany I, Ghisdal P, Mullier B, Wood M, Provins L, Kaminski RM, et al. Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors. Epilepsia. 2020;61:914\u201323. https:\/\/doi.org\/10.1111\/epi.16497.","journal-title":"Epilepsia"},{"key":"628_CR64","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1038\/bjp.2008.198","volume":"154","author":"A Matagne","year":"2009","unstructured":"Matagne A, Margineanu D-G, Kenda B, Michel P, Klitgaard H. Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A: Anticonvulsive properties of brivaracetam. Br J Pharmacol. 2009;154:1662\u201371. https:\/\/doi.org\/10.1038\/bjp.2008.198.","journal-title":"Br J Pharmacol"},{"key":"628_CR65","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/pr.2012.151","volume":"73","author":"DM Talos","year":"2013","unstructured":"Talos DM, Chang M, Kosaras B, Fitzgerald E, Murphy A, Folkerth RD, et al. Antiepileptic effects of levetiracetam in a rodent neonatal seizure model. Pediatr Res. 2013;73:24\u201330. https:\/\/doi.org\/10.1038\/pr.2012.151.","journal-title":"Pediatr Res"},{"key":"628_CR66","doi-asserted-by":"publisher","unstructured":"Kulick CV, Gutherz SB, Beck VC, Medvedeva N, Soper C, Forcelli PA. Profile of anticonvulsant action of levetiracetam, tiagabine and phenobarbital against seizures evoked by DMCM (methyl-6,7-dimethoxy-4-ethyl-\u03b2-carboline-3-carboxylate) in neonatal rats. Eur J Pharmacol 2014;743:63\u20138. https:\/\/doi.org\/10.1016\/j.ejphar.2014.09.016.","DOI":"10.1016\/j.ejphar.2014.09.016"},{"key":"628_CR67","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.nbd.2016.12.023","volume":"99","author":"L Morin","year":"2017","unstructured":"Morin L, Enderlin J, Leger P-L, Perrotte G, Bonnin P, Dupuis N, et al. Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model. Neurobiol Dis. 2017;99:145\u201353. https:\/\/doi.org\/10.1016\/j.nbd.2016.12.023.","journal-title":"Neurobiol Dis"},{"key":"628_CR68","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1111\/epi.12973","volume":"56","author":"N Dupuis","year":"2015","unstructured":"Dupuis N, Matagne A, Staelens L, Dournaud P, Desnous B, Gressens P, et al. Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature rats. Epilepsia. 2015;56:800\u20135. https:\/\/doi.org\/10.1111\/epi.12973.","journal-title":"Epilepsia"},{"key":"628_CR69","doi-asserted-by":"publisher","first-page":"fcaa183","DOI":"10.1093\/braincomms\/fcaa183","volume":"2","author":"P Muglia","year":"2020","unstructured":"Muglia P, Hannestad J, Brandt C, DeBruyn S, Germani M, Lacroix B, et al. Padsevonil randomized phase IIa trial in treatment-resistant focal epilepsy: a translational approach. Brain Commun. 2020;2:fcaa183. https:\/\/doi.org\/10.1093\/braincomms\/fcaa183.","journal-title":"Brain Commun"},{"key":"628_CR70","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/jp.2013.116","volume":"33","author":"NL Maitre","year":"2013","unstructured":"Maitre NL, Smolinsky C, Slaughter JC, Stark AR. Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures. J Perinatol. 2013;33:841\u20136. https:\/\/doi.org\/10.1038\/jp.2013.116.","journal-title":"J Perinatol"},{"key":"628_CR71","doi-asserted-by":"publisher","first-page":"105814","DOI":"10.1016\/j.nbd.2022.105814","volume":"171","author":"C Ikonomidou","year":"2022","unstructured":"Ikonomidou C, Wang SH, Fuhler NA, Larson S, Capuano S, Brunner KR, et al. Mild hypothermia fails to protect infant macaques from brain injury caused by prolonged exposure to antiseizure drugs. Neurobiol Dis. 2022;171:105814. https:\/\/doi.org\/10.1016\/j.nbd.2022.105814.","journal-title":"Neurobiol Dis"},{"key":"628_CR72","doi-asserted-by":"publisher","first-page":"107318","DOI":"10.1016\/j.eplepsyres.2024.107318","volume":"201","author":"A Ghosh","year":"2024","unstructured":"Ghosh A, Quinlan S, Forcelli PA. Anti-seizure medication-induced developmental cell death in neonatal rats is unaltered by history of hypoxia. Epilepsy Res. 2024;201:107318. https:\/\/doi.org\/10.1016\/j.eplepsyres.2024.107318.","journal-title":"Epilepsy Res"},{"issue":"Suppl 5","key":"628_CR73","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1528-1167.2007.01285.x","volume":"48","author":"J Kim","year":"2007","unstructured":"Kim J, Kondratyev A, Tomita Y, Gale K. Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain. Epilepsia. 2007;48(Suppl 5):19\u201326.","journal-title":"Epilepsia"},{"key":"628_CR74","unstructured":"https:\/\/panache.ninds.nih.gov\/CurrentModels.aspx n.d."},{"key":"628_CR75","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/ana.21082","volume":"61","author":"L Vel\u00edsek","year":"2007","unstructured":"Vel\u00edsek L, Jehle K, Asche S, Vel\u00edskov\u00e1 J. Model of infantile spasms induced by N-methyl-D-aspartic acid in prenatally impaired brain. Ann Neurol. 2007;61:109\u201319. https:\/\/doi.org\/10.1002\/ana.21082.","journal-title":"Ann Neurol"},{"key":"628_CR76","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1111\/j.1528-1167.2011.03220.x","volume":"52","author":"T Chachua","year":"2011","unstructured":"Chachua T, Yum M-S, Vel\u00ed\u0161kov\u00e1 J, Vel\u00ed\u0161ek L. Validation of the rat model of cryptogenic infantile spasms: validation of the infantile spasms model. Epilepsia. 2011;52:1666\u201377. https:\/\/doi.org\/10.1111\/j.1528-1167.2011.03220.x.","journal-title":"Epilepsia"},{"key":"628_CR77","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jneumeth.2015.09.023","volume":"260","author":"H Sun","year":"2016","unstructured":"Sun H, Juul HM, Jensen FE. Models of hypoxia and ischemia-induced seizures. J Neurosci Methods. 2016;260:252\u201360. https:\/\/doi.org\/10.1016\/j.jneumeth.2015.09.023.","journal-title":"J Neurosci Methods"},{"key":"628_CR78","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1111\/epi.16925","volume":"62","author":"CD Pernici","year":"2021","unstructured":"Pernici CD, Mensah JA, Dahle EJ, Johnson KJ, Handy L, Buxton L, et al. Development of an antiseizure drug screening platform for Dravet syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program. Epilepsia. 2021;62:1665\u201376. https:\/\/doi.org\/10.1111\/epi.16925.","journal-title":"Epilepsia"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-024-00628-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43440-024-00628-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-024-00628-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T01:04:49Z","timestamp":1726016689000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43440-024-00628-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,19]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["628"],"URL":"https:\/\/doi.org\/10.1007\/s43440-024-00628-y","relation":{},"ISSN":["1734-1140","2299-5684"],"issn-type":[{"value":"1734-1140","type":"print"},{"value":"2299-5684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,19]]},"assertion":[{"value":"5 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Quinlan, Witherspoon.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conducted experiments"}},{"value":"Quinlan, Witherspoon, Forcelli.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Performed data analysis"}},{"value":"Quinlan, Witherspoon, Forcelli.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Wrote or contributed to the writing of the manuscript"}},{"value":"The authors have no conflicts to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}