{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:15:33Z","timestamp":1780442133802,"version":"3.54.1"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacol. Rep"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s43440-025-00747-0","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T22:19:22Z","timestamp":1751494762000},"page":"1283-1294","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Behavioral tests to assess short- and long-lasting sensorimotor deficits following transient focal cerebral ischemia in rodents"],"prefix":"10.1007","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7789-6528","authenticated-orcid":false,"given":"Enrique","family":"Garc\u00eda-Alfonso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2345-1923","authenticated-orcid":false,"given":"Jeney","family":"Ram\u00edrez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-4620","authenticated-orcid":false,"given":"Maylin","family":"Wong-Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-5854","authenticated-orcid":false,"given":"Luis Arturo","family":"Fonseca-Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9436-235X","authenticated-orcid":false,"given":"Yanay","family":"Montano-Peguero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-2446","authenticated-orcid":false,"given":"Daniela","family":"Risco-Acevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-4518","authenticated-orcid":false,"given":"Yanier","family":"N\u00fa\u00f1ez-Figueredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"issue":"6","key":"747_CR1","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1177\/17474930241246955","volume":"19","author":"L Zhang","year":"2024","unstructured":"Zhang L, Lu H, Yang C Global, regional, and national burden of stroke from 1990 to 2019: a temporal trend analysis based on the Global Burden of Disease Study 2019. Int J Stroke. 2024;19(6):686\u201394. https:\/\/doi.org\/10.1177\/17474930241246955","journal-title":"Int J Stroke"},{"key":"747_CR2","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1007\/978-3-030-88832-9_97","volume-title":"Ischemic Stroke: basic Pathophysiology and Clinical Implication. Neuroscience in the 21st Century: from Basic to Clinical","author":"P Mergenthaler","year":"2022","unstructured":"Mergenthaler P, Dirnagl U, Kunz A Ischemic Stroke: basic Pathophysiology and Clinical Implication. Neuroscience in the 21st Century: from Basic to Clinical. Springer; 2022. 3807\u201327. https:\/\/doi.org\/10.1007\/978-3-030-88832-9_97"},{"issue":"3","key":"747_CR3","doi-asserted-by":"publisher","first-page":"e46","DOI":"10.1161\/STR.0000000000000158","volume":"49","author":"WJ Powers","year":"2018","unstructured":"Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. 2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke. 2018;49 (3):e46\u2013e99. https:\/\/doi.org\/10.1161\/STR.0000000000000158","journal-title":"Stroke"},{"issue":"7","key":"747_CR4","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.mayocp.2014.03.001","volume":"89","author":"JE Fugate","year":"2014","unstructured":"Fugate JE, Rabinstein AA Update on intravenous recombinant tissue plasminogen activator for acute ischemic stroke. Mayo Clin Proc. 2014;89(7):960\u201372. https:\/\/doi.org\/10.1016\/j.mayocp.2014.03.001","journal-title":"Mayo Clin Proc"},{"issue":"8","key":"747_CR5","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1161\/STROKEAHA.106.475483","volume":"38","author":"YS Ng","year":"2007","unstructured":"Ng YS, Stein J, Ning M, Black-Schaffer RM Comparison of clinical characteristics and functional outcomes of ischemic stroke in different vascular territories. Stroke. 2007;38(8):2309\u201314. https:\/\/doi.org\/10.1161\/STROKEAHA.106.475483","journal-title":"Stroke"},{"issue":"9","key":"747_CR6","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1161\/STROKEAHA.117.017112","volume":"48","author":"F Bosetti","year":"2017","unstructured":"Bosetti F, Koenig JI, Ayata C, Back SA, Becker K, Broderick JP, et al. Translational stroke research: vision and opportunities. Stroke. 2017;48(9):2632\u201337. https:\/\/doi.org\/10.1161\/STROKEAHA.117.017112","journal-title":"Stroke"},{"key":"747_CR7","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/jnc.13516","volume":"139","author":"G Llovera","year":"2016","unstructured":"Llovera G, Liesz A. The next step in translational research: lessons learned from the first preclinical randomized controlled trial. J Neurochem. 2016;139:271\u201379. https:\/\/doi.org\/10.1111\/jnc.13516","journal-title":"J Neurochem"},{"issue":"7","key":"747_CR8","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1161\/STROKEAHA.117.017866","volume":"48","author":"JP Broderick","year":"2017","unstructured":"Broderick JP, Adeoye O, Elm J Evolution of the modified Rankin scale and its use in future stroke trials. Stroke. 2017;48(7):2007\u201312. https:\/\/doi.org\/10.1161\/STROKEAHA.117.017866","journal-title":"Stroke"},{"key":"747_CR9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2147\/CIA.S32405","volume":"8","author":"JK Harrison","year":"2013","unstructured":"Harrison JK, McArthur KS, Quinn TJ. Assessment scales in stroke: clinimetric and clinical considerations. Clin Interv Aging. 2013;8:201\u201311. https:\/\/doi.org\/10.2147\/CIA.S32405","journal-title":"Clin Interv Aging"},{"issue":"12","key":"747_CR10","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1161\/01.str.30.12.2752","volume":"30","author":"STAI Roundtable","year":"1999","unstructured":"Roundtable STAI Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke. 1999;30(12):2752\u201358. https:\/\/doi.org\/10.1161\/01.str.30.12.2752","journal-title":"Stroke"},{"issue":"6","key":"747_CR11","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1161\/STROKEAHA.108.541128","volume":"40","author":"M Fisher","year":"2009","unstructured":"Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, et al. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009;40(6):2244\u201350. https:\/\/doi.org\/10.1161\/STROKEAHA.108.541128","journal-title":"Stroke"},{"issue":"4","key":"747_CR12","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1161\/STROKEAHA.118.023927","volume":"50","author":"SI Savitz","year":"2019","unstructured":"Savitz SI, Baron\u2013, Fisher M, Consortium SX Stroke treatment academic industry roundtable X: brain cytoprotection therapies in the reperfusion era. Stroke. 2019;50(4):1026\u201331. https:\/\/doi.org\/10.1161\/STROKEAHA.118.023927","journal-title":"Stroke"},{"issue":"8","key":"747_CR13","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1093\/brain\/awx126","volume":"140","author":"AA Neuhaus","year":"2017","unstructured":"Neuhaus AA, Couch Y, Hadley G, Buchan AM Neuroprotection in stroke: the importance of collaboration and reproducibility. Brain. 2017;140(8):2079\u201392. https:\/\/doi.org\/10.1093\/brain\/awx126","journal-title":"Brain"},{"key":"747_CR14","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s12975-021-00907-3","volume":"12","author":"W Chen","year":"2021","unstructured":"Chen W, Xie L, Yu F, Li Y, Chen C, Xie W, et al. Zebrafish as a model for in-depth mechanistic study for stroke. Transl Stroke Res. 2021;12:695\u2013710. https:\/\/doi.org\/10.1007\/s12975-021-00907-3","journal-title":"Transl Stroke Res"},{"issue":"1","key":"747_CR15","doi-asserted-by":"publisher","first-page":"5787","DOI":"10.1038\/s41598-021-85348-6","volume":"11","author":"Y Kim","year":"2021","unstructured":"Kim Y, Lee YB, Bae SK, Oh SS,\u2013 C Development of a photochemical thrombosis investigation system to obtain a rabbit ischemic stroke model. Sci Rep. 2021;11(1):5787. https:\/\/doi.org\/10.1038\/s41598-021-85348-6","journal-title":"Sci Rep"},{"issue":"5","key":"747_CR16","first-page":"459","volume":"59","author":"BT Kang","year":"2009","unstructured":"Kang BT, Jang DP, Gu SH, Lee JH, Jung DI, Lim CY, et al. MRI features in a canine model of ischemic stroke: correlation between lesion volume and neurobehavioral status during the subacute stage. Comp Med. 2009;59(5)459\u201364.","journal-title":"Comp Med"},{"issue":"2","key":"747_CR17","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.neulet.2011.05.036","volume":"499","author":"T Maki","year":"2011","unstructured":"Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, et al. Watershed infarcts in a multiple microembolic model of monkey. Neurosci Lett. 2011;499(2):80\u201383. https:\/\/doi.org\/10.1016\/j.neulet.2011.05.036","journal-title":"Neurosci Lett"},{"key":"747_CR18","doi-asserted-by":"publisher","first-page":"146778","DOI":"10.1016\/j.brainres.2020.146778","volume":"1736","author":"EE Kaiser","year":"2020","unstructured":"Kaiser EE, Waters ES, Fagan MM, Scheulin KM, Platt SR, Jeon JH, et al. Characterization of tissue and functional deficits in a clinically translational pig model of acute ischemic stroke. Brain Res. 2020;1736:146778. https:\/\/doi.org\/10.1016\/j.brainres.2020.146778","journal-title":"Brain Res"},{"issue":"3","key":"747_CR19","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/17460441.2019.1573984","volume":"14","author":"DM Hermann","year":"2019","unstructured":"Hermann DM, Popa-Wagner A, Kleinschnitz C, Doeppner TR Animal models of ischemic stroke and their impact on drug discovery. Expert Opin Drug Discov. 2019;14(3):315\u201326. https:\/\/doi.org\/10.1080\/17460441.2019.1573984","journal-title":"Expert Opin Drug Discov"},{"issue":"1","key":"747_CR20","doi-asserted-by":"publisher","first-page":"25176","DOI":"10.1038\/srep25176","volume":"6","author":"R Verma","year":"2016","unstructured":"Verma R, Harris NM, Friedler BD, Crapser J, Patel AR, Venna V, et al. Reversal of the detrimental effects of post-stroke social isolation by pair-housing is mediated by activation of BDNF-MAPK\/ERK in aged mice. Sci Rep. 2016;6(1):25176. https:\/\/doi.org\/10.1038\/srep25176","journal-title":"Sci Rep"},{"issue":"1","key":"747_CR21","doi-asserted-by":"publisher","first-page":"e351","DOI":"10.1038\/tp.2013.128","volume":"4","author":"V Venna","year":"2014","unstructured":"Venna V, Xu Y, Doran S, Patrizz A, McCullough L Social interaction plays a critical role in neurogenesis and recovery after stroke. Transl Psychiatry. 2014;4(1):e351\u2013e. https:\/\/doi.org\/10.1038\/tp.2013.128","journal-title":"Transl Psychiatry"},{"key":"747_CR22","doi-asserted-by":"publisher","first-page":"622911","DOI":"10.3389\/fnhum.2021.622911","volume":"15","author":"X Zhang","year":"2021","unstructured":"Zhang X, Liu JY, Liao WJ, Chen XP. Differential effects of physical and social enriched environment on angiogenesis in male rats after cerebral ischemia\/reperfusion injury. Front Hum Neurosci. 2021;15:622911. https:\/\/doi.org\/10.3389\/fnhum.2021.622911","journal-title":"Front Hum Neurosci"},{"issue":"6","key":"747_CR23","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.pnpbp.2005.06.005","volume":"29","author":"A Kocer","year":"2005","unstructured":"Kocer A, Ilhan A, Ince N, Bilge C The related causes in very early morning onset of stroke. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(6):983\u201388. https:\/\/doi.org\/10.1016\/j.pnpbp.2005.06.005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"6","key":"747_CR24","first-page":"280","volume":"4","author":"PK Kamat","year":"2021","unstructured":"Kamat PK, Khan MB, Wood K, Siddiqui S, Rudic DR, Dhandapani K, et al. Preclinical evaluation of circadian rhythm in ischemic stroke outcomes. Cond Med. 2021;4(6)280.","journal-title":"Cond Med"},{"issue":"4","key":"747_CR25","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.10.001","volume":"22","author":"BD Rakai","year":"2013","unstructured":"Rakai BD, Antle MC Lesion Size and Behavioral Deficits after Endothelin-1\u2013Induced Ischemia are not Dependent on Time of Day. J Stroke Cerebrovasc Dis. 2013;22(4):397\u2013405. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2011.10.001","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"4","key":"747_CR26","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1161\/STROKEAHA.121.036050","volume":"53","author":"A Taha","year":"2022","unstructured":"Taha A, Bobi J, Dammers R, Dijkhuizen RM, Dreyer AY, Van Es AC, et al. Comparison of large animal models for acute ischemic stroke: which model to use? Stroke. 2022;53(4):1411\u201322. https:\/\/doi.org\/10.1161\/STROKEAHA.121.036050","journal-title":"Stroke"},{"issue":"5","key":"747_CR27","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1161\/STROKEAHA.113.004075","volume":"45","author":"U Dirnagl","year":"2014","unstructured":"Dirnagl U, Endres M Found in translation: preclinical stroke research predicts human pathophysiology, clinical phenotypes, and therapeutic outcomes. Stroke. 2014;45(5):1510\u201318. https:\/\/doi.org\/10.1161\/STROKEAHA.113.004075","journal-title":"Stroke"},{"issue":"4731","key":"747_CR28","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1126\/science.393475","volume":"230","author":"JA Zivin","year":"1985","unstructured":"Zivin JA, Fisher M, DeGirolami U, Hemenway CC, Stashak JA Tissue plasminogen activator reduces neurological damage after cerebral embolism. Science. 1985;230(4731):1289\u201392. https:\/\/doi.org\/10.1126\/science.393475","journal-title":"Science"},{"issue":"11","key":"747_CR29","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1177\/0271678X1879985","volume":"38","author":"TM Hietamies","year":"2018","unstructured":"Hietamies TM, Ostrowski C, Pei Z, Feng L, McCabe C, Work LM, et al. Variability of functional outcome measures used in animal models of stroke and vascular cognitive impairment\u2013a review of contemporary studies. J Cereb Blood Flow Metab. 2018;38(11):1872\u201384. https:\/\/doi.org\/10.1177\/0271678X1879985","journal-title":"J Cereb Blood Flow Metab"},{"issue":"9","key":"747_CR30","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1038\/jcbfm.2013.91","volume":"33","author":"MA Eckert","year":"2013","unstructured":"Eckert MA, Vu Q, Xie K, Yu J, Liao W, Cramer SC, et al. Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke. J Cerebl Blood Flow Metab. 2013;33(9):1322\u201334. https:\/\/doi.org\/10.1038\/jcbfm.2013.91","journal-title":"J Cerebl Blood Flow Metab"},{"issue":"3","key":"747_CR31","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1161\/01.STR.17.3.472","volume":"17","author":"JB Bederson","year":"1986","unstructured":"Bederson JB, Pitts LH, Tsuji M, Nishimura M, Davis R, Bartkowski H Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 1986;17(3):472\u201376. https:\/\/doi.org\/10.1161\/01.STR.17.3.472","journal-title":"Stroke"},{"issue":"4","key":"747_CR32","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1161\/01.STR.26.4.627","volume":"26","author":"JH Garcia","year":"1995","unstructured":"Garcia JH, Wagner S, Liu KF, Xj H Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats: statistical validation. Stroke. 1995;26(4):627\u201335. https:\/\/doi.org\/10.1161\/01.STR.26.4.627","journal-title":"Stroke"},{"issue":"10","key":"747_CR33","doi-asserted-by":"publisher","first-page":"607","DOI":"10.33588\/rn.5310.2011016","volume":"53","author":"JG Zarruk","year":"2011","unstructured":"Zarruk JG, Garc\u00eda-Y\u00e9benes I, Romera VG, Ballesteros I, Moraga A, Cuartero MI, et al. Neurological tests for functional outcome assessment in rodent models of ischaemic stroke. Rev Neurol. 2011;53(10):607\u201318. https:\/\/doi.org\/10.33588\/rn.5310.2011016","journal-title":"Rev Neurol"},{"issue":"10","key":"747_CR34","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1161\/STROKEAHA.119.026652","volume":"50","author":"M Bieber","year":"2019","unstructured":"Bieber M, Gronewold J, Scharf AC, Schuhmann MK, Langhauser F, Hopp S, et al. Validity and reliability of neurological scores in mice exposed to middle cerebral artery occlusion. Stroke. 2019;50(10):2875\u201382. https:\/\/doi.org\/10.1161\/STROKEAHA.119.026652","journal-title":"Stroke"},{"issue":"2","key":"747_CR35","doi-asserted-by":"publisher","first-page":"312","DOI":"10.4103\/1673-5374.290899","volume":"16","author":"J Zhong","year":"2021","unstructured":"Zhong J, Li RW, Wang J, Wang Y, Ge HF, Xian JS, et al. Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke. Neural Regen Res. 2021;16(2):312\u201318. https:\/\/doi.org\/10.4103\/1673-5374.290899","journal-title":"Neural Regen Res"},{"key":"747_CR36","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.3389\/fneur.2019.01299","volume":"10","author":"J Zhang","year":"2019","unstructured":"Zhang J, Jiang Y, Liu N, Shen T, Jung HW, Liu J, et al. A network-based method for mechanistic investigation and neuroprotective effect on post-treatment of senkyunolid-H against cerebral ischemic stroke in mouse. Front Neurol. 2019;10:1299. https:\/\/doi.org\/10.3389\/fneur.2019.01299","journal-title":"Front Neurol"},{"key":"747_CR37","doi-asserted-by":"publisher","first-page":"175982","DOI":"10.1016\/j.ejphar.2023.175982","volume":"957","author":"X Yuan","year":"2023","unstructured":"Yuan X, Ye W, Chen L, Luo D, Zhou L, Qiu Y, et al. URB597 exerts neuroprotective effects against transient brain ischemia injury in mice by regulating autophagic flux and necroptosis. Eur J Pharmacol. 2023;957:175982. https:\/\/doi.org\/10.1016\/j.ejphar.2023.175982","journal-title":"Eur J Pharmacol"},{"key":"747_CR38","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.neuropharm.2014.06.009","volume":"85","author":"Y Nunez-Figueredo","year":"2014","unstructured":"Nunez-Figueredo Y, Ram\u00edrez-S\u00e1nchez J, Hansel G, Pires ENS, Merino N, Valdes O, et al. A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo. Neuropharmacology. 2014;85:517\u201327. https:\/\/doi.org\/10.1016\/j.neuropharm.2014.06.009","journal-title":"Neuropharmacology"},{"key":"747_CR39","doi-asserted-by":"publisher","first-page":"174025","DOI":"10.1016\/j.ejphar.2021.174025","volume":"899","author":"J Ram\u00edrez-S\u00e1nchez","year":"2021","unstructured":"Ram\u00edrez-S\u00e1nchez J, Wong-Guerra M, Fonseca-Fonseca LA, Sim\u00f5es-Pires EN, Garc\u00eda-Pupo L, Ochoa-Rodr\u00edguez E, et al. Novel arylidene malonate derivative, KM-34, showed neuroprotective effects on in vitro and in vivo models of ischemia\/reperfusion. Eur J Pharmacol. 2021;899:174025. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174025","journal-title":"Eur J Pharmacol"},{"key":"747_CR40","doi-asserted-by":"publisher","unstructured":"Rousselet E, Kriz J, Seidah NG Mouse model of intraluminal MCAO: cerebral infarct evaluation by cresyl violet staining. J Vis Exp. 2012(69):4038. https:\/\/doi.org\/10.3791\/4038","DOI":"10.3791\/4038"},{"issue":"1","key":"747_CR41","doi-asserted-by":"publisher","first-page":"1552127","DOI":"10.1186\/s13287-022-03189-0","volume":"2021","author":"Y Ran","year":"2021","unstructured":"Ran Y, Su W, Gao F, Ding Z, Yang S, Ye L, et al. Curcumin ameliorates white matter injury after ischemic stroke by inhibiting microglia\/macrophage pyroptosis through NF-\u03baB suppression and NLRP3 inflammasome inhibition. Oxid Med Cell Longev. 2021;2021(1):1552127. https:\/\/doi.org\/10.1186\/s13287-022-03189-0","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"747_CR42","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0028-3908(00)00005-8","volume":"39","author":"T Schallert","year":"2000","unstructured":"Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology. 2000;39(5):777\u201387. https:\/\/doi.org\/10.1016\/S0028-3908(00)00005-8","journal-title":"Neuropharmacology"},{"key":"747_CR43","doi-asserted-by":"publisher","first-page":"110353","DOI":"10.1016\/j.biopha.2020.110353","volume":"130","author":"GX Ni","year":"2020","unstructured":"Ni GX, Liang C, Wang J, Duan CQ, Wang P, Wang Y. Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis in MCAO rats though BDNF-TrkB signaling pathway. Biomed Pharmacother. 2020;130:110353. https:\/\/doi.org\/10.1016\/j.biopha.2020.110353","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"747_CR44","doi-asserted-by":"publisher","first-page":"1849428","DOI":"10.1155\/2021\/1849428","volume":"2021","author":"L Luo","year":"2021","unstructured":"Luo L, Liu M, Xie H, Fan Y, Zhang J, Liu L, et al. High-Intensity Interval Training Improves Physical Function, Prevents Muscle Loss, and Modulates Macrophage-Mediated Inflammation in Skeletal Muscle of Cerebral Ischemic Mice. Mediators Inflamm. 2021;2021(1):1849428. https:\/\/doi.org\/10.1155\/2021\/1849428","journal-title":"Mediators Inflamm"},{"issue":"1","key":"747_CR45","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1155\/2021\/1552127","volume":"13","author":"Y Ran","year":"2022","unstructured":"Ran Y, Dong Y, Li Y, Xie J, Zeng S, Liang C, et al. Mesenchymal stem cell aggregation mediated by integrin \u03b14\/VCAM-1 after intrathecal transplantation in MCAO rats. Stem Cell Res Ther. 2022;13(1):507. https:\/\/doi.org\/10.1155\/2021\/1552127","journal-title":"Stem Cell Res Ther"},{"key":"747_CR46","doi-asserted-by":"publisher","first-page":"113854","DOI":"10.1016\/j.expneurol.2021.113854","volume":"346","author":"S Li","year":"2021","unstructured":"Li S, Hua X, Zheng M, Wu J, Ma Z, Xing X, et al. PLXNA2 knockdown promotes M2 microglia polarization through mTOR\/STAT3 signaling to improve functional recovery in rats after cerebral ischemia\/reperfusion injury. Exp Neurol. 2021;346:113854. https:\/\/doi.org\/10.1016\/j.expneurol.2021.113854","journal-title":"Exp Neurol"},{"issue":"12","key":"747_CR47","doi-asserted-by":"publisher","first-page":"5341","DOI":"10.7150\/thno.42077","volume":"10","author":"M P\u00e9nzes","year":"2020","unstructured":"P\u00e9nzes M, T\u00far\u00f3s D, M\u00e1th\u00e9 D, Szigeti K, Heged\u0171s N, Rauscher A\u00c1, et al. Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke. Theranostics. 2020;10(12):5341. https:\/\/doi.org\/10.7150\/thno.42077","journal-title":"Theranostics"},{"key":"747_CR48","doi-asserted-by":"publisher","unstructured":"Ram\u00edrez-S\u00e1nchez J, Rex A, McCann S, Schulze D, Wong-Guerra M, Fonseca-Fonseca LA, et al. A randomized, controlled, two-center preclinical trial assessing the efficacy of a new benzodiazepine\u2013dihydropyridine hybrid molecule (JM-20) in rodent models of ischemic stroke. bioRxiv. 2024:2024.03. 08. 584085. https:\/\/doi.org\/10.1101\/2024.03.08.584085","DOI":"10.1101\/2024.03.08.584085"},{"issue":"8","key":"747_CR49","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1038\/jcbfm.2014.94","volume":"34","author":"J Boltze","year":"2014","unstructured":"Boltze J, Lukomska B, Jolkkonen J, consortium\u2013 Mesenchymal stromal cells in stroke: improvement of motor recovery or functional compensation? J Cereb Blood Flow Metab. 2014;34(8):1420\u201321. https:\/\/doi.org\/10.1038\/jcbfm.2014.94","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"747_CR50","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nrn.2017.26","volume":"18","author":"TA Jones","year":"2017","unstructured":"Jones TA Motor compensation and its effects on neural reorganization after stroke. Nat Rev Neurosci. 2017;18(5):267\u201380. https:\/\/doi.org\/10.1038\/nrn.2017.26","journal-title":"Nat Rev Neurosci"},{"key":"747_CR51","doi-asserted-by":"publisher","unstructured":"Kerr AL, Tennant KA Compensatory limb use and behavioral assessment of motor skill learning following sensorimotor cortex injury in a mouse model of ischemic stroke. J Vis Exp. 2014(89):51602. https:\/\/doi.org\/10.3791\/51602","DOI":"10.3791\/51602"},{"issue":"3","key":"747_CR52","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/0091-3057(82)90452-X","volume":"16","author":"T Schallert","year":"1982","unstructured":"Schallert T, Upchurch M, Lobaugh N, Farrar S, Spirduso W, Gilliam P, et al. Tactile extinction: distinguishing between sensorimotor and motor asymmetries in rats with unilateral nigrostriatal damage. Pharmacol Biochem Behav. 1982;16(3):455\u201362. https:\/\/doi.org\/10.1016\/0091-3057(82)90452-X","journal-title":"Pharmacol Biochem Behav"},{"issue":"10","key":"747_CR53","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1038\/nprot.2007.359","volume":"2","author":"RJ Komotar","year":"2007","unstructured":"Komotar RJ, Kim GH, Sughrue ME, Otten ML, Rynkowski MA, Kellner CP, et al. Neurologic assessment of somatosensory dysfunction following an experimental rodent model of cerebral ischemia. Nat Protoc. 2007;2(10):2345\u201347. https:\/\/doi.org\/10.1038\/nprot.2007.359","journal-title":"Nat Protoc"},{"issue":"2","key":"747_CR54","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jneumeth.2012.12.021","volume":"213","author":"M Balkaya","year":"2013","unstructured":"Balkaya M, Kr\u00f6ber J, Gertz K, Peruzzaro S, Endres M Characterization of long-term functional outcome in a murine model of mild brain ischemia. J Neurosci Methods. 2013;213(2):179\u201387. https:\/\/doi.org\/10.1016\/j.jneumeth.2012.12.021","journal-title":"J Neurosci Methods"},{"issue":"1","key":"747_CR55","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jneumeth.2009.04.009","volume":"181","author":"KA Tennant","year":"2009","unstructured":"Tennant KA, Jones TA Sensorimotor behavioral effects of endothelin-1 induced small cortical infarcts in C57BL\/6 mice. J Neurosci Methods. 2009;181(1):18\u201326. https:\/\/doi.org\/10.1016\/j.jneumeth.2009.04.009","journal-title":"J Neurosci Methods"},{"issue":"1","key":"747_CR56","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.expneurol.2009.11.007","volume":"222","author":"S Soleman","year":"2010","unstructured":"Soleman S, Yip P, Leasure JL, Moon L Sustained sensorimotor impairments after endothelin-1 induced focal cerebral ischemia (stroke) in aged rats. Exp Neurol. 2010;222(1):13\u201324. https:\/\/doi.org\/10.1016\/j.expneurol.2009.11.007","journal-title":"Exp Neurol"},{"issue":"1","key":"747_CR57","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1006\/exnr.1998.6893","volume":"154","author":"J Napieralski","year":"1998","unstructured":"Napieralski J, Banks R, Chesselet M Motor and somatosensory deficits following uni-and bilateral lesions of the cortex induced by aspiration or thermocoagulation in the adult rat. Exp Neurol. 1998;154(1):80\u201388. https:\/\/doi.org\/10.1006\/exnr.1998.6893","journal-title":"Exp Neurol"},{"key":"747_CR58","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.bbr.2013.12.027","volume":"261","author":"M Liguz-Lecznar","year":"2014","unstructured":"Liguz-Lecznar M, Zakrzewska R, Daniszewska K, Kossut M. Functional assessment of sensory functions after photothrombotic stroke in the barrel field of mice. Behav Brain Res. 2014;261:202\u201309. https:\/\/doi.org\/10.1016\/j.bbr.2013.12.027","journal-title":"Behav Brain Res"},{"issue":"2","key":"747_CR59","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.expneurol.2006.09.006","volume":"203","author":"V Bou\u00ebt","year":"2007","unstructured":"Bou\u00ebt V, Freret T, Toutain J, Divoux D, Boulouard M, Schumann-Bard P Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse. Exp Neurol. 2007;203(2):555\u201367. https:\/\/doi.org\/10.1016\/j.expneurol.2006.09.006","journal-title":"Exp Neurol"},{"issue":"1","key":"747_CR60","doi-asserted-by":"publisher","first-page":"9912325","DOI":"10.1155\/2021\/9912325","volume":"2021","author":"YM Zhang","year":"2021","unstructured":"Zhang YM, Xu H, Chen S, Sun H Electroacupuncture regulates endoplasmic reticulum stress and ameliorates neuronal injury in rats with acute ischemic stroke. Evid Based Complement Alternat Med. 2021;2021(1):9912325. https:\/\/doi.org\/10.1155\/2021\/9912325","journal-title":"Evid Based Complement Alternat Med"},{"key":"747_CR61","doi-asserted-by":"publisher","first-page":"962","DOI":"10.3389\/fnins.2018.00962","volume":"12","author":"HL Zhu","year":"2018","unstructured":"Zhu HL, Liu ZP, Yang WY, Dong DW, Zhao Y, Yang B, et al. Liraglutide ameliorates \u03b2-amyloid deposits and secondary damage in the ipsilateral thalamus and sensory deficits after focal cerebral infarction in rats. Front Neurosci. 2018;12:962. https:\/\/doi.org\/10.3389\/fnins.2018.00962","journal-title":"Front Neurosci"},{"issue":"1","key":"747_CR62","doi-asserted-by":"publisher","first-page":"893401","DOI":"10.1155\/2010\/893401","volume":"2010","author":"SI Park","year":"2010","unstructured":"Park SI, Jang DK, Han YM, Sunwoo YY, Park MS, Chung YA, et al. Effect of combination therapy with sodium ozagrel and panax ginseng on transient cerebral ischemia model in rats. Biomed Res Int. 2010;2010(1):893401. https:\/\/doi.org\/10.1155\/2010\/893401","journal-title":"Biomed Res Int"},{"issue":"3","key":"747_CR63","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.neuroscience.2004.07.019","volume":"128","author":"D Adkins","year":"2004","unstructured":"Adkins D, Voorhies A, Jones T Behavioral and neuroplastic effects of focal endothelin-1 induced sensorimotor cortex lesions. Neuroscience. 2004;128(3):473\u201386. https:\/\/doi.org\/10.1016\/j.neuroscience.2004.07.019","journal-title":"Neuroscience"},{"issue":"1","key":"747_CR64","doi-asserted-by":"publisher","first-page":"e86621","DOI":"10.1371\/journal.pone.0086621","volume":"9","author":"A Shehadah","year":"2014","unstructured":"Shehadah A, Chen J, Pal A, He S, Zeitlin A, Cui X, et al. Human placenta-derived adherent cell treatment of experimental stroke promotes functional recovery after stroke in young adult and older rats. PLoS One. 2014;9(1):e86621. https:\/\/doi.org\/10.1371\/journal.pone.0086621","journal-title":"PLoS One"},{"key":"747_CR65","doi-asserted-by":"publisher","first-page":"102000","DOI":"10.1016\/j.jchemneu.2021.102000","volume":"117","author":"M Owjfard","year":"2021","unstructured":"Owjfard M, Taghadosi Z, Bigdeli MR, Safari A, Zarifkar A, Borhani-Haghighi A, et al. Effect of nicorandil on the spatial arrangement of primary motor cortical neurons in the sub-acute phase of stroke in a rat model. J Chem Neuroanat. 2021;117:102000. https:\/\/doi.org\/10.1016\/j.jchemneu.2021.102000","journal-title":"J Chem Neuroanat"},{"issue":"1","key":"747_CR66","doi-asserted-by":"publisher","first-page":"31843","DOI":"10.1038\/srep31843","volume":"6","author":"SW Kim","year":"2016","unstructured":"Kim SW, Lee HK, Kim ID, Lee H, Luo L, Park JY, et al. Robust neuroprotective effects of 2-((2-oxopropanoyl) oxy)-4-(trifluoromethyl) benzoic acid (OPTBA), a HTB\/pyruvate ester, in the postischemic rat brain. Sci Rep. 2016;6(1):31843. https:\/\/doi.org\/10.1038\/srep31843","journal-title":"Sci Rep"},{"issue":"2","key":"747_CR67","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1161\/STROKEAHA.107.49247","volume":"39","author":"V Prinz","year":"2008","unstructured":"Prinz V, Laufs U, Gertz K, Kronenberg G, Balkaya M, Leithner C, et al. Intravenous rosuvastatin for acute stroke treatment: an animal study. Stroke. 2008;39(2):433\u201338. https:\/\/doi.org\/10.1161\/STROKEAHA.107.49247","journal-title":"Stroke"},{"key":"747_CR68","doi-asserted-by":"publisher","first-page":"107748","DOI":"10.1016\/j.neuropharm.2019.107748","volume":"158","author":"X Yang","year":"2019","unstructured":"Yang X, Feng P, Zhang X, Li D, Wang R, Ji C, et al. The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke. Neuropharmacology. 2019;158:107748. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.107748","journal-title":"Neuropharmacology"},{"key":"747_CR69","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3389\/fncel.2014.00365","volume":"8","author":"HA Kim","year":"2014","unstructured":"Kim HA, Whittle SC, Lee S, Chu HX, Zhang SR, Wei Z, et al. Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains. Front Cell Neurosci. 2014;8:365. https:\/\/doi.org\/10.3389\/fncel.2014.00365","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"747_CR70","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.bbr.2009.08.011","volume":"205","author":"A Ferrara","year":"2009","unstructured":"Ferrara A, El Bejaoui S, Seyen S, Tirelli E, Plumier JC The usefulness of operant conditioning procedures to assess long-lasting deficits following transient focal ischemia in mice. Behav Brain Res. 2009;205(2):525\u201334. https:\/\/doi.org\/10.1016\/j.bbr.2009.08.011","journal-title":"Behav Brain Res"},{"issue":"8","key":"747_CR71","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1161\/01.STR.31.8.1939","volume":"31","author":"K Hattori","year":"2000","unstructured":"Hattori K, Lee H, Hurn PD, Crain BJ, Traystman RJ, DeVries AC Cognitive deficits after focal cerebral ischemia in mice. Stroke. 2000;31(8):1939\u201344. https:\/\/doi.org\/10.1161\/01.STR.31.8.1939","journal-title":"Stroke"},{"key":"747_CR72","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.brainres.2009.01.061","volume":"1265","author":"G Royl","year":"2009","unstructured":"Royl G, Balkaya M, Lehmann S, Lehnardt S, Stohlmann K, Lindauer U, et al. Effects of the PDE5-inhibitor vardenafil in a mouse stroke model. Brain Res. 2009;1265:148\u201357. https:\/\/doi.org\/10.1016\/j.brainres.2009.01.061","journal-title":"Brain Res"},{"issue":"1","key":"747_CR73","doi-asserted-by":"publisher","first-page":"7598","DOI":"10.1038\/s41598-022-11793-6","volume":"12","author":"A Knezic","year":"2022","unstructured":"Knezic A, Broughton BR, Widdop RE, McCarthy CA Optimising the photothrombotic model of stroke in the C57BI\/6 and FVB\/N strains of mouse. Sci Rep. 2022;12(1):7598. https:\/\/doi.org\/10.1038\/s41598-022-11793-6","journal-title":"Sci Rep"},{"issue":"8","key":"747_CR74","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/j.bbi.2011.06.015","volume":"25","author":"B Manwani","year":"2011","unstructured":"Manwani B, Liu F, Xu Y, Persky R, Li J, McCullough LD Functional recovery in aging mice after experimental stroke. Brain Behav Immun. 2011;25(8):1689\u2013700. https:\/\/doi.org\/10.1016\/j.bbi.2011.06.015","journal-title":"Brain Behav Immun"},{"key":"747_CR75","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/978-1-4939-5620-3","volume-title":"Neuromethods","author":"R Bernard","year":"2016","unstructured":"Bernard R, Balkaya M, Rex A Behavioral Testing in Rodent Models of Stroke, Part I. Dirnagl U editor. Rodent Models of Stroke. Neuromethods. 2016; vol. 120: 199\u2013223. Humana Press, New York, NY. https:\/\/doi.org\/10.1007\/978-1-4939-5620-3"},{"issue":"1","key":"747_CR76","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.expneurol.2004.01.004","volume":"187","author":"X Li","year":"2004","unstructured":"Li X, Blizzard KK, Zeng Z, DeVries AC, Hurn PD, McCullough LD Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender. Exp Neurol. 2004;187(1):94\u2013104. https:\/\/doi.org\/10.1016\/j.expneurol.2004.01.004","journal-title":"Exp Neurol"},{"issue":"1","key":"747_CR77","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/jcbfm.2008.88","volume":"29","author":"T Abe","year":"2009","unstructured":"Abe T, Kunz A, Shimarnura M, Zhou P, Anrather J, Iadecola C The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic. J Cereb Blood Flow Metab. 2009;29(1):66\u201372. https:\/\/doi.org\/10.1038\/jcbfm.2008.88","journal-title":"J Cereb Blood Flow Metab"},{"key":"747_CR78","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.brainres.2007.11.075","volume":"1196","author":"J Hao","year":"2008","unstructured":"Hao J, Mdzinarishvili A, Abbruscato TJ, Klein J, Geldenhuys WJ, Van der Schyf CJ, et al. Neuroprotection in mice by NGP1-01 after transient focal brain ischemia. Brain Res. 2008;1196:113\u201320. https:\/\/doi.org\/10.1016\/j.brainres.2007.11.075","journal-title":"Brain Res"},{"issue":"1","key":"747_CR79","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/jcbfm.2009.19","volume":"30","author":"M Brenneman","year":"2010","unstructured":"Brenneman M, Sharma S, Harting M, Strong R, Cox Jr CS, Aronowski J, et al. Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats. J Cereb Blood Flow Metab. 2010;30(1):140\u201349. https:\/\/doi.org\/10.1038\/jcbfm.2009.19","journal-title":"J Cereb Blood Flow Metab"},{"key":"747_CR80","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.brainres.2013.08.014","volume":"1533","author":"T Tao","year":"2013","unstructured":"Tao T, Liu Y, Zhang J, Xu Y, Li W, Zhao M. Therapeutic hypercapnia improves functional recovery and attenuates injury via antiapoptotic mechanisms in a rat focal cerebral ischemia\/reperfusion model. Brain Res. 2013;1533:52\u201362. https:\/\/doi.org\/10.1016\/j.brainres.2013.08.014","journal-title":"Brain Res"},{"issue":"6","key":"747_CR81","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/jnr.22614","volume":"89","author":"B Yang","year":"2011","unstructured":"Yang B, Strong R, Sharma S, Brenneman M, Mallikarjunarao K, Xi X, et al. Therapeutic time window and dose response of autologous bone marrow mononuclear cells for ischemic stroke. J Neurosci Res. 2011;89(6):833\u201339. https:\/\/doi.org\/10.1002\/jnr.22614","journal-title":"J Neurosci Res"},{"key":"747_CR82","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.bbr.2017.09.008","volume":"336","author":"FF Alamri","year":"2018","unstructured":"Alamri FF, Al Shoyaib A, Biggers A, Jayaraman S, Guindon J, Karamyan VT. Applicability of the grip strength and automated von Frey tactile sensitivity tests in the mouse photothrombotic model of stroke. Behav Brain Res. 2018;336:250\u201355. https:\/\/doi.org\/10.1016\/j.bbr.2017.09.008","journal-title":"Behav Brain Res"},{"issue":"4","key":"747_CR83","doi-asserted-by":"publisher","first-page":"153","DOI":"10.56499\/jppres16.126_4.4.153","volume":"4","author":"Y N\u00fa\u00f1ez Figueredo","year":"2016","unstructured":"N\u00fa\u00f1ez Figueredo Y, Ram\u00edrez-Sanchez J, Hansel G, Pardo-Andreu GL, Merino N, Aparicio G, et al. Therapeutic potential of the novel hybrid molecule JM-20 against focal cortical ischemia in rats. J Pharm Pharmacogn Res. 2016;4(4):153\u201358. https:\/\/doi.org\/10.56499\/jppres16.126_4.4.153","journal-title":"J Pharm Pharmacogn Res"},{"issue":"3","key":"747_CR84","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3390\/cells11030485","volume":"11","author":"MP Nucci","year":"2022","unstructured":"Nucci MP, Oliveira FA, Ferreira JM, Pinto YO, Alves AH, Mamani JB, et al. Effect of cell therapy and exercise training in a stroke model, considering the cell track by molecular image and behavioral analysis. Cells. 2022;11(3):485. https:\/\/doi.org\/10.3390\/cells11030485","journal-title":"Cells"},{"key":"747_CR85","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.brainres.2008.07.086","volume":"1234","author":"K Takahashi","year":"2008","unstructured":"Takahashi K, Yasuhara T, Shingo T, Muraoka K, Kameda M, Takeuchi A, et al. Embryonic neural stem cells transplanted in middle cerebral artery occlusion model of rats demonstrated potent therapeutic effects, compared to adult neural stem cells. Brain Res. 2008;1234:172\u201382. https:\/\/doi.org\/10.1016\/j.brainres.2008.07.086","journal-title":"Brain Res"},{"issue":"2","key":"747_CR86","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jneumeth.2012.05.018","volume":"208","author":"L Zvejniece","year":"2012","unstructured":"Zvejniece L, Svalbe B, Liepinsh E, Pulks E, Dambrova M The sensorimotor and cognitive deficits in rats following 90-and 120-min transient occlusion of the middle cerebral artery. J Neurosci Methods. 2012;208(2):197\u2013204. https:\/\/doi.org\/10.1016\/j.jneumeth.2012.05.018","journal-title":"J Neurosci Methods"},{"issue":"2","key":"747_CR87","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/s11481-019-09903-9","volume":"15","author":"CC Hsu","year":"2020","unstructured":"Hsu CC, Kuo TW, Liu WP, Chang CP, Lin HJ Calycosin preserves BDNF\/TrkB signaling and reduces post-stroke neurological injury after cerebral ischemia by reducing accumulation of hypertrophic and TNF-\u03b1-containing microglia in rats. J Neuroimmune Pharmacol. 2020;15(2):326\u201339. https:\/\/doi.org\/10.1007\/s11481-019-09903-9","journal-title":"J Neuroimmune Pharmacol"},{"issue":"1","key":"747_CR88","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1046\/j.0953-816x.2001.01843.x","volume":"15","author":"M Lundblad","year":"2002","unstructured":"Lundblad M, Andersson M, Winkler C, Kirik D, Wierup N, Cenci MA Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson\u2019s disease. Eur J Neurosci. 2002;15(1):120\u201332. https:\/\/doi.org\/10.1046\/j.0953-816x.2001.01843.x","journal-title":"Eur J Neurosci"},{"issue":"3","key":"747_CR89","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1002\/jps.3030460322","volume":"46","author":"N Dunham","year":"1957","unstructured":"Dunham N, Miya T A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice. J Am Pharm Assoc. 1957;46(3):208\u201309. https:\/\/doi.org\/10.1002\/jps.3030460322","journal-title":"J Am Pharm Assoc"},{"key":"747_CR90","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/BF00537801","volume":"259","author":"B Jones","year":"1968","unstructured":"Jones B, Roberts D. A rotarod suitable for quantitative measurements of motor incoordination in naive mice. Naunyn Schmiedebergs Arch Pharmacol. 1968;259:211. https:\/\/doi.org\/10.1007\/BF00537801","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"5","key":"747_CR91","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/S0028-3908(99)00262-2","volume":"39","author":"A Hunter","year":"2000","unstructured":"Hunter A, Hatcher J, Virley D, Nelson P, Irving E, Hadingham S, et al. Functional assessments in mice and rats after focal stroke. Neuropharmacology. 2000;39(5):806\u201316. https:\/\/doi.org\/10.1016\/S0028-3908(99)00262-2","journal-title":"Neuropharmacology"},{"issue":"7","key":"747_CR92","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/01.WCB.0000125365.83980.00","volume":"24","author":"CL Gibson","year":"2004","unstructured":"Gibson CL, Murphy SP Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice. J Cereb Blood Flow Metab. 2004;24(7):805\u201313. https:\/\/doi.org\/10.1097\/01.WCB.0000125365.83980.00","journal-title":"J Cereb Blood Flow Metab"},{"issue":"13","key":"747_CR93","doi-asserted-by":"publisher","first-page":"6975","DOI":"10.3390\/ijms23136975","volume":"23","author":"JA Kim","year":"2022","unstructured":"Kim JA, Kim YY, Lee SH, Jung C, Kim MH, Kim DY Neuroprotective effect of macrophage migration inhibitory factor (MIF) in a mouse model of ischemic stroke. Int J Mol Sci. 2022;23(13):6975. https:\/\/doi.org\/10.3390\/ijms23136975","journal-title":"Int J Mol Sci"},{"issue":"9","key":"747_CR94","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1097\/00004647-200009000-00006","volume":"20","author":"Y Li","year":"2000","unstructured":"Li Y, Chopp M, Chen J, Wang L, Gautam SC, Xu YX, et al. Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J Cereb Blood Flow Metab. 2000;20(9):1311\u201319. https:\/\/doi.org\/10.1097\/00004647-200009000-00006","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"747_CR95","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.surneu.2006.08.077","volume":"67","author":"JK Lee","year":"2007","unstructured":"Lee JK, Park MS, Kim YS, Moon KS, Joo SP, Kim TS, et al. Photochemically induced cerebral ischemia in a mouse model. Surg Neurol. 2007;67(6):620\u201325. https:\/\/doi.org\/10.1016\/j.surneu.2006.08.077","journal-title":"Surg Neurol"},{"issue":"10","key":"747_CR96","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1161\/01.STR.28.10.2060","volume":"28","author":"DC Rogers","year":"1997","unstructured":"Rogers DC, Campbell CA, Stretton JL, Mackay KB Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke. 1997;28(10):2060\u201366. https:\/\/doi.org\/10.1161\/01.STR.28.10.2060","journal-title":"Stroke"},{"issue":"2","key":"747_CR97","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0166-4328(95)00237-5","volume":"78","author":"NI Wood","year":"1996","unstructured":"Wood NI, Sopesen BV, Roberts JC, Pambakian P, Rothaul AL, Hunter AJ, et al. Motor dysfunction in a photothrombotic focal ischaemia model. Behav Brain Res. 1996;78(2):113\u201320. https:\/\/doi.org\/10.1016\/0166-4328(95)00237-5","journal-title":"Behav Brain Res"},{"issue":"5","key":"747_CR98","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/S0028-3908(00)00006-X","volume":"39","author":"J Chen","year":"2000","unstructured":"Chen J, Li Y, Chopp M Intracerebral transplantation of bone marrow with BDNF after MCAo in rat. Neuropharmacology. 2000;39(5):711\u201316. https:\/\/doi.org\/10.1016\/S0028-3908(00)00006-X","journal-title":"Neuropharmacology"},{"issue":"11","key":"747_CR99","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1161\/hs1101.098367","volume":"32","author":"J Chen","year":"2001","unstructured":"Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke. 2001;32(11):2682\u201388. https:\/\/doi.org\/10.1161\/hs1101.098367","journal-title":"Stroke"},{"issue":"1","key":"747_CR100","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1038\/s41598-019-38750-0","volume":"9","author":"WM He","year":"2019","unstructured":"He WM, Ying-Fu L, Wang H, Peng YP Delayed treatment of \u03b15 GABAA receptor inverse agonist improves functional recovery by enhancing neurogenesis after cerebral ischemia-reperfusion injury in rat MCAO model. Sci Rep. 2019;9(1):2287. https:\/\/doi.org\/10.1038\/s41598-019-38750-0","journal-title":"Sci Rep"},{"issue":"1","key":"747_CR101","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/ana.22386","volume":"70","author":"M Xie","year":"2011","unstructured":"Xie M, Yi C, Luo X, Xu S, Yu Z, Tang Y, et al. Glial gap junctional communication involvement in hippocampal damage after middle cerebral artery occlusion. Ann Neurol. 2011;70(1):121\u201332. https:\/\/doi.org\/10.1002\/ana.22386","journal-title":"Ann Neurol"},{"key":"747_CR102","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.nbd.2013.06.014","volume":"59","author":"W Li","year":"2013","unstructured":"Li W, Huang R, Shetty RA, Thangthaeng N, Liu R, Chen Z, et al. Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model. Neurobiol Dis. 2013;59:18\u201325. https:\/\/doi.org\/10.1016\/j.nbd.2013.06.014","journal-title":"Neurobiol Dis"},{"issue":"4","key":"747_CR103","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0149-7634(01)00017-3","volume":"25","author":"AC DeVries","year":"2001","unstructured":"DeVries AC, Nelson RJ, Traystman RJ, Hurn PD Cognitive and behavioral assessment in experimental stroke research: will it prove useful? Neurosci Biobehav Rev. 2001;25(4):325\u201342. https:\/\/doi.org\/10.1016\/S0149-7634(01)00017-3","journal-title":"Neurosci Biobehav Rev"},{"key":"747_CR104","doi-asserted-by":"publisher","unstructured":"Callaghan RM, Yang H, Moloney RD, Waeber C Behavioural assessment of neuropsychiatric outcomes in rodent stroke models. J Cereb Blood Flow Metab. 2025:0271678\u00d7251317369. https:\/\/doi.org\/10.1177\/0271678X2513173","DOI":"10.1177\/0271678X2513173"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-025-00747-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43440-025-00747-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-025-00747-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T03:05:08Z","timestamp":1758078308000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43440-025-00747-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":104,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["747"],"URL":"https:\/\/doi.org\/10.1007\/s43440-025-00747-0","relation":{},"ISSN":["1734-1140","2299-5684"],"issn-type":[{"value":"1734-1140","type":"print"},{"value":"2299-5684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]},"assertion":[{"value":"24 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}