{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:58:18Z","timestamp":1783648698015,"version":"3.55.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"CONACyT-FOSISS","award":["261459"],"award-info":[{"award-number":["261459"]}]},{"name":"C\u00e1tedras CONACyT","award":["1683"],"award-info":[{"award-number":["1683"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacol. Rep"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s43440-025-00771-0","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T07:29:15Z","timestamp":1755156555000},"page":"1428-1439","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic variants in GRIN2B and NTRK2 on the etiology and treatment response to valproate and lithium in patients with bipolar disorder"],"prefix":"10.1007","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-501X","authenticated-orcid":false,"given":"Beatriz","family":"Camarena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-5940","authenticated-orcid":false,"given":"Marco Antonio","family":"Sanabrais-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9924-1434","authenticated-orcid":false,"given":"Carlo Esteban","family":"Sotelo-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3654-9922","authenticated-orcid":false,"given":"Joanna","family":"Jim\u00e9nez-Pav\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-807X","authenticated-orcid":false,"given":"Pamela","family":"Morales-Cedillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-2996","authenticated-orcid":false,"given":"Hiram","family":"Ortega-Ort\u00edz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-7685","authenticated-orcid":false,"given":"Claudia","family":"Becerra-Palars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"771_CR1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Arlington, VA; 2013.","DOI":"10.1176\/appi.books.9780890425596"},{"issue":"10265","key":"771_CR2","first-page":"1841","volume":"396","author":"RS McIntyre","year":"2020","unstructured":"McIntyre RS, Berk M, Brietzke E, Goldstein BI, L\u00f3pez-Jaramillo C, Kessing LV, et al. Bipolar Disorders Lancet. 2020;396(10265):1841\u201356.","journal-title":"Bipolar Disorders Lancet"},{"issue":"3","key":"771_CR3","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/BF03256238","volume":"11","author":"T Bremer","year":"2007","unstructured":"Bremer T, Diamond C, McKinney R, Shehktman T, Barrett TB, Herold C, Kelsoe JR. The pharmacogenetics of lithium response depends upon clinical co-morbidity. Mol Diagn Ther. 2007;11(3):161\u201370.","journal-title":"Mol Diagn Ther"},{"key":"771_CR4","doi-asserted-by":"crossref","unstructured":"Squassina A, Manchia M, Del Zompo M. Pharmacogenomics of mood stabilizers in the treatment of bipolar disorder. Hum Genomics Proteom. 2010:159761.","DOI":"10.4061\/2010\/159761"},{"key":"771_CR5","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.brainres.2008.05.084","volume":"1235","author":"CL Bowden","year":"2008","unstructured":"Bowden CL. Bipolar pathophysiology and development of improved treatments. Brain Res. 2008;1235:92\u20137.","journal-title":"Brain Res"},{"issue":"1","key":"771_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/ajmg.c.20013","volume":"123C","author":"JW Smoller","year":"2003","unstructured":"Smoller JW, Christine TF. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet C Semin Med Genet. 2003;123\u00a0C(1):48\u201358.","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"2","key":"771_CR7","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1176\/appi.ajp.161.2.217","volume":"161","author":"JR Geddes","year":"2004","unstructured":"Geddes JR, Burgess S, Hawton K, Jamison K, Goodwin GM. Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. Am J Psychiat. 2004;161(2):217\u201322.","journal-title":"Am J Psychiat"},{"key":"771_CR8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12888-016-0732-x","volume":"16","author":"KJ Oedegaard","year":"2016","unstructured":"Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, et al. The pharmacogenomics of bipolar disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016;16:129.","journal-title":"BMC Psychiatry"},{"issue":"1\u20133","key":"771_CR9","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jad.2007.03.003","volume":"104","author":"J Garnham","year":"2007","unstructured":"Garnham J, Munro A, Slaney C, Macdougall M, Passmore M, Duffy A, et al. Prophylactic treatment response in bipolar disorder: results of a naturalistic observation study. J Affect Disord. 2007;104(1\u20133):185\u201390.","journal-title":"J Affect Disord"},{"issue":"5","key":"771_CR10","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/j.1399-5618.2005.00244.x","volume":"7","author":"N Kleindienst","year":"2005","unstructured":"Kleindienst N, Engel R, Greil W. Which clinical factors predict response to prophylactic lithium? A systematic review for bipolar disorders. Bipolar Disord. 2005;7(5):404\u201317.","journal-title":"Bipolar Disord"},{"key":"771_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1192\/S000712500029243X","volume":"Suppl 21","author":"P Grof","year":"1993","unstructured":"Grof P, Alda M, Grof E, Fox D, Cameron P. The challenge of predicting response to stabilizing lithium treatment. The importance of patient selection. Br J Psychiatry. 1993;Suppl 21:16\u20139.","journal-title":"Br J Psychiatry"},{"issue":"10","key":"771_CR12","doi-asserted-by":"publisher","first-page":"942","DOI":"10.4088\/JCP.v63n1013","volume":"63","author":"P Grof","year":"2002","unstructured":"Grof P, Duffy A, Cavazzoni P, Grof E, Garnham J, MacDougall M, et al. Is response to prophylactic lithium a Familial trait? J Clin Psychiatry. 2002;63(10):942\u20137.","journal-title":"J Clin Psychiatry"},{"issue":"6","key":"771_CR13","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1034\/j.1399-5618.2001.30606.x","volume":"3","author":"M Alda","year":"2001","unstructured":"Alda M. Genetic factors and treatment of mood disorders. Bipolar Disord. 2001;3(6):318\u201324.","journal-title":"Bipolar Disord"},{"issue":"2","key":"771_CR14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/acps.13062","volume":"140","author":"TP Hui","year":"2019","unstructured":"Hui TP, Kandola A, Shen L, Lewis G, Osborn DPJ, Geddes JR, Hayes JF. A systematic review and meta-analysis of clinical predictors of lithium response in bipolar disorder. Acta Psychiatr Scand. 2019;140(2):94\u2013115.","journal-title":"Acta Psychiatr Scand"},{"issue":"1","key":"771_CR15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s40345-020-00199-w","volume":"8","author":"J Lee","year":"2020","unstructured":"Lee J, Baek JH, Lee D, Ahn SW, Yang SY, Choi Y, et al. Defining phenotypes of long-term lithium and valproate response, including combination therapy: a modified application of the Alda scale in patients with bipolar disorders. Int J Bipolar Disord. 2020;8(1):36.","journal-title":"Int J Bipolar Disord"},{"issue":"4","key":"771_CR16","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1177\/0269881109102919","volume":"23","author":"GM Goodwin","year":"2009","unstructured":"Goodwin GM. Evidence-based guidelines for treating bipolar disorder: revised second edition\u2014recommendations from the British association for psychopharmacology. J Psychopharmacol. 2009;23(4):346\u201388.","journal-title":"J Psychopharmacol"},{"issue":"7","key":"771_CR17","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1038\/sj.npp.1300190","volume":"28","author":"L Gyulai","year":"2003","unstructured":"Gyulai L, Bowden CL, McElroy SL, Calabrese JR, Petty F, Swann AC, et al. Maintenance efficacy of divalproex in the prevention of bipolar depression. Neuropsychopharmacol. 2003;28(7):1374\u201382.","journal-title":"Neuropsychopharmacol"},{"issue":"1","key":"771_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.coph.2006.07.005","volume":"7","author":"G Shaltiel","year":"2007","unstructured":"Shaltiel G, Chen G, Manji HK. Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder. Curr Opin Pharmacol. 2007;7(1):22\u20136.","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"771_CR19","doi-asserted-by":"publisher","first-page":"e32966","DOI":"10.1002\/ajmg.b.32966","volume":"195","author":"AM Rodr\u00edguez-Ram\u00edrez","year":"2024","unstructured":"Rodr\u00edguez-Ram\u00edrez AM, Cedillo-R\u00edos V, Sanabrais-Jim\u00e9nez MA, Becerra-Palars C, Hern\u00e1ndez-Mu\u00f1oz S, Ortega-Ort\u00edz H, Camarena-Medellin B. Association of BDNF risk variant and dorsolateral cortical thickness with long-term treatment response to valproate in type I bipolar disorder: an exploratory study. Am J Med Genet B Neuropsychiatr Genet. 2024;195(3):e32966.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"2","key":"771_CR20","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s12031-013-9956-0","volume":"50","author":"Z Wang","year":"2013","unstructured":"Wang Z, Fan J, Gao K, Li Z, Yi Z, Wang L, et al. Neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene associated with treatment response to mood stabilizers in patients with bipolar I disorder. J Mol Neurosci. 2013;50(2):305\u201310.","journal-title":"J Mol Neurosci"},{"issue":"5","key":"771_CR21","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1073\/pnas.95.5.2642","volume":"95","author":"S Nonaka","year":"1998","unstructured":"Nonaka S, Hough CJ, Chuang DM. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Proc Natl Acad Sci U S A. 1998;95(5):2642\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"771_CR22","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1016\/S0021-9258(18)53849-7","volume":"268","author":"T Ishii","year":"1993","unstructured":"Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, et al. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem. 1993;268(4):2836\u201343.","journal-title":"J Biol Chem"},{"issue":"1","key":"771_CR23","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1006\/geno.1994.1366","volume":"22","author":"P Mandich","year":"1994","unstructured":"Mandich P, Schito AM, Bellone E, Antonacci R, Finelli P, Rocchi M, Ajmar F. Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12. Genomics. 1994;22(1):216\u20138.","journal-title":"Genomics"},{"key":"771_CR24","doi-asserted-by":"crossref","unstructured":"Korinek M, Serra MC, Abdel Rahman F, Dobrovolski M, Kuchtiak V, Abramova V et al. Disease-associated variants in GRIN1, GRIN2A and GRIN2B genes: insights into NMDA receptor structure, function, and pathophysiology. Physiol Res. 2024; Preprint at http:\/\/www.biomed.cas.cz\/physiolres\/prepress\/935346.pdf","DOI":"10.33549\/physiolres.935346"},{"issue":"1","key":"771_CR25","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1159\/000314708","volume":"62","author":"TG Schulze","year":"2010","unstructured":"Schulze TG, Alda M, Adli M, Akula N, Ardau R, Bui ET, et al. The international consortium on lithium genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. Neuropsychobiology. 2010;62(1):72\u20138.","journal-title":"Neuropsychobiology"},{"key":"771_CR26","volume-title":"R: A Language and environment for statistical computing","author":"R Core Team","year":"2018","unstructured":"R Core Team. R: A Language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2018. https:\/\/www.R-project.org."},{"issue":"12","key":"771_CR27","doi-asserted-by":"publisher","first-page":"5251","DOI":"10.1038\/s41380-023-02149-1","volume":"28","author":"AT Amare","year":"2023","unstructured":"Amare AT, Thalamuthu A, Schubert KO, Fullerton JM, Ahmed M, Hartmann S, et al. Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder. Mol Psychiatry. 2023;28(12):5251\u201361.","journal-title":"Mol Psychiatry"},{"issue":"1","key":"771_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40345-024-00328-9","volume":"12","author":"E Ferensztajn-Rochowiak","year":"2024","unstructured":"Ferensztajn-Rochowiak E, Lewitzka U, Ch\u0142opocka-Wo\u017aniak M, Rybakowski JK. Effectiveness of ultra-long-term lithium treatment: relevant factors and case series. Int J Bipolar Disord. 2024;12(1):7.","journal-title":"Int J Bipolar Disord"},{"issue":"4","key":"771_CR29","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1192\/bjp.2022.28","volume":"220","author":"M Cearns","year":"2022","unstructured":"Cearns M, Amare AT, Schubert KO, Thalamuthu A, Frank J, Streit F, et al. Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach. Br J Psychiatry. 2022;220(4):219\u201328.","journal-title":"Br J Psychiatry"},{"issue":"1","key":"771_CR30","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41398-024-02865-4","volume":"14","author":"M Herrera-Rivero","year":"2024","unstructured":"Herrera-Rivero M, Guti\u00e9rrez-Fragoso K, International Consortium on Lithium Genetics (ConLi\u2009+\u2009Gen), Kurtz J, Baune BT. Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder. Trans Psychiat. 2024;14(1):174.","journal-title":"Trans Psychiat"},{"issue":"2","key":"771_CR31","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/acps.13692","volume":"150","author":"K Scott","year":"2024","unstructured":"Scott K, O\u2019Donovan C, Brancati GE, Cervantes P, Ardau R, Manchia M, et al. Phenotypic clustering of bipolar disorder supports stratification by lithium responsiveness over diagnostic subtypes. Acta Psychiatr Scand. 2024;150(2):91\u2013104.","journal-title":"Acta Psychiatr Scand"},{"issue":"1","key":"771_CR32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40345-024-00341-y","volume":"12","author":"M Herrera-Rivero","year":"2024","unstructured":"Herrera-Rivero M, Adli M, Akiyama K, Akula N, Amare AT, Ardau R, et al. Exploring the genetics of lithium response in bipolar disorders. Int J Bipolar Disord. 2024;12(1):20.","journal-title":"Int J Bipolar Disord"},{"key":"771_CR33","doi-asserted-by":"publisher","first-page":"136590","DOI":"10.1016\/j.neulet.2022.136590","volume":"777","author":"JK Rybakowski","year":"2022","unstructured":"Rybakowski JK, Ferensztajn-Rochowiak E. Mini-review: anomalous association between lithium data and lithium use. Neurosci Lett. 2022;777:136590.","journal-title":"Neurosci Lett"},{"issue":"1","key":"771_CR34","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40345-017-0093-5","volume":"5","author":"SW Ahn","year":"2017","unstructured":"Ahn SW, Baek JH, Yang SY, Kim Y, Cho Y, Choi Y, et al. Long-term response to mood stabilizer treatment and its clinical correlates in patients with bipolar disorders: a retrospective observational study. Int J Bipolar Disord. 2017;5(1):24.","journal-title":"Int J Bipolar Disord"},{"issue":"3","key":"771_CR35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.psychres.2008.05.010","volume":"168","author":"B Kim","year":"2009","unstructured":"Kim B, Kim CY, Lee MJ, Joo YH. Preliminary evidence on the association between XBP1-116\u00a0C\/G polymorphism and response to prophylactic treatment with valproate in bipolar disorders. Psychiatry Res. 2009;168(3):209\u201312.","journal-title":"Psychiatry Res"},{"issue":"4","key":"771_CR36","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1176\/appi.focus.20230009","volume":"21","author":"K Keramatian","year":"2023","unstructured":"Keramatian K, Chithra NK, Yatham LN. The CANMAT and ISBD guidelines for the treatment of bipolar disorder: summary and a 2023 update of evidence. Focus. 2023;21(4):344\u201353.","journal-title":"Focus"},{"issue":"2","key":"771_CR37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11920-015-0658-x","volume":"18","author":"SJ Khan","year":"2016","unstructured":"Khan SJ, Fersh ME, Ernst C, Klipstein K, Albertini ES, Lusskin SI. Bipolar disorder in pregnancy and postpartum: principles of management. Curr Psychiatry Rep. 2016;18(2):13.","journal-title":"Curr Psychiatry Rep"},{"issue":"3\u20134","key":"771_CR38","doi-asserted-by":"publisher","first-page":"121","DOI":"10.2298\/MPNS1604121O","volume":"69","author":"M Okanovi\u0107","year":"2016","unstructured":"Okanovi\u0107 M, Zivanovi\u0107 O. Valproate, bipolar disorder and polycystic ovarian syndrome. Med Pregl. 2016;69(3\u20134):121\u20136.","journal-title":"Med Pregl"},{"issue":"1","key":"771_CR39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/bdi.13366","volume":"26","author":"B Singh","year":"2024","unstructured":"Singh B, Yocum AK, Strawbridge R, et al. Patterns of pharmacotherapy for bipolar disorder: A GBC survey. Bipolar Disord. 2024;26(1):22\u201332.","journal-title":"Bipolar Disord"},{"issue":"2\u20133","key":"771_CR40","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.schres.2006.02.001","volume":"84","author":"L Martucci","year":"2006","unstructured":"Martucci L, Wong AH, De Luca V, Likhodi O, Wong GW, King N, Kennedy JL. N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: polymorphisms and mRNA levels. Schizophr Res. 2006;84(2\u20133):214\u201321.","journal-title":"Schizophr Res"},{"issue":"6","key":"771_CR41","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1086\/497703","volume":"77","author":"MD Fallin","year":"2005","unstructured":"Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA, et al. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am J Hum Genet. 2005;77(6):918\u201336.","journal-title":"Am J Hum Genet"},{"issue":"11","key":"771_CR42","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/GIM.0b013e318159a37c","volume":"9","author":"D Avramopoulos","year":"2007","unstructured":"Avramopoulos D, Lasseter VK, Fallin MD, Wolyniec PS, McGrath JA, Nestadt G, et al. Stage II follow-up on a linkage scan for bipolar disorder in the ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene. Genet Med. 2007;9(11):745\u201351.","journal-title":"Genet Med"},{"issue":"1\u20132","key":"771_CR43","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.psychres.2009.11.026","volume":"185","author":"Q Zhao","year":"2011","unstructured":"Zhao Q, Che R, Zhang Z, Wang P, Li J, Li Y, et al. Positive association between GRIN2B gene and bipolar disorder in the Chinese Han population. Psychiat Res. 2011;185(1\u20132):290\u20132.","journal-title":"Psychiat Res"},{"issue":"4 Pt 2","key":"771_CR44","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1080\/15622970802514968","volume":"10","author":"A Szczepankiewicz","year":"2009","unstructured":"Szczepankiewicz A, Skibinska M, Rybakowski J, Leszczynska-Rodziewicz A, Tomaszewska M, Twarowska-Hauser J. Lack of association of three GRIN2B polymorphisms with bipolar disorder. World J Biol Psychiatry. 2009;10(4 Pt 2):469\u201373.","journal-title":"World J Biol Psychiatry"},{"issue":"1","key":"771_CR45","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s11011-015-9762-1","volume":"31","author":"S Dalvie","year":"2016","unstructured":"Dalvie S, Fabbri C, Ramesar R, Serretti A, Stein DJ. Glutamatergic and HPA-axis pathway genes in bipolar disorder comorbid with alcohol- and substance use disorders. Metab Brain Dis. 2016;31(1):183\u20139.","journal-title":"Metab Brain Dis"},{"issue":"3","key":"771_CR46","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/S1734-1140(09)70085-4","volume":"61","author":"A Szczepankiewicz","year":"2009","unstructured":"Szczepankiewicz A, Skibi\u0144ska M, Suwalska A, Hauser J, Rybakowski JK. No association of three GRIN2B polymorphisms with lithium response in bipolar patients. Pharmacol Rep. 2009;61(3):448\u201352.","journal-title":"Pharmacol Rep"},{"issue":"3","key":"771_CR47","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1177\/0269881111415736","volume":"26","author":"JK Rybakowski","year":"2012","unstructured":"Rybakowski JK, Czerski P, Dmitrzak-Weglarz M, Kliwicki S, Leszczynska-Rodziewicz A, Permoda-Osip A, et al. Clinical and pathogenic aspects of candidate genes for lithium prophylactic efficacy. J Psychopharmacol. 2012;26(3):368\u201373.","journal-title":"J Psychopharmacol"},{"issue":"2","key":"771_CR48","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.neulet.2012.01.061","volume":"512","author":"HJ Yoo","year":"2012","unstructured":"Yoo HJ, Cho IH, Park M, Yang SY, Kim SA. Family based association of GRIN2A and GRIN2B with Korean autism spectrum disorders. Neurosci Lett. 2012;512(2):89\u201393.","journal-title":"Neurosci Lett"},{"key":"771_CR49","doi-asserted-by":"publisher","first-page":"1348387","DOI":"10.3389\/fgene.2024.1348387","volume":"15","author":"D Zou","year":"2024","unstructured":"Zou D, Zeng Q, Liu P, Wei Y, Guo R, Zhu Y, He RR. Association of glutamate receptor gene polymorphisms with attention-deficit hyperactivity disorder susceptibility: a systematic review and meta-analysis. Front Genet. 2024;15:1348387.","journal-title":"Front Genet"},{"issue":"6","key":"771_CR50","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1101\/gr.229102","volume":"12","author":"WJ Kent","year":"2002","unstructured":"Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, Haussler D. The human genome browser at UCSC. Genome Res. 2002;12(6):996\u20131006.","journal-title":"Genome Res"},{"issue":"6","key":"771_CR51","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.cell.2015.02.029","volume":"160","author":"V Presnyak","year":"2015","unstructured":"Presnyak V, Alhusaini N, Chen YH, Martin S, Morris N, Kline N, et al. Codon optimality is a major determinant of mRNA stability. Cell. 2015;160(6):1111\u201324.","journal-title":"Cell"},{"issue":"2","key":"771_CR52","doi-asserted-by":"publisher","first-page":"e0228730","DOI":"10.1371\/journal.pone.0228730","volume":"15","author":"ME Forrest","year":"2020","unstructured":"Forrest ME, Pinkard O, Martin S, Sweet TJ, Hanson G, Coller J. Codon and amino acid content are associated with mRNA stability in mammalian cells. PLoS ONE. 2020;15(2):e0228730.","journal-title":"PLoS ONE"},{"key":"771_CR53","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jpsychires.2014.08.006","volume":"58","author":"R Pinacho","year":"2014","unstructured":"Pinacho R, Valdiz\u00e1n EM, Pilar-Cuellar F, Prades R, Tarrag\u00f3 T, Haro JM, et al. Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia. J Psychiat Res. 2014;58:189\u201396.","journal-title":"J Psychiat Res"},{"issue":"1","key":"771_CR54","first-page":"82","volume":"14","author":"X Zhou","year":"2009","unstructured":"Zhou X, Nie Z, Roberts A, Zhang D, Sebat, Malhotra D, Kelsoe JR. Reduced expression of the Sp4 gene in bipolar disorder and schizophrenia. Mol Psychiat. 2009;14(1):82\u201392.","journal-title":"Mol Psychiat"},{"issue":"10","key":"771_CR55","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1016\/j.euroneuro.2015.05.006","volume":"25","author":"R Pinacho","year":"2015","unstructured":"Pinacho R, Saia G, Fust\u00e9 M, Mel\u00e9ndez-P\u00e9rez I, Villalta-Gil V, Haro JM, et al. Transcription factor SP4 phosphorylation is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjects. Eur Neuropsychopharmacol. 2015;25(10):1650\u201360.","journal-title":"Eur Neuropsychopharmacol"},{"issue":"20","key":"771_CR56","doi-asserted-by":"publisher","first-page":"17785","DOI":"10.1074\/jbc.M209430200","volume":"278","author":"IJ Arinze","year":"2003","unstructured":"Arinze IJ, Kawai Y. Sp family of transcription factors is involved in valproic acid-induced expression of Galphai2. J Biol Chem. 2003;278(20):17785\u201391.","journal-title":"J Biol Chem"},{"issue":"13","key":"771_CR57","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.3390\/nu14132673","volume":"14","author":"M Moreno-Torres","year":"2022","unstructured":"Moreno-Torres M, Guzm\u00e1n C, Petrov PD, Jover R. Valproate and Short-Chain fatty acids activate transcription of the human vitamin D receptor gene through a proximal GC-Rich DNA region containing two putative Sp1 binding sites. Nutrients. 2022;14(13):2673.","journal-title":"Nutrients"},{"issue":"1","key":"771_CR58","first-page":"113","volume":"80","author":"J Zhang","year":"2014","unstructured":"Zhang J, Lanuza GM, Britanova O, Rouaux C, Suliman-Barkat R, Cebri\u00e1n-Silla A, et al. Sustained activity-dependent Inhibition via Npas4 regulates excitatory-inhibitory balance within neural circuits. Neuron. 2014;80(1):113\u201328.","journal-title":"Neuron"},{"issue":"1","key":"771_CR59","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1186\/s12888-024-05869-y","volume":"24","author":"L Zhao","year":"2024","unstructured":"Zhao L, Bo Q, Zhang Z, Li F, Zhou Y, Wang C. Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study. BMC Psychiatry. 2024;24(1):428.","journal-title":"BMC Psychiatry"},{"issue":"9","key":"771_CR60","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1111\/jnc.16098","volume":"168","author":"A Chaves-Filho","year":"2024","unstructured":"Chaves-Filho A, Eyres C, Bl\u00f6baum L, Landwehr A, Tremblay M\u00c8. The emerging neuroimmune hypothesis of bipolar disorder: an updated overview of neuroimmune and microglial findings. J Neurochem. 2024;168(9):1780\u2013816.","journal-title":"J Neurochem"},{"issue":"3","key":"771_CR61","first-page":"e90070","volume":"9","author":"Y Chu","year":"2014","unstructured":"Chu Y, Hughes S, Chan SL, Mobley WC. KLF12 regulates NGF-Induced neurite outgrowth through a CREB-Dependent mechanism. PLoS ONE. 2014;9(3):e90070.","journal-title":"PLoS ONE"},{"issue":"1","key":"771_CR62","first-page":"85","volume":"43","author":"K Takahashi","year":"2002","unstructured":"Takahashi K, Liu FC, Oishi T, Mori T, Higo N, Hayashi M, Takahashi H. Expression of transcription factor Sp2 in the primate cerebral cortex. Neurosci Res. 2002;43(1):85\u201392.","journal-title":"Neurosci Res"},{"issue":"3","key":"771_CR63","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/acn3.39","volume":"1","author":"TM Pierson","year":"2014","unstructured":"Pierson TM, Yuan H, Marsh ED, Fuentes-Fajardo K, Adams DR, Markello T, et al. GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine. Ann Clin Transl Neurol. 2014;1(3):190\u20138.","journal-title":"Ann Clin Transl Neurol"},{"issue":"3","key":"771_CR64","doi-asserted-by":"publisher","first-page":"107523","DOI":"10.1016\/j.ymgme.2023.107523","volume":"138","author":"B den Hollander","year":"2023","unstructured":"den Hollander B, Veenvliet ARJ, Rothuizen-Lindenschot M, van Essen P, Peters G, et al. Evidence for effect of L-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder. Mol Genet Metab. 2023;138(3):107523.","journal-title":"Mol Genet Metab"},{"issue":"1","key":"771_CR65","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/ajmg.b.30084","volume":"132B","author":"JH Adams","year":"2005","unstructured":"Adams JH, Wigg KG, King N, Burcescu I, Vetr\u00f3 A, Kiss E, et al. Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders. Am J Med Genet B Neuropsychiatr Genet. 2005;132B(1):90\u20135.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"8","key":"771_CR66","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/mp.2009.43","volume":"14","author":"EN Smith","year":"2009","unstructured":"Smith EN, Bloss CS, Badner JA, Barrett T, Belmonte PL, Berrettini W, et al. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry. 2009;14(8):755\u201363.","journal-title":"Mol Psychiatry"},{"issue":"11","key":"771_CR67","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.2217\/14622416.9.11.1595","volume":"9","author":"M Dmitrzak-Weglarz","year":"2008","unstructured":"Dmitrzak-Weglarz M, Rybakowski JK, Suwalska A, Skibinska M, Leszczynska-Rodziewicz A, Szczepankiewicz A, Hauser J. Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients. Pharmacogenomics. 2008;9(11):1595\u2013603.","journal-title":"Pharmacogenomics"},{"key":"771_CR68","doi-asserted-by":"publisher","first-page":"1559496","DOI":"10.3389\/fgene.2025.1559496","volume":"16","author":"JW Mugo","year":"2025","unstructured":"Mugo JW, Mulder N, Chimusa ER. Data simulation to optimize frameworks for genome-wide association studies in diverse populations. Front Genet. 2025;16:1559496.","journal-title":"Front Genet"},{"issue":"3","key":"771_CR69","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1503\/jpn.100048","volume":"36","author":"RM Thompson","year":"2011","unstructured":"Thompson RM, Weickert CS, Wyatt E, Webster MJ, Decreased BDNF. trkB-TK\u2009+\u2009and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. J Psychiatry Neurosci. 2011;36(3):195\u2013203.","journal-title":"J Psychiatry Neurosci"},{"issue":"14","key":"771_CR70","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.jpsychires.2009.03.008","volume":"43","author":"JS Dunham","year":"2009","unstructured":"Dunham JS, Deakin JF, Miyajima F, Payton A, Toro CT. Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains. J Psychiatr Res. 2009;43(14):1175\u201384.","journal-title":"J Psychiatr Res"},{"issue":"1\u20132","key":"771_CR71","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1615\/CritRevNeurobiol.v16.i12.90","volume":"16","author":"DM Chuang","year":"2004","unstructured":"Chuang DM. Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases? Crit Rev Neurobiol. 2004;16(1\u20132):83\u201390.","journal-title":"Crit Rev Neurobiol"},{"issue":"5","key":"771_CR72","doi-asserted-by":"publisher","first-page":"741","DOI":"10.3390\/brainsci13050741","volume":"13","author":"JK Rybakowski","year":"2023","unstructured":"Rybakowski JK. Mood stabilizers of first and second generation. Brain Sci. 2023;13(5):741.","journal-title":"Brain Sci"},{"issue":"3","key":"771_CR73","doi-asserted-by":"publisher","first-page":"e100","DOI":"10.1192\/bjo.2024.51","volume":"10","author":"F Bartoli","year":"2024","unstructured":"Bartoli F, Bassetti C, Gazzola M, Gianfelice L, Cavaleri D, Crocamo C, Carr\u00e0 G. Prevalence and correlates of manic\/hypomanic and depressive predominant Polarity in bipolar disorder: systematic review and meta-analysis. B J Psych Open. 2024;10(3):e100.","journal-title":"B J Psych Open"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-025-00771-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43440-025-00771-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-025-00771-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:16:59Z","timestamp":1758082619000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43440-025-00771-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":73,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["771"],"URL":"https:\/\/doi.org\/10.1007\/s43440-025-00771-0","relation":{},"ISSN":["1734-1140","2299-5684"],"issn-type":[{"value":"1734-1140","type":"print"},{"value":"2299-5684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]},"assertion":[{"value":"17 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The investigation was conducted in accordance with the latest version of the Declaration of Helsinki. Informed consent was obtained from all participants. The study protocol was approved by the Scientific Committee (No. IC-16024.0) and the Research Ethics Committee of the National Institute of Psychiatry Ramon de la Fuente Mu\u00f1iz (No. CEI\/C\/030\/2015).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}