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The minimum number of animals and intensity of noxious stimuli were used to achieve consistent results. All animal experiments were approved by the Ethics Committee on Animal Use (CEUA) of the Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil (ID: 30124).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable, as this study did not involve human subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}