{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:51:54Z","timestamp":1791492714657,"version":"4.3.4"},"reference-count":280,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacol. Rep"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s43440-026-00827-9","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T03:54:36Z","timestamp":1769572476000},"page":"351-373","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The synaptic triad in depression: how stress-related pathways converge on BDNF, NMDA receptor, and MMP-9"],"prefix":"10.1007","volume":"78","author":[{"given":"Bartosz Adam","family":"Frycz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Dutsch-Wicherek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"P\u0142aza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Szulc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bijata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8343-2340","authenticated-orcid":false,"given":"Jakub","family":"Wlodarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3834-2175","authenticated-orcid":false,"given":"Joanna","family":"Dzwonek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"827_CR1","doi-asserted-by":"publisher","DOI":"10.17179\/EXCLI2017-480","author":"H Yaribeygi","year":"2017","unstructured":"Yaribeygi H, Panahi Y, Sahraei H, Johnston TP, Sahebkar A. The impact of stress on body function: a review. Excli J 16Doc1057 ISSN 1611\u20132156 [Internet]. IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund; 2017. https:\/\/doi.org\/10.17179\/EXCLI2017-480.","journal-title":"Excli J"},{"key":"827_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-025-00806-6","author":"MM Bose","year":"2025","unstructured":"Bose MM, Govindula A, Nampoothiri M, Arora D, Mudgal J. The HPA axis and kynurenine pathway: exploring the role of stress and neuroinflammation in treatment-resistant depression. Pharmacol Rep [Internet]. 2025. https:\/\/doi.org\/10.1007\/s43440-025-00806-6. cited 2025 Dec 16.","journal-title":"Pharmacol Rep"},{"key":"827_CR3","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s11920-016-0723-0","volume":"18","author":"SSY Li","year":"2016","unstructured":"Li SSY, Liddell BJ, Nickerson A. The relationship between post-migration stress and psychological disorders in refugees and asylum seekers. Curr Psychiatry Rep. 2016;18:82. https:\/\/doi.org\/10.1007\/s11920-016-0723-0.","journal-title":"Curr Psychiatry Rep"},{"key":"827_CR4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jad.2020.08.001","volume":"277","author":"J Xiong","year":"2020","unstructured":"Xiong J, Lipsitz O, Nasri F, Lui LMW, Gill H, Phan L, et al. Impact of COVID-19 pandemic on mental health in the general population: a systematic review. J Affect Disord. 2020;277:55\u201364. https:\/\/doi.org\/10.1016\/j.jad.2020.08.001.","journal-title":"J Affect Disord"},{"key":"827_CR5","doi-asserted-by":"publisher","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders [Internet]. DSM-5-TR. American Psychiatric Association Publishing; 2022. https:\/\/doi.org\/10.1176\/appi.books.9780890425787.","DOI":"10.1176\/appi.books.9780890425787"},{"key":"827_CR6","first-page":"356","volume-title":"Cognitive therapy and the emotional disorders","author":"AT Beck","year":"1976","unstructured":"Beck AT. Cognitive therapy and the emotional disorders. Oxford, England: International Universities Press; 1976. p. 356."},{"key":"827_CR7","doi-asserted-by":"publisher","unstructured":"Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the national comorbidity survey replication (NCS-R). JAMA. 2003;289:3095. https:\/\/doi.org\/10.1001\/jama.289.23.3095.","DOI":"10.1001\/jama.289.23.3095"},{"key":"827_CR8","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41398-022-01900-6","volume":"12","author":"SI Franklyn","year":"2022","unstructured":"Franklyn SI, Stewart J, Beaurepaire C, Thaw E, McQuaid RJ. Developing symptom clusters: linking inflammatory biomarkers to depressive symptom profiles. Transl Psychiatry. 2022;12:133. https:\/\/doi.org\/10.1038\/s41398-022-01900-6.","journal-title":"Transl Psychiatry"},{"key":"827_CR9","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/pcn.12299","volume":"69","author":"H Kunugi","year":"2015","unstructured":"Kunugi H, Hori H, Ogawa S. Biochemical markers subtyping major depressive disorder. Psychiatry Clin Neurosci. 2015;69:597\u2013608. https:\/\/doi.org\/10.1111\/pcn.12299.","journal-title":"Psychiatry Clin Neurosci"},{"key":"827_CR10","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.2147\/NDT.S114542","volume":"13","author":"R Strawbridge","year":"2017","unstructured":"Strawbridge R, Young AH, Cleare AJ. Biomarkers for depression: recent insights, current challenges and future prospects. Neuropsychiatr Dis Treat. 2017;13:1245\u201362. https:\/\/doi.org\/10.2147\/NDT.S114542.","journal-title":"Neuropsychiatr Dis Treat"},{"key":"827_CR11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jad.2017.09.052","volume":"233","author":"MF Juruena","year":"2018","unstructured":"Juruena MF, Bocharova M, Agustini B, Young AH. Atypical depression and non-atypical depression: is HPA axis function a biomarker? A systematic review. J Affect Disord. 2018;233:45\u201367. https:\/\/doi.org\/10.1016\/j.jad.2017.09.052.","journal-title":"J Affect Disord"},{"key":"827_CR12","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/mp.2012.144","volume":"18","author":"F Lamers","year":"2013","unstructured":"Lamers F, Vogelzangs N, Merikangas KR, De Jonge P, Beekman ATF, Penninx BWJH. Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Mol Psychiatry. 2013;18:692\u201399. https:\/\/doi.org\/10.1038\/mp.2012.144.","journal-title":"Mol Psychiatry"},{"key":"827_CR13","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1038\/s41380-022-01661-0","volume":"28","author":"J Moncrieff","year":"2023","unstructured":"Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry. 2023;28:3243\u201356. https:\/\/doi.org\/10.1038\/s41380-022-01661-0.","journal-title":"Mol Psychiatry"},{"key":"827_CR14","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1371\/journal.pmed.0050045","volume-title":"PLoS Med","author":"I Kirsch","year":"2008","unstructured":"Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT. Initial severity and antidepressant benefits: a meta-analysis of data submitted to the food and drug administration. Hay P, editor. PLoS Med. 2008;5:e45. https:\/\/doi.org\/10.1371\/journal.pmed.0050045."},{"key":"827_CR15","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3122\/jabfm.2014.01.130145","volume":"27","author":"SY Lin","year":"2014","unstructured":"Lin SY, Stevens MB. The symptom cluster-based approach to individualize patient-centered treatment for major depression. J Am Board Fam Med. 2014;27:151\u201359. https:\/\/doi.org\/10.3122\/jabfm.2014.01.130145.","journal-title":"J Am Board Fam Med"},{"key":"827_CR16","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1001\/jamapsychiatry.2017.0025","volume":"74","author":"AM Chekroud","year":"2017","unstructured":"Chekroud AM, Gueorguieva R, Krumholz HM, Trivedi MH, Krystal JH, McCarthy G. Reevaluating the efficacy and predictability of antidepressant treatments: a symptom clustering approach. JAMA Psychiatry. 2017;74:370. https:\/\/doi.org\/10.1001\/jamapsychiatry.2017.0025.","journal-title":"JAMA Psychiatry"},{"key":"827_CR17","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/s41386-024-02044-5","volume":"50","author":"J Saelens","year":"2025","unstructured":"Saelens J, Gramser A, Watzal V, Zarate CA, Lanzenberger R, Kraus C. Relative effectiveness of antidepressant treatments in treatment-resistant depression: a systematic review and network meta-analysis of randomized controlled trials. Neuropsychopharmacology. 2025;50:913\u201319. https:\/\/doi.org\/10.1038\/s41386-024-02044-5.","journal-title":"Neuropsychopharmacology"},{"key":"827_CR18","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1056\/NEJMoa2302399","volume":"388","author":"A Anand","year":"2023","unstructured":"Anand A, Mathew SJ, Sanacora G, Murrough JW, Goes FS, Altinay M, et al. Ketamine versus ECT for nonpsychotic treatment-resistant major depression. N Engl J Med. 2023;388:2315\u201325. https:\/\/doi.org\/10.1056\/NEJMoa2302399.","journal-title":"N Engl J Med"},{"key":"827_CR19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4736","author":"S Rizvi","year":"2019","unstructured":"Rizvi S, Khan AM. Use of transcranial magnetic stimulation for depression. Cureus [Internet]. 2019. https:\/\/doi.org\/10.7759\/cureus.4736.","journal-title":"Cureus"},{"key":"827_CR20","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nm.4050","volume":"22","author":"RS Duman","year":"2016","unstructured":"Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med. 2016;22:238\u201349. https:\/\/doi.org\/10.1038\/nm.4050.","journal-title":"Nat Med"},{"key":"827_CR21","doi-asserted-by":"publisher","first-page":"636","DOI":"10.2174\/1570159x13666150630175044","volume":"13","author":"JD Rosenblat","year":"2015","unstructured":"Rosenblat JD, McIntyre RS, Alves GS, Fountoulakis KN, Carvalho AF. Beyond monoamines-novel targets for treatment-resistant depression: a comprehensive review. Curr Neuropharmacol. 2015;13:636\u201355. https:\/\/doi.org\/10.2174\/1570159x13666150630175044.","journal-title":"Curr Neuropharmacol"},{"key":"827_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09820-3","author":"AD Grotzinger","year":"2025","unstructured":"Grotzinger AD, Werme J, Peyrot WJ, Frei O, De Leeuw C, Bicks LK, et al. Mapping the genetic landscape across 14 psychiatric disorders. Nature [Internet]. 2025. https:\/\/doi.org\/10.1038\/s41586-025-09820-3.","journal-title":"Nature"},{"key":"827_CR23","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","volume":"59","author":"RS Duman","year":"2006","unstructured":"Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry. 2006;59:1116\u201327. https:\/\/doi.org\/10.1016\/j.biopsych.2006.02.013.","journal-title":"Biol Psychiatry"},{"key":"827_CR24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/dneu.20758","volume":"70","author":"E Castr\u00e9n","year":"2010","unstructured":"Castr\u00e9n E, Rantam\u00e4ki T. The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity. Dev Neurobiol. 2010;70:289\u201397. https:\/\/doi.org\/10.1002\/dneu.20758.","journal-title":"Dev Neurobiol"},{"key":"827_CR25","doi-asserted-by":"publisher","first-page":"28587","DOI":"10.1074\/jbc.M110.125740","volume":"285","author":"C Finsterwald","year":"2010","unstructured":"Finsterwald C, Fiumelli H, Cardinaux J-R, Martin J-L. Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate. J Biol Chem. 2010;285:28587\u201395. https:\/\/doi.org\/10.1074\/jbc.M110.125740.","journal-title":"J Biol Chem"},{"key":"827_CR26","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1006\/mcne.1998.0684","volume":"11","author":"T Zigova","year":"1998","unstructured":"Zigova T, Pencea V, Wiegand SJ, Luskin MB. Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci. 1998;11:234\u201345. https:\/\/doi.org\/10.1006\/mcne.1998.0684.","journal-title":"Mol Cell Neurosci"},{"key":"827_CR27","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/374450a0","volume":"374","author":"A Acheson","year":"1995","unstructured":"Acheson A, Conover JC, Fandl JP, DeChiara TM, Russell M, Thadani A, et al. A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature. 1995;374:450\u201353. https:\/\/doi.org\/10.1038\/374450a0.","journal-title":"Nature"},{"key":"827_CR28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/08977190410001723308","volume":"22","author":"DK Binder","year":"2004","unstructured":"Binder DK, Scharfman HE. Brain-derived neurotrophic factor. Growth Factors Chur Switz. 2004;22:123\u201331. https:\/\/doi.org\/10.1080\/08977190410001723308.","journal-title":"Growth Factors Chur Switz"},{"key":"827_CR29","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1007\/s00213-018-4950-4","volume":"235","author":"MJF Levy","year":"2018","unstructured":"Levy MJF, Boulle F, Steinbusch HW, Hove DLA, Kenis G, Lanfumey L. Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression. Psychopharmacol (Berl). 2018;235:2195\u2013220. https:\/\/doi.org\/10.1007\/s00213-018-4950-4.","journal-title":"Psychopharmacol (Berl)"},{"key":"827_CR30","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1098\/rstb.2011.0357","volume":"367","author":"RS Duman","year":"2012","unstructured":"Duman RS, Li N. A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists. Philos Trans R Soc Lond B Biol Sci. 2012;367:2475\u201384. https:\/\/doi.org\/10.1098\/rstb.2011.0357.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"827_CR31","doi-asserted-by":"publisher","first-page":"626906","DOI":"10.3389\/fnbeh.2021.626906","volume":"15","author":"B Arosio","year":"2021","unstructured":"Arosio B, Guerini FR, Voshaar RCO, Aprahamian I. Blood brain-derived neurotrophic factor (BDNF) and major depression: do we have a translational perspective? Front Behav Neurosci. 2021;15:626906. https:\/\/doi.org\/10.3389\/fnbeh.2021.626906.","journal-title":"Front Behav Neurosci"},{"key":"827_CR32","doi-asserted-by":"publisher","first-page":"100630","DOI":"10.1016\/j.jadr.2023.100630","volume":"14","author":"R Philpotts","year":"2023","unstructured":"Philpotts R, Gillan N, Barrow M, Seidler K. Stress-induced alterations in hippocampal BDNF in the pathophysiology of major depressive disorder and the antidepressant effect of saffron. J Affect Disord Rep. 2023;14:100630. https:\/\/doi.org\/10.1016\/j.jadr.2023.100630.","journal-title":"J Affect Disord Rep"},{"key":"827_CR33","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/mp.2009.67","volume":"15","author":"D Taliaz","year":"2010","unstructured":"Taliaz D, Stall N, Dar DE, Zangen A. Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry. 2010;15:80\u201392. https:\/\/doi.org\/10.1038\/mp.2009.67.","journal-title":"Mol Psychiatry"},{"key":"827_CR34","doi-asserted-by":"publisher","first-page":"104502","DOI":"10.1016\/j.ajp.2025.104502","volume":"108","author":"M Chen","year":"2025","unstructured":"Chen M, Jin J, Bi H, Zhang Y, Sun M, Li X, et al. Advances in the study of NMDA receptors in depression pathogenesis and the antidepressant efficacy of their antagonists. Asian J Psychiatry. 2025;108:104502. https:\/\/doi.org\/10.1016\/j.ajp.2025.104502.","journal-title":"Asian J Psychiatry"},{"key":"827_CR35","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/npp.2015.171","volume":"41","author":"BS McEwen","year":"2016","unstructured":"McEwen BS, Nasca C, Gray JD. Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol. 2016;41:3\u201323. https:\/\/doi.org\/10.1038\/npp.2015.171.","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"key":"827_CR36","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuron.2019.03.013","volume":"102","author":"RS Duman","year":"2019","unstructured":"Duman RS, Sanacora G, Krystal JH. Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments. Neuron. 2019;102:75\u201390. https:\/\/doi.org\/10.1016\/j.neuron.2019.03.013.","journal-title":"Neuron"},{"key":"827_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/8388527","volume-title":"Anal cell pathol","author":"S Wang","year":"2021","unstructured":"Wang S, Liu X, Shi W, Qi Q, Zhang G, Li Y, et al. Mechanism of chronic stress-induced glutamatergic neuronal damage in the basolateral amygdaloid nucleus. Lim YP, editor. Anal Cell Pathol. 2021;2021:1\u201314. https:\/\/doi.org\/10.1155\/2021\/8388527."},{"key":"827_CR38","doi-asserted-by":"publisher","first-page":"6521","DOI":"10.3390\/ijms25126521","volume":"25","author":"N Nicosia","year":"2024","unstructured":"Nicosia N, Giovenzana M, Misztak P, Mingardi J, Musazzi L. Glutamate-mediated excitotoxicity in the pathogenesis and treatment of neurodevelopmental and adult mental disorders. Int J Mol Sci. 2024;25:6521. https:\/\/doi.org\/10.3390\/ijms25126521.","journal-title":"Int J Mol Sci"},{"key":"827_CR39","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuropharm.2011.07.036","volume":"62","author":"G Sanacora","year":"2012","unstructured":"Sanacora G, Treccani G, Popoli M. Towards a glutamate hypothesis of depression. Neuropharmacology. 2012;62:63\u201377. https:\/\/doi.org\/10.1016\/j.neuropharm.2011.07.036.","journal-title":"Neuropharmacology"},{"key":"827_CR40","doi-asserted-by":"publisher","unstructured":"Bertollo AG, Santos CF, Bagatini MD, Ign\u00e1cio ZM. Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression. Front Neurosci. 2025;19. https:\/\/doi.org\/10.3389\/fnins.2025.1541075.","DOI":"10.3389\/fnins.2025.1541075"},{"key":"827_CR41","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.biopsych.2006.09.027","volume":"62","author":"S Reppermund","year":"2007","unstructured":"Reppermund S, Zihl J, Lucae S, Horstmann S, Kloiber S, Holsboer F, et al. Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation. Biol Psychiatry. 2007;62:400\u201306. https:\/\/doi.org\/10.1016\/j.biopsych.2006.09.027.","journal-title":"Biol Psychiatry"},{"key":"827_CR42","doi-asserted-by":"publisher","unstructured":"Mikulska J, Juszczyk G, Gawro\u0144ska-Grzywacz M, Herbet M. HPA axis in the pathomechanism of depression and schizophrenia: new therapeutic strategies based on its participation. Brain Sci. 2021;11. https:\/\/doi.org\/10.3390\/brainsci11101298.","DOI":"10.3390\/brainsci11101298"},{"key":"827_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2004.01.006","volume":"125","author":"JJ Radley","year":"2004","unstructured":"Radley JJ, Sisti HM, Hao J, Rocher AB, McCall T, Hof PR, et al. Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex. Neuroscience. 2004;125:1\u20136. https:\/\/doi.org\/10.1016\/j.neuroscience.2004.01.006.","journal-title":"Neuroscience"},{"key":"827_CR44","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.brainres.2015.12.043","volume":"1645","author":"BS McEwen","year":"2016","unstructured":"McEwen BS. Stress-induced remodeling of hippocampal CA3 pyramidal neurons. Brain Res. 2016;1645:50\u201354. https:\/\/doi.org\/10.1016\/j.brainres.2015.12.043.","journal-title":"Brain Res"},{"key":"827_CR45","doi-asserted-by":"publisher","first-page":"7870","DOI":"10.1523\/JNEUROSCI.1184-06.2006","volume":"26","author":"C Liston","year":"2006","unstructured":"Liston C, Miller MM, Goldwater DS, Radley JJ, Rocher AB, Hof PR, et al. Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting. J Neurosci Off J Soc Neurosci. 2006;26:7870\u201374. https:\/\/doi.org\/10.1523\/JNEUROSCI.1184-06.2006.","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"827_CR46","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.biopsych.2017.05.013","volume":"82","author":"TJ Schoenfeld","year":"2017","unstructured":"Schoenfeld TJ, McCausland HC, Morris HD, Padmanaban V, Cameron HA. Stress and loss of adult neurogenesis differentially reduce hippocampal volume. Biol Psychiatry. 2017;82:914\u201323. https:\/\/doi.org\/10.1016\/j.biopsych.2017.05.013.","journal-title":"Biol Psychiatry"},{"key":"827_CR47","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1139\/jpn.0902","volume":"34","author":"H Anisman","year":"2009","unstructured":"Anisman H. Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder. J Psychiatry Neurosci Jpn. 2009;34:4\u201320. https:\/\/doi.org\/10.1139\/jpn.0902.","journal-title":"J Psychiatry Neurosci Jpn"},{"key":"827_CR48","doi-asserted-by":"publisher","first-page":"4881","DOI":"10.1038\/s41380-025-03085-y","volume":"30","author":"X Feng","year":"2025","unstructured":"Feng X, Jia M, Cai M, Zhu T, Hashimoto K, Yang J-J. Central-peripheral neuroimmune dynamics in psychological stress and depression: insights from current research. Mol Psychiatry. 2025;30:4881\u201398. https:\/\/doi.org\/10.1038\/s41380-025-03085-y.","journal-title":"Mol Psychiatry"},{"key":"827_CR49","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/j.amjmed.2025.05.044","volume":"138","author":"M Ring","year":"2025","unstructured":"Ring M. An integrative approach to HPA axis dysfunction: from recognition to recovery. Am J Med. 2025;138:1451\u201363. https:\/\/doi.org\/10.1016\/j.amjmed.2025.05.044.","journal-title":"Am J Med"},{"key":"827_CR50","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/npp.2016.90","volume":"42","author":"C M\u00e9nard","year":"2017","unstructured":"M\u00e9nard C, Pfau ML, Hodes GE, Russo SJ. Immune and neuroendocrine mechanisms of stress vulnerability and resilience. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol. 2017;42:62\u201380. https:\/\/doi.org\/10.1038\/npp.2016.90.","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"key":"827_CR51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12974-024-03312-3","volume":"22","author":"W Jiao","year":"2025","unstructured":"Jiao W, Lin J, Deng Y, Ji Y, Liang C, Wei S, et al. The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms. J Neuroinflammation. 2025;22:10. https:\/\/doi.org\/10.1186\/s12974-024-03312-3.","journal-title":"J Neuroinflammation"},{"key":"827_CR52","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.psyneuen.2017.01.035","volume":"78","author":"X Chen","year":"2017","unstructured":"Chen X, Gianferante D, Hanlin L, Fiksdal A, Breines JG, Thoma M, et al. HPA-axis and inflammatory reactivity to acute stress is related with basal HPA-axis activity. Psychoneuroendocrinology. 2017;78:168\u201376. https:\/\/doi.org\/10.1016\/j.psyneuen.2017.01.035.","journal-title":"Psychoneuroendocrinology"},{"key":"827_CR53","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1159\/000104854","volume":"13","author":"BE Leonard","year":"2006","unstructured":"Leonard BE. HPA and immune axes in stress: involvement of the serotonergic system. Neuroimmunomodulation. 2006;13:268\u201376. https:\/\/doi.org\/10.1159\/000104854.","journal-title":"Neuroimmunomodulation"},{"key":"827_CR54","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3109\/10253891003667862","volume":"13","author":"A Ahmad","year":"2010","unstructured":"Ahmad A, Rasheed N, Banu N, Palit G. Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress. Stress Amst Neth. 2010;13:355\u201364. https:\/\/doi.org\/10.3109\/10253891003667862.","journal-title":"Stress Amst Neth"},{"key":"827_CR55","doi-asserted-by":"publisher","first-page":"e18369","DOI":"10.1016\/j.heliyon.2023.e18369","volume":"9","author":"H Zhou","year":"2023","unstructured":"Zhou H, Wang K, Xu Z, Liu D, Wang Y, Guo M. Chronic unpredictable stress induces depression\/anxiety-related behaviors and alterations of hippocampal monoamine receptor mRNA expression in female mice at different ages. Heliyon. 2023;9:e18369. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e18369.","journal-title":"Heliyon"},{"key":"827_CR56","doi-asserted-by":"publisher","first-page":"115023","DOI":"10.1016\/j.bbr.2024.115023","volume":"467","author":"A D\u00edez-Solinska","year":"2024","unstructured":"D\u00edez-Solinska A, Go\u00f1i-Balentziaga O, Beitia-Oyarzabal G, Mu\u00f1oz-Culla M, Vegas O, Azkona G. Chronic defeat stress induces monoamine level dysregulation in the prefrontal cortex but not in the hippocampus of OF1 male mice. Behav Brain Res. 2024;467:115023. https:\/\/doi.org\/10.1016\/j.bbr.2024.115023.","journal-title":"Behav Brain Res"},{"key":"827_CR57","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.brainres.2011.12.049","volume":"1476","author":"F Mora","year":"2012","unstructured":"Mora F, Segovia G, Arco A, Blas M, Garrido P. Stress, neurotransmitters, corticosterone and body-brain integration. Brain Res. 2012;1476:71\u201385. https:\/\/doi.org\/10.1016\/j.brainres.2011.12.049.","journal-title":"Brain Res"},{"key":"827_CR58","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.mehy.2011.06.021","volume":"77","author":"WN Marsden","year":"2011","unstructured":"Marsden WN. Stressor-induced NMDAR dysfunction as a unifying hypothesis for the aetiology, pathogenesis and comorbidity of clinical depression. Med Hypotheses. 2011;77:508\u201328. https:\/\/doi.org\/10.1016\/j.mehy.2011.06.021.","journal-title":"Med Hypotheses"},{"key":"827_CR59","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2147\/NDT.S268012","volume":"17","author":"F Ren","year":"2021","unstructured":"Ren F, Guo R. Synaptic microenvironment in depressive disorder: insights from synaptic plasticity. Neuropsychiatr Dis Treat. 2021;17:157\u201365. https:\/\/doi.org\/10.2147\/NDT.S268012.","journal-title":"Neuropsychiatr Dis Treat"},{"key":"827_CR60","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1523\/JNEUROSCI.22-05-01532.2002","volume":"22","author":"S-W Ying","year":"2002","unstructured":"Ying S-W, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TVP, et al. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of arc synthesis. J Neurosci Off J Soc Neurosci. 2002;22:1532\u201340. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-05-01532.2002.","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"827_CR61","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/s41380-019-0426-0","volume":"24","author":"VS Sohal","year":"2019","unstructured":"Sohal VS, Rubenstein JLR. Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders. Mol Psychiatry. 2019;24:1248\u201357. https:\/\/doi.org\/10.1038\/s41380-019-0426-0.","journal-title":"Mol Psychiatry"},{"key":"827_CR62","doi-asserted-by":"publisher","first-page":"7281","DOI":"10.1523\/JNEUROSCI.23-19-07281.2003","volume":"23","author":"V Korz","year":"2003","unstructured":"Korz V, Frey JU. Stress-related modulation of hippocampal long-term potentiation in rats: involvement of adrenal steroid receptors. J Neurosci Off J Soc Neurosci. 2003;23:7281\u201387. https:\/\/doi.org\/10.1523\/JNEUROSCI.23-19-07281.2003.","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"827_CR63","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.brainres.2009.03.055","volume":"1273","author":"F Neugebauer","year":"2009","unstructured":"Neugebauer F, Korz V, Frey JU. Modulation of extracellular monoamine transmitter concentrations in the hippocampus after weak and strong tetanization of the perforant path in freely moving rats. Brain Res. 2009;1273:29\u201338. https:\/\/doi.org\/10.1016\/j.brainres.2009.03.055.","journal-title":"Brain Res"},{"key":"827_CR64","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.mjafi.2020.09.014","volume":"79","author":"VS Chauhan","year":"2023","unstructured":"Chauhan VS, Khan SA, Kulhari K. Correlation of brain-derived neurotrophic factor with severity of depression and treatment response. Med J Armed Forces India. 2023;79:451\u201357. https:\/\/doi.org\/10.1016\/j.mjafi.2020.09.014.","journal-title":"Med J Armed Forces India"},{"key":"827_CR65","doi-asserted-by":"publisher","first-page":"110532","DOI":"10.1016\/j.celrep.2022.110532","volume":"38","author":"M Bijata","year":"2022","unstructured":"Bijata M, B\u0105czy\u0144ska E, M\u00fcller FE, Bijata K, Masternak J, Krzystyniak A, et al. Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior. Cell Rep. 2022;38:110532. https:\/\/doi.org\/10.1016\/j.celrep.2022.110532.","journal-title":"Cell Rep"},{"key":"827_CR66","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.08.569797","author":"D Legutko","year":"2024","unstructured":"Legutko D, Ku\u017aniewska B, Kalita K, Yasuda R, Kaczmarek L, Michaluk P. BDNF signaling requires matrix metalloproteinase-9 during structural synaptic plasticity. BioRxiv Prepr Serv Biol. 2024. https:\/\/doi.org\/10.1101\/2023.12.08.569797.","journal-title":"BioRxiv Prepr Serv Biol"},{"key":"827_CR67","doi-asserted-by":"publisher","first-page":"eadx2369","DOI":"10.1126\/sciadv.adx2369","volume":"11","author":"D Legutko","year":"2025","unstructured":"Legutko D, Bijoch L, Olszak G, Ku\u017aniewska B, Kalita K, Yasuda R, et al. BDNF-driven synaptic plasticity requires autocrine matrix metalloproteinase-9 activity. Sci Adv. 2025;11:eadx2369. https:\/\/doi.org\/10.1126\/sciadv.adx2369.","journal-title":"Sci Adv"},{"key":"827_CR68","doi-asserted-by":"publisher","first-page":"4995","DOI":"10.1038\/ncomms5995","volume":"5","author":"MA Van Der Kooij","year":"2014","unstructured":"Van Der Kooij MA, Fantin M, Rejmak E, Grosse J, Zanoletti O, Fournier C, et al. Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations. Nat Commun. 2014;5:4995. https:\/\/doi.org\/10.1038\/ncomms5995.","journal-title":"Nat Commun"},{"key":"827_CR69","doi-asserted-by":"publisher","first-page":"861843","DOI":"10.3389\/fneur.2022.861843","volume":"13","author":"H Li","year":"2022","unstructured":"Li H, Sheng Z, Khan S, Zhang R, Liu Y, Zhang Y, et al. Matrix metalloproteinase-9 as an important contributor to the pathophysiology of depression. Front Neurol. 2022;13:861843. https:\/\/doi.org\/10.3389\/fneur.2022.861843.","journal-title":"Front Neurol"},{"key":"827_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.07.084","author":"T Bartsch","year":"2015","unstructured":"Bartsch T, Wulff P. The hippocampus in aging and disease: from plasticity to vulnerability. United States; 2015. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.07.084.","journal-title":"U States"},{"key":"827_CR71","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1134\/S0006297917030014","volume":"82","author":"N Gulyaeva","year":"2017","unstructured":"Gulyaeva N. Molecular mechanisms of neuroplasticity: an expanding universe. Biochem Biokhimiia. 2017;82:237\u201342. https:\/\/doi.org\/10.1134\/S0006297917030014.","journal-title":"Biochem Biokhimiia"},{"key":"827_CR72","doi-asserted-by":"publisher","first-page":"e00464","DOI":"10.1016\/j.neurot.2024.e00464","volume":"21","author":"Q Song","year":"2024","unstructured":"Song Q, S E, Zhang Z, Liang Y. Neuroplasticity in the transition from acute to chronic pain. Neurother J Am Soc Exp Neurother. 2024;21:e00464. https:\/\/doi.org\/10.1016\/j.neurot.2024.e00464.","journal-title":"Neurother J Am Soc Exp Neurother"},{"key":"827_CR73","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.biopsych.2024.10.016","volume":"97","author":"EJ Hermans","year":"2025","unstructured":"Hermans EJ, Hendler T, Kalisch R. Building resilience: the stress response as a driving force for neuroplasticity and adaptation. Biol Psychiatry. 2025;97:330\u201338. https:\/\/doi.org\/10.1016\/j.biopsych.2024.10.016.","journal-title":"Biol Psychiatry"},{"key":"827_CR74","doi-asserted-by":"publisher","first-page":"11","DOI":"10.31887\/DCNS.2013.15.1\/jhenley","volume":"15","author":"JM Henley","year":"2013","unstructured":"Henley JM, Wilkinson KA. AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging. Dialogues Clin Neurosci. 2013;15:11\u201327. https:\/\/doi.org\/10.31887\/DCNS.2013.15.1\/jhenley.","journal-title":"Dialogues Clin Neurosci"},{"key":"827_CR75","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1016\/j.celrep.2018.07.073","volume":"24","author":"D Niculescu","year":"2018","unstructured":"Niculescu D, Michaelsen-Preusse K, G\u00fcner \u00dc, Dorland R, Wierenga CJ, Lohmann C. A BDNF-mediated push-pull plasticity mechanism for synaptic Clustering. Cell Rep. 2018;24:2063\u201374. https:\/\/doi.org\/10.1016\/j.celrep.2018.07.073.","journal-title":"Cell Rep"},{"key":"827_CR76","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/sj.npp.1301574","volume":"33","author":"C Pittenger","year":"2008","unstructured":"Pittenger C, Duman RS. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol. 2008;33:88\u2013109. https:\/\/doi.org\/10.1038\/sj.npp.1301574.","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"key":"827_CR77","doi-asserted-by":"publisher","first-page":"101","DOI":"10.18388\/pb.2018_119","volume":"64","author":"L Kaczmarek","year":"2018","unstructured":"Kaczmarek L. From c-Fos to MMP-9: In control of synaptic plasticity to produce healthy and diseased mind, a personal view. Postepy Biochem. 2018;64:101\u201309. https:\/\/doi.org\/10.18388\/pb.2018_119.","journal-title":"Postepy Biochem"},{"key":"827_CR78","doi-asserted-by":"publisher","first-page":"100728","DOI":"10.1016\/j.bbih.2024.100728","volume":"36","author":"J Xiao","year":"2024","unstructured":"Xiao J, Huang J, Yolken RH. Elevated matrix metalloproteinase-9 associated with reduced cerebellar perineuronal nets in female mice with toxoplasmosis. Brain Behav Immun - Health. 2024;36:100728. https:\/\/doi.org\/10.1016\/j.bbih.2024.100728.","journal-title":"Brain Behav Immun - Health"},{"key":"827_CR79","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/dneu.20774","volume":"70","author":"S Cohen-Cory","year":"2010","unstructured":"Cohen-Cory S, Kidane AH, Shirkey NJ, Marshak S. Brain-derived neurotrophic factor and the development of structural neuronal connectivity. Dev Neurobiol. 2010;70:271\u201388. https:\/\/doi.org\/10.1002\/dneu.20774.","journal-title":"Dev Neurobiol"},{"key":"827_CR80","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/j.celrep.2018.07.020","volume":"24","author":"P-Y Lin","year":"2018","unstructured":"Lin P-Y, Kavalali ET, Monteggia LM. Genetic dissection of presynaptic and postsynaptic BDNF-TrkB signaling in synaptic efficacy of CA3-CA1 synapses. Cell Rep. 2018;24:1550\u201361. https:\/\/doi.org\/10.1016\/j.celrep.2018.07.020.","journal-title":"Cell Rep"},{"key":"827_CR81","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1007\/s00018-019-03180-8","volume":"76","author":"A Beroun","year":"2019","unstructured":"Beroun A, Mitra S, Michaluk P, Pijet B, Stefaniuk M, Kaczmarek L. Mmps in learning and memory and neuropsychiatric disorders. Cell Mol Life Sci. 2019;76:3207\u201328. https:\/\/doi.org\/10.1007\/s00018-019-03180-8.","journal-title":"Cell Mol Life Sci"},{"key":"827_CR82","doi-asserted-by":"publisher","first-page":"4643","DOI":"10.1038\/s41467-021-24810-5","volume":"12","author":"S Martinelli","year":"2021","unstructured":"Martinelli S, Anderzhanova EA, Bajaj T, Wiechmann S, Dethloff F, Weckmann K, et al. Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nat Commun. 2021;12:4643. https:\/\/doi.org\/10.1038\/s41467-021-24810-5.","journal-title":"Nat Commun"},{"key":"827_CR83","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/glia.24464","volume":"72","author":"AG Kokkosis","year":"2024","unstructured":"Kokkosis AG, Madeira MM, Hage Z, Valais K, Koliatsis D, Resutov E, et al. Chronic psychosocial stress triggers microglial-\/macrophage-induced inflammatory responses leading to neuronal dysfunction and depressive-related behavior. Glia. 2024;72:111\u201332. https:\/\/doi.org\/10.1002\/glia.24464.","journal-title":"Glia"},{"key":"827_CR84","first-page":"2346","volume":"122","author":"Z He","year":"2009","unstructured":"He Z, Huang Z, Chen X, Zou Z. Effects of matrix metalloproteinase 9 inhibition on the blood brain barrier and inflammation in rats following cardiopulmonary resuscitation. Chin Med J (Engl). 2009;122:2346\u201351.","journal-title":"Chin Med J (Engl)"},{"key":"827_CR85","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1161\/STROKEAHA.107.500868","volume":"39","author":"A Rosell","year":"2008","unstructured":"Rosell A, Cuadrado E, Ortega-Aznar A, Hern\u00e1ndez-Guillamon M, Lo EH, Montaner J. MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke. 2008;39:1121\u201326. https:\/\/doi.org\/10.1161\/STROKEAHA.107.500868.","journal-title":"Stroke"},{"key":"827_CR86","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.brainresbull.2020.11.005","volume":"166","author":"M Wang","year":"2021","unstructured":"Wang M, Xie Y, Qin D. Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases. Brain Res Bull. 2021;166:172\u201384. https:\/\/doi.org\/10.1016\/j.brainresbull.2020.11.005.","journal-title":"Brain Res Bull"},{"key":"827_CR87","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s41398-021-01667-2","volume":"11","author":"B Yang","year":"2021","unstructured":"Yang B, Wang L, Nie Y, Wei W, Xiong W. proBDNF expression induces apoptosis and inhibits synaptic regeneration by regulating the RhoA-JNK pathway in an in vitro post-stroke depression model. Transl Psychiatry. 2021;11:578. https:\/\/doi.org\/10.1038\/s41398-021-01667-2.","journal-title":"Transl Psychiatry"},{"key":"827_CR88","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.3390\/ijms26104926","volume":"26","author":"M Mitrovic","year":"2025","unstructured":"Mitrovic M, Selakovic D, Jovicic N, Ljujic B, Rosic G. BDNF\/proBDNF interplay in the mediation of neuronal apoptotic mechanisms in neurodegenerative diseases. Int J Mol Sci. 2025;26:4926. https:\/\/doi.org\/10.3390\/ijms26104926.","journal-title":"Int J Mol Sci"},{"key":"827_CR89","doi-asserted-by":"crossref","unstructured":"Romash IR, Vynnyk MI. Peculiarities of brain-derived neurotrophic factor and matrix metaloproteinase-9 expression dynamics in patients with paranoid schizophrenia depending on the duration of the disease. Wiadomosci Lek Wars Pol 1960. 2021;74:2728\u201332.","DOI":"10.36740\/WLek202111108"},{"key":"827_CR90","doi-asserted-by":"publisher","unstructured":"Wang F, Pan F, Shapiro LA, Huang JH. Stress induced neuroplasticity and mental disorders. Neural Plast. 2017;2017:9634501. https:\/\/doi.org\/10.1155\/2017\/9634501.","DOI":"10.1155\/2017\/9634501"},{"key":"827_CR91","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1523\/JNEUROSCI.15-03-01768.1995","volume":"15","author":"MA Smith","year":"1995","unstructured":"Smith MA, Makino S, Kvetnansky R, Post RM. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci Off J Soc Neurosci. 1995;15:1768\u201377. https:\/\/doi.org\/10.1523\/JNEUROSCI.15-03-01768.1995.","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"827_CR92","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1365-2826.2005.01390.x","volume":"18","author":"AC Hansson","year":"2006","unstructured":"Hansson AC, Sommer WH, Metsis M, Str\u00f6mberg I, Agnati LF, Fuxe K. Corticosterone actions on the hippocampal brain-derived neurotrophic factor expression are mediated by Exon IV promoter. J Neuroendocrinol. 2006;18:104\u201314. https:\/\/doi.org\/10.1111\/j.1365-2826.2005.01390.x.","journal-title":"J Neuroendocrinol"},{"key":"827_CR93","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/s0304-3940(99)00335-3","volume":"267","author":"M Nibuya","year":"1999","unstructured":"Nibuya M, Takahashi M, Russell DS, Duman RS. Repeated stress increases catalytic TrkB mRNA in rat hippocampus. Neurosci Lett. 1999;267:81\u201384. https:\/\/doi.org\/10.1016\/s0304-3940(99)00335-3.","journal-title":"Neurosci Lett"},{"key":"827_CR94","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1126\/science.1086446","volume":"302","author":"WG Chen","year":"2003","unstructured":"Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC, et al. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science. 2003;302:885\u201389. https:\/\/doi.org\/10.1126\/science.1086446.","journal-title":"Science"},{"key":"827_CR95","doi-asserted-by":"publisher","first-page":"14960","DOI":"10.1073\/pnas.1516016112","volume":"112","author":"C Nasca","year":"2015","unstructured":"Nasca C, Zelli D, Bigio B, Piccinin S, Scaccianoce S, Nistic\u00f2 R, et al. Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity. Proc Natl Acad Sci USA. 2015;112:14960\u201365. https:\/\/doi.org\/10.1073\/pnas.1516016112.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"827_CR96","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.bbrc.2017.05.157","volume":"489","author":"M Choi","year":"2017","unstructured":"Choi M, Lee SH, Park MH, Kim Y-S, Son H. Ketamine induces brain-derived neurotrophic factor expression via phosphorylation of histone deacetylase 5 in rats. Biochem Biophys Res Commun. 2017;489:420\u201325. https:\/\/doi.org\/10.1016\/j.bbrc.2017.05.157.","journal-title":"Biochem Biophys Res Commun"},{"key":"827_CR97","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s00018-023-04817-5","volume":"80","author":"DD Li Puma","year":"2023","unstructured":"Li Puma DD, Colussi C, Bandiera B, Puliatti G, Rinaudo M, Cocco S, et al. Interleukin 1\u03b2 triggers synaptic and memory deficits in Herpes simplex virus type-1-infected mice by downregulating the expression of synaptic plasticity-related genes via the epigenetic MeCP2\/HDAC4 complex. Cell Mol Life Sci CMLS. 2023;80:172. https:\/\/doi.org\/10.1007\/s00018-023-04817-5.","journal-title":"Cell Mol Life Sci CMLS"},{"key":"827_CR98","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S0165-5728(02)00270-9","volume":"133","author":"EV Yang","year":"2002","unstructured":"Yang EV, Bane CM, MacCallum RC, Kiecolt-Glaser JK, Malarkey WB, Glaser R. Stress-related modulation of matrix metalloproteinase expression. J Neuroimmunol. 2002;133:144\u201350. https:\/\/doi.org\/10.1016\/S0165-5728(02)00270-9.","journal-title":"J Neuroimmunol"},{"key":"827_CR99","doi-asserted-by":"publisher","unstructured":"Anderson RM, Johnson SB, Lingg RT, Hinz DC, Romig-Martin SA, Radley JJ. Evidence for similar prefrontal structural and functional alterations in male and female rats following chronic stress or glucocorticoid exposure. Cereb Cortex N Y N. 1991. 2020;30:353\u201370. https:\/\/doi.org\/10.1093\/cercor\/bhz092.","DOI":"10.1093\/cercor\/bhz092"},{"key":"827_CR100","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.tins.2012.08.006","volume":"35","author":"N Sousa","year":"2012","unstructured":"Sousa N, Almeida OFX. Disconnection and reconnection: the morphological basis of (mal)adaptation to stress. Trends Neurosci. 2012;35:742\u201351. https:\/\/doi.org\/10.1016\/j.tins.2012.08.006.","journal-title":"Trends Neurosci"},{"key":"827_CR101","doi-asserted-by":"publisher","first-page":"16074","DOI":"10.1073\/pnas.1110444108","volume":"108","author":"C Liston","year":"2011","unstructured":"Liston C, Gan W-B. Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo. Proc Natl Acad Sci USA. 2011;108:16074\u201379. https:\/\/doi.org\/10.1073\/pnas.1110444108.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"827_CR102","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0079-6123(00)26026-3","volume":"126","author":"G Rajkowska","year":"2000","unstructured":"Rajkowska G. Histopathology of the prefrontal cortex in major depression: what does it tell us about dysfunctional monoaminergic circuits? Prog Brain Res. 2000;126:397\u2013412. https:\/\/doi.org\/10.1016\/S0079-6123(00)26026-3.","journal-title":"Prog Brain Res"},{"key":"827_CR103","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/s0006-3223(00)00950-1","volume":"48","author":"G Rajkowska","year":"2000","unstructured":"Rajkowska G. Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biol Psychiatry. 2000;48:766\u201377. https:\/\/doi.org\/10.1016\/s0006-3223(00)00950-1.","journal-title":"Biol Psychiatry"},{"key":"827_CR104","doi-asserted-by":"publisher","unstructured":"Cotter D, Mackay D, Chana G, Beasley C, Landau S, Everall IP. Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder. Cereb Cortex N Y N. 1991. 2002;12:386\u201394. https:\/\/doi.org\/10.1093\/cercor\/12.4.386.","DOI":"10.1093\/cercor\/12.4.386"},{"key":"827_CR105","doi-asserted-by":"publisher","first-page":"107865","DOI":"10.1016\/j.celrep.2020.107865","volume":"32","author":"F Agasse","year":"2020","unstructured":"Agasse F, Mendez-David I, Christaller W, Carpentier R, Braz BY, David DJ, et al. Chronic corticosterone elevation suppresses adult hippocampal neurogenesis by hyperphosphorylating huntingtin. Cell Rep. 2020;32:107865. https:\/\/doi.org\/10.1016\/j.celrep.2020.107865.","journal-title":"Cell Rep"},{"key":"827_CR106","doi-asserted-by":"publisher","first-page":"852680","DOI":"10.3389\/fnins.2022.852680","volume":"16","author":"G Kempermann","year":"2022","unstructured":"Kempermann G. What is adult hippocampal neurogenesis good for? Front Neurosci. 2022;16:852680. https:\/\/doi.org\/10.3389\/fnins.2022.852680.","journal-title":"Front Neurosci"},{"key":"827_CR107","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41539-022-00133-y","volume":"7","author":"KL Jones","year":"2022","unstructured":"Jones KL, Zhou M, Jhaveri DJ. Dissecting the role of adult hippocampal neurogenesis towards resilience versus susceptibility to stress-related mood disorders. NPJ Sci Learn. 2022;7:16. https:\/\/doi.org\/10.1038\/s41539-022-00133-y.","journal-title":"NPJ Sci Learn"},{"key":"827_CR108","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1073\/pnas.0307294101","volume":"101","author":"LP Reagan","year":"2004","unstructured":"Reagan LP, Rosell DR, Wood GE, Spedding M, Mu\u00f1oz C, Rothstein J, et al. Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine. Proc Natl Acad Sci USA. 2004;101:2179\u201384. https:\/\/doi.org\/10.1073\/pnas.0307294101.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"827_CR109","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1134\/S0006297923050012","volume":"88","author":"N Gulyaeva","year":"2023","unstructured":"Gulyaeva N. Glucocorticoids orchestrate adult hippocampal plasticity: growth points and translational aspects. Biochem Biokhimiia. 2023;88:565\u201389. https:\/\/doi.org\/10.1134\/S0006297923050012.","journal-title":"Biochem Biokhimiia"},{"key":"827_CR110","doi-asserted-by":"publisher","first-page":"100554","DOI":"10.1016\/j.bbih.2022.100554","volume":"26","author":"B Richardson","year":"2022","unstructured":"Richardson B, MacPherson A, Bambico F. Neuroinflammation and neuroprogression in depression: effects of alternative drug treatments. Brain Behav Immun - Health. 2022;26:100554. https:\/\/doi.org\/10.1016\/j.bbih.2022.100554.","journal-title":"Brain Behav Immun - Health"},{"key":"827_CR111","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.bbi.2006.03.005","volume":"21","author":"MG Frank","year":"2007","unstructured":"Frank MG, Baratta M, Sprunger DB, Watkins LR, Maier SF. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun. 2007;21:47\u201359. https:\/\/doi.org\/10.1016\/j.bbi.2006.03.005.","journal-title":"Brain Behav Immun"},{"key":"827_CR112","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12974-025-03512-5","volume":"22","author":"F Placeres-Uray","year":"2025","unstructured":"Placeres-Uray F, Gorthy AS, Torres MD, Atkins CM. Inhibition of microglia priming by NLRP3 reduces the impact of early life stress and mild TBI. J Neuroinflammation. 2025;22:185. https:\/\/doi.org\/10.1186\/s12974-025-03512-5.","journal-title":"J Neuroinflammation"},{"key":"827_CR113","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/j.1460-9568.2010.07343.x","volume":"32","author":"MS Beattie","year":"2010","unstructured":"Beattie MS, Ferguson AR, Bresnahan JC. AMPA-receptor trafficking and injury-induced cell death. Eur J Neurosci. 2010;32:290\u201397. https:\/\/doi.org\/10.1111\/j.1460-9568.2010.07343.x.","journal-title":"Eur J Neurosci"},{"key":"827_CR114","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1021\/acschemneuro.8b00511","volume":"10","author":"GA Prieto","year":"2019","unstructured":"Prieto GA, Smith ED, Tong L, Nguyen M, Cotman CW. Inhibition of LTP-Induced translation by IL-1\u03b2 reduces the level of newly synthesized proteins in hippocampal dendrites. ACS Chem Neurosci. 2019;10:1197\u2013203. https:\/\/doi.org\/10.1021\/acschemneuro.8b00511.","journal-title":"ACS Chem Neurosci"},{"key":"827_CR115","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1001\/archpsyc.1997.01830190015002","volume":"54","author":"RS Duman","year":"1997","unstructured":"Duman RS. A molecular and cellular theory of depression. Arch Gen Psychiatry. 1997;54:597. https:\/\/doi.org\/10.1001\/archpsyc.1997.01830190015002.","journal-title":"Arch Gen Psychiatry"},{"key":"827_CR116","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3349\/ymj.2010.51.5.661","volume":"51","author":"S-S Shi","year":"2010","unstructured":"Shi S-S, Shao S, Yuan B, Pan F, Li Z-L. Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. Yonsei Med J. 2010;51:661. https:\/\/doi.org\/10.3349\/ymj.2010.51.5.661.","journal-title":"Yonsei Med J"},{"key":"827_CR117","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.brainres.2006.06.077","volume":"1110","author":"JPR Jacobsen","year":"2006","unstructured":"Jacobsen JPR, M\u00f8rk A. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain Res. 2006;1110:221\u201325. https:\/\/doi.org\/10.1016\/j.brainres.2006.06.077.","journal-title":"Brain Res"},{"key":"827_CR118","doi-asserted-by":"publisher","first-page":"CPath.S12530","DOI":"10.4137\/CPath.S12530","volume":"6","author":"R Banerjee","year":"2013","unstructured":"Banerjee R, Ghosh AK, Ghosh B, Bhattacharyya S, Mondal AC. Decreased mRNA and protein expression of BDNF, NGF, and their receptors in the hippocampus from suicide: an analysis in human postmortem brain. Clin Med Insights Pathol. 2013;6:CPath.S12530. https:\/\/doi.org\/10.4137\/CPath.S12530.","journal-title":"Clin Med Insights Pathol"},{"key":"827_CR119","doi-asserted-by":"publisher","first-page":"1247422","DOI":"10.3389\/fnmol.2023.1247422","volume":"16","author":"T Numakawa","year":"2023","unstructured":"Numakawa T, Kajihara R. Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases. Front Mol Neurosci. 2023;16:1247422. https:\/\/doi.org\/10.3389\/fnmol.2023.1247422.","journal-title":"Front Mol Neurosci"},{"key":"827_CR120","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/nn1903","volume":"10","author":"A Yoshii","year":"2007","unstructured":"Yoshii A, Constantine-Paton M. BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Nat Neurosci. 2007;10:702\u201311. https:\/\/doi.org\/10.1038\/nn1903.","journal-title":"Nat Neurosci"},{"key":"827_CR121","doi-asserted-by":"publisher","unstructured":"Dickerson F, Katsafanas E, Origoni A, Rowe K, Khan S, Mukhtar F, et al. Levels of matrix metalloproteinase 9 (MMP-9) are elevated in persons with major depressive disorder who have had a recent suicide attempt. Brain Behav Immun - Health. 2025;101163. https:\/\/doi.org\/10.1016\/j.bbih.2025.101163.","DOI":"10.1016\/j.bbih.2025.101163"},{"key":"827_CR122","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1242\/jcs.090852","volume":"124","author":"P Michaluk","year":"2011","unstructured":"Michaluk P, Wawrzyniak M, Alot P, Szczot M, Wyrembek P, Mercik K, et al. Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology. J Cell Sci. 2011;124:3369\u201380. https:\/\/doi.org\/10.1242\/jcs.090852.","journal-title":"J Cell Sci"},{"key":"827_CR123","doi-asserted-by":"publisher","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","volume":"15","author":"M Nibuya","year":"1995","unstructured":"Nibuya M, Morinobu S, Duman R. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci. 1995;15:7539\u201347. https:\/\/doi.org\/10.1523\/JNEUROSCI.15-11-07539.1995.","journal-title":"J Neurosci"},{"key":"827_CR124","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1523\/JNEUROSCI.16-07-02365.1996","volume":"16","author":"M Nibuya","year":"1996","unstructured":"Nibuya M, Nestler E, Duman R. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci. 1996;16:2365\u201372. https:\/\/doi.org\/10.1523\/JNEUROSCI.16-07-02365.1996.","journal-title":"J Neurosci"},{"key":"827_CR125","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1523\/JNEUROSCI.22-08-03251.2002","volume":"22","author":"Y Shirayama","year":"2002","unstructured":"Shirayama Y, Chen A-H, Nakagawa S, Russell DS, Duman RS. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci. 2002;22:3251\u201361. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-08-03251.2002.","journal-title":"J Neurosci"},{"key":"827_CR126","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/S0006-3223(03)00073-8","volume":"54","author":"CA Altar","year":"2003","unstructured":"Altar CA, Whitehead RE, Chen R, W\u00f6rtwein G, Madsen TM. Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biol Psychiatry. 2003;54:703\u201309. https:\/\/doi.org\/10.1016\/S0006-3223(03)00073-8.","journal-title":"Biol Psychiatry"},{"key":"827_CR127","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neulet.2017.09.011","volume":"660","author":"S Enomoto","year":"2017","unstructured":"Enomoto S, Shimizu K, Nibuya M, Suzuki E, Nagata K, Kondo T. Activated brain-derived neurotrophic factor\/TrkB signaling in rat dorsal and ventral hippocampi following 10-day electroconvulsive seizure treatment. Neurosci Lett. 2017;660:45\u201350. https:\/\/doi.org\/10.1016\/j.neulet.2017.09.011.","journal-title":"Neurosci Lett"},{"key":"827_CR128","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0278-5846(03)00173-8","volume":"28","author":"UG Kang","year":"2004","unstructured":"Kang UG, Roh M-S, Jung J-R, Shin SY, Lee YH, Park J-B, et al. Activation of protein kinase B (Akt) signaling after electroconvulsive shock in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:41\u201344. https:\/\/doi.org\/10.1016\/S0278-5846(03)00173-8.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"827_CR129","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00213-021-06015-2","volume":"239","author":"SH Kim","year":"2022","unstructured":"Kim SH, Yu HS, Huh S, Kang UG, Kim YS. Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex. Psychopharmacol (Berl). 2022;239:443\u201354. https:\/\/doi.org\/10.1007\/s00213-021-06015-2.","journal-title":"Psychopharmacol (Berl)"},{"key":"827_CR130","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.biopsych.2021.05.008","volume":"90","author":"E Castr\u00e9n","year":"2021","unstructured":"Castr\u00e9n E, Monteggia LM. Brain-derived neurotrophic factor signaling in depression and antidepressant action. Biol Psychiatry. 2021;90:128\u201336. https:\/\/doi.org\/10.1016\/j.biopsych.2021.05.008.","journal-title":"Biol Psychiatry"},{"key":"827_CR131","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jpsychires.2016.08.004","volume":"83","author":"RB Rocha","year":"2016","unstructured":"Rocha RB, Dondossola ER, Grande AJ, Colonetti T, Ceretta LB, Passos IC, et al. Increased BDNF levels after electroconvulsive therapy in patients with major depressive disorder: a meta-analysis study. J Psychiatr Res. 2016;83:47\u201353. https:\/\/doi.org\/10.1016\/j.jpsychires.2016.08.004.","journal-title":"J Psychiatr Res"},{"key":"827_CR132","doi-asserted-by":"publisher","first-page":"114857","DOI":"10.1016\/j.psychres.2022.114857","volume":"317","author":"S Meshkat","year":"2022","unstructured":"Meshkat S, Alnefeesi Y, Jawad MY, Di Vincenzo DJ, Rodrigues BN, Ceban F, et al. Brain-derived neurotrophic factor (BDNF) as a biomarker of treatment response in patients with treatment resistant depression (TRD): a systematic review & meta-analysis. Psychiatry Res. 2022;317:114857. https:\/\/doi.org\/10.1016\/j.psychres.2022.114857.","journal-title":"Psychiatry Res"},{"key":"827_CR133","doi-asserted-by":"publisher","first-page":"yw019","DOI":"10.1093\/ijnp\/pyw019","volume":"19","author":"C Shibasaki","year":"2016","unstructured":"Shibasaki C, Takebayashi M, Itagaki K, Abe H, Kajitani N, Okada-Tsuchioka M, et al. Altered serum levels of matrix metalloproteinase-2, -9 in response to electroconvulsive therapy for mood disorders. Int J Neuropsychopharmacol. 2016;19:yw019. https:\/\/doi.org\/10.1093\/ijnp\/pyw019.","journal-title":"Int J Neuropsychopharmacol"},{"key":"827_CR134","doi-asserted-by":"publisher","first-page":"100389","DOI":"10.1016\/j.bbih.2021.100389","volume":"18","author":"D Loef","year":"2021","unstructured":"Loef D, Vansteelandt K, Oudega ML, Van Eijndhoven P, Carlier A, Van Exel E, et al. The ratio and interaction between neurotrophin and immune signaling during electroconvulsive therapy in late-life depression. Brain Behav Immun - Health. 2021;18:100389. https:\/\/doi.org\/10.1016\/j.bbih.2021.100389.","journal-title":"Brain Behav Immun - Health"},{"key":"827_CR135","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1503\/jpn.140322","volume":"41","author":"F Bouckaert","year":"2016","unstructured":"Bouckaert F, De Winter F-L, Emsell L, Dols A, Rhebergen D, Wampers M, et al. Grey matter volume increase following electroconvulsive therapy in patients with late life depression: a longitudinal MRI study. J Psychiatry Neurosci. 2016;41:105\u201314. https:\/\/doi.org\/10.1503\/jpn.140322.","journal-title":"J Psychiatry Neurosci"},{"key":"827_CR136","doi-asserted-by":"publisher","first-page":"172837","DOI":"10.1016\/j.pbb.2019.172837","volume":"188","author":"S Deyama","year":"2020","unstructured":"Deyama S, Duman RS. Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine. Pharmacol Biochem Behav. 2020;188:172837. https:\/\/doi.org\/10.1016\/j.pbb.2019.172837.","journal-title":"Pharmacol Biochem Behav"},{"key":"827_CR137","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/s41593-023-01316-5","volume":"26","author":"R Moliner","year":"2023","unstructured":"Moliner R, Girych M, Brunello CA, Kovaleva V, Biojone C, Enkavi G, et al. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB. Nat Neurosci. 2023;26:1032\u201341. https:\/\/doi.org\/10.1038\/s41593-023-01316-5.","journal-title":"Nat Neurosci"},{"key":"827_CR138","doi-asserted-by":"publisher","first-page":"104371","DOI":"10.1016\/j.drudis.2025.104371","volume":"30","author":"S Castanheira","year":"2025","unstructured":"Castanheira S, Gomes CV, Bicker J, Fortuna A. Novel mechanisms underlying rapid-acting antidepressants: ketamine-like compounds, neurosteroid GABAkines, and psychedelics. Drug Discov Today. 2025;30:104371. https:\/\/doi.org\/10.1016\/j.drudis.2025.104371.","journal-title":"Drug Discov Today"},{"key":"827_CR139","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/ijnp\/pyy022","volume":"21","author":"F Chen","year":"2018","unstructured":"Chen F, Danladi J, Ardalan M, Elfving B, M\u00fcller HK, Wegener G, et al. A critical role of mitochondria in BDNF-Associated synaptic plasticity after one-week Vortioxetine treatment. Int J Neuropsychopharmacol. 2018;21:603\u201315. https:\/\/doi.org\/10.1093\/ijnp\/pyy022.","journal-title":"Int J Neuropsychopharmacol"},{"key":"827_CR140","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/7260130","volume":"2017","author":"C Phillips","year":"2017","unstructured":"Phillips C. Brain-derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection. Neural Plast. 2017;2017:1\u201317. https:\/\/doi.org\/10.1155\/2017\/7260130.","journal-title":"Neural Plast"},{"key":"827_CR141","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrn3820","volume":"15","author":"RP Bazinet","year":"2014","unstructured":"Bazinet RP, Lay\u00e9 S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014;15:771\u201385. https:\/\/doi.org\/10.1038\/nrn3820.","journal-title":"Nat Rev Neurosci"},{"key":"827_CR142","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.mehy.2006.06.019","volume":"68","author":"S-J Tsai","year":"2007","unstructured":"Tsai S-J. TrkB partial agonists: potential treatment strategy for major depression. Med Hypotheses. 2007;68:674\u201376. https:\/\/doi.org\/10.1016\/j.mehy.2006.06.019.","journal-title":"Med Hypotheses"},{"key":"827_CR143","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1038\/s41380-023-02193-x","volume":"28","author":"Y-T Hu","year":"2023","unstructured":"Hu Y-T, Tan Z-L, Hirjak D, Northoff G. Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA- and glutamatergic alterations. Mol Psychiatry. 2023;28:3257\u201366. https:\/\/doi.org\/10.1038\/s41380-023-02193-x.","journal-title":"Mol Psychiatry"},{"key":"827_CR144","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/mp.2008.106","volume":"15","author":"M Banasr","year":"2010","unstructured":"Banasr M, Chowdhury GMI, Terwilliger R, Newton SS, Duman RS, Behar KL, et al. Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Mol Psychiatry. 2010;15:501\u201311. https:\/\/doi.org\/10.1038\/mp.2008.106.","journal-title":"Mol Psychiatry"},{"key":"827_CR145","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neuron.2013.06.028","volume":"79","author":"BS McEwen","year":"2013","unstructured":"McEwen BS, Morrison JH. The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course. Neuron. 2013;79:16\u201329. https:\/\/doi.org\/10.1016\/j.neuron.2013.06.028.","journal-title":"Neuron"},{"key":"827_CR146","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1093\/ijnp\/pyab002","volume":"24","author":"C Fee","year":"2021","unstructured":"Fee C, Prevot TD, Misquitta K, Knutson DE, Li G, Mondal P, et al. Behavioral deficits induced by somatostatin-Positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation. Int J Neuropsychopharmacol. 2021;24:505\u201318. https:\/\/doi.org\/10.1093\/ijnp\/pyab002.","journal-title":"Int J Neuropsychopharmacol"},{"key":"827_CR147","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1017\/S1461145709990587","volume":"13","author":"B Karolewicz","year":"2010","unstructured":"Karolewicz B, Maciag D, O\u2019Dwyer G, Stockmeier CA, Feyissa AM, Rajkowska G. Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression. Int J Neuropsychopharmacol. 2010;13:411. https:\/\/doi.org\/10.1017\/S1461145709990587.","journal-title":"Int J Neuropsychopharmacol"},{"key":"827_CR148","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/mp.2010.120","volume":"16","author":"B Luscher","year":"2011","unstructured":"Luscher B, Shen Q, Sahir N. The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry. 2011;16:383\u2013406. https:\/\/doi.org\/10.1038\/mp.2010.120.","journal-title":"Mol Psychiatry"},{"key":"827_CR149","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3389\/fncir.2016.00076","volume":"10","author":"I Yavorska","year":"2016","unstructured":"Yavorska I, Wehr M. Somatostatin-expressing inhibitory interneurons in cortical circuits. Front Neural Circuits. 2016;10:76. https:\/\/doi.org\/10.3389\/fncir.2016.00076.","journal-title":"Front Neural Circuits"},{"key":"827_CR150","doi-asserted-by":"publisher","first-page":"4271","DOI":"10.3390\/ijms26094271","volume":"26","author":"C Toader","year":"2025","unstructured":"Toader C, Serban M, Munteanu O, Covache-Busuioc R-A, Enyedi M, Ciurea AV, et al. From synaptic plasticity to neurodegeneration: BDNF as a transformative target in medicine. Int J Mol Sci. 2025;26:4271. https:\/\/doi.org\/10.3390\/ijms26094271.","journal-title":"Int J Mol Sci"},{"key":"827_CR151","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1172\/JCI130808","volume":"130","author":"DM Gerhard","year":"2020","unstructured":"Gerhard DM, Pothula S, Liu R-J, Wu M, Li X-Y, Girgenti MJ, et al. GABA interneurons are the cellular trigger for ketamine\u2019s rapid antidepressant actions. J Clin Invest. 2020;130:1336\u201349. https:\/\/doi.org\/10.1172\/JCI130808.","journal-title":"J Clin Invest"},{"key":"827_CR152","doi-asserted-by":"publisher","unstructured":"Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Novel molecular targets for mood disorders and psychosis: proceedings of a workshop [Internet]. Bain L, Matney C, Stroud C, editors. Washington, D.C: National Academies Press; 2021. p. 26218. https:\/\/doi.org\/10.17226\/26218.","DOI":"10.17226\/26218"},{"key":"827_CR153","doi-asserted-by":"publisher","first-page":"109325","DOI":"10.1016\/j.neuropharm.2022.109325","volume":"223","author":"T Kato","year":"2023","unstructured":"Kato T. Role of mTOR1 signaling in the antidepressant effects of ketamine and the potential of mTORC1 activators as novel antidepressants. Neuropharmacology. 2023;223:109325. https:\/\/doi.org\/10.1016\/j.neuropharm.2022.109325.","journal-title":"Neuropharmacology"},{"key":"827_CR154","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/bs.apha.2020.04.005","volume-title":"Adv Pharmacol","author":"K Suzuki","year":"2020","unstructured":"Suzuki K, Monteggia LM. The role of eEF2 kinase in the rapid antidepressant actions of ketamine. Adv Pharmacol [Internet]. Elsevier; 2020. p. 79\u201399. https:\/\/doi.org\/10.1016\/bs.apha.2020.04.005."},{"key":"827_CR155","doi-asserted-by":"publisher","first-page":"13658","DOI":"10.3390\/ijms252413658","volume":"25","author":"Z Antos","year":"2024","unstructured":"Antos Z, \u017bukow X, Bursztynowicz L, Jakub\u00f3w P. Beyond NMDA receptors: a narrative review of Ketamine\u2019s rapid and multifaceted mechanisms in depression treatment. Int J Mol Sci. 2024;25:13658. https:\/\/doi.org\/10.3390\/ijms252413658.","journal-title":"Int J Mol Sci"},{"key":"827_CR156","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuropharm.2012.09.008","volume":"65","author":"Y Ago","year":"2013","unstructured":"Ago Y, Yano K, Araki R, Hiramatsu N, Kita Y, Kawasaki T, et al. Metabotropic glutamate 2\/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. Neuropharmacology. 2013;65:29\u201338. https:\/\/doi.org\/10.1016\/j.neuropharm.2012.09.008.","journal-title":"Neuropharmacology"},{"key":"827_CR157","doi-asserted-by":"publisher","unstructured":"Wilson CA, Robertson L, Ayre K, Hendon JL, Dawson S, Bridges C, et al. Brexanolone, zuranolone and related neurosteroid GABAA receptor positive allosteric modulators for postnatal depression. Cochrane Central Editorial Service, editor. Cochrane Database Syst Rev [Internet]. 2025. https:\/\/doi.org\/10.1002\/14651858.CD014624.pub2.","DOI":"10.1002\/14651858.CD014624.pub2"},{"key":"827_CR158","doi-asserted-by":"publisher","first-page":"11637","DOI":"10.3390\/ijms252111637","volume":"25","author":"V Konsta","year":"2024","unstructured":"Konsta V, Paschou M, Koti N, Vlachou ME, Livanos P, Xilouri M, et al. Neurosteroids alter p-ERK levels and tau distribution, restraining the effects of high extracellular calcium. Int J Mol Sci. 2024;25:11637. https:\/\/doi.org\/10.3390\/ijms252111637.","journal-title":"Int J Mol Sci"},{"key":"827_CR159","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/s41386-022-01453-8","volume":"48","author":"A Jannati","year":"2023","unstructured":"Jannati A, Oberman LM, Rotenberg A, Pascual-Leone A. Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation. Neuropsychopharmacology. 2023;48:191\u2013208. https:\/\/doi.org\/10.1038\/s41386-022-01453-8.","journal-title":"Neuropsychopharmacology"},{"key":"827_CR160","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.brs.2016.01.006","volume":"9","author":"A Suppa","year":"2016","unstructured":"Suppa A, Huang Y-Z, Funke K, Ridding MC, Cheeran B, Di Lazzaro V, et al. Ten years of theta burst stimulation in humans: established knowledge, unknowns and prospects. Brain Stimulat. 2016;9:323\u201335. https:\/\/doi.org\/10.1016\/j.brs.2016.01.006.","journal-title":"Brain Stimulat"},{"key":"827_CR161","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.cogbrainres.2005.01.014","volume":"24","author":"LM Oberman","year":"2005","unstructured":"Oberman LM, Hubbard EM, McCleery JP, Altschuler EL, Ramachandran VS, Pineda JA. EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Cogn Brain Res. 2005;24:190\u201398. https:\/\/doi.org\/10.1016\/j.cogbrainres.2005.01.014.","journal-title":"Cogn Brain Res"},{"key":"827_CR162","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.clinph.2007.01.021","volume":"118","author":"Y-Z Huang","year":"2007","unstructured":"Huang Y-Z, Chen R-S, Rothwell JC, Wen H-Y. The after-effect of human theta burst stimulation is NMDA receptor dependent. Clin Neurophysiol. 2007;118:1028\u201332. https:\/\/doi.org\/10.1016\/j.clinph.2007.01.021.","journal-title":"Clin Neurophysiol"},{"key":"827_CR163","doi-asserted-by":"publisher","first-page":"3222","DOI":"10.1038\/s41467-025-58187-6","volume":"16","author":"D Momi","year":"2025","unstructured":"Momi D, Wang Z, Parmigiani S, Mikulan E, Bastiaens SP, Oveisi MP, et al. Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks. Nat Commun. 2025;16:3222. https:\/\/doi.org\/10.1038\/s41467-025-58187-6.","journal-title":"Nat Commun"},{"key":"827_CR164","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41398-024-02942-8","volume":"14","author":"BN Ozkan","year":"2024","unstructured":"Ozkan BN, Bozali K, Boylu ME, Velioglu HA, Aktas S, Kirpinar I, et al. Altered blood parameters in \u201cmajor depression\u201d patients receiving repetitive transcranial magnetic stimulation (rTMS) therapy: a randomized case-control study. Transl Psychiatry. 2024;14:264. https:\/\/doi.org\/10.1038\/s41398-024-02942-8.","journal-title":"Transl Psychiatry"},{"key":"827_CR165","doi-asserted-by":"publisher","first-page":"5717","DOI":"10.1113\/jphysiol.2008.159905","volume":"586","author":"B Cheeran","year":"2008","unstructured":"Cheeran B, Talelli P, Mori F, Koch G, Suppa A, Edwards M, et al. A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS. J Physiol. 2008;586:5717\u201325. https:\/\/doi.org\/10.1113\/jphysiol.2008.159905.","journal-title":"J Physiol"},{"key":"827_CR166","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1176\/appi.ajp.160.3.577","volume":"160","author":"G Sanacora","year":"2003","unstructured":"Sanacora G, Mason GF, Rothman DL, Hyder F, Ciarcia JJ, Ostroff RB, et al. Increased cortical GABA concentrations in depressed patients receiving ECT. Am J Psychiatry. 2003;160:577\u201379. https:\/\/doi.org\/10.1176\/appi.ajp.160.3.577.","journal-title":"Am J Psychiatry"},{"key":"827_CR167","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.semcdb.2018.09.011","volume":"89","author":"D Testa","year":"2019","unstructured":"Testa D, Prochiantz A, Di Nardo AA. Perineuronal nets in brain physiology and disease. Semin Cell Dev Biol. 2019;89:125\u201335. https:\/\/doi.org\/10.1016\/j.semcdb.2018.09.011.","journal-title":"Semin Cell Dev Biol"},{"key":"827_CR168","doi-asserted-by":"publisher","first-page":"107607","DOI":"10.1016\/j.psyneuen.2025.107607","volume":"181","author":"L Jiang","year":"2025","unstructured":"Jiang L, Xue L, Juruena MF. The impact of early life stress on the hypothalamic-pituitary-adrenal axis in unipolar major depression: a systematic review. Psychoneuroendocrinology. 2025;181:107607. https:\/\/doi.org\/10.1016\/j.psyneuen.2025.107607.","journal-title":"Psychoneuroendocrinology"},{"key":"827_CR169","doi-asserted-by":"publisher","unstructured":"Knezevic E, Nenic K, Milanovic V, Knezevic NN. The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders. Cells. 2023;12. https:\/\/doi.org\/10.3390\/cells12232726.","DOI":"10.3390\/cells12232726"},{"key":"827_CR170","doi-asserted-by":"publisher","first-page":"193","DOI":"10.4103\/1110-1083.202375","volume":"53","author":"S Ahmed","year":"2016","unstructured":"Ahmed S, Moussa F, Moustafa A, Ayoub D. Cortisol level in depressed patients and its relation with suicidal risk and anhedonia. Egypt J Neurol Psychiatry Neurosurg. 2016;53:193. https:\/\/doi.org\/10.4103\/1110-1083.202375.","journal-title":"Egypt J Neurol Psychiatry Neurosurg"},{"key":"827_CR171","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.biopsych.2004.06.003","volume":"56","author":"C Otte","year":"2004","unstructured":"Otte C, Marmar CR, Pipkin SS, Moos R, Browner WS, Whooley MA. Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: the heart and soul study. Biol Psychiatry. 2004;56:241\u201347. https:\/\/doi.org\/10.1016\/j.biopsych.2004.06.003.","journal-title":"Biol Psychiatry"},{"key":"827_CR172","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1001\/archpsyc.1980.01780200039004","volume":"37","author":"L Tr\u00e4skman","year":"1980","unstructured":"Tr\u00e4skman L. Cortisol in the CSF of depressed and suicidal patients. Arch Gen Psychiatry. 1980;37:761. https:\/\/doi.org\/10.1001\/archpsyc.1980.01780200039004.","journal-title":"Arch Gen Psychiatry"},{"key":"827_CR173","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/S0306-4522(03)00105-2","volume":"119","author":"K Mizoguchi","year":"2003","unstructured":"Mizoguchi K, Ishige A, Aburada M, Tabira T. Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus. Neuroscience. 2003;119:887\u201397. https:\/\/doi.org\/10.1016\/S0306-4522(03)00105-2.","journal-title":"Neuroscience"},{"key":"827_CR174","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1210\/endo.138.1.4835","volume":"138","author":"C Behl","year":"1997","unstructured":"Behl C, Lezoualc\u2019h F, Trapp T, Widmann M, Skutella T, Holsboer F. Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro. Endocrinology. 1997;138:101\u201306. https:\/\/doi.org\/10.1210\/endo.138.1.4835.","journal-title":"Endocrinology"},{"key":"827_CR175","doi-asserted-by":"publisher","first-page":"e067735","DOI":"10.1002\/alz.067735","volume":"19","author":"M Daniilidou","year":"2023","unstructured":"Daniilidou M, Hagman G, Holleman J, Sindi S, Solomon A, Sandebring-Matton A, et al. Associations of cortisol with neuroinflammation biomarkers in a memory clinic cohort. Alzheimers Dement. 2023;19:e067735. https:\/\/doi.org\/10.1002\/alz.067735.","journal-title":"Alzheimers Dement"},{"key":"827_CR176","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/sj.mp.4001250","volume":"8","author":"MC Austin","year":"2003","unstructured":"Austin MC, Janosky JE, Murphy HA. Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men. Mol Psychiatry. 2003;8:324\u201332. https:\/\/doi.org\/10.1038\/sj.mp.4001250.","journal-title":"Mol Psychiatry"},{"key":"827_CR177","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/mp.2009.141","volume":"15","author":"EB Binder","year":"2010","unstructured":"Binder EB, Nemeroff CB. The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol Psychiatry. 2010;15:574\u201388. https:\/\/doi.org\/10.1038\/mp.2009.141.","journal-title":"Mol Psychiatry"},{"key":"827_CR178","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S0196-9781(01)00398-9","volume":"22","author":"ME Keck","year":"2001","unstructured":"Keck ME, Holsboer F. Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders. Peptides. 2001;22:835\u201344. https:\/\/doi.org\/10.1016\/S0196-9781(01)00398-9.","journal-title":"Peptides"},{"key":"827_CR179","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.neuroscience.2012.08.065","volume":"239","author":"D Suri","year":"2013","unstructured":"Suri D, Vaidya VA. Glucocorticoid regulation of brain-derived neurotrophic factor: relevance to hippocampal structural and functional plasticity. Neuroscience. 2013;239:196\u2013213. https:\/\/doi.org\/10.1016\/j.neuroscience.2012.08.065.","journal-title":"Neuroscience"},{"key":"827_CR180","doi-asserted-by":"publisher","first-page":"14075","DOI":"10.1073\/pnas.0906791106","volume":"106","author":"EY Yuen","year":"2009","unstructured":"Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen BS, Yan Z. Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory. Proc Natl Acad Sci. 2009;106:14075\u201379. https:\/\/doi.org\/10.1073\/pnas.0906791106.","journal-title":"Proc Natl Acad Sci"},{"key":"827_CR181","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1017\/neu.2024.34","volume":"37","author":"KM Ryan","year":"2025","unstructured":"Ryan KM, Corrigan M, Murphy TM, McLoughlin DM, Harkin A. Gene expression of kynurenine pathway enzymes in depression and following electroconvulsive therapy. Acta Neuropsychiatr. 2025;37:e34. https:\/\/doi.org\/10.1017\/neu.2024.34.","journal-title":"Acta Neuropsychiatr"},{"key":"827_CR182","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.neuropharm.2013.03.013","volume":"71","author":"BB Garc\u00eda-Iglesias","year":"2013","unstructured":"Garc\u00eda-Iglesias BB, Mendoza-Garrido ME, Guti\u00e9rrez-Ospina G, Rangel-Barajas C, Noyola-D\u00edaz M, Terr\u00f3n JA. Sensitization of restraint-induced corticosterone secretion after chronic restraint in rats: involvement of 5-HT7 receptors. Neuropharmacology. 2013;71:216\u201327. https:\/\/doi.org\/10.1016\/j.neuropharm.2013.03.013.","journal-title":"Neuropharmacology"},{"key":"827_CR183","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1016\/S0960-894X(02)00690-X","volume":"12","author":"IT Forbes","year":"2002","unstructured":"Forbes IT, Douglas S, Gribble AD, Ife RJ, Lightfoot AP, Garner AE, et al. SB-656104-A: a novel 5-HT7 receptor antagonist with improved in vivo properties. Bioorg Med Chem Lett. 2002;12:3341\u201344. https:\/\/doi.org\/10.1016\/S0960-894X(02)00690-X.","journal-title":"Bioorg Med Chem Lett"},{"key":"827_CR184","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0022-3956(00)00016-9","volume":"34","author":"AW Zobel","year":"2000","unstructured":"Zobel AW, Nickel T, K\u00fcnzel HE, Ackl N, Sonntag A, Ising M, et al. Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J Psychiatr Res. 2000;34:171\u201381. https:\/\/doi.org\/10.1016\/S0022-3956(00)00016-9.","journal-title":"J Psychiatr Res"},{"key":"827_CR185","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.4088\/JCP.12m07804","volume":"73","author":"G Griebel","year":"2012","unstructured":"Griebel G, Beesk\u00e9 S, Stahl SM. The vasopressin V1b receptor antagonist SSR149415 in the treatment of major depressive and generalized anxiety disorders: results from 4 randomized, double-blind, placebo-controlled studies. J Clin Psychiatry. 2012;73:1403\u201311. https:\/\/doi.org\/10.4088\/JCP.12m07804.","journal-title":"J Clin Psychiatry"},{"key":"827_CR186","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1097\/00004714-200110000-00009","volume":"21","author":"JK Belanoff","year":"2001","unstructured":"Belanoff JK, Flores BH, Kalezhan M, Sund B, Schatzberg AF. Rapid reversal of psychotic depression using mifepristone. J Clin Psychopharmacol. 2001;21:516\u201321. https:\/\/doi.org\/10.1097\/00004714-200110000-00009.","journal-title":"J Clin Psychopharmacol"},{"key":"827_CR187","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1001\/archpsyc.61.12.1235","volume":"61","author":"H Jahn","year":"2004","unstructured":"Jahn H, Schick M, Kiefer F, Kellner M, Yassouridis A, Wiedemann K. Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial. Arch Gen Psychiatry. 2004;61:1235. https:\/\/doi.org\/10.1001\/archpsyc.61.12.1235.","journal-title":"Arch Gen Psychiatry"},{"key":"827_CR188","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1176\/ajp.156.4.646","volume":"156","author":"OM Wolkowitz","year":"1999","unstructured":"Wolkowitz OM, Reus VI, Keebler A, Nelson N, Friedland M, Brizendine L, et al. Double-blind treatment of major depression with dehydroepiandrosterone. Am J Psychiatry. 1999;156:646\u201349. https:\/\/doi.org\/10.1176\/ajp.156.4.646.","journal-title":"Am J Psychiatry"},{"key":"827_CR189","doi-asserted-by":"publisher","first-page":"4928","DOI":"10.1038\/s41380-022-01755-9","volume":"27","author":"MG Codagnone","year":"2022","unstructured":"Codagnone MG, Kara N, Ratsika A, Levone BR, van de Wouw M, Tan LA, et al. Inhibition of FKBP51 induces stress resilience and alters hippocampal neurogenesis. Mol Psychiatry. 2022;27:4928\u201338. https:\/\/doi.org\/10.1038\/s41380-022-01755-9.","journal-title":"Mol Psychiatry"},{"key":"827_CR190","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nrn3138","volume":"13","author":"M Popoli","year":"2011","unstructured":"Popoli M, Yan Z, McEwen BS, Sanacora G. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nat Rev Neurosci. 2011;13:22\u201337. https:\/\/doi.org\/10.1038\/nrn3138.","journal-title":"Nat Rev Neurosci"},{"key":"827_CR191","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neuroscience.2012.09.017","volume":"239","author":"F Jeanneteau","year":"2013","unstructured":"Jeanneteau F, Chao MV. Are BDNF and glucocorticoid activities calibrated? Neuroscience. 2013;239:173\u201395. https:\/\/doi.org\/10.1016\/j.neuroscience.2012.09.017.","journal-title":"Neuroscience"},{"key":"827_CR192","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.psyneuen.2016.07.219","volume":"73","author":"AK Lundberg","year":"2016","unstructured":"Lundberg AK, J\u00f6nsson S, Stenmark J, Kristenson M, Jonasson L. Stress-induced release of matrix metalloproteinase-9 in patients with coronary artery disease: the possible influence of cortisol. Psychoneuroendocrinology. 2016;73:117\u201324. https:\/\/doi.org\/10.1016\/j.psyneuen.2016.07.219.","journal-title":"Psychoneuroendocrinology"},{"key":"827_CR193","doi-asserted-by":"publisher","first-page":"1538026","DOI":"10.3389\/fncel.2025.1538026","volume":"19","author":"K Zhao","year":"2025","unstructured":"Zhao K, Zhang Y, Yang S, Xiang L, Wu S, Dong J, et al. Neuroinflammation and stress-induced pathophysiology in major depressive disorder: mechanisms and therapeutic implications. Front Cell Neurosci. 2025;19:1538026. https:\/\/doi.org\/10.3389\/fncel.2025.1538026.","journal-title":"Front Cell Neurosci"},{"key":"827_CR194","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1152\/physrev.00039.2016","volume":"98","author":"R Dantzer","year":"2018","unstructured":"Dantzer R. Neuroimmune interactions: from the brain to the immune system and vice versa. Physiol Rev. 2018;98:477\u2013504. https:\/\/doi.org\/10.1152\/physrev.00039.2016.","journal-title":"Physiol Rev"},{"key":"827_CR195","doi-asserted-by":"publisher","first-page":"594394","DOI":"10.3389\/fphar.2020.594394","volume":"11","author":"S Hidese","year":"2021","unstructured":"Hidese S, Hattori K, Sasayama D, Tsumagari T, Miyakawa T, Matsumura R, et al. Cerebrospinal fluid inflammatory cytokine levels in patients with major psychiatric disorders: a multiplex immunoassay study. Front Pharmacol. 2021;11:594394. https:\/\/doi.org\/10.3389\/fphar.2020.594394.","journal-title":"Front Pharmacol"},{"key":"827_CR196","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.psychres.2013.03.002","volume":"209","author":"M Gazal","year":"2013","unstructured":"Gazal M, Souza LD, Fucolo BA, Wiener CD, Silva RA, Pinheiro RT, et al. The impact of cognitive behavioral therapy on IL-6 levels in unmedicated women experiencing the first episode of depression: a pilot study. Psychiatry Res. 2013;209:742\u201345. https:\/\/doi.org\/10.1016\/j.psychres.2013.03.002.","journal-title":"Psychiatry Res"},{"key":"827_CR197","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41582-025-01116-4","volume":"21","author":"M Maes","year":"2025","unstructured":"Maes M, Almulla AF, You Z, Zhang Y. Neuroimmune, metabolic and oxidative stress pathways in major depressive disorder. Nat Rev Neurol. 2025;21:473\u201389. https:\/\/doi.org\/10.1038\/s41582-025-01116-4.","journal-title":"Nat Rev Neurol"},{"key":"827_CR198","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.bbi.2017.11.020","volume":"69","author":"GM Khandaker","year":"2018","unstructured":"Khandaker GM, Zammit S, Burgess S, Lewis G, Jones PB. Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort. Brain Behav Immun. 2018;69:264\u201372. https:\/\/doi.org\/10.1016\/j.bbi.2017.11.020.","journal-title":"Brain Behav Immun"},{"key":"827_CR199","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.psychres.2017.03.012","volume":"252","author":"C Lavebratt","year":"2017","unstructured":"Lavebratt C, Herring MP, Liu JJ, Wei YB, Bossoli D, Hallgren M, et al. Interleukin-6 and depressive symptom severity in response to physical exercise. Psychiatry Res. 2017;252:270\u201376. https:\/\/doi.org\/10.1016\/j.psychres.2017.03.012.","journal-title":"Psychiatry Res"},{"key":"827_CR200","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.3390\/ijms21062194","volume":"21","author":"E-C Ting","year":"2020","unstructured":"Ting E-C, Yang AC, Tsai S-J. Role of interleukin-6 in depressive disorder. Int J Mol Sci. 2020;21:2194. https:\/\/doi.org\/10.3390\/ijms21062194.","journal-title":"Int J Mol Sci"},{"key":"827_CR201","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jagp.2019.05.011","volume":"28","author":"N Sonsin-Diaz","year":"2020","unstructured":"Sonsin-Diaz N, Gottesman RF, Fracica E, Walston J, Windham BG, Knopman DS, et al. Chronic systemic inflammation is associated with symptoms of late-life depression: the ARIC study. Am J Geriatr Psychiatry. 2020;28:87\u201398. https:\/\/doi.org\/10.1016\/j.jagp.2019.05.011.","journal-title":"Am J Geriatr Psychiatry"},{"key":"827_CR202","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1176\/appi.ajp.2020.20060947","volume":"178","author":"MC Pitharouli","year":"2021","unstructured":"Pitharouli MC, Hagenaars SP, Glanville KP, Coleman JRI, Hotopf M, Lewis CM, et al. Elevated C-reactive protein in patients with depression, independent of genetic, health, and psychosocial factors: results from the UK biobank. Am J Psychiatry. 2021;178:522\u201329. https:\/\/doi.org\/10.1176\/appi.ajp.2020.20060947.","journal-title":"Am J Psychiatry"},{"key":"827_CR203","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1523\/JNEUROSCI.2394-15.2016","volume":"36","author":"DB McKim","year":"2016","unstructured":"McKim DB, Niraula A, Tarr AJ, Wohleb ES, Sheridan JF, Godbout JP. Neuroinflammatory dynamics underlie memory impairments after repeated social defeat. J Neurosci. 2016;36:2590\u2013604. https:\/\/doi.org\/10.1523\/JNEUROSCI.2394-15.2016.","journal-title":"J Neurosci"},{"key":"827_CR204","doi-asserted-by":"publisher","first-page":"106573","DOI":"10.1016\/j.nbd.2024.106573","volume":"199","author":"L Chang","year":"2024","unstructured":"Chang L, Wei Y, Qu Y, Zhao M, Zhou X, Long Y, et al. Role of oxidative phosphorylation in the antidepressant effects of arketamine via the vagus nerve-dependent spleen-brain axis. Neurobiol Dis. 2024;199:106573. https:\/\/doi.org\/10.1016\/j.nbd.2024.106573.","journal-title":"Neurobiol Dis"},{"key":"827_CR205","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuro.2024.11.006","volume":"106","author":"AS Al-Shami","year":"2025","unstructured":"Al-Shami AS, Haroun M, Essawy AE, Moussa N, Abd Elkader H-T. Early-life bisphenol a exposure causes detrimental age-related changes in anxiety, depression, learning, and memory in juvenile and adult male rats: involvement of NMDAR\/PSD-95-PTEN\/AKT signaling pathway. NeuroToxicology. 2025;106:17\u201336. https:\/\/doi.org\/10.1016\/j.neuro.2024.11.006.","journal-title":"NeuroToxicology"},{"key":"827_CR206","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nrn849","volume":"3","author":"JJ Kim","year":"2002","unstructured":"Kim JJ, Diamond DM. The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci. 2002;3:453\u201362. https:\/\/doi.org\/10.1038\/nrn849.","journal-title":"Nat Rev Neurosci"},{"key":"827_CR207","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1017\/S1461145709009924","volume":"12","author":"RA Khairova","year":"2009","unstructured":"Khairova RA, Machado-Vieira R, Du J, Manji HK. A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol. 2009;12:561. https:\/\/doi.org\/10.1017\/S1461145709009924.","journal-title":"Int J Neuropsychopharmacol"},{"key":"827_CR208","doi-asserted-by":"publisher","first-page":"6734","DOI":"10.1523\/JNEUROSCI.1510-05.2005","volume":"25","author":"L Bernardino","year":"2005","unstructured":"Bernardino L, Xapelli S, Silva AP, Jakobsen B, Poulsen FR, Oliveira CR, et al. Modulator effects of interleukin-1\u03b2 and tumor necrosis factor-\u03b1 on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. J Neurosci. 2005;25:6734\u201344. https:\/\/doi.org\/10.1523\/JNEUROSCI.1510-05.2005.","journal-title":"J Neurosci"},{"key":"827_CR209","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1017\/S1740925X05000608","volume":"1","author":"D Leonoudakis","year":"2004","unstructured":"Leonoudakis D, Braithwaite SP, Beattie MS, Beattie EC. TNF\u03b1-induced AMPA-receptor trafficking in CNS neurons; relevance to excitotoxicity? Neuron Glia Biol. 2004;1:263\u201373. https:\/\/doi.org\/10.1017\/S1740925X05000608.","journal-title":"Neuron Glia Biol"},{"key":"827_CR210","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/npp.2016.199","volume":"42","author":"E Haroon","year":"2017","unstructured":"Haroon E, Miller AH, Sanacora G. Inflammation, glutamate, and glia: a trio of trouble in mood disorders. Neuropsychopharmacology. 2017;42:193\u2013215. https:\/\/doi.org\/10.1038\/npp.2016.199.","journal-title":"Neuropsychopharmacology"},{"key":"827_CR211","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/7854_2016_12","volume-title":"Inflamm-Assoc Depress Evid Mech Implic [Internet]","author":"J Savitz","year":"2016","unstructured":"Savitz J. Role of kynurenine metabolism pathway activation in major depressive disorders. In: Dantzer R, Capuron L, editors. Inflamm-Assoc Depress Evid Mech Implic [Internet]. Cham: Springer International Publishing; 2016. p. 249\u201367. https:\/\/doi.org\/10.1007\/7854_2016_12."},{"key":"827_CR212","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/j.1471-4159.2008.05430.x","volume":"106","author":"M Woo","year":"2008","unstructured":"Woo M, Park J, Choi I, Kim W, Kim H. Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia. J Neurochem. 2008;106:770\u201380. https:\/\/doi.org\/10.1111\/j.1471-4159.2008.05430.x.","journal-title":"J Neurochem"},{"key":"827_CR213","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S1471-4906(01)02023-3","volume":"22","author":"G Opdenakker","year":"2001","unstructured":"Opdenakker G, Van Den Steen PE, Van Damme J. Gelatinase B: a tuner and amplifier of immune functions. Trends Immunol. 2001;22:571\u201379. https:\/\/doi.org\/10.1016\/S1471-4906(01)02023-3.","journal-title":"Trends Immunol"},{"key":"827_CR214","doi-asserted-by":"publisher","first-page":"77","DOI":"10.5498\/wjp.v12.i1.77","volume":"12","author":"GA Porter","year":"2022","unstructured":"Porter GA, O\u2019Connor JC. Brain-derived neurotrophic factor and inflammation in depression: pathogenic partners in crime? World J Psychiatry. 2022;12:77\u201397. https:\/\/doi.org\/10.5498\/wjp.v12.i1.77.","journal-title":"World J Psychiatry"},{"key":"827_CR215","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1002\/glia.23790","volume":"68","author":"P Raghunatha","year":"2020","unstructured":"Raghunatha P, Vosoughi A, Kauppinen TM, Jackson MF. Microglial NMDA receptors drive pro-inflammatory responses via PARP-1\/TRMP2 signaling. Glia. 2020;68:1421\u201334. https:\/\/doi.org\/10.1002\/glia.23790.","journal-title":"Glia"},{"key":"827_CR216","doi-asserted-by":"publisher","first-page":"7872","DOI":"10.12998\/wjcc.v10.i22.7872","volume":"10","author":"Z Wang","year":"2022","unstructured":"Wang Z, Wu Q, Wang Q. Effect of celecoxib on improving depression: a systematic review and meta-analysis. World J Clin Cases. 2022;10:7872\u201382. https:\/\/doi.org\/10.12998\/wjcc.v10.i22.7872.","journal-title":"World J Clin Cases"},{"key":"827_CR217","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1001\/2013.jamapsychiatry.4","volume":"70","author":"CL Raison","year":"2013","unstructured":"Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF, et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry. 2013;70:31. https:\/\/doi.org\/10.1001\/2013.jamapsychiatry.4.","journal-title":"JAMA Psychiatry"},{"key":"827_CR218","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.bbr.2018.07.001","volume":"356","author":"C Zhang","year":"2019","unstructured":"Zhang C, Zhang Y-P, Li Y-Y, Liu B-P, Wang H-Y, Li K-W, et al. Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat. Behav Brain Res. 2019;356:348\u201357. https:\/\/doi.org\/10.1016\/j.bbr.2018.07.001.","journal-title":"Behav Brain Res"},{"key":"827_CR219","doi-asserted-by":"publisher","first-page":"107011","DOI":"10.1016\/j.nbd.2025.107011","volume":"213","author":"Y Zhong","year":"2025","unstructured":"Zhong Y, Pi C, Zuo Y, Wei Y, Li W, Jiang Y, et al. The P2X7 receptor in depression: novel insights and therapeutic implications. Neurobiol Dis. 2025;213:107011. https:\/\/doi.org\/10.1016\/j.nbd.2025.107011.","journal-title":"Neurobiol Dis"},{"key":"827_CR220","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1177\/02698811211026426","volume":"35","author":"E Kopra","year":"2021","unstructured":"Kopra E, Mondelli V, Pariante C, Nikkheslat N. Ketamine\u2019s effect on inflammation and kynurenine pathway in depression: a systematic review. J Psychopharmacol (Oxf). 2021;35:934\u201345. https:\/\/doi.org\/10.1177\/02698811211026426.","journal-title":"J Psychopharmacol (Oxf)"},{"key":"827_CR221","doi-asserted-by":"publisher","first-page":"e62991","DOI":"10.7759\/cureus.62991","volume":"16","author":"AN Patel","year":"2024","unstructured":"Patel AN, Varma J, Ganguly B. Evidence of the immunomodulatory effects of selective serotonin reuptake inhibitors in patients with depression through a systematic review. Cureus. 2024;16:e62991. https:\/\/doi.org\/10.7759\/cureus.62991.","journal-title":"Cureus"},{"key":"827_CR222","doi-asserted-by":"publisher","first-page":"1490300","DOI":"10.3389\/fnins.2024.1490300","volume":"18","author":"F-J Liu","year":"2024","unstructured":"Liu F-J, Wu J, Gong L-J, Yang H-S, Chen H. Non-invasive vagus nerve stimulation in anti-inflammatory therapy: mechanistic insights and future perspectives. Front Neurosci. 2024;18:1490300. https:\/\/doi.org\/10.3389\/fnins.2024.1490300.","journal-title":"Front Neurosci"},{"key":"827_CR223","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1056\/NEJMra073096","volume":"358","author":"RH Belmaker","year":"2008","unstructured":"Belmaker RH, Agam G. Major depressive disorder. N Engl J Med. 2008;358:55\u201368. https:\/\/doi.org\/10.1056\/NEJMra073096.","journal-title":"N Engl J Med"},{"key":"827_CR224","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/nature07455","volume":"455","author":"V Krishnan","year":"2008","unstructured":"Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature. 2008;455:894\u2013902. https:\/\/doi.org\/10.1038\/nature07455.","journal-title":"Nature"},{"key":"827_CR225","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/S0140-6736(72)93021-8","volume":"300","author":"D Janowsky","year":"1972","unstructured":"Janowsky D, Davis J, El-Yousef MK, Sekerke HJ. A cholinergic-adrenergic hypothesis of mania and depression. Lancet. 1972;300:632\u201335. https:\/\/doi.org\/10.1016\/S0140-6736(72)93021-8.","journal-title":"Lancet"},{"key":"827_CR226","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1001\/archpsyc.1965.01730060001001","volume":"13","author":"WE Bunney","year":"1965","unstructured":"Bunney WE. Norepinephrine in depressive reactions: a review. Arch Gen Psychiatry. 1965;13:483. https:\/\/doi.org\/10.1001\/archpsyc.1965.01730060001001.","journal-title":"Arch Gen Psychiatry"},{"key":"827_CR227","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1176\/ajp.122.5.509","volume":"122","author":"JJ Schildkraut","year":"1965","unstructured":"Schildkraut JJ. The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry. 1965;122:509\u201322. https:\/\/doi.org\/10.1176\/ajp.122.5.509.","journal-title":"Am J Psychiatry"},{"key":"827_CR228","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1001\/archpsyc.65.5.521","volume":"65","author":"G Hasler","year":"2008","unstructured":"Hasler G, Fromm S, Carlson PJ, Luckenbaugh DA, Waldeck T, Geraci M, et al. Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects. Arch Gen Psychiatry. 2008;65:521. https:\/\/doi.org\/10.1001\/archpsyc.65.5.521.","journal-title":"Arch Gen Psychiatry"},{"key":"827_CR229","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.tins.2011.11.004","volume":"35","author":"RS Duman","year":"2012","unstructured":"Duman RS, Voleti B. Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends Neurosci. 2012;35:47\u201356. https:\/\/doi.org\/10.1016\/j.tins.2011.11.004.","journal-title":"Trends Neurosci"},{"key":"827_CR230","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/s41398-022-02290-5","volume":"12","author":"M Shen","year":"2022","unstructured":"Shen M, Lv D, Liu X, Wang C. ERK\/mTOR signaling may underlying the antidepressant actions of rapastinel in mice. Transl Psychiatry. 2022;12:522. https:\/\/doi.org\/10.1038\/s41398-022-02290-5.","journal-title":"Transl Psychiatry"},{"key":"827_CR231","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1021\/cr078224o","volume":"108","author":"DE Nichols","year":"2008","unstructured":"Nichols DE, Nichols CD. Serotonin receptors. Chem Rev. 2008;108:1614\u201341. https:\/\/doi.org\/10.1021\/cr078224o.","journal-title":"Chem Rev"},{"key":"827_CR232","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/sj.mp.4001401","volume":"9","author":"Z Bhagwagar","year":"2004","unstructured":"Bhagwagar Z, Rabiner EA, Sargent PA, Grasby PM, Cowen PJ. Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635. Mol Psychiatry. 2004;9:386\u201392. https:\/\/doi.org\/10.1038\/sj.mp.4001401.","journal-title":"Mol Psychiatry"},{"key":"827_CR233","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1186\/s12888-016-1025-0","volume":"16","author":"L Wang","year":"2016","unstructured":"Wang L, Zhou C, Zhu D, Wang X, Fang L, Zhong J, et al. Serotonin-1A receptor alterations in depression: a meta-analysis of molecular imaging studies. BMC Psychiatry. 2016;16:319. https:\/\/doi.org\/10.1186\/s12888-016-1025-0.","journal-title":"BMC Psychiatry"},{"key":"827_CR234","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1001\/archpsyc.57.2.174","volume":"57","author":"PA Sargent","year":"2000","unstructured":"Sargent PA, Kjaer KH, Bench CJ, Rabiner EA, Messa C, Meyer J, et al. Brain Serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Arch Gen Psychiatry. 2000;57:174. https:\/\/doi.org\/10.1001\/archpsyc.57.2.174.","journal-title":"Arch Gen Psychiatry"},{"key":"827_CR235","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3390\/brainsci15040384","volume":"15","author":"W Zhang","year":"2025","unstructured":"Zhang W, Jin Y, Zhou F-M. Chronic fluoxetine treatment desensitizes serotoninergic inhibition of GABAergic inputs and intrinsic excitability of dorsal raphe serotonin neurons. Brain Sci. 2025;15:384. https:\/\/doi.org\/10.3390\/brainsci15040384.","journal-title":"Brain Sci"},{"key":"827_CR236","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00213-009-1626-0","volume":"206","author":"PB Hedlund","year":"2009","unstructured":"Hedlund PB. The 5-HT7 receptor and disorders of the nervous system: an overview. Psychopharmacol (Berl). 2009;206:345\u201354. https:\/\/doi.org\/10.1007\/s00213-009-1626-0.","journal-title":"Psychopharmacol (Berl)"},{"key":"827_CR237","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.neuropharm.2004.11.015","volume":"48","author":"M Guscott","year":"2005","unstructured":"Guscott M, Bristow LJ, Hadingham K, Rosahl TW, Beer MS, Stanton JA, et al. Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression. Neuropharmacology. 2005;48:492\u2013502. https:\/\/doi.org\/10.1016\/j.neuropharm.2004.11.015.","journal-title":"Neuropharmacology"},{"key":"827_CR238","doi-asserted-by":"publisher","first-page":"9867","DOI":"10.1523\/JNEUROSCI.1162-14.2014","volume":"34","author":"H Sidhu","year":"2014","unstructured":"Sidhu H, Dansie LE, Hickmott PW, Ethell DW, Ethell IM. Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model. J Neurosci Off J Soc Neurosci. 2014;34:9867\u201379. https:\/\/doi.org\/10.1523\/JNEUROSCI.1162-14.2014.","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"827_CR239","doi-asserted-by":"publisher","first-page":"385","DOI":"10.31887\/DCNS.2008.10.4\/gracagni","volume":"10","author":"G Racagni","year":"2008","unstructured":"Racagni G, Popoli M. Cellular and molecular mechanisms in the long-term action of antidepressants. Dialogues Clin Neurosci. 2008;10:385\u2013400. https:\/\/doi.org\/10.31887\/DCNS.2008.10.4\/gracagni.","journal-title":"Dialogues Clin Neurosci"},{"key":"827_CR240","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1192\/S0007125000291745","volume":"155","author":"A \u00c5berg-Wistedt","year":"1989","unstructured":"\u00c5berg-Wistedt A. The antidepressant effects of 5-HT uptake inhibitors. Br J Psychiatry. 1989;155:32\u201340. https:\/\/doi.org\/10.1192\/S0007125000291745.","journal-title":"Br J Psychiatry"},{"key":"827_CR241","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/s41467-018-08256-w","volume":"10","author":"J Grandjean","year":"2019","unstructured":"Grandjean J, Corcoba A, Kahn MC, Upton AL, Deneris ES, Seifritz E, et al. A brain-wide functional map of the serotonergic responses toacute stress and fluoxetine. Nat Commun. 2019;10:350. https:\/\/doi.org\/10.1038\/s41467-018-08256-w.","journal-title":"Nat Commun"},{"key":"827_CR242","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1023\/A:1006986824213","volume":"19","author":"C S\u00e1nchez","year":"1999","unstructured":"S\u00e1nchez C, Hyttel J. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell Mol Neurobiol. 1999;19:467\u201389. https:\/\/doi.org\/10.1023\/A:1006986824213.","journal-title":"Cell Mol Neurobiol"},{"key":"827_CR243","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/BF00634454","volume":"99","author":"E Sanders-Bush","year":"1989","unstructured":"Sanders-Bush E, Breeding M, Knoth K, Tsutsumi M. Sertraline-induced desensitization of the serotonin 5HT-2 receptor transmembrane signaling system. Psychopharmacol (Berl). 1989;99:64\u201369. https:\/\/doi.org\/10.1007\/BF00634454.","journal-title":"Psychopharmacol (Berl)"},{"key":"827_CR244","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1038\/sj.npp.1300488","volume":"29","author":"E Tiraboschi","year":"2004","unstructured":"Tiraboschi E, Tardito D, Kasahara J, Moraschi S, Pruneri P, Gennarelli M, et al. Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades. Neuropsychopharmacology. 2004;29:1831\u201340. https:\/\/doi.org\/10.1038\/sj.npp.1300488.","journal-title":"Neuropsychopharmacology"},{"key":"827_CR245","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1111\/j.1471-4159.1989.tb08564.x","volume":"53","author":"EJ Nestler","year":"1989","unstructured":"Nestler EJ, Terwilliger RZ, Duman RS. Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex. J Neurochem. 1989;53:1644\u201347. https:\/\/doi.org\/10.1111\/j.1471-4159.1989.tb08564.x.","journal-title":"J Neurochem"},{"key":"827_CR246","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0922-4106(89)90060-6","volume":"172","author":"J Perez","year":"1989","unstructured":"Perez J, Tinelli D, Brunello N, Racagni G. cAMP-dependent phosphorylation of soluble and crude microtubule fractions of rat cerebral cortex after prolonged desmethylimipramine treatment. Eur J Pharmacol Mol Pharmacol. 1989;172:305\u201316. https:\/\/doi.org\/10.1016\/0922-4106(89)90060-6.","journal-title":"Eur J Pharmacol Mol Pharmacol"},{"key":"827_CR247","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1159\/000501885","volume":"5","author":"CJ Blacker","year":"2019","unstructured":"Blacker CJ, Millischer V, Webb LM, Ho AMC, Schalling M, Frye MA, et al. EAAT2 as a research target in bipolar disorder and unipolar depression: a systematic review. Complex Psychiatry. 2019;5:44\u201359. https:\/\/doi.org\/10.1159\/000501885.","journal-title":"Complex Psychiatry"},{"key":"827_CR248","doi-asserted-by":"publisher","unstructured":"Frizzo ME. Can a selective serotonin reuptake inhibitor act as a glutamatergic modulator? Curr Ther Res. 2017;87:9\u201312. https:\/\/doi.org\/10.1016\/j.curtheres.2017.07.001.","DOI":"10.1016\/j.curtheres.2017.07.001"},{"key":"827_CR249","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.pharmthera.2014.07.001","volume":"145","author":"C Sanchez","year":"2015","unstructured":"Sanchez C, Asin KE, Artigas F. Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacol Ther. 2015;145:43\u201357. https:\/\/doi.org\/10.1016\/j.pharmthera.2014.07.001.","journal-title":"Pharmacol Ther"},{"key":"827_CR250","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3389\/fpsyt.2019.00771","volume":"10","author":"D Bennabi","year":"2019","unstructured":"Bennabi D, Haffen E, Van Waes V. Vortioxetine for cognitive enhancement in major depression: from animal models to clinical Research. Front Psychiatry. 2019;10:771. https:\/\/doi.org\/10.3389\/fpsyt.2019.00771.","journal-title":"Front Psychiatry"},{"key":"827_CR251","doi-asserted-by":"publisher","first-page":"4418","DOI":"10.1523\/JNEUROSCI.2387-19.2020","volume":"40","author":"S Alaiyed","year":"2020","unstructured":"Alaiyed S, McCann M, Mahajan G, Rajkowska G, Stockmeier CA, Kellar KJ, et al. Venlafaxine stimulates an MMP-9-dependent increase in excitatory\/inhibitory balance in a stress model of depression. J Neurosci. 2020;40:4418\u201331. https:\/\/doi.org\/10.1523\/JNEUROSCI.2387-19.2020.","journal-title":"J Neurosci"},{"key":"827_CR252","doi-asserted-by":"publisher","first-page":"709719","DOI":"10.3389\/fphar.2021.709719","volume":"12","author":"SI Galkina","year":"2021","unstructured":"Galkina SI, Golenkina EA, Fedorova NV, Ksenofontov AL, Serebryakova MV, Arifulin EA, et al. Inhibition of neutrophil secretion upon adhesion as a basis for the anti-inflammatory effect of the tricyclic antidepressant imipramine. Front Pharmacol. 2021;12:709719. https:\/\/doi.org\/10.3389\/fphar.2021.709719.","journal-title":"Front Pharmacol"},{"key":"827_CR253","doi-asserted-by":"publisher","first-page":"eaai8753","DOI":"10.1126\/scitranslmed.aai8753","volume":"9","author":"D Riga","year":"2017","unstructured":"Riga D, Kramvis I, Koskinen MK, Van Bokhoven P, Van Der Harst JE, Heistek TS, et al. Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats. Sci Transl Med. 2017;9:eaai8753. https:\/\/doi.org\/10.1126\/scitranslmed.aai8753.","journal-title":"Sci Transl Med"},{"key":"827_CR254","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1126\/science.adf0435","volume":"379","author":"MV Vargas","year":"2023","unstructured":"Vargas MV, Dunlap LE, Dong C, Carter SJ, Tombari RJ, Jami SA, et al. Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science. 2023;379:700\u201306. https:\/\/doi.org\/10.1126\/science.adf0435.","journal-title":"Science"},{"key":"827_CR255","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.bbr.2014.07.016","volume":"277","author":"AL Halberstadt","year":"2015","unstructured":"Halberstadt AL. Recent advances in the neuropsychopharmacology of serotonergic hallucinogens. Behav Brain Res. 2015;277:99\u2013120. https:\/\/doi.org\/10.1016\/j.bbr.2014.07.016.","journal-title":"Behav Brain Res"},{"key":"827_CR256","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3390\/ph16040603","volume":"16","author":"R Mlambo","year":"2023","unstructured":"Mlambo R, Liu J, Wang Q, Tan S, Chen C. Receptors involved in mental disorders and the use of clozapine, chlorpromazine, olanzapine, and aripiprazole to treat mental disorders. Pharmaceuticals. 2023;16:603. https:\/\/doi.org\/10.3390\/ph16040603.","journal-title":"Pharmaceuticals"},{"key":"827_CR257","doi-asserted-by":"publisher","first-page":"9532","DOI":"10.3390\/ijms21249532","volume":"21","author":"D Grinchii","year":"2020","unstructured":"Grinchii D, Dremencov E. Mechanism of action of atypical antipsychotic drugs in mood disorders. Int J Mol Sci. 2020;21:9532. https:\/\/doi.org\/10.3390\/ijms21249532.","journal-title":"Int J Mol Sci"},{"key":"827_CR258","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.2174\/1570159X21666230727140843","volume":"21","author":"M Olivola","year":"2023","unstructured":"Olivola M, Bassetti N, Parente S, Arienti V, Civardi SC, Topa PA, et al. Cognitive effects of lurasidone and cariprazine: a mini SystematicReview. Curr Neuropharmacol. 2023;21:2431\u201346. https:\/\/doi.org\/10.2174\/1570159X21666230727140843.","journal-title":"Curr Neuropharmacol"},{"key":"827_CR259","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1017\/S1461145711000150","volume":"15","author":"F Fumagalli","year":"2012","unstructured":"Fumagalli F, Calabrese F, Luoni A, Bolis F, Racagni G, Riva MA. Modulation of BDNF expression by repeated treatment with the novel antipsychotic lurasidone under basal condition and in response to acute stress. Int J Neuropsychopharmacol. 2012;15:235\u201346. https:\/\/doi.org\/10.1017\/S1461145711000150.","journal-title":"Int J Neuropsychopharmacol"},{"key":"827_CR260","doi-asserted-by":"publisher","unstructured":"Luoni A, Macchi F, Papp M, Molteni R, Riva MA. Lurasidone exerts antidepressant properties in the chronic mild stress model through the regulation of synaptic and neuroplastic mechanisms in the rat prefrontal cortex. Int J Neuropsychopharmacol [Internet]. 2015;18. https:\/\/doi.org\/10.1093\/ijnp\/pyu061. cited 2025 Nov 13].","DOI":"10.1093\/ijnp\/pyu061"},{"key":"827_CR261","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3390\/life15030391","volume":"15","author":"F Mucci","year":"2025","unstructured":"Mucci F, Arone A, Gurrieri R, Weiss F, Russomanno G, Marazziti D. Third-generation antipsychotics: the quest for the key to neurotrophism. Life. 2025;15:391. https:\/\/doi.org\/10.3390\/life15030391.","journal-title":"Life"},{"key":"827_CR262","doi-asserted-by":"publisher","first-page":"5682","DOI":"10.3390\/ijms25115682","volume":"25","author":"\u00c1 Barab\u00e1ssy","year":"2024","unstructured":"Barab\u00e1ssy \u00c1, Dombi ZB, N\u00e9meth G. D3 receptor-targeted cariprazine: insights from lab to bedside. Int J Mol Sci. 2024;25:5682. https:\/\/doi.org\/10.3390\/ijms25115682.","journal-title":"Int J Mol Sci"},{"key":"827_CR263","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0084-3970(08)70778-3","volume":"2008","author":"JC Ballenger","year":"2008","unstructured":"Ballenger JC. Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial. Yearb Psychiatry Appl Ment Health. 2008;2008:200\u201301. https:\/\/doi.org\/10.1016\/S0084-3970(08)70778-3.","journal-title":"Yearb Psychiatry Appl Ment Health"},{"key":"827_CR264","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1001\/archpsyc.63.10.1121","volume":"63","author":"ML Furey","year":"2006","unstructured":"Furey ML, Drevets WC. Antidepressant efficacy of the antimuscarinic drug Scopolamine: a randomized, placebo-controlled clinical trial. Arch Gen Psychiatry. 2006;63:1121. https:\/\/doi.org\/10.1001\/archpsyc.63.10.1121.","journal-title":"Arch Gen Psychiatry"},{"key":"827_CR265","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.biopsych.2017.06.017","volume":"83","author":"S Ghosal","year":"2018","unstructured":"Ghosal S, Bang E, Yue W, Hare BD, Lepack AE, Girgenti MJ, et al. Activity-dependent brain-derived neurotrophic factor release is required for the rapid antidepressant actions of scopolamine. Biol Psychiatry. 2018;83:29\u201337. https:\/\/doi.org\/10.1016\/j.biopsych.2017.06.017.","journal-title":"Biol Psychiatry"},{"key":"827_CR266","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.biopsych.2013.04.025","volume":"74","author":"B Voleti","year":"2013","unstructured":"Voleti B, Navarria A, Liu R-J, Banasr M, Li N, Terwilliger R, et al. Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses. Biol Psychiatry. 2013;74:742\u201349. https:\/\/doi.org\/10.1016\/j.biopsych.2013.04.025.","journal-title":"Biol Psychiatry"},{"key":"827_CR267","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/654085","volume":"2011","author":"PS Murray","year":"2011","unstructured":"Murray PS, Holmes PV. An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus. Int J Pept. 2011;2011:1\u201312. https:\/\/doi.org\/10.1155\/2011\/654085.","journal-title":"Int J Pept"},{"key":"827_CR268","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1101\/lm.6.3.257","volume":"6","author":"RA Crozier","year":"1999","unstructured":"Crozier RA, Black IB, Plummer MR. Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons. Learn Mem Cold Spring Harb N. 1999;6:257\u201366.","journal-title":"Learn Mem Cold Spring Harb N"},{"key":"827_CR269","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1101\/lm.56003","volume":"10","author":"M Mizuno","year":"2003","unstructured":"Mizuno M, Yamada K, He J, Nakajima A, Nabeshima T. Involvement of BDNF receptor TrkB in spatial memory formation. Learn Mem. 2003;10:108\u201315. https:\/\/doi.org\/10.1101\/lm.56003.","journal-title":"Learn Mem"},{"key":"827_CR270","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1523\/JNEUROSCI.4359-05.2006","volume":"26","author":"V Nagy","year":"2006","unstructured":"Nagy V, Bozdagi O, Matynia A, Balcerzyk M, Okulski P, Dzwonek J, et al. Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory. J Neurosci. 2006;26:1923\u201334. https:\/\/doi.org\/10.1523\/JNEUROSCI.4359-05.2006.","journal-title":"J Neurosci"},{"key":"827_CR271","doi-asserted-by":"publisher","first-page":"6007","DOI":"10.1523\/JNEUROSCI.5346-08.2009","volume":"29","author":"P Michaluk","year":"2009","unstructured":"Michaluk P, Mikasova L, Groc L, Frischknecht R, Choquet D, Kaczmarek L. Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin \u03b21 signaling. J Neurosci. 2009;29:6007\u201312. https:\/\/doi.org\/10.1523\/JNEUROSCI.5346-08.2009.","journal-title":"J Neurosci"},{"key":"827_CR272","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1128\/MCB.00008-13","volume":"33","author":"B Kuzniewska","year":"2013","unstructured":"Kuzniewska B, Rejmak E, Malik AR, Jaworski J, Kaczmarek L, Kalita K. Brain-derived neurotrophic factor induces matrix metalloproteinase 9 expression in neurons via the serum response factor\/c-Fos pathway. Mol Cell Biol. 2013;33:2149\u201362. https:\/\/doi.org\/10.1128\/MCB.00008-13.","journal-title":"Mol Cell Biol"},{"key":"827_CR273","doi-asserted-by":"publisher","first-page":"175909142211045","DOI":"10.1177\/17590914221104566","volume":"14","author":"AM Rodr\u00edguez","year":"2022","unstructured":"Rodr\u00edguez AM, Rodr\u00edguez J, Giambartolomei GH. Microglia at the crossroads of pathogen-induced neuroinflammation. ASN Neuro. 2022;14:17590914221104566. https:\/\/doi.org\/10.1177\/17590914221104566.","journal-title":"ASN Neuro"},{"key":"827_CR274","doi-asserted-by":"publisher","first-page":"e42676","DOI":"10.1371\/journal.pone.0042676","volume-title":"PLoS ONE","author":"T Yoshida","year":"2012","unstructured":"Yoshida T, Ishikawa M, Niitsu T, Nakazato M, Watanabe H, Shiraishi T, et al. Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. Yoshikawa T, editor. PLoS ONE. 2012;7:e42676. https:\/\/doi.org\/10.1371\/journal.pone.0042676."},{"key":"827_CR275","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1002\/syn.20529","volume":"62","author":"M Benekareddy","year":"2008","unstructured":"Benekareddy M, Mehrotra P, Kulkarni VA, Ramakrishnan P, Dias BG, Vaidya VA. Antidepressant treatments regulate matrix metalloproteinases-2 and -9 (MMP-2\/MMP-9) and tissue inhibitors of the metalloproteinases (TIMPS 1-4) in the adult rat hippocampus. Synapse. 2008;62:590\u2013600. https:\/\/doi.org\/10.1002\/syn.20529.","journal-title":"Synapse"},{"key":"827_CR276","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1111\/jnc.14671","volume":"148","author":"S Alaiyed","year":"2019","unstructured":"Alaiyed S, Bozzelli PL, Caccavano A, Wu JY, Conant K. Venlafaxine stimulates PNN proteolysis and MMP -9-dependent enhancement of gamma power; relevance to antidepressant efficacy. J Neurochem. 2019;148:810\u201321. https:\/\/doi.org\/10.1111\/jnc.14671.","journal-title":"J Neurochem"},{"key":"827_CR277","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.bbrc.2016.09.070","volume":"479","author":"H Abe","year":"2016","unstructured":"Abe H, Hisaoka-Nakashima K, Kajitani N, Okada-Tsuchioka M, Yano R, Itagaki K, et al. The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells. Biochem Biophys Res Commun. 2016;479:907\u201312. https:\/\/doi.org\/10.1016\/j.bbrc.2016.09.070.","journal-title":"Biochem Biophys Res Commun"},{"key":"827_CR278","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/ajmg.b.32616","volume":"177","author":"B Hing","year":"2018","unstructured":"Hing B, Sathyaputri L, Potash JB. A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2018;177:143\u201367. https:\/\/doi.org\/10.1002\/ajmg.b.32616.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"827_CR279","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.jad.2014.05.020","volume":"166","author":"B Dell\u05f3osso","year":"2014","unstructured":"Dell\u05f3osso B, D\u05f3addario C, Carlotta Palazzo M, Benatti B, Camuri G, Galimberti D, et al. Epigenetic modulation of BDNF gene: differences in DNA methylation between unipolar and bipolar patients. J Affect Disord. 2014;166:330\u201333. https:\/\/doi.org\/10.1016\/j.jad.2014.05.020.","journal-title":"J Affect Disord"},{"key":"827_CR280","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jad.2011.09.025","volume":"139","author":"CJ Jackson","year":"2012","unstructured":"Jackson CJ, Izadikah Z, Oei TPS. Mechanisms underlying REBT in mood disordered patients: predicting depression from the hybrid model of learning. J Affect Disord. 2012;139:30\u201339. https:\/\/doi.org\/10.1016\/j.jad.2011.09.025.","journal-title":"J Affect Disord"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-026-00827-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43440-026-00827-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-026-00827-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:35:13Z","timestamp":1773196513000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43440-026-00827-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":280,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["827"],"URL":"https:\/\/doi.org\/10.1007\/s43440-026-00827-9","relation":{},"ISSN":["1734-1140","2299-5684"],"issn-type":[{"value":"1734-1140","type":"print"},{"value":"2299-5684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"21 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}