{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:18:28Z","timestamp":1785860308804,"version":"3.56.0"},"reference-count":282,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacol. Rep"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s43440-026-00860-8","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:50:20Z","timestamp":1782132620000},"page":"945-980","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decoding the serotonin\u2013alcohol crosstalk: the role of central serotonergic dysregulation in alcohol use disorder"],"prefix":"10.1007","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9716-6661","authenticated-orcid":false,"given":"Magdalena","family":"Zaniewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"3","key":"860_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0006-3223(98)00139-5","volume":"44","author":"I Lucki","year":"1998","unstructured":"Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry. 1998;44(3):151\u201362. https:\/\/doi.org\/10.1016\/S0006-3223(98)00139-5.","journal-title":"Biol Psychiatry"},{"issue":"2","key":"860_CR2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1159\/000279322","volume":"85","author":"S Matthes","year":"2010","unstructured":"Matthes S, Mosienko V, Bashammakh S, Alenina N, Bader M. Tryptophan hydroxylase as novel target for the treatment of depressive disorders. Pharmacology. 2010;85(2):95\u2013109. https:\/\/doi.org\/10.1159\/000279322.","journal-title":"Pharmacology"},{"issue":"1","key":"860_CR3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1079\/PNS19870018","volume":"46","author":"PD Leathwood","year":"1987","unstructured":"Leathwood PD. Tryptophan availability and serotonin synthesis. Proc. Nutr. Soc. 1987;46(1):143\u201356. https:\/\/doi.org\/10.1079\/PNS19870018.","journal-title":"Proc. Nutr. Soc"},{"issue":"8","key":"860_CR4","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1017\/S1092852900018848","volume":"8","author":"JA Gingrich","year":"2003","unstructured":"Gingrich JA, Ansorge MS, Merker R, Weisstaub N, Zhou M. New Lessons from knockout mice: the role of serotonin during development and its possible contribution to the origins of neuropsychiatric disorders. CNS Spectr. 2003;8(8):572\u201377. https:\/\/doi.org\/10.1017\/S1092852900018848.","journal-title":"CNS Spectr"},{"issue":"10","key":"860_CR5","doi-asserted-by":"publisher","first-page":"881","DOI":"10.2165\/00007256-200636100-00006","volume":"36","author":"R Meeusen","year":"2006","unstructured":"Meeusen R, Watson P, Hasegawa H, Roelands B, Piacentini MF. Central fatigue: the serotonin hypothesis and beyond. Sports Med. 2006;36(10):881\u2013909. https:\/\/doi.org\/10.2165\/00007256-200636100-00006.","journal-title":"Sports Med"},{"key":"860_CR6","doi-asserted-by":"publisher","unstructured":"Mavanji V, Pomonis B, Kotz CM. Orexin, serotonin, and energy balance. WIREs Mechanisms Disease. 2022, 14;14(1). https:\/\/doi.org\/10.1002\/WSBM.1536.","DOI":"10.1002\/WSBM.1536"},{"issue":"5603","key":"860_CR7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1126\/science.1078197","volume":"299","author":"DJ Walther","year":"2003","unstructured":"Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science. 2003;299(5603):76. https:\/\/doi.org\/10.1126\/science.1078197","journal-title":"Sci (1979)"},{"issue":"7","key":"860_CR8","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1021\/CN5003573","volume":"6","author":"C Marcinkiewcz","year":"2015","unstructured":"Marcinkiewcz C. Serotonergic systems in the pathophysiology of ethanol dependence: relevance to clinical alcoholism. ACS Chem. Neurosci. 2015;6(7):1026\u201339. https:\/\/doi.org\/10.1021\/CN5003573.","journal-title":"ACS Chem. Neurosci"},{"key":"860_CR9","doi-asserted-by":"publisher","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of mental disorders. Diagnostic Stat Man Ment Disord. 2022. https:\/\/doi.org\/10.1176\/appi.books.9780890425787.","DOI":"10.1176\/appi.books.9780890425787"},{"key":"860_CR10","unstructured":"WHO. Global status report on alcohol and health and treatment of substance use disorders. 2024. Geneva."},{"issue":"1","key":"860_CR11","first-page":"65","volume":"21","author":"M Oscar-Berman","year":"1997","unstructured":"Oscar-Berman M, Shagrin B, Evert DL, Epstein C. Impairments of brain and behavior: the neurological effects of alcohol. Alcohol Health Res World. 1997;21(1):65\u201375.","journal-title":"Alcohol Health Res World"},{"issue":"11","key":"860_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/NU13113938","volume":"13","author":"D Nutt","year":"2021","unstructured":"Nutt D, Hayes A, Fonville L, Zafar R, Palmer EOC, Paterson L, et al. Alcohol and the brain. Nutrients. 2021;13(11):13. https:\/\/doi.org\/10.3390\/NU13113938.","journal-title":"Nutrients"},{"issue":"5","key":"860_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/BIOMEDICINES10051192","volume":"10","author":"W Yang","year":"2022","unstructured":"Yang W, Singla R, Maheshwari O, Fontaine CJ, Gil-Mohapel J. Alcohol use disorder: neurobiology and therapeutics. Biomedicines. 2022;10(5):10. https:\/\/doi.org\/10.3390\/BIOMEDICINES10051192.","journal-title":"Biomedicines"},{"issue":"2","key":"860_CR14","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1152\/PHYSREV.00013.2008","volume":"89","author":"R Spanagel","year":"2009","unstructured":"Spanagel R. Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev. 2009;89(2):649\u2013705. https:\/\/doi.org\/10.1152\/PHYSREV.00013.2008.","journal-title":"Physiol Rev"},{"issue":"1","key":"860_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.annemergmed.2024.02.016","volume":"84","author":"M Gottlieb","year":"2024","unstructured":"Gottlieb M, Chien N, Long B. Managing alcohol withdrawal syndrome. Ann Emerg Med. 2024;84(1):29\u201339. https:\/\/doi.org\/10.1016\/j.annemergmed.2024.02.016.","journal-title":"Ann Emerg Med"},{"issue":"9","key":"860_CR16","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/IJMS22094837","volume":"22","author":"M Kanova","year":"2021","unstructured":"Kanova M, Kohout P. Serotonin\u2014its synthesis and roles in the healthy and the critically Ill. IJMS. 2021;22(9):22. https:\/\/doi.org\/10.3390\/IJMS22094837.","journal-title":"IJMS"},{"key":"860_CR17","doi-asserted-by":"publisher","unstructured":"Cheng Y, Magnard R, Langdon AJ, Lee D, Janak PH, Janak P. Chronic ethanol exposure produces persistent impairment in cognitive flexibility and decision signals in the striatum. BioRxiv, 2025: 2024.03.10.584332. https:\/\/doi.org\/10.1101\/2024.03.10.584332.","DOI":"10.1101\/2024.03.10.584332"},{"issue":"1","key":"860_CR18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0306-4522(96)00109-1","volume":"74","author":"F Melis","year":"1996","unstructured":"Melis F, Stancampiano R, Imperato A, Carta G, Fadda F. Chronic ethanol consumption in rats: correlation between memory performance and hippocampal acetylcholine release in vivo. Neuroscience. 1996;74(1):155\u201359. https:\/\/doi.org\/10.1016\/0306-4522(96)00109-1.","journal-title":"Neuroscience"},{"issue":"2","key":"860_CR19","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S0031-9384(98)00301-1","volume":"66","author":"NV Lukoyanov","year":"1999","unstructured":"Lukoyanov NV, Madeira MD, Paula\u2013Barbosa MM. Behavioral and neuroanatomical consequences of chronic ethanol intake and withdrawal. Physiol Behav. 1999;66(2):337\u201346. https:\/\/doi.org\/10.1016\/S0031-9384(98)00301-1.","journal-title":"Physiol Behav"},{"key":"860_CR20","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.biopha.2021.111306","volume":"137","author":"B Jiang","year":"2021","unstructured":"Jiang B, Yang W, Xiu Z, Zhang L, Ren X, Wang L, et al. An in vivo explorative study to observe the protective effects of puerariae flos extract on chronic ethanol exposure and withdrawal male mice. Biomed Pharmacother. 2021;137:137. https:\/\/doi.org\/10.1016\/j.biopha.2021.111306.","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"860_CR21","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1177\/026988110201600404","volume":"16","author":"JS Silvestre","year":"2002","unstructured":"Silvestre JS, Pallar\u00e9s M, Nadal R, Ferr\u00e9 N. Opposite effects of ethanol and ketamine in the elevated plus-maze test in Wistar rats undergoing a chronic oral voluntary consumption procedure. J Psychopharmacol. 2002;16(4):305\u201312. https:\/\/doi.org\/10.1177\/026988110201600404.","journal-title":"J Psychopharmacol"},{"issue":"5","key":"860_CR22","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.euroneuro.2010.07.006","volume":"21","author":"MG Pisu","year":"2011","unstructured":"Pisu MG, Mostallino MC, Dore R, Maciocco E, Secci PP, Serra M. Effects of voluntary ethanol consumption on emotional state and stress responsiveness in socially isolated rats. Eur Neuropsychopharmacol. 2011;21(5):414\u201325. https:\/\/doi.org\/10.1016\/j.euroneuro.2010.07.006.","journal-title":"Eur Neuropsychopharmacol"},{"issue":"2","key":"860_CR23","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.bbr.2012.07.036","volume":"235","author":"M Morales-Mulia","year":"2012","unstructured":"Morales-Mulia M, Estrada-Camarena E, Amaya MI, Mej\u00eda-Maur\u00edes S, Sollozo-Dupont I, Mengod G, et al. Anxiolytic effects of ethanol are partially related to a reduced expression of adenylyl cyclase 5 but not to \u03bc-opioid receptor activation in rat nucleus accumbens. Behavioural Brain Res. 2012;235(2):189\u201394. https:\/\/doi.org\/10.1016\/j.bbr.2012.07.036.","journal-title":"Behavioural Brain Res"},{"issue":"5","key":"860_CR24","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1111\/j.1530-0277.1998.tb03695.x","volume":"22","author":"MJ Eckardt","year":"1998","unstructured":"Eckardt MJ, File SE, Gessa GL, Grant KA, Guerri C, Hoffman PL, et al. Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin Exp Res. 1998;22(5):998\u20131040. https:\/\/doi.org\/10.1111\/j.1530-0277.1998.tb03695.x.","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"860_CR25","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/S002130050988","volume":"144","author":"R Ciccocioppo","year":"1999","unstructured":"Ciccocioppo R, Panocka I, Froldi R, Colombo G, Gessa G, Massi M. Antidepressant-like effect of ethanol revealed in the forced swimming test in Sardinian alcohol-preferring rats. Psychopharmacol (Berl). 1999;144(2):151\u201357. https:\/\/doi.org\/10.1007\/S002130050988.","journal-title":"Psychopharmacol (Berl)"},{"issue":"5","key":"860_CR26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/CELLS11050874","volume":"11","author":"M Zaniewska","year":"2022","unstructured":"Zaniewska M, Mosienko V, Bader M, Alenina N. Tph2 gene expression defines ethanol drinking behavior in mice. Cells. 2022;11(5):11. https:\/\/doi.org\/10.3390\/CELLS11050874.","journal-title":"Cells"},{"issue":"6","key":"860_CR27","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.pnpbp.2006.03.028","volume":"30","author":"E Sa\u01e7lam","year":"2006","unstructured":"Sa\u01e7lam E, Kayir H, \u00c7elik T, Uzbay T. Effects of escitalopram on ethanol withdrawal syndrome in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(6):1027\u201332. https:\/\/doi.org\/10.1016\/j.pnpbp.2006.03.028.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"860_CR28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00008877-199812001-00090","volume":"9","author":"S H\u00f6lter","year":"1998","unstructured":"H\u00f6lter S, Engelmann M, Kirschke C, Liebsch G, Landgraf R, Spanagel R. Long-term ethanol self-administration with repeated ethanol deprivation episodes changes ethanol drinking pattern and increases anxiety-related behaviour during ethanol deprivation in rats. Behav Pharmacol. 1998;9(1):41\u201348.","journal-title":"Behav Pharmacol"},{"issue":"10","key":"860_CR29","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1111\/J.1530-0277.2002.TB02448.X","volume":"26","author":"GR Valdez","year":"2002","unstructured":"Valdez GR, Roberts AJ, Chan K, Davis H, Brennan M, Zorrilla EP, et al. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcohol Clin Exp Res. 2002;26(10):1494\u2013501. https:\/\/doi.org\/10.1111\/J.1530-0277.2002.TB02448.X.","journal-title":"Alcohol Clin Exp Res"},{"issue":"4","key":"860_CR30","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/ACER.14785","volume":"46","author":"NA Quijano Card\u00e9","year":"2022","unstructured":"Quijano Card\u00e9 NA, De Biasi M. Behavioral characterization of withdrawal following chronic voluntary ethanol consumption via intermittent two-bottle choice points to different susceptibility categories. Alcohol Clin Exp Res. 2022;46(4):614. https:\/\/doi.org\/10.1111\/ACER.14785.","journal-title":"Alcohol Clin Exp Res"},{"issue":"6","key":"860_CR31","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1037\/a0025922","volume":"125","author":"KA Badanich","year":"2011","unstructured":"Badanich KA, Becker HC, Woodward JJ. Effects of chronic intermittent ethanol exposure on orbitofrontal and medial prefrontal cortex-dependent behaviors in mice. Behav Neurosci. 2011;125(6):879\u201391. https:\/\/doi.org\/10.1037\/a0025922.","journal-title":"Behav Neurosci"},{"issue":"6","key":"860_CR32","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1007\/S43440-023-00545-6","volume":"75","author":"M Zaniewska","year":"2023","unstructured":"Zaniewska M, Alenina N, Fr\u00f6hler S, Chen W, Bader M. Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT2C receptor in the mouse brain. Pharmacol Rep. 2023, 75;75(6):1502\u201321. https:\/\/doi.org\/10.1007\/S43440-023-00545-6.","journal-title":"Pharmacol Rep"},{"key":"860_CR33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.alcohol.2017.01.015","volume":"61","author":"MA Roni","year":"2017","unstructured":"Roni MA, Rahman S. Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice. Alcohol. 2017;61:63\u201370. https:\/\/doi.org\/10.1016\/j.alcohol.2017.01.015.","journal-title":"Alcohol"},{"key":"860_CR34","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/B978-0-444-62619-6.00028-8","volume":"125","author":"LM Squeglia","year":"2014","unstructured":"Squeglia LM, Jacobus J, Tapert SF. The effect of alcohol use on human adolescent brain structures and systems. Handb Clin Neurol. 2014;125:501\u201310. https:\/\/doi.org\/10.1016\/B978-0-444-62619-6.00028-8.","journal-title":"Handb Clin Neurol"},{"issue":"1","key":"860_CR35","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/S00213-013-3090-0","volume":"229","author":"SM Gorka","year":"2013","unstructured":"Gorka SM, Fitzgerald DA, King AC, Phan KL. Alcohol attenuates amygdala\u2013frontal connectivity during processing social signals in heavy social drinkers. Psychopharmacol (Berl). 2013;229(1):141\u201354. https:\/\/doi.org\/10.1007\/S00213-013-3090-0.","journal-title":"Psychopharmacol (Berl)"},{"issue":"1","key":"860_CR36","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.neuroimage.2010.11.062","volume":"55","author":"CS Sripada","year":"2011","unstructured":"Sripada CS, Angstadt M, McNamara P, King AC, Phan KL. Effects of alcohol on brain responses to social signals of threat in humans. Neuroimage. 2011;55(1):371\u201380. https:\/\/doi.org\/10.1016\/j.neuroimage.2010.11.062.","journal-title":"Neuroimage"},{"issue":"7","key":"860_CR37","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/S007020170038","volume":"108","author":"DF Braus","year":"2001","unstructured":"Braus DF, Wrase J, Gr\u00fcsser S, Hermann D, Ruf M, Flor H, et al. Alcohol-associated stimuli activate the ventral striatum in abstinent alcoholics. J Neural Transm. 2001;108(7):887\u201394. https:\/\/doi.org\/10.1007\/S007020170038.","journal-title":"J Neural Transm"},{"issue":"5","key":"860_CR38","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0924-9338(02)00676-4","volume":"17","author":"J Wrase","year":"2002","unstructured":"Wrase J, Gr\u00fcsser SM, Klein S, Diener C, Hermann D, Flor H, et al. Development of alcohol-associated cues and cue-induced brain activation in alcoholics. Eur Psychiatr. 2002;17(5):287\u201391. https:\/\/doi.org\/10.1016\/S0924-9338(02)00676-4.","journal-title":"Eur Psychiatr"},{"issue":"4","key":"860_CR39","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1001\/ARCHPSYC.58.4.345","volume":"58","author":"MS George","year":"2001","unstructured":"George MS, Anton RF, Bloomer C, Teneback C, Drobes DJ, Lorberbaum JP, et al. Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues. Arch Gen Psychiatry. 2001;58(4):345\u201352. https:\/\/doi.org\/10.1001\/ARCHPSYC.58.4.345.","journal-title":"Arch Gen Psychiatry"},{"issue":"7","key":"860_CR40","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1176\/APPI.AJP.158.7.1075","volume":"158","author":"F Schneider","year":"2001","unstructured":"Schneider F, Habel U, Wagner M, Franke P, Salloum JB, Shah NJ, et al. Subcortical correlates of craving in recently abstinent alcoholic patients. AJP. 2001;158(7):1075\u201383. https:\/\/doi.org\/10.1176\/APPI.AJP.158.7.1075.","journal-title":"AJP"},{"key":"860_CR41","doi-asserted-by":"publisher","unstructured":"Gr\u00fcsser SM, Wrase J, Klein S, Hermann D, Smolka MN, Ruf M, et al. Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics. Psychopharmacol (Berl). 2004;175(3):296\u2013302. https:\/\/doi.org\/10.1007\/S00213-004-1828-4.","DOI":"10.1007\/S00213-004-1828-4"},{"issue":"6","key":"860_CR42","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1111\/J.1530-0277.2009.00916.X","volume":"33","author":"C Vilpoux","year":"2009","unstructured":"Vilpoux C, Warnault V, Pierrefiche O, Daoust M, Naassila M. Ethanol-sensitive brain regions in rat and mouse: a cartographic review, using immediate early gene expression. Alcohol Clin Exp Res. 2009;33(6):945\u201369. https:\/\/doi.org\/10.1111\/J.1530-0277.2009.00916.X.","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"860_CR43","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0163-7258(99)00040-6","volume":"84","author":"HJ Little","year":"1999","unstructured":"Little HJ. The contribution of electrophysiology to knowledge of the acute and chronic effects of ethanol. Pharmacol Ther. 1999;84(3):333\u201353. https:\/\/doi.org\/10.1016\/S0163-7258(99)00040-6.","journal-title":"Pharmacol Ther"},{"issue":"2","key":"860_CR44","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/BJP.2008.30","volume":"154","author":"V Vengeliene","year":"2008","unstructured":"Vengeliene V, Bilbao A, Molander A, Spanagel R. Neuropharmacology of alcohol addiction. Br J Pharmacol. 2008;154(2):299. https:\/\/doi.org\/10.1038\/BJP.2008.30.","journal-title":"Br J Pharmacol"},{"key":"860_CR45","first-page":"1","volume":"232","author":"A Dahlstr\u00f6m","year":"1964","unstructured":"Dahlstr\u00f6m A, Fuxe K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand Suppl. 1964, Suppl, 232:1\u201355.","journal-title":"Acta Physiol Scand Suppl"},{"key":"860_CR46","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/J.ICS.2007.07.046","volume":"1304","author":"RP Vertes","year":"2007","unstructured":"Vertes RP, Linley SB. Comparison of projections of the dorsal and median raphe nuclei, with some functional considerations. Int Congr Ser. 2007;1304:98\u2013120. https:\/\/doi.org\/10.1016\/J.ICS.2007.07.046.","journal-title":"Int Congr Ser"},{"issue":"3","key":"860_CR47","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s12035-011-8214-0","volume":"44","author":"MV Puig","year":"2011","unstructured":"Puig MV, Gulledge AT. Serotonin and prefrontal cortex function: neurons, networks, and circuits. Mol Neurobiol. 2011;44(3):449\u201364. https:\/\/doi.org\/10.1007\/s12035-011-8214-0.","journal-title":"Mol Neurobiol"},{"key":"860_CR48","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/B978-0-444-64125-0.00002-5","volume":"31","author":"M Soiza-Reilly","year":"2020","unstructured":"Soiza-Reilly M, Gaspar P. From B1 to B9: a guide through hindbrain serotonin neurons with additional views from multidimensional characterization. Handb Behav Neurosci. 2020;31:23\u201340. https:\/\/doi.org\/10.1016\/B978-0-444-64125-0.00002-5.","journal-title":"Handb Behav Neurosci"},{"issue":"1","key":"860_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-022-35346-7","volume":"13","author":"H Kawai","year":"2022","unstructured":"Kawai H, Bouchekioua Y, Nishitani N, Niitani K, Izumi S, Morishita H, et al. Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion. Nat Commun. 2022;13(1):1\u201322. https:\/\/doi.org\/10.1038\/s41467-022-35346-7.","journal-title":"Nat Commun"},{"key":"860_CR50","doi-asserted-by":"publisher","first-page":"8","DOI":"10.7554\/ELIFE.49424","volume":"8","author":"J Ren","year":"2019","unstructured":"Ren J, Isakova A, Friedmann D, Zeng J, Grutzner SM, Pun A, et al. Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei. Elife. 2019;8:8. https:\/\/doi.org\/10.7554\/ELIFE.49424.","journal-title":"Elife"},{"issue":"2","key":"860_CR51","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.cell.2018.07.043","volume":"175","author":"J Ren","year":"2018","unstructured":"Ren J, Friedmann D, Xiong J, Liu CD, Ferguson BR, Weerakkody T, et al. Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems. Cell. 2018;175(2):472\u201387.e20. https:\/\/doi.org\/10.1016\/j.cell.2018.07.043.","journal-title":"Cell"},{"issue":"1","key":"860_CR52","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0006-8993(90)91179-K","volume":"512","author":"JS Ferraro","year":"1990","unstructured":"Ferraro JS, Steger RW. Diurnal variations in brain serotonin are driven by the photic cycle and are not circadian in nature. Brain Res. 1990;512(1):121\u201324. https:\/\/doi.org\/10.1016\/0006-8993(90)91179-K.","journal-title":"Brain Res"},{"issue":"3","key":"860_CR53","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/SYN.10229","volume":"49","author":"ST Bland","year":"2003","unstructured":"Bland ST, Twining C, Watkins LR, Maier SF. Stressor controllability modulates stress-induced serotonin but not dopamine efflux in the nucleus accumbens shell. Synapse. 2003;49(3):206\u201308. https:\/\/doi.org\/10.1002\/SYN.10229.","journal-title":"Synapse"},{"issue":"1\u20132","key":"860_CR54","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0304-3940(93)90565-3","volume":"162","author":"H Kawahara","year":"1993","unstructured":"Kawahara H, Yoshida M, Yokoo H, Nishi M, Tanaka M. Psychological stress increases serotonin release in the rat amygdala and prefrontal cortex assessed by in vivo microdialysis. Neurosci Lett. 1993;162(1\u20132):81\u201384. https:\/\/doi.org\/10.1016\/0304-3940(93)90565-3.","journal-title":"Neurosci Lett"},{"issue":"3","key":"860_CR55","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0304-3940(96)12982-7","volume":"215","author":"M Matsuo","year":"1996","unstructured":"Matsuo M, Kataoka Y, Mataki S, Kato Y, Oi K. Conflict situation increases serotonin release in rat dorsal hippocampus: in vivo study with microdialysis and Vogel test. Neurosci Lett. 1996;215(3):197\u2013200. https:\/\/doi.org\/10.1016\/0304-3940(96)12982-7.","journal-title":"Neurosci Lett"},{"issue":"3","key":"860_CR56","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1001\/ARCHPSYC.1996.01830030029006","volume":"53","author":"ML F\u00fcs-Aime","year":"1996","unstructured":"F\u00fcs-Aime ML. Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics. Arch Gen Psychiatry. 1996;53(3):211\u201316. https:\/\/doi.org\/10.1001\/ARCHPSYC.1996.01830030029006.","journal-title":"Arch Gen Psychiatry"},{"issue":"9","key":"860_CR57","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/0024-3205(74)90320-8","volume":"15","author":"M Hamon","year":"1974","unstructured":"Hamon M, Glowinski J. Regulation of serotonin synthesis. Life Sci. 1974;15(9):1533\u201348. https:\/\/doi.org\/10.1016\/0024-3205(74)90320-8.","journal-title":"Life Sci"},{"issue":"4","key":"860_CR58","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/J.EURONEURO.2008.12.005","volume":"19","author":"L Gutknecht","year":"2009","unstructured":"Gutknecht L, Kriegebaum C, Waider J, Schmitt A, Lesch K. Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. Eur Neuropsychopharmacol. 2009;19(4):266\u201382. https:\/\/doi.org\/10.1016\/J.EURONEURO.2008.12.005.","journal-title":"Eur Neuropsychopharmacol"},{"key":"860_CR59","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/0-306-47141-8_10","volume":"13","author":"M Virkkunen","year":"1997","unstructured":"Virkkunen M, Linnoila M. Serotonin in early-onset alcoholism. Recent Dev Alcohol. 1997;13:173\u201389. https:\/\/doi.org\/10.1007\/0-306-47141-8_10.","journal-title":"Recent Dev Alcohol"},{"issue":"2","key":"860_CR60","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S0006-3223(96)00217-X","volume":"41","author":"JJ Mann","year":"1997","unstructured":"Mann JJ, Malone KM. Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biol Psychiatry. 1997;41(2):162\u201371. https:\/\/doi.org\/10.1016\/S0006-3223(96)00217-X.","journal-title":"Biol Psychiatry"},{"issue":"1","key":"860_CR61","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/J.1749-6632.1997.TB52359.X","volume":"836","author":"M \u00c5sberg","year":"1997","unstructured":"\u00c5sberg M. Neurotransmitters and suicidal behavior. The evidence from cerebrospinal fluid studies. Ann New Y Acad Sci. 1997;836(1):158\u201381. https:\/\/doi.org\/10.1111\/J.1749-6632.1997.TB52359.X.","journal-title":"Ann New Y Acad Sci"},{"issue":"4","key":"860_CR62","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/SJ.MP.4001949","volume":"12","author":"HG Ruh\u00e9","year":"2007","unstructured":"Ruh\u00e9 HG, Mason NS, Schene AH. Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol. Psychiatry. 2007;12(4):331\u201359. https:\/\/doi.org\/10.1038\/SJ.MP.4001949.","journal-title":"Mol. Psychiatry"},{"issue":"9056","key":"860_CR63","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/S0140-6736(96)07044-4","volume":"349","author":"KA Smith","year":"1997","unstructured":"Smith KA, Fairburn CG, Cowen PJ. Relapse of depression after rapid depletion of tryptophan. Lancet. 1997;349(9056):915\u201319. https:\/\/doi.org\/10.1016\/S0140-6736(96)07044-4.","journal-title":"Lancet"},{"issue":"10","key":"860_CR64","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1177\/0269881116648317","volume":"30","author":"T Furmark","year":"2016","unstructured":"Furmark T, Marteinsdottir I, Frick A, Heurling K, Tillfors M, Appel L, et al. Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder. J Psychopharmacol. 2016;30(10):1028\u201335. https:\/\/doi.org\/10.1177\/0269881116648317.","journal-title":"J Psychopharmacol"},{"issue":"1","key":"860_CR65","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/J.1749-6632.1997.TB52354.X","volume":"836","author":"JD Higley","year":"1997","unstructured":"Higley JD, Linnoila M. Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmission. Ann New Y Acad Sci. 1997;836(1):39\u201356. https:\/\/doi.org\/10.1111\/J.1749-6632.1997.TB52354.X.","journal-title":"Ann New Y Acad Sci"},{"issue":"3","key":"860_CR66","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/BF00307184","volume":"135","author":"H Baumgarten","year":"1972","unstructured":"Baumgarten H, Lachenmayer L. 5, 7-dihydroxytryptamine: improvement in chemical lesioning of indoleamine neurons in the mammalian brain. Z.Zellforsch. 1972;135(3):399\u2013414. https:\/\/doi.org\/10.1007\/BF00307184.","journal-title":"Z.Zellforsch"},{"issue":"25","key":"860_CR67","doi-asserted-by":"publisher","first-page":"10332","DOI":"10.1073\/pnas.0810793106","volume":"106","author":"N Alenina","year":"2009","unstructured":"Alenina N, Kikic D, Todiras M, Mosienko V, Qadri F, Plehm R, et al. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci USA. 2009;106(25):10332\u201337. https:\/\/doi.org\/10.1073\/pnas.0810793106.","journal-title":"Proc Natl Acad Sci USA"},{"key":"860_CR68","doi-asserted-by":"publisher","unstructured":"Savelieva KV, Zhao S, Pogorelov VM, Rajan I, Yang Q, Cullinan E, et al. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One. 2008;3(10):e3301. https:\/\/doi.org\/10.1371\/journal.pone.0003301.","DOI":"10.1371\/journal.pone.0003301"},{"issue":"3","key":"860_CR69","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1098\/RSBL.2015.0057","volume":"11","author":"D Beis","year":"2015","unstructured":"Beis D, Holzwarth K, Flinders M, Bader M, W\u00f6hr M, Alenina N. Brain serotonin deficiency leads to social communication deficits in mice. Biol Lett. 2015;11(3):11. https:\/\/doi.org\/10.1098\/RSBL.2015.0057.","journal-title":"Biol Lett"},{"key":"860_CR70","doi-asserted-by":"publisher","unstructured":"Mosienko V, Bert B, Beis D, Matthes S, Fink H, Bader M, et al. Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin. Transl Psychiatry. 2012;2(5):e122. https:\/\/doi.org\/10.1038\/tp.2012.44.","DOI":"10.1038\/tp.2012.44"},{"issue":"14","key":"860_CR71","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1007\/s00213-015-3879-0","volume":"232","author":"L Gutknecht","year":"2015","unstructured":"Gutknecht L, Popp S, Waider J, Sommerlandt FMJ, G\u00f6ppner C, Post A, et al. Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice. Psychopharmacol (Berl). 2015;232(14):2429\u201341. https:\/\/doi.org\/10.1007\/s00213-015-3879-0.","journal-title":"Psychopharmacol (Berl)"},{"issue":"6","key":"860_CR72","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1111\/J.1471-4159.2012.07739.X","volume":"121","author":"M Angoa-P\u00e9rez","year":"2012","unstructured":"Angoa-P\u00e9rez M, Kane MJ, Briggs DI, Sykes CE, Shah MM, Francescutti DM, et al. Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. J Neurochem. 2012;121(6):974\u201384. https:\/\/doi.org\/10.1111\/J.1471-4159.2012.07739.X.","journal-title":"J Neurochem"},{"issue":"1","key":"860_CR73","doi-asserted-by":"publisher","first-page":"11847","DOI":"10.1038\/S41598-018-30291-2","volume":"8","author":"G Maddaloni","year":"2018","unstructured":"Maddaloni G, Migliarini S, Napolitano F, Giorgi A, Nazzi S, Biasci D, et al. Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Sci Rep. 2018;8(1):11847. https:\/\/doi.org\/10.1038\/S41598-018-30291-2.","journal-title":"Sci Rep"},{"key":"860_CR74","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/FCELL.2019.00065","volume":"7","author":"M van Lingen","year":"2019","unstructured":"van Lingen M, Sidorova M, Alenina N, Klempin F. Lack of brain serotonin affects feeding and differentiation of newborn Cells in the adult hypothalamus. Front. Cell Dev. Biol. 2019;7:7. https:\/\/doi.org\/10.3389\/FCELL.2019.00065.","journal-title":"Front. Cell Dev. Biol"},{"issue":"10","key":"860_CR75","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/MP.2012.128","volume":"18","author":"S Migliarini","year":"2013","unstructured":"Migliarini S, Pacini G, Pelosi B, Lunardi G, Pasqualetti M. Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation. Mol. Psychiatry. 2013;18(10):1106\u201318. https:\/\/doi.org\/10.1038\/MP.2012.128.","journal-title":"Mol. Psychiatry"},{"issue":"10","key":"860_CR76","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1021\/CN500096G","volume":"5","author":"M Angoa-P\u00e9rez","year":"2014","unstructured":"Angoa-P\u00e9rez M, Kane MJ, Briggs DI, Herrera-Mundo N, Sykes CE, Francescutti DM, et al. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS Chem. Neurosci. 2014;5(10):908\u201319. https:\/\/doi.org\/10.1021\/CN500096G.","journal-title":"ACS Chem. Neurosci"},{"key":"860_CR77","doi-asserted-by":"publisher","unstructured":"Maddaloni G, Migliarini S, Napolitano F, Giorgi A, Biasci D, De FA, et al. Serotonin buffers hippocampal neuroplasticity and emotional behavior. BioRxiv. 2017;123646. https:\/\/doi.org\/10.1101\/123646.","DOI":"10.1101\/123646"},{"issue":"1","key":"860_CR78","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/J.NEURON.2004.12.014","volume":"45","author":"X Zhang","year":"2005","unstructured":"Zhang X, Gainetdinov R, Beaulieu J, Sotnikova T, Burch L, Williams R, et al. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron. 2005;45(1):11\u201316. https:\/\/doi.org\/10.1016\/J.NEURON.2004.12.014.","journal-title":"Neuron"},{"issue":"7","key":"860_CR79","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/MP.2011.50","volume":"17","author":"JPR Jacobsen","year":"2012","unstructured":"Jacobsen JPR, Siesser WB, Sachs BD, Peterson S, Cools MJ, Setola V, et al. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Mol. Psychiatry. 2012;17(7):694\u2013704. https:\/\/doi.org\/10.1038\/MP.2011.50.","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"860_CR80","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1073\/PNAS.0711496105","volume":"105","author":"JM Beaulieu","year":"2008","unstructured":"Beaulieu JM, Zhang X, Rodriguiz RM, Sotnikova TD, Cools MJ, Wetsel WC, et al. Role of GSK3\u03b2 in behavioral abnormalities induced by serotonin deficiency. Proc Natl Acad Sci USA. 2008;105(4):1333\u201338. https:\/\/doi.org\/10.1073\/PNAS.0711496105.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"860_CR81","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nrn2284","volume":"9","author":"DL Murphy","year":"2008","unstructured":"Murphy DL, Lesch KP. Targeting the murine serotonin transporter: insights into human neurobiology. Nat. Rev. Neurosci. 2008;9(2):85\u201396. https:\/\/doi.org\/10.1038\/nrn2284.","journal-title":"Nat. Rev. Neurosci"},{"issue":"1","key":"860_CR82","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1471-2210-11-3","volume":"11","author":"PR Moya","year":"2011","unstructured":"Moya PR, Fox MA, Jensen CL, Laporte JL, French HT, Wendland JR, et al. Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC Pharmacol. 2011;11(1):3. https:\/\/doi.org\/10.1186\/1471-2210-11-3.","journal-title":"BMC Pharmacol"},{"issue":"3","key":"860_CR83","doi-asserted-by":"publisher","first-page":"213","DOI":"10.5114\/AIN.2024.149307","volume":"37","author":"A Borrego-Ruiz","year":"2024","unstructured":"Borrego-Ruiz A. A current overview on adolescent alcohol misuse and its potential negative impacts. ain. 2024;37(3):213\u201340. https:\/\/doi.org\/10.5114\/AIN.2024.149307.","journal-title":"ain"},{"issue":"8","key":"860_CR84","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1001\/ARCHPSYC.1981.01780330019001","volume":"38","author":"CR Cloninger","year":"1981","unstructured":"Cloninger CR. Inheritance of alcohol abuse: Cross-fostering analysis of adopted men. Arch Gen Psychiatry. 1981;38(8):861\u201368. https:\/\/doi.org\/10.1001\/ARCHPSYC.1981.01780330019001.","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"860_CR85","first-page":"18","volume":"20","author":"CR Cloninger","year":"1996","unstructured":"Cloninger CR, Sigvardsson S, Bohman M. Type I and type II alcoholism: an Update. Alcohol Health Res World. 1996;20(1):18.","journal-title":"Alcohol Health Res World"},{"issue":"8","key":"860_CR86","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1001\/ARCHPSYC.1992.01820080007002","volume":"49","author":"T Babor","year":"1992","unstructured":"Babor T, et al. Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry. 1992;49(8):599\u2013608. https:\/\/doi.org\/10.1001\/ARCHPSYC.1992.01820080007002.","journal-title":"Arch Gen Psychiatry"},{"issue":"9","key":"860_CR87","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1007\/S00702-005-0412-3","volume":"113","author":"K Berglund","year":"2006","unstructured":"Berglund K, Fahlke C, Berggren U, Eriksson M, Balldin J. Personality profile in type I alcoholism: long duration of alcohol intake and low serotonergic activity are predictive factors of anxiety proneness. J Neural Transm (Vienna). 2006;113(9):1287\u201398. https:\/\/doi.org\/10.1007\/S00702-005-0412-3.","journal-title":"J Neural Transm (Vienna)"},{"issue":"10","key":"860_CR88","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1097\/01.ALC.0000090143.00703.07","volume":"27","author":"M Johann","year":"2003","unstructured":"Johann M, Bobbe G, Putzhammer A, Wodarz N. Comorbidity of alcohol dependence with attention-deficit hyperactivity disorder: differences in phenotype with increased severity of the substance disorder, but not in genotype (serotonin transporter and 5-hydroxytryptamine-2c receptor). Alcohol Clin Exp Res. 2003;27(10):1527\u201334. https:\/\/doi.org\/10.1097\/01.ALC.0000090143.00703.07.","journal-title":"Alcohol Clin Exp Res"},{"key":"860_CR89","doi-asserted-by":"publisher","unstructured":"Koller G, Bondy B, Preuss UW, Zill P, Soyka M. The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients. Behav Brain Funct. 2006, 2;2(1). https:\/\/doi.org\/10.1186\/1744-9081-2-7.","DOI":"10.1186\/1744-9081-2-7"},{"issue":"9","key":"860_CR90","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1111\/J.1530-0277.1996.TB01696.X","volume":"20","author":"H Kranzler","year":"1996","unstructured":"Kranzler H, Burleson J, Brown J, Babor T. Fluoxetine treatment seems to reduce the beneficial effects of cognitive-behavioral therapy in type B alcoholics. Alcohol Clin Exp Res. 1996;20(9):1534\u201341. https:\/\/doi.org\/10.1111\/J.1530-0277.1996.TB01696.X.","journal-title":"Alcohol Clin Exp Res"},{"issue":"7","key":"860_CR91","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1111\/j.1530-0277.2000.tb04648.x","volume":"24","author":"H Pettinati","year":"2000","unstructured":"Pettinati H, Volpicelli J, Kranzler H, Luck G, Rukstalis M, Cnaan A. Sertraline treatment for alcohol dependence: interactive effects of medication and alcoholic subtype. Alcohol Clin Exp Res. 2000;24(7):1041\u201349. https:\/\/doi.org\/10.1111\/j.1530-0277.2000.tb04648.x.","journal-title":"Alcohol Clin Exp Res"},{"issue":"6","key":"860_CR92","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/J.1600-0404.1987.TB03605.X","volume":"76","author":"P Wester","year":"1987","unstructured":"Wester P, Puu G, Reiz S, Winblad B, Wester PO. Increased monoamine metabolite concentrations and cholinesterase activities in cerebrospinal fluid of patients with acute stroke. Acta Neurologica Scandinavica. 1987;76(6):473\u201379. https:\/\/doi.org\/10.1111\/J.1600-0404.1987.TB03605.X.","journal-title":"Acta Neurologica Scandinavica"},{"issue":"8101","key":"860_CR93","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/d41586-026-00283-8","volume":"650","author":"D Adam","year":"2026","unstructured":"Adam D. The \u2018bible for psychiatry\u2019 is getting a rewrite: your guide to the next DSM. Nature. 2026;650(8101):282\u201383. https:\/\/doi.org\/10.1038\/d41586-026-00283-8.","journal-title":"Nature"},{"issue":"6","key":"860_CR94","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1111\/add.15735","volume":"117","author":"JA Puddephatt","year":"2022","unstructured":"Puddephatt JA, Irizar P, Jones A, Gage SH, Goodwin L. Associations of common mental disorder with alcohol use in the adult general population: a systematic review and meta-analysis. Addict (Abingdon, Engl). 2022;117(6):1543\u201372. https:\/\/doi.org\/10.1111\/add.15735.","journal-title":"Addict (Abingdon, Engl)"},{"issue":"11","key":"860_CR95","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.2174\/1570159x21666230403080624","volume":"21","author":"M Di Nicola","year":"2023","unstructured":"Di Nicola M, Pepe M, Panaccione I, Moccia L, Janiri L, Sani G. Update on pharmacological treatment for comorbid major depressiveand alcohol use disorders: the role of Extended-release Trazodone. CN. 2023;21(11):2195\u2013205. https:\/\/doi.org\/10.2174\/1570159x21666230403080624.","journal-title":"CN"},{"issue":"3","key":"860_CR96","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1007\/s13311-020-00851-4","volume":"17","author":"SL Leong","year":"2020","unstructured":"Leong SL, Glue P, Manning P, Vanneste S, Lim LJ, Mohan A, et al. Anterior cingulate cortex implants for alcohol addiction: a feasibility study. Neurotherapeutics. 2020;17(3):1287\u201399. https:\/\/doi.org\/10.1007\/s13311-020-00851-4.","journal-title":"Neurotherapeutics"},{"issue":"2","key":"860_CR97","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1369-1600.2009.00194.x","volume":"15","author":"M Heilig","year":"2010","unstructured":"Heilig M, Egli M, Crabbe JC, Becker HC. REVIEW: acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? Addict Biol. 2010;15(2):169\u201384. https:\/\/doi.org\/10.1111\/j.1369-1600.2009.00194.x.","journal-title":"Addict Biol"},{"key":"860_CR98","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/J.BBI.2022.07.160","volume":"107","author":"KM Khan","year":"2023","unstructured":"Khan KM, Bierlein-De La Rosa G, Biggerstaff N, Pushpavathi Selvakumar G, Wang R, Mason S, et al. Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood. Brain Behav Immun. 2023;107:419\u201331. https:\/\/doi.org\/10.1016\/J.BBI.2022.07.160.","journal-title":"Brain Behav Immun"},{"issue":"4","key":"860_CR99","doi-asserted-by":"publisher","first-page":"432","DOI":"10.35946\/arcr.v34.4.07","volume":"34","author":"R Sinha","year":"2012","unstructured":"Sinha R. How does stress lead to risk of alcohol relapse? ARCR. 2012;34(4):432. https:\/\/doi.org\/10.35946\/arcr.v34.4.07.","journal-title":"ARCR"},{"issue":"2","key":"860_CR100","doi-asserted-by":"publisher","first-page":"05","DOI":"10.35946\/arcr.v40.2.05","volume":"40","author":"MIB Guinle","year":"2020","unstructured":"Guinle MIB. The role of stress, trauma, and negative affect in the development of alcohol misuse and alcohol use disorders in women. ARCR. 2020;40(2):05. https:\/\/doi.org\/10.35946\/arcr.v40.2.05.","journal-title":"ARCR"},{"key":"860_CR101","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fpsyt.2020.620612","volume":"11","author":"K Yazdi","year":"2020","unstructured":"Yazdi K, Fuchs-Leitner I, Rosenleitner J, Gerstgrasser NW. Impact of the COVID-19 pandemic on patients with alcohol use disorder and associated risk factors for relapse. Front. Psychiatry. 2020;11:11. https:\/\/doi.org\/10.3389\/fpsyt.2020.620612.","journal-title":"Front. Psychiatry"},{"issue":"3","key":"860_CR102","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s002130000411","volume":"150","author":"AD L\u00ea","year":"2000","unstructured":"L\u00ea AD, Harding S, Juzytsch W, Watchus J, Shalev U, Shaham Y. The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats. Psychopharmacol (Berl). 2000;150(3):317\u201324. https:\/\/doi.org\/10.1007\/s002130000411.","journal-title":"Psychopharmacol (Berl)"},{"key":"860_CR103","doi-asserted-by":"publisher","first-page":"171607","DOI":"10.3389\/fncel.2016.00045","volume":"10","author":"RI Anderson","year":"2016","unstructured":"Anderson RI, Lopez MF, Becker HC. Stress-induced enhancement of ethanol intake in C57Bl\/6J mice with a history of chronic ethanol exposure: involvement of kappa opioid receptors. Front. Cell. Neurosci. 2016;10:171607. https:\/\/doi.org\/10.3389\/fncel.2016.00045.","journal-title":"Front. Cell. Neurosci"},{"issue":"7","key":"860_CR104","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1007\/s00213-022-06120-w","volume":"239","author":"YS Mineur","year":"2022","unstructured":"Mineur YS, Garcia-Rivas V, Thomas MA, Soares AR, McKee SA, Picciotto MR. Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways. Psychopharmacol (Berl). 2022;239(7):2041\u201361. https:\/\/doi.org\/10.1007\/s00213-022-06120-w.","journal-title":"Psychopharmacol (Berl)"},{"key":"860_CR105","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.neuropharm.2017.01.037","volume":"122","author":"SK Blaine","year":"2017","unstructured":"Blaine SK, Sinha SR. Alcohol, stress, and glucocorticoids: from risk to dependence and relapse in alcohol use disorders. Neuropharmacology. 2017;122:136. https:\/\/doi.org\/10.1016\/j.neuropharm.2017.01.037.","journal-title":"Neuropharmacology"},{"issue":"1","key":"860_CR106","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/jnr.24703","volume":"100","author":"JD Lorente","year":"2022","unstructured":"Lorente JD, Cuitavi J, Campos-Jurado Y, Hip\u00f3lito L. Pain-induced alterations in the dynorphinergic system within the mesocorticolimbic pathway: implication for alcohol addiction. J Neurosci Res. 2022;100(1):165\u201382. https:\/\/doi.org\/10.1002\/jnr.24703.","journal-title":"J Neurosci Res"},{"issue":"2","key":"860_CR107","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1177\/0269881115622238","volume":"30","author":"M Gonz\u00e1lez-Sep\u00falveda","year":"2016","unstructured":"Gonz\u00e1lez-Sep\u00falveda M, Pozo OJ, Marcos J, Valverde O. Chronic pain causes a persistent anxiety state leading to increased ethanol intake in CD1 mice. J Psychopharmacol. 2016;30(2):188\u2013203. https:\/\/doi.org\/10.1177\/0269881115622238.","journal-title":"J Psychopharmacol"},{"issue":"1","key":"860_CR108","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/j.pain.0000000000001386","volume":"160","author":"D De Gregorio","year":"2019","unstructured":"De Gregorio D, McLaughlin RJ, Posa L, Ochoa-Sanchez R, Enns J, Lopez-Canul M, et al. Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Pain. 2019;160(1):136\u201350. https:\/\/doi.org\/10.1097\/j.pain.0000000000001386.","journal-title":"Pain"},{"issue":"07","key":"860_CR109","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1017\/S0033291719000667","volume":"49","author":"R Polimanti","year":"2019","unstructured":"Polimanti R, Peterson RE, Ong JS, MacGregor S, Edwards AC, Clarke TK, et al. Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. Psychol Med. 2019;49(07):1218\u201326. https:\/\/doi.org\/10.1017\/S0033291719000667.","journal-title":"Psychol Med"},{"issue":"1","key":"860_CR110","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0165-1781(80)90012-8","volume":"2","author":"NE Rosenthal","year":"1980","unstructured":"Rosenthal NE, Davenport Y, Cowdry RW, Webster MH, Goodwin FK. Monoamine metabolites in cerebrospinal fluid of depressive subgroups. Psychiatry Res. 1980;2(1):113\u201319. https:\/\/doi.org\/10.1016\/0165-1781(80)90012-8.","journal-title":"Psychiatry Res"},{"issue":"4","key":"860_CR111","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1111\/J.1530-0277.2007.00610.X","volume":"32","author":"MD Underwood","year":"2008","unstructured":"Underwood MD, Mann JJ, Huang YY, Arango V. Family history of alcoholism is associated with lower 5-HT2A receptor binding in the prefrontal cortex. Alcohol Clin Exp Res. 2008;32(4):593\u201399. https:\/\/doi.org\/10.1111\/J.1530-0277.2007.00610.X.","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"860_CR112","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/0091-3057(94)90077-9","volume":"49","author":"CS Aulakh","year":"1994","unstructured":"Aulakh CS, Tolliver T, Wozniak KM, Hill JL, Murphy DL. Functional and biochemical evidence for altered serotonergic function in the fawn-hooded rat strain. Pharmacol Biochem Behav. 1994;49(3):615\u201320. https:\/\/doi.org\/10.1016\/0091-3057(94)90077-9.","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"860_CR113","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1093\/OXFORDJOURNALS.ALCALC.A008386","volume":"33","author":"P Devoto","year":"1998","unstructured":"Devoto P, Colombo G, Stefanini E, Gessa GL. Serotonin is reduced in the frontal cortex of Sardinian ethanol-preferring rats. Alcohol Alcohol. 1998;33(3):226\u201329. https:\/\/doi.org\/10.1093\/OXFORDJOURNALS.ALCALC.A008386.","journal-title":"Alcohol Alcohol"},{"issue":"1","key":"860_CR114","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0014-2999(99)00239-3","volume":"373","author":"R Ciccocioppo","year":"1999","unstructured":"Ciccocioppo R, Angeletti S, Colombo G, Gessa G, Massi M. Autoradiographic analysis of 5-HT2A binding sites in the brain of Sardinian alcohol-preferring and nonpreferring rats. Eur J Pharmacol. 1999;373(1):13\u201319. https:\/\/doi.org\/10.1016\/S0014-2999(99)00239-3.","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"860_CR115","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0741-8329(90)90005-W","volume":"7","author":"WJ McBride","year":"1990","unstructured":"McBride WJ, Murphy JM, Lumeng L, Li TK. Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats. Alcohol. 1990;7(3):199\u2013205. https:\/\/doi.org\/10.1016\/0741-8329(90)90005-W.","journal-title":"Alcohol"},{"issue":"1","key":"860_CR116","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0091-3057(82)90026-0","volume":"16","author":"JM Murphy","year":"1982","unstructured":"Murphy JM, McBride WJ, Lumeng L, Li TK. Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats. Pharmacol Biochem Behav. 1982;16(1):145\u201349. https:\/\/doi.org\/10.1016\/0091-3057(82)90026-0.","journal-title":"Pharmacol Biochem Behav"},{"issue":"6","key":"860_CR117","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S0741-8329(91)90034-T","volume":"8","author":"FC Zhou","year":"1991","unstructured":"Zhou FC, Bledsoe S, Lumeng L, Li TK. Immunostained serotonergic fibers are decreased in selected brain regions of alcohol-preferring rats. Alcohol. 1991;8(6):425\u201331. https:\/\/doi.org\/10.1016\/S0741-8329(91)90034-T.","journal-title":"Alcohol"},{"issue":"5","key":"860_CR118","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/0741-8329(94)90024-8","volume":"11","author":"FC Zhou","year":"1994","unstructured":"Zhou FC, Pu CF, Murphy J, Lumeng L, Li TK. Serotonergic neurons in the alcohol preferring rats. Alcohol. 1994;11(5):397\u2013403. https:\/\/doi.org\/10.1016\/0741-8329(94)90024-8.","journal-title":"Alcohol"},{"issue":"3","key":"860_CR119","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0022-3565(24)38077-2","volume":"288","author":"A Smith","year":"1999","unstructured":"Smith A, Weiss F. Ethanol exposure differentially alters central monoamine neurotransmission in alcohol-preferring versus -nonpreferring rats. J Pharmacol Exp Ther. 1999;288(3):1223\u201328. https:\/\/doi.org\/10.1016\/S0022-3565(24)38077-2.","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"860_CR120","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/S007020200023","volume":"109","author":"LAC Lucas","year":"2002","unstructured":"Lucas LAC, McMillen BA. Differences in brain area concentrations of dopamine and serotonin in myers\u2019 high ethanol preferring (mHEP) and outbred rats. J Neural Transm. 2002;109(3):279\u201392. https:\/\/doi.org\/10.1007\/S007020200023.","journal-title":"J Neural Transm"},{"issue":"1","key":"860_CR121","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0031-9384(72)90138-2","volume":"8","author":"L Ahtee","year":"1972","unstructured":"Ahtee L, Eriksson K. 5-hydroxytryptamine and 5-hydroxyindolylacetic acid content in brain of rat strains selected for their alcohol intake. Physiol Behav. 1972;8(1):123\u201326. https:\/\/doi.org\/10.1016\/0031-9384(72)90138-2.","journal-title":"Physiol Behav"},{"issue":"7","key":"860_CR122","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.3390\/IJERPH6071980","volume":"6","author":"A Drago","year":"2009","unstructured":"Drago A, Liappas I, Petio C, Albani D, Forloni G, Malitas P, et al. Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features. IJERPH. 2009;6(7):1980\u201390. https:\/\/doi.org\/10.3390\/IJERPH6071980.","journal-title":"IJERPH"},{"key":"860_CR123","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/J.NEULET.2015.07.037","volume":"604","author":"A Plemenita\u0161","year":"2015","unstructured":"Plemenita\u0161 A, Kores Plesni\u010dar B, Kastelic M, Porcelli S, Serretti A, Dol\u017ean V. Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms. Neurosci Lett. 2015;604:86\u201390. https:\/\/doi.org\/10.1016\/J.NEULET.2015.07.037.","journal-title":"Neurosci Lett"},{"issue":"8","key":"860_CR124","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1038\/SJ.NPP.1301318","volume":"32","author":"P Zill","year":"2007","unstructured":"Zill P, Preuss UW, Koller G, Bondy B, Soyka M. SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide. Neuropsychopharmacology. 2007;32(8):1687\u201394. https:\/\/doi.org\/10.1038\/SJ.NPP.1301318.","journal-title":"Neuropsychopharmacology"},{"key":"860_CR125","first-page":"127","volume":"32 Suppl 1","author":"G Mokrovi\u0107","year":"2008","unstructured":"Mokrovi\u0107 G, Matosi\u0107 A, Hranilovi\u0107 D, Tefulj J, Novokmet M, Oreskovi\u0107 D, et al. Alcohol dependence and polymorphisms of serotonin-related genes: association studies. Coll Antropol. 2008;32 Suppl 1:127\u201331.","journal-title":"Coll Antropol"},{"issue":"3\u20134","key":"860_CR126","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1111\/J.1369-1600.2008.00118.X","volume":"13","author":"P Gacek","year":"2008","unstructured":"Gacek P, Conner T, Tennen H, Kranzler H, Covault J. GENETIC STUDY: tryptophan hydroxylase 2 gene and alcohol use among college students. Addict Biol. 2008;13(3\u20134):440\u201348. https:\/\/doi.org\/10.1111\/J.1369-1600.2008.00118.X.","journal-title":"Addict Biol"},{"issue":"3","key":"860_CR127","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/J.1530-0277.2010.01372.X","volume":"35","author":"A Agrawal","year":"2011","unstructured":"Agrawal A, Lynskey M, Todorov A, Schrage A, Littlefield A, Grant J, et al. A candidate gene association study of alcohol consumption in young women. Alcohol: Clin Exp Res. 2011;35(3):550\u201358. https:\/\/doi.org\/10.1111\/J.1530-0277.2010.01372.X.","journal-title":"Alcohol: Clin Exp Res"},{"key":"860_CR128","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.psychres.2020.113563","volume":"295","author":"IC C\u00e9spedes","year":"2021","unstructured":"C\u00e9spedes IC, Ota VK, Mazzotti DR, Wscieklica T, Conte R, Galdur\u00f3z JCF, et al. Association between polymorphism in gene related to the dopamine circuit and motivations for drinking in patients with alcohol use disorder. Psychiatry Res. 2021;295:295. https:\/\/doi.org\/10.1016\/j.psychres.2020.113563.","journal-title":"Psychiatry Res"},{"issue":"11","key":"860_CR129","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1016\/j.jpsychires.2013.07.013","volume":"47","author":"Y Pan","year":"2013","unstructured":"Pan Y, Luo X, Liu X, Wu LY, Zhang Q, Wang L, et al. Genome-wide association studies of maximum number of drinks. J Psychiatric Res. 2013;47(11):1717\u201324. https:\/\/doi.org\/10.1016\/j.jpsychires.2013.07.013.","journal-title":"J Psychiatric Res"},{"issue":"5","key":"860_CR130","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1093\/ALCALC\/AGG110","volume":"38","author":"AI Herman","year":"2003","unstructured":"Herman AI, Philbeck JW, Vasilopoulos NL, Depetrillo PB. Serotonin transporter promoter polymorphism and differences in alcohol consumption behaviour in a college student population. Alcohol Alcohol. 2003;38(5):446\u201349. https:\/\/doi.org\/10.1093\/ALCALC\/AGG110.","journal-title":"Alcohol Alcohol"},{"issue":"1","key":"860_CR131","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/AJMG.B.30132","volume":"133B","author":"R Feinn","year":"2005","unstructured":"Feinn R, Nellissery M, Kranzler HR. Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am J Med Genet Pt B. 2005;133B(1):79\u201384. https:\/\/doi.org\/10.1002\/AJMG.B.30132.","journal-title":"Am J Med Genet Pt B"},{"issue":"3","key":"860_CR132","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0304-3940(98)00347-4","volume":"248","author":"T T\u00fcrker","year":"1998","unstructured":"T\u00fcrker T, Sodmann R, Goebel U, Jatzke S, Knapp M, Lesch KP, et al. High ethanol tolerance in young adults is associated with the low- activity variant of the promoter of the human serotonin transporter gene. Neurosci Lett. 1998;248(3):147\u201350. https:\/\/doi.org\/10.1016\/S0304-3940(98)00347-4.","journal-title":"Neurosci Lett"},{"issue":"8","key":"860_CR133","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1111\/J.1530-0277.2009.00962.X","volume":"33","author":"N Ait-Daoud","year":"2009","unstructured":"Ait-Daoud N, Roache JD, Dawes MA, Liu L, Wang XQ, Javors MA, et al. Can serotonin transporter genotype predict craving in alcoholism? Alcohol Clin Exp Res. 2009;33(8):1329\u201335. https:\/\/doi.org\/10.1111\/J.1530-0277.2009.00962.X.","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"860_CR134","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/00041444-200209000-00005","volume":"12","author":"EM Hill","year":"2002","unstructured":"Hill EM, Stoltenberg SF, Bullard KH, Li S, Zucker RA, Burmeister M. Antisocial alcoholism and serotonin-related polymorphisms: association tests. Psychiatric Genet. 2002;12(3):143\u201353. https:\/\/doi.org\/10.1097\/00041444-200209000-00005.","journal-title":"Psychiatric Genet"},{"issue":"1","key":"860_CR135","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1159\/000173008","volume":"15","author":"YS Lee","year":"2009","unstructured":"Lee YS, Choi SW, Han DH, Kim DJ, Joe KH. Clinical manifestation of alcohol withdrawal symptoms related to genetic polymorphisms of two serotonin receptors and serotonin transporter. Eur Addict Res. 2009;15(1):39\u201346. https:\/\/doi.org\/10.1159\/000173008.","journal-title":"Eur Addict Res"},{"issue":"12","key":"860_CR136","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/IJMS25126563","volume":"25","author":"A Boro\u0144","year":"2024","unstructured":"Boro\u0144 A, Suchanecka A, Chmielowiec K, Chmielowiec J, Lachowicz M, Stro\u0144ska-Pluta A, et al. Association study of serotonin 1A receptor gene, personality, and anxiety in women with alcohol use disorder. IJMS. 2024;25(12):25. https:\/\/doi.org\/10.3390\/IJMS25126563.","journal-title":"IJMS"},{"issue":"1","key":"860_CR137","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0361-9230(01)00641-4","volume":"57","author":"P Gorwood","year":"2002","unstructured":"Gorwood P, Aissi F, Batel P, Ad\u00e8s J, Cohen-Salmon C, Hamon M, et al. Reappraisal of the serotonin 5-HT1B receptor gene in alcoholism: of mice and men. Brain Res Bull. 2002;57(1):103\u201307. https:\/\/doi.org\/10.1016\/S0361-9230(01)00641-4.","journal-title":"Brain Res Bull"},{"issue":"1","key":"860_CR138","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/SJ.NPP.1300000","volume":"28","author":"YY Huang","year":"2003","unstructured":"Huang YY, Oquendo MA, Harkavy Friedman JM, Greenhill LL, Brodsky B, Malone KM, et al. Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. Neuropsychopharmacology. 2003;28(1):163\u201369. https:\/\/doi.org\/10.1038\/SJ.NPP.1300000.","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"860_CR139","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/AJMG.B.20064","volume":"121B","author":"R Sinha","year":"2003","unstructured":"Sinha R, Cloninger CR, Parsian A. Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism. Am J Med Genet Pt B. 2003;121B(1):83\u201388. https:\/\/doi.org\/10.1002\/AJMG.B.20064.","journal-title":"Am J Med Genet Pt B"},{"issue":"6","key":"860_CR140","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/AJMG.1473","volume":"105","author":"T Cigler","year":"2001","unstructured":"Cigler T, Steven Laforge K, McHugh PF, Kapadia SU, Leal SM, Kreek MJ. Novel and previously reported single-nucleotide polymorphisms in the human 5-HT 1B receptor gene: No association with cocaine or alcohol abuse or dependence. Am J Med Genet. 2001;105(6):489\u201397. https:\/\/doi.org\/10.1002\/AJMG.1473.","journal-title":"Am J Med Genet"},{"issue":"11","key":"860_CR141","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0006-3223(01)01366-X","volume":"51","author":"HFS Sun","year":"2002","unstructured":"Sun HFS, Chang YT, Fann CSJ, Chang CJ, Chen YH, Hsu YP, et al. Association study of novel human serotonin 5-HT1B polymorphisms with alcohol dependence in Taiwanese Han. Biol Psychiatry. 2002;51(11):896\u2013901. https:\/\/doi.org\/10.1016\/S0006-3223(01)01366-X.","journal-title":"Biol Psychiatry"},{"key":"860_CR142","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2010.12.039","volume":"1376","author":"JX Cao","year":"2011","unstructured":"Cao JX, Hu J, Ye XM, Xia Y, Haile CA, Kosten TR, et al. Association between the 5-HTR1B gene polymorphisms and alcohol dependence in a Han Chinese population. Brain Res. 2011;1376:1\u20139. https:\/\/doi.org\/10.1016\/j.brainres.2010.12.039.","journal-title":"Brain Res"},{"issue":"2","key":"860_CR143","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/ACER.12963","volume":"40","author":"LSH Wu","year":"2016","unstructured":"Wu LSH, Lee CS, Weng TY, Wang KHT, Cheng ATA. Association study of gene polymorphisms in GABA, serotonin, dopamine, and alcohol metabolism pathways with alcohol dependence in Taiwanese Han men. Alcohol Clin Exp Res. 2016;40(2):284\u201390. https:\/\/doi.org\/10.1111\/ACER.12963.","journal-title":"Alcohol Clin Exp Res"},{"issue":"1\u20132","key":"860_CR144","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.drugalcdep.2011.09.020","volume":"122","author":"V Contini","year":"2012","unstructured":"Contini V, Bertuzzi GP, Polina ER, Hunemeier T, Hendler EM, Hutz MH, et al. A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence. Drug Alcohol Depen. 2012;122(1\u20132):100\u201304. https:\/\/doi.org\/10.1016\/j.drugalcdep.2011.09.020.","journal-title":"Drug Alcohol Depen"},{"issue":"4","key":"860_CR145","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/S007020200042","volume":"109","author":"Y Hasegawa","year":"2002","unstructured":"Hasegawa Y, Higuchi S, Matsushita S, Miyaoka H. Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. J Neural Transm (Vienna). 2002;109(4):513\u201321. https:\/\/doi.org\/10.1007\/S007020200042.","journal-title":"J Neural Transm (Vienna)"},{"issue":"11","key":"860_CR146","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1001\/ARCHPSYC.55.11.989","volume":"55","author":"J Lappalainen","year":"1998","unstructured":"Lappalainen J, Long JC, Eggert M, Ozaki N, Robin RW, Brown GL, et al. Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Arch Gen Psychiatry. 1998;55(11):989\u201394. https:\/\/doi.org\/10.1001\/ARCHPSYC.55.11.989.","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"860_CR147","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/S00702-003-0064-0","volume":"111","author":"M Soyka","year":"2004","unstructured":"Soyka M, Preuss UW, Koller G, Zill P, Bondy B. Association of 5-HT1B receptor gene and antisocial behavior in alcoholism. J Neural Transm. 2004;111(1):101\u201309. https:\/\/doi.org\/10.1007\/S00702-003-0064-0.","journal-title":"J Neural Transm"},{"issue":"1","key":"860_CR148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0165-1781(00)00215-8","volume":"97","author":"C Fehr","year":"2000","unstructured":"Fehr C, Grintschuk N, Szegedi A, Anghelescu I, Klawe C, Singer P, et al. The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. Psychiatry Res. 2000;97(1):1\u201310. https:\/\/doi.org\/10.1016\/S0165-1781(00)00215-8.","journal-title":"Psychiatry Res"},{"key":"860_CR149","doi-asserted-by":"publisher","first-page":"339","DOI":"10.2147\/NDT.S191457","volume":"15","author":"DS Strac","year":"2019","unstructured":"Strac DS, Erjavec GN, Perkovic MN, Nenadic-Sviglin K, Konjevod M, Grubor M, et al. The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse. NDT 2019, 15: 339\u201347. https:\/\/doi.org\/10.2147\/NDT.S191457.","journal-title":"NDT"},{"issue":"4","key":"860_CR150","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.pnpbp.2009.03.016","volume":"33","author":"PA Saiz","year":"2009","unstructured":"Saiz PA, Garcia-Portilla MP, Florez G, Arango C, Corcoran P, Morales B, et al. Differential role of serotonergic polymorphisms in alcohol and heroin dependence. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(4):695\u2013700. https:\/\/doi.org\/10.1016\/j.pnpbp.2009.03.016.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"860_CR151","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/SJ.MP.4000474","volume":"4","author":"T Nakamura","year":"1999","unstructured":"Nakamura T, Matsushita S, Nishiguchi N, Kimura M, Yoshino A, Higuchi S. Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence. Mol. Psychiatry. 1999;4(1):85\u201388. https:\/\/doi.org\/10.1038\/SJ.MP.4000474.","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"860_CR152","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000054888","volume":"43","author":"UW Preuss","year":"2001","unstructured":"Preuss UW, Koller G, Bondy B, Bahlmann M, Soyka M. Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders. Neuropsychobiology. 2001;43(3):186\u201391. https:\/\/doi.org\/10.1159\/000054888.","journal-title":"Neuropsychobiology"},{"issue":"2","key":"860_CR153","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/s1734-1140(12)70787-9","volume":"64","author":"Ma\u0142gorzata Wrzosek","year":"2012","unstructured":"Wrzosek M, Jakubczyk A, Wrzosek M, Matsumoto H, \u0141ukaszkiewicz J, Brower K.J, et al. Serotonin 2A receptor gene (HTR2A) polymorphism in alcohol-dependent patients. Pharmacological Rep. 2012;64(2):449\u201353. https:\/\/doi.org\/10.1016\/s1734-1140(12)70787-9","journal-title":"Pharmacological Rep"},{"issue":"1","key":"860_CR154","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jpsychires.2011.09.001","volume":"46","author":"A Jakubczyk","year":"2012","unstructured":"Jakubczyk A, Wrzosek M, Lukaszkiewicz J, Sadowska-Mazuryk J, Matsumoto H, \u015aliwerska E, et al. The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients. J Psychiatric Res. 2012;46(1):44\u201349. https:\/\/doi.org\/10.1016\/j.jpsychires.2011.09.001.","journal-title":"J Psychiatric Res"},{"issue":"4","key":"860_CR155","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.jpsychires.2012.12.004","volume":"47","author":"A Jakubczyk","year":"2013","unstructured":"Jakubczyk A, Klimkiewicz A, Kopera M, Krasowska A, Wrzosek M, Matsumoto H, et al. The CC genotype in the T102C HTR2A polymorphism predicts relapse in individuals after alcohol treatment. J Psychiatric Res. 2013;47(4):527\u201333. https:\/\/doi.org\/10.1016\/j.jpsychires.2012.12.004.","journal-title":"J Psychiatric Res"},{"issue":"5","key":"860_CR156","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/S0278-5846(01)00171-3","volume":"25","author":"C Fehr","year":"2001","unstructured":"Fehr C, Schleicher A, Szegedi A, Anghelescu I, Klawe C, Hiemke C, et al. Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. Prog Neuropsychopharmacol Biol Psychiatry. 2001;25(5):965\u201382. https:\/\/doi.org\/10.1016\/S0278-5846(01)00171-3.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"860_CR157","doi-asserted-by":"crossref","unstructured":"Hwu H, Chen C. Association of 5HT2A receptor gene polymorphism and alcohol abuse with behavior problems. Am J Med Genet. 2000;96(6):797\u2013800. https:\/\/doi.org\/10.1002\/1096-8628(20001204)96:6<797::aid-ajmg20>3.0.co;2-k","DOI":"10.1002\/1096-8628(20001204)96:6<797::AID-AJMG20>3.0.CO;2-K"},{"issue":"5","key":"860_CR158","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0006-3223(98)00248-0","volume":"45","author":"MA Schuckit","year":"1999","unstructured":"Schuckit MA, Mazzanti C, Smith TL, Ahmed U, Radel M, Iwata N, et al. Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA\u03b16 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. Biol Psychiatry. 1999;45(5):647\u201351. https:\/\/doi.org\/10.1016\/S0006-3223(98)00248-0.","journal-title":"Biol Psychiatry"},{"issue":"5","key":"860_CR159","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1093\/ALCALC\/AGH086","volume":"39","author":"S Mottagui-Tabar","year":"2004","unstructured":"Mottagui-Tabar S, McCarthy S, Reinemund J, Andersson B, Wahlestedt C, Heilig M. Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors. Alcohol Alcohol. 2004;39(5):380\u201385. https:\/\/doi.org\/10.1093\/ALCALC\/AGH086.","journal-title":"Alcohol Alcohol"},{"key":"860_CR160","doi-asserted-by":"crossref","unstructured":"Samochowiec J, Smolka M, Winterer G, Rommelspacher H, Schmidt L, Sander T. Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability. Am J Med Genet. 1999;88(2):126\u201330. https:\/\/doi.org\/10.1002\/(SICI)1096-8628(19990416)88:2%3C126::AID-AJMG6%3E3.0.CO;2-M","DOI":"10.1002\/(SICI)1096-8628(19990416)88:2<126::AID-AJMG6>3.0.CO;2-M"},{"issue":"11","key":"860_CR161","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/MP.2010.94","volume":"16","author":"MA Enoch","year":"2011","unstructured":"Enoch MA, Gorodetsky E, Hodgkinson C, Roy A, Goldman D. Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence. Mol. Psychiatry. 2011;16(11):1139\u201346. https:\/\/doi.org\/10.1038\/MP.2010.94.","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"860_CR162","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.alcohol.2008.09.005","volume":"43","author":"F Ducci","year":"2009","unstructured":"Ducci F, Enoch MA, Yuan Q, Shen PH, White K V, Hodgkinson C, et al. HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power\u2014an intermediate phenotype for alcoholism and co-morbid behaviors. Alcohol. 2009;43(1):73\u201384. https:\/\/doi.org\/10.1016\/j.alcohol.2008.09.005.","journal-title":"Alcohol"},{"issue":"9","key":"860_CR163","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1111\/ACER.12482","volume":"38","author":"JH Kim","year":"2014","unstructured":"Kim JH, Park BL, Cheong HS, Bae JS, Kim LH, Kim JW, et al. Association between HTR7 genetic polymorphisms and alcohol dependence, using the alcohol use disorders identification test (AUDIT). Alcohol Clin Exp Res. 2014;38(9):2354\u201361. https:\/\/doi.org\/10.1111\/ACER.12482.","journal-title":"Alcohol Clin Exp Res"},{"issue":"6","key":"860_CR164","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/S00439-007-0443-Y","volume":"122","author":"GL Chen","year":"2008","unstructured":"Chen GL, Vallender EJ, Miller GM. Functional characterization of the human TPH2 5\u2032 regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Hum Genet. 2008;122(6):645\u201357. https:\/\/doi.org\/10.1007\/S00439-007-0443-Y.","journal-title":"Hum Genet"},{"issue":"1","key":"860_CR165","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/J.BIOPSYCHO.2007.12.002","volume":"79","author":"M Reuter","year":"2008","unstructured":"Reuter M, Esslinger C, Montag C, Lis S, Gallhofer B, Kirsch P. A functional variant of the tryptophan hydroxylase 2 gene impacts working memory: a genetic imaging study. Biol. Psychol. 2008;79(1):111\u201317. https:\/\/doi.org\/10.1016\/J.BIOPSYCHO.2007.12.002.","journal-title":"Biol. Psychol"},{"issue":"11","key":"860_CR166","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1007\/S00702-005-0391-4","volume":"112","author":"T Canli","year":"2005","unstructured":"Canli T, Congdon E, Gutknecht L, Constable RT, Lesch KP. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J Neural Transm. 2005;112(11):1479\u201385. https:\/\/doi.org\/10.1007\/S00702-005-0391-4.","journal-title":"J Neural Transm"},{"issue":"1\u20133","key":"860_CR167","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jad.2012.03.047","volume":"142","author":"L Mandelli","year":"2012","unstructured":"Mandelli L, Antypa N, Nearchou FA, Vaiopoulos C, Stefanis CN, Serretti A, et al. The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism. J Educ Chang Affective Disord. 2012;142(1\u20133):82\u201389. https:\/\/doi.org\/10.1016\/j.jad.2012.03.047.","journal-title":"J Educ Chang Affective Disord"},{"key":"860_CR168","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1017\/S1461145706007437","volume":"10","author":"L Gutknecht","year":"2007","unstructured":"Gutknecht L, Jacob C, Strobel A, Kriegebaum C, M\u00fcller J, Zeng Y, et al. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. Int J Neuropsychopharmacol. 2007;10:309\u201320. https:\/\/doi.org\/10.1017\/S1461145706007437.","journal-title":"Int J Neuropsychopharmacol"},{"issue":"2","key":"860_CR169","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1089\/CAP.2012.0020","volume":"23","author":"B Rotberg","year":"2013","unstructured":"Rotberg B, Kronenberg S, Carmel M, Frisch A, Brent D, Zalsman G, et al. Additive effects of 5-HTTLPR (serotonin transporter) and tryptophan hydroxylase 2 G-703T gene polymorphisms on the clinical response to citalopram among children and adolescents with depression and anxiety disorders. J Child Adolesc Psychopharmacol. 2013;23(2):117\u201322. https:\/\/doi.org\/10.1089\/CAP.2012.0020.","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"3","key":"860_CR170","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/S00213-003-1663-Z","volume":"172","author":"MA Casu","year":"2004","unstructured":"Casu MA, Pisu C, Lobina C, Pani L. Immunocytochemical study of the forebrain serotonergic innervation in Sardinian alcohol-preferring rats. Psychopharmacol (Berl). 2004;172(3):341\u201351. https:\/\/doi.org\/10.1007\/S00213-003-1663-Z.","journal-title":"Psychopharmacol (Berl)"},{"issue":"3","key":"860_CR171","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1111\/j.1471-4159.2005.03604.x","volume":"96","author":"SA Sakowski","year":"2006","unstructured":"Sakowski SA, Geddes TJ, Kuhn DM. Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function. J Neurochem. 2006;96(3):758\u201365. https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03604.x.","journal-title":"J Neurochem"},{"issue":"7","key":"860_CR172","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1111\/J.1530-0277.1999.TB04287.X","volume":"23","author":"VJ Whatley","year":"1999","unstructured":"Whatley VJ, Johnson TE, Erwin VG. Identification and confirmation of quantitative trait loci regulating alcohol consumption in congenic strains of mice. Alcohol Clin Exp Res. 1999;23(7):1262\u201371. https:\/\/doi.org\/10.1111\/J.1530-0277.1999.TB04287.X.","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"860_CR173","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/J.ALCOHOL.2007.12.006","volume":"42","author":"N Yoneyama","year":"2008","unstructured":"Yoneyama N, Crabbe JC, Ford MM, Murillo A, Finn DA. Voluntary ethanol consumption in 22 inbred mouse strains. Alcohol. 2008;42(3):149\u201360. https:\/\/doi.org\/10.1016\/J.ALCOHOL.2007.12.006.","journal-title":"Alcohol"},{"issue":"5681","key":"860_CR174","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1126\/science.1097540","volume":"305","author":"X Zhang","year":"2004","unstructured":"Zhang X, Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Sci (1979). 2004;305(5681):217. https:\/\/doi.org\/10.1126\/science.1097540.","journal-title":"Sci (1979)"},{"issue":"5","key":"860_CR175","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/BF01073111","volume":"17","author":"G Elmer","year":"1987","unstructured":"Elmer G, Meisch R, George F. Mouse strain differences in operant self-administration of ethanol. Behav Genet. 1987;17(5):439\u201351. https:\/\/doi.org\/10.1007\/BF01073111.","journal-title":"Behav Genet"},{"issue":"8","key":"860_CR176","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1093\/JN\/132.8.2288","volume":"132","author":"MG Tordoff","year":"2002","unstructured":"Tordoff MG, Pilchak DM, Williams JA, McDaniel AH, Bachmanov AA. The maintenance diets of C57BL\/6J and 129X1\/SvJ mice influence their taste solution preferences: implications for large-scale phenotyping projects. J Nutr. 2002;132(8):2288\u201397. https:\/\/doi.org\/10.1093\/JN\/132.8.2288.","journal-title":"J Nutr"},{"issue":"6","key":"860_CR177","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1111\/J.1471-4159.2011.07379.X","volume":"118","author":"H Bach","year":"2011","unstructured":"Bach H, Arango V, Huang YY, Leong S, John Mann J, Underwood MD. Neuronal tryptophan hydroxylase expression in BALB\/cJ and C57Bl\/6J mice. J Neurochem. 2011;118(6):1067\u201374. https:\/\/doi.org\/10.1111\/J.1471-4159.2011.07379.X.","journal-title":"J Neurochem"},{"key":"860_CR178","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neuropharm.2014.05.015","volume":"85","author":"V Mosienko","year":"2014","unstructured":"Mosienko V, Matthes S, Hirth N, Beis D, Flinders M, Bader M, et al. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. 2014;85:73\u201380. https:\/\/doi.org\/10.1016\/j.neuropharm.2014.05.015.","journal-title":"Neuropharmacology"},{"issue":"6","key":"860_CR179","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/cpz1.831","volume":"3","author":"V Vierkant","year":"2023","unstructured":"Vierkant V, Xie X, Wang X, Wang J. Experimental models of alcohol use disorder and their application for pathophysiological investigations. Curr Protocol. 2023;3(6):3. https:\/\/doi.org\/10.1002\/cpz1.831.","journal-title":"Curr Protocol"},{"issue":"1","key":"860_CR180","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0","volume":"88","author":"B Greenberg","year":"1999","unstructured":"Greenberg B, Tolliver T, Huang S, Li Q, Bengel D, Murphy D. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet. 1999;88(1):83\u201387. https:\/\/doi.org\/10.1002\/(SICI)1096-8628(19990205)88:1%3C83::AID-AJMG15%3E3.0.CO;2-0.","journal-title":"Am J Med Genet"},{"issue":"10","key":"860_CR181","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1523\/JNEUROSCI.3769-04.2005","volume":"25","author":"SP David","year":"2005","unstructured":"David SP, Murthy NV, Rabiner EA, Munaf\u00f3 MR, Johnstone EC, Jacob R, et al. A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J Neurosci. 2005;25(10):2586\u201390. https:\/\/doi.org\/10.1523\/JNEUROSCI.3769-04.2005.","journal-title":"J Neurosci"},{"issue":"5","key":"860_CR182","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1086\/503850","volume":"78","author":"XZ Hu","year":"2006","unstructured":"Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet. 2006;78(5):815. https:\/\/doi.org\/10.1086\/503850.","journal-title":"Am J Hum Genet"},{"key":"860_CR183","doi-asserted-by":"publisher","unstructured":"Avula R, Rand A, Black JL, O\u2019Kane DJ. Simultaneous genotyping of multiple polymorphisms in human serotonin transporter gene and detection of novel allelic variants. Transl Psychiatry. 2011;1(8):e32\u201332. https:\/\/doi.org\/10.1038\/tp.2011.34.","DOI":"10.1038\/tp.2011.34"},{"issue":"5292","key":"860_CR184","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1126\/SCIENCE.274.5292.1527","volume":"274","author":"KP Lesch","year":"1996","unstructured":"Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Sci (1979). 1996;274(5292):1527\u201331. https:\/\/doi.org\/10.1126\/SCIENCE.274.5292.1527.","journal-title":"Sci (1979)"},{"issue":"1\u20133","key":"860_CR185","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jad.2007.07.028","volume":"107","author":"EP Hayden","year":"2008","unstructured":"Hayden EP, Dougherty LR, Maloney B, Olino TM, Sheikh H, Durbin CE, et al. Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism. J Educ Chang Affective Disord. 2008;107(1\u20133):227\u201330. https:\/\/doi.org\/10.1016\/j.jad.2007.07.028.","journal-title":"J Educ Chang Affective Disord"},{"issue":"7","key":"860_CR186","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1111\/J.1530-0277.1999.TB04289.X","volume":"23","author":"H Ishiguro","year":"1999","unstructured":"Ishiguro H, Saito T, Akazawa S, Mitushio H, Tada K, Enomoto M, et al. Association between drinking-related antisocial behavior and a polymorphism in the serotonin transporter gene in a Japanese population. Alcohol Clin Exp Res. 1999;23(7):1281\u201384. https:\/\/doi.org\/10.1111\/J.1530-0277.1999.TB04289.X.","journal-title":"Alcohol Clin Exp Res"},{"key":"860_CR187","doi-asserted-by":"publisher","unstructured":"Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D, et al. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry. 2000;47(7):643\u201349. https:\/\/doi.org\/10.1016\/S0006-3223(99)00171-7.","DOI":"10.1016\/S0006-3223(99)00171-7"},{"issue":"1","key":"860_CR188","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/S00702-009-0331-9","volume":"117","author":"H Budde","year":"2010","unstructured":"Budde H, Sander T, Wernicke C, M\u00fcller A, Gallinat J, Schmidt LG, et al. Serotonin transporter promoter polymorphism and dopaminergic sensitivity in alcoholics. J Neural Transm (Vienna). 2010;117(1):133\u201338. https:\/\/doi.org\/10.1007\/S00702-009-0331-9.","journal-title":"J Neural Transm (Vienna)"},{"key":"860_CR189","doi-asserted-by":"publisher","unstructured":"MacKenzie A, Quinn J. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proceedings of the National Academy of Sciences. 1999;96(26):15251\u201355. https:\/\/doi.org\/10.1073\/PNAS.96.26.15251","DOI":"10.1073\/PNAS.96.26.15251"},{"issue":"12","key":"860_CR190","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1038\/MP.2016.6","volume":"21","author":"M Gupta","year":"2016","unstructured":"Gupta M, Neavin D, Liu D, Biernacka J, Hall-Flavin D, Bobo W V, et al. TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics. Mol. Psychiatry. 2016;21(12):1717\u201325. https:\/\/doi.org\/10.1038\/MP.2016.6.","journal-title":"Mol. Psychiatry"},{"issue":"7","key":"860_CR191","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.1038\/S41380-020-0855-9","volume":"26","author":"MF Ho","year":"2021","unstructured":"Ho MF, Zhang C, Zhang L, Wei L, Zhou Y, Moon I, et al. TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response. Mol. Psychiatry. 2021;26(7):3122\u201333. https:\/\/doi.org\/10.1038\/S41380-020-0855-9.","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"860_CR192","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/S41467-019-09480-8","volume":"10","author":"HR Kranzler","year":"2019","unstructured":"Kranzler HR, Zhou H, Kember RL, Vickers Smith R, Justice AC, Damrauer S, et al. Genome-wide association study of alcohol consumption and use disorder in 274, 424 individuals from multiple populations. Nat Commun. 2019;10(1):10. https:\/\/doi.org\/10.1038\/S41467-019-09480-8.","journal-title":"Nat Commun"},{"issue":"11","key":"860_CR193","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1176\/AJP.156.11.1771","volume":"156","author":"DG LeMarquand","year":"1999","unstructured":"LeMarquand DG, Benkelfat C, Pihl RO, Palmour RM, Young SN. Behavioral disinhibition induced by tryptophan depletion in nonalcoholic young men with multigenerational family histories of paternal alcoholism. AJP. 1999;156(11):1771\u201379. https:\/\/doi.org\/10.1176\/AJP.156.11.1771.","journal-title":"AJP"},{"issue":"1","key":"860_CR194","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00213-007-0763-6","volume":"193","author":"DM Dougherty","year":"2007","unstructured":"Dougherty DM, Marsh DM, Mathias CW, Dawes MA, Bradley DM, Morgan CJ, et al. The effects of alcohol on laboratory-measured impulsivity after L-Tryptophan depletion or loading. Psychopharmacol (Berl). 2007;193(1):137\u201350. https:\/\/doi.org\/10.1007\/s00213-007-0763-6.","journal-title":"Psychopharmacol (Berl)"},{"issue":"7","key":"860_CR195","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1111\/j.1530-0277.2002.tb02629.x","volume":"26","author":"IL Petrakis","year":"2002","unstructured":"Petrakis IL, Buonopane A, O\u2019Malley S, Cermik O, Trevisan L, Boutros NN, et al. The effect of tryptophan depletion on alcohol self-administration in non-treatment-seeking alcoholic individuals. Alcohol Clin Exp Res. 2002;26(7):969\u201375. https:\/\/doi.org\/10.1111\/j.1530-0277.2002.tb02629.x.","journal-title":"Alcohol Clin Exp Res"},{"issue":"8","key":"860_CR196","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1111\/j.1530-0277.2001.tb02329.x","volume":"25","author":"I Petrakis","year":"2001","unstructured":"Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krysta J. Effect of tryptophan depletion on alcohol cue-induced craving in abstinent alcoholic patients. Alcohol Clin Exp Res. 2001;25(8):1151\u201355. https:\/\/doi.org\/10.1111\/j.1530-0277.2001.tb02329.x.","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"860_CR197","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1007\/S00213-003-1588-6","volume":"171","author":"A Pierucci-Lagha","year":"2004","unstructured":"Pierucci-Lagha A, Feinn R, Modesto-Lowe V, Swift R, Nellissery M, Covault J, et al. Effects of rapid tryptophan depletion on mood and urge to drink in patients with co-morbid major depression and alcohol dependence. Psychopharmacol (Berl). 2004;171(3):340\u201348. https:\/\/doi.org\/10.1007\/S00213-003-1588-6.","journal-title":"Psychopharmacol (Berl)"},{"issue":"2","key":"860_CR198","first-page":"109","volume":"53","author":"M Jessa","year":"2001","unstructured":"Jessa M, Krza\u015bcik P, Kostowski W. Neonatal treatment with 5, 7-dihydroxytryptamine induces decrease in alcohol drinking in adult animals. Pol J Pharmacol. 2001;53(2):109\u201316.","journal-title":"Pol J Pharmacol"},{"issue":"1\u20132","key":"860_CR199","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0166-4328(98)00159-4","volume":"102","author":"\u00c5K Johansson","year":"1999","unstructured":"Johansson \u00c5K, Bergvall \u00c5H, Hansen S. Behavioral disinhibition following basal forebrain excitotoxin lesions: alcohol consumption, defensive aggression, impulsivity and serotonin levels. Behavioural Brain Res. 1999;102(1\u20132):17\u201329. https:\/\/doi.org\/10.1016\/S0166-4328(98)00159-4.","journal-title":"Behavioural Brain Res"},{"issue":"2","key":"860_CR200","first-page":"363","volume":"10","author":"R Myers","year":"1975","unstructured":"Myers R, Melchior C. Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain. Res Commun Chem Pathol Pharmacol. 1975;10(2):363\u201378.","journal-title":"Res Commun Chem Pathol Pharmacol"},{"issue":"1\u20132","key":"860_CR201","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0006-8993(95)00701-Q","volume":"693","author":"A Adell","year":"1995","unstructured":"Adell A, Myers R. Selective destruction of midbrain raphe nuclei by 5, 7-DHT: is brain 5-HT involved in alcohol drinking in Sprague-Dawley rats? Brain Res. 1995;693(1\u20132):70\u201379. https:\/\/doi.org\/10.1016\/0006-8993(95)00701-Q.","journal-title":"Brain Res"},{"key":"860_CR202","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bbr.2015.06.013","volume":"295","author":"RK Vasudeva","year":"2015","unstructured":"Vasudeva RK, Hobby AR, Kirby LG. Ethanol consumption in the Sprague\u2013Dawley rat increases sensitivity of the dorsal raphe nucleus to 5,7-dihydroxytryptamine. Behavioural Brain Res. 2015;295:35\u201344. https:\/\/doi.org\/10.1016\/j.bbr.2015.06.013.","journal-title":"Behavioural Brain Res"},{"issue":"7","key":"860_CR203","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1111\/J.1530-0277.1996.TB01120.X","volume":"20","author":"J Wang","year":"1996","unstructured":"Wang J, Shum A, Lin T, Wang Y. Central serotonergic lesions increase voluntary alcohol consumption in Sprague Dawley rats: moderation by long-term ethanol administration. Alcohol Clin Exp Res. 1996;20(7):1252\u201359. https:\/\/doi.org\/10.1111\/J.1530-0277.1996.TB01120.X.","journal-title":"Alcohol Clin Exp Res"},{"key":"860_CR204","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/J.NEUROPHARM.2013.09.010","volume":"77","author":"B Sachs","year":"2014","unstructured":"Sachs B, Salahi A, Caron M. Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice. Neuropharmacology. 2014;77:177\u201384. https:\/\/doi.org\/10.1016\/J.NEUROPHARM.2013.09.010.","journal-title":"Neuropharmacology"},{"key":"860_CR205","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/J.NEULET.2015.10.045","volume":"609","author":"F Lemay","year":"2015","unstructured":"Lemay F, Dor\u00e9 F, Beaulieu J. Increased ethanol consumption despite taste aversion in mice with a human tryptophan hydroxylase 2 loss of function mutation. Neurosci Lett. 2015;609:194\u201397. https:\/\/doi.org\/10.1016\/J.NEULET.2015.10.045.","journal-title":"Neurosci Lett"},{"issue":"1","key":"860_CR206","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/S002130050425","volume":"134","author":"R Ciccocioppo","year":"1997","unstructured":"Ciccocioppo R, Panocka I, Polidori C, Dourish CT, Massi M. Blockade of pre-and post-synaptic 5-HT 1A receptors does not modify the effect of fluoxetine or 5-hydroxytryptophan on ethanol and food intake in rats. Psychopharmacol (Berl). 1997;134(1):55\u201363. https:\/\/doi.org\/10.1007\/S002130050425.","journal-title":"Psychopharmacol (Berl)"},{"issue":"5","key":"860_CR207","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/SYN.20239","volume":"59","author":"AK Halladay","year":"2006","unstructured":"Halladay AK, Wagner GC, Sekowski A, Rothman RB, Baumann MH, Fisher H. Alterations in alcohol consumption, withdrawal seizures, and monoamine transmission in rats treated with phentermine and 5-hydroxy-L-tryptophan. Synapse. 2006;59(5):277\u201389. https:\/\/doi.org\/10.1002\/SYN.20239.","journal-title":"Synapse"},{"issue":"4","key":"860_CR208","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/alcalc\/agg095","volume":"38","author":"S Kela\u00ef","year":"2003","unstructured":"Kela\u00ef S, A\u00efssi F, Lesch KP, Cohen-Salmon C, Hamon M, Lanfumey L. Alcohol intake after serotonin transporter inactivation in mice. Alcohol Alcohol. 2003;38(4):386\u201389. https:\/\/doi.org\/10.1093\/alcalc\/agg095","journal-title":"Alcohol Alcohol"},{"issue":"10","key":"860_CR209","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1007\/S00213-022-06195-5","volume":"239","author":"S Hussain","year":"2022","unstructured":"Hussain S, Lesscher HMD, Day DJ, Ellenbroek BA. Genetics and epigenetics: paternal adolescent ethanol consumption in serotonin transporter knock-out rats and offspring sensitivity to ethanol. Psychopharmacol (Berl). 2022;239(10):3145\u201359. https:\/\/doi.org\/10.1007\/S00213-022-06195-5.","journal-title":"Psychopharmacol (Berl)"},{"issue":"2","key":"860_CR210","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1134\/S0026893316010027","volume":"50","author":"V Bazovkina D","year":"2016","unstructured":"Bazovkina D V, Tsybko AS, Filimonova EA, Ilchibaeva T V, Naumenko VS. Influence of chronic alcohol treatment on the expression of the Bdnf, Bax, bcl-xL, and CASP3 genes in the mouse brain: role of the C1473G polymorphism in the gene encoding tryptophan hydroxylase 2. Mol Biol. 2016;50(2):262\u201369. https:\/\/doi.org\/10.1134\/S0026893316010027","journal-title":"Mol Biol"},{"issue":"3","key":"860_CR211","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1134\/S000629792303001X","volume":"88","author":"V Bazovkina D","year":"2023","unstructured":"Bazovkina D V, Fursenko D V, Naumenko VS, Kulikov A V. The role of C1473G polymorphism in mouse triptophan hydroxylase 2 gene in the acute effects of ethanol on the c-fos gene expression and metabolism of biogenic amines in the brain. Biochem Moscow. 2023;88(3):291\u2013302. https:\/\/doi.org\/10.1134\/S000629792303001X.","journal-title":"Biochem Moscow"},{"issue":"3","key":"860_CR212","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0376-8716(83)90063-7","volume":"12","author":"O Beck","year":"1983","unstructured":"Beck O, Borg S, Sedvall G. Tryptophan levels in human cerebrospinal fluid after acute and chronic ethanol consumption. Drug Alcohol Depen. 1983;12(3):217\u201322. https:\/\/doi.org\/10.1016\/0376-8716(83)90063-7.","journal-title":"Drug Alcohol Depen"},{"issue":"3","key":"860_CR213","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1159\/000283913","volume":"14","author":"CM Banki","year":"1981","unstructured":"Banki CM, Molnar G. Cerebrospinal fluid amine metabolites in delirium tremens. Psychopathology. 1981;14(3):167\u201377. https:\/\/doi.org\/10.1159\/000283913.","journal-title":"Psychopathology"},{"issue":"11","key":"860_CR214","doi-asserted-by":"publisher","first-page":"12900","DOI":"10.1096\/fj.201900491RR","volume":"33","author":"P Gim\u00e9nez-G\u00f3mez","year":"2019","unstructured":"Gim\u00e9nez-G\u00f3mez P, P\u00e9rez-Hern\u00e1ndez M, O\u2019Shea E, Caso JR, Mart\u00edn-Hernandez D, Cervera LA, et al. Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice. The FASEB J. 2019;33(11):12900. https:\/\/doi.org\/10.1096\/fj.201900491RR.","journal-title":"The FASEB J"},{"key":"860_CR215","doi-asserted-by":"publisher","unstructured":"Gil de Biedma-Elduayen L, Gim\u00e9nez-G\u00f3mez P, Morales-Puerto N, Vidal R, \u00c1 \u00c1, N\u00fa\u00f1ez-de la Calle C, et al. The kynurenine pathway as a potential link between ethanol-induced behavioral alterations and neuroinflammation. Front Pharmacol. 2025;16:16. https:\/\/doi.org\/10.3389\/fphar.2025.1628527.","DOI":"10.3389\/fphar.2025.1628527"},{"issue":"2","key":"860_CR216","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0376-8716(81)90030-2","volume":"7","author":"M Hjorth","year":"1981","unstructured":"Hjorth M, Bille M, Smith DF. Serum tryptophan levels in alcoholics. Drug Alcohol Depen. 1981;7(2):157\u201361. https:\/\/doi.org\/10.1016\/0376-8716(81)90030-2.","journal-title":"Drug Alcohol Depen"},{"issue":"3","key":"860_CR217","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1001\/ARCHPSYC.1989.01810030037005","volume":"46","author":"L Buydens-Branchey","year":"1989","unstructured":"Buydens-Branchey L. Age of alcoholism onset: II. Relationship to susceptibility to serotonin precursor availability. Arch Gen Psychiatry. 1989;46(3):231\u201336. https:\/\/doi.org\/10.1001\/ARCHPSYC.1989.01810030037005.","journal-title":"Arch Gen Psychiatry"},{"issue":"5","key":"860_CR218","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/J.1530-0277.2007.00365.X","volume":"31","author":"M Underwood","year":"2007","unstructured":"Underwood M, Mann J, Arango V. Morphometry of dorsal raphe nucleus serotonergic neurons in alcoholism. Alcohol Clin Exp Res. 2007;31(5):837\u201345. https:\/\/doi.org\/10.1111\/J.1530-0277.2007.00365.X.","journal-title":"Alcohol Clin Exp Res"},{"issue":"7","key":"860_CR219","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1111\/acer.12414","volume":"38","author":"H Bach","year":"2014","unstructured":"Bach H, Arango V, Kassir SA, Tsaava T, Dwork AJ, Mann JJ, et al. Alcoholics have more tryptophan hydroxylase 2 mRNA and protein in the dorsal and median raphe nuclei. Alcohol Clin Exp Res. 2014;38(7):1894\u2013901. https:\/\/doi.org\/10.1111\/acer.12414.","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"860_CR220","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/J.1530-0277.2008.00820.X","volume":"33","author":"M Nishikawa","year":"2009","unstructured":"Nishikawa M, Diksic M, Sakai Y, Kumano H, Charney D, Palacios-Boix J, et al. Alterations in brain serotonin synthesis in male alcoholics measured using positron emission tomography. Alcohol Clin Exp Res. 2009;33(2):233\u201339. https:\/\/doi.org\/10.1111\/J.1530-0277.2008.00820.X.","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"860_CR221","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/SYN.20278","volume":"60","author":"W Bonkale","year":"2006","unstructured":"Bonkale W, Turecki G, Austin M. Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus. Synapse. 2006;60(1):81\u201385. https:\/\/doi.org\/10.1002\/SYN.20278.","journal-title":"Synapse"},{"key":"860_CR222","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.ALCOHOL.2020.04.002","volume":"87","author":"N Popova","year":"2020","unstructured":"Popova N, Ilchibaeva T, Antonov E, Pershina A, Bazovkina D, Naumenko V. On the interaction between BDNF and serotonin systems: the effects of long-term ethanol consumption in mice. Alcohol. 2020;87:1\u201315. https:\/\/doi.org\/10.1016\/J.ALCOHOL.2020.04.002.","journal-title":"Alcohol"},{"issue":"4","key":"860_CR223","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1176\/APPI.AJP.159.4.599","volume":"159","author":"T Mantere","year":"2002","unstructured":"Mantere T, Tupala E, Hall H, S\u00e4rkioja T, R\u00e4s\u00e4nen P, Bergstr\u00f6m K, et al. Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects: a whole-hemisphere autoradiography study. AJP. 2002;159(4):599\u2013606. https:\/\/doi.org\/10.1176\/APPI.AJP.159.4.599.","journal-title":"AJP"},{"issue":"1","key":"860_CR224","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/J.1530-0277.2006.00261.X","volume":"31","author":"AK Brown","year":"2007","unstructured":"Brown AK, George DT, Fujita M, Liow JS, Ichise M, Hibbeln J, et al. PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. Alcohol Clin Exp Res. 2007;31(1):28\u201332. https:\/\/doi.org\/10.1111\/J.1530-0277.2006.00261.X.","journal-title":"Alcohol Clin Exp Res"},{"issue":"11","key":"860_CR225","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1176\/AJP.155.11.1544","volume":"155","author":"A Heinz","year":"1998","unstructured":"Heinz A, Ragan P, Jones DW, Hommer D, Williams W, Knable MB, et al. Reduced central serotonin transporters in alcoholism. AJP. 1998;155(11):1544\u201349. https:\/\/doi.org\/10.1176\/AJP.155.11.1544.","journal-title":"AJP"},{"key":"860_CR226","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.pnpbp.2024.111124","volume":"135","author":"A Cieslik-Starkiewicz","year":"2024","unstructured":"Cieslik-Starkiewicz A, Piksa M, Noworyta K, Solich J, Pabian P, Latocha K, et al. Unveiling the power of optimism: exploring behavioral and neuromolecular correlates of alcohol seeking and drinking in rats with biased judgement. Prog Neuropsychopharmacol Biol Psychiatry. 2024;135:135. https:\/\/doi.org\/10.1016\/j.pnpbp.2024.111124.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"3","key":"860_CR227","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0741-8329(85)90106-5","volume":"2","author":"S Borg","year":"1985","unstructured":"Borg S, Kvande H, Liljeberg P, Mossberg D, Valverius P. 5-hydroxyindoleacetic acid in cerebrospinal fluid in alcoholic patients under different clinical conditions. Alcohol. 1985;2(3):415\u201318. https:\/\/doi.org\/10.1016\/0741-8329(85)90106-5.","journal-title":"Alcohol"},{"issue":"2","key":"860_CR228","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1001\/archpsyc.1979.01780020114013","volume":"36","author":"JC Ballenger","year":"1979","unstructured":"Ballenger JC. Alcohol and central serotonin metabolism in Man. Arch Gen Psychiatry. 1979;36(2):224\u201327. https:\/\/doi.org\/10.1001\/archpsyc.1979.01780020114013.","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"860_CR229","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/S00213-006-0641-7","volume":"190","author":"KK Szumlinski","year":"2007","unstructured":"Szumlinski KK, Diab ME, Friedman R, Henze LM, Lominac KD, Bowers MS. Accumbens neurochemical adaptations produced by binge-like alcohol consumption. Psychopharmacol (Berl). 2007;190(4):415\u201331. https:\/\/doi.org\/10.1007\/S00213-006-0641-7.","journal-title":"Psychopharmacol (Berl)"},{"issue":"10","key":"860_CR230","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.1523\/JNEUROSCI.16-10-03474.1996","volume":"16","author":"F Weiss","year":"1996","unstructured":"Weiss F, Parsons LH, Schulteis G, Hyyti\u00e4 P, Lorang MT, Bloom FE, et al. Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. J Neurosci. 1996;16(10):3474\u201385. https:\/\/doi.org\/10.1523\/JNEUROSCI.16-10-03474.1996.","journal-title":"J Neurosci"},{"issue":"1","key":"860_CR231","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1124\/JPET.103.059790","volume":"309","author":"RJ Thielen","year":"2004","unstructured":"Thielen RJ, Engleman EA, Rodd ZA, Murphy JM, Lumeng L, Li TK, et al. Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats. J Pharmacol Exp Ther. 2004;309(1):216\u201325. https:\/\/doi.org\/10.1124\/JPET.103.059790.","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"860_CR232","doi-asserted-by":"publisher","first-page":"790","DOI":"10.3390\/BRAINSCI3020790","volume":"3","author":"P Jaatinen","year":"2013","unstructured":"Jaatinen P, Sarviharju M, Raivio N, Eriksson CJP, Hervonen A, Kiianmaa K. Effects of lifelong ethanol consumption on brain monoamine transmitters in alcohol-preferring Alko alcohol (AA) rats. Brain Sci. 2013;3(2):790\u201399. https:\/\/doi.org\/10.3390\/BRAINSCI3020790.","journal-title":"Brain Sci"},{"issue":"7","key":"860_CR233","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/S10571-008-9281-2","volume":"28","author":"KG Akash","year":"2008","unstructured":"Akash KG, Balarama KS, Paulose CS. Enhanced 5-HT2A receptor status in the hypothalamus and corpus striatum of ethanol-treated rats. Cell Mol Neurobiol. 2008;28(7):1017\u201325. https:\/\/doi.org\/10.1007\/S10571-008-9281-2.","journal-title":"Cell Mol Neurobiol"},{"issue":"1","key":"860_CR234","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/BF00969186","volume":"15","author":"E Kempf","year":"1990","unstructured":"Kempf E, Kempf J, Ebel A. Alcohol withdrawal-induced changes in brain biogenic amines in mice: influence of the genotype. Neurochem Res. 1990;15(1):69\u201375. https:\/\/doi.org\/10.1007\/BF00969186.","journal-title":"Neurochem Res"},{"issue":"3","key":"860_CR235","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1093\/alcalc\/agg055","volume":"38","author":"AA Patkar","year":"2003","unstructured":"Patkar AA. Changes in plasma noradrenaline and serotonin levels and craving during alcohol withdrawal. Alcohol Alcohol. 2003;38(3):224\u201331. https:\/\/doi.org\/10.1093\/alcalc\/agg055.","journal-title":"Alcohol Alcohol"},{"issue":"3","key":"860_CR236","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3109\/00952990.2016.1160098","volume":"42","author":"YH Xu","year":"2016","unstructured":"Xu YH, Wang LL, Shi L, Lei JP, Miao Q, Liu TQ, et al. The association of HTR3A mRNA expression and craving in Han Chinese alcohol-dependent patients: a preliminary study. Am J Drug Alcohol Abuse. 2016;42(3):316\u201324. https:\/\/doi.org\/10.3109\/00952990.2016.1160098.","journal-title":"Am J Drug Alcohol Abuse"},{"issue":"2","key":"860_CR237","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/S0893-133X(99)00030-5","volume":"21","author":"YY Huang","year":"1999","unstructured":"Huang YY. Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue. Neuropsychopharmacology. 1999;21(2):238\u201346. https:\/\/doi.org\/10.1016\/S0893-133X(99)00030-5.","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"860_CR238","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0376-8716(01)00154-5","volume":"65","author":"U Berggren","year":"2002","unstructured":"Berggren U, Eriksson M, Fahlke C, Balldin J. Is long-term heavy alcohol consumption toxic for brain serotonergic neurons? Relationship between years of excessive alcohol consumption and serotonergic neurotransmission. Drug Alcohol Depen. 2002;65(2):159\u201365. https:\/\/doi.org\/10.1016\/S0376-8716(01)00154-5.","journal-title":"Drug Alcohol Depen"},{"issue":"1","key":"860_CR239","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/J.1530-0277.2011.01598.X","volume":"36","author":"C Fahlke","year":"2012","unstructured":"Fahlke C, Berggren U, Berglund KJ, Zetterberg H, Blennow K, Engel JA, et al. Neuroendocrine assessment of serotonergic, dopaminergic, and noradrenergic functions in alcohol-dependent individuals. Alcohol Clin Exp Res. 2012;36(1):97\u2013103. https:\/\/doi.org\/10.1111\/J.1530-0277.2011.01598.X.","journal-title":"Alcohol Clin Exp Res"},{"issue":"11","key":"860_CR240","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1111\/j.1530-0277.2002.tb02464.x","volume":"26","author":"D Gotjen","year":"2002","unstructured":"Gotjen D, Szabo Z, Lee S, Wand G. Hormone responses to citalopram in abstinent alcohol dependent subjects. Alcohol Clin Exp Res. 2002;26(11):1625\u201331. https:\/\/doi.org\/10.1111\/j.1530-0277.2002.tb02464.x.","journal-title":"Alcohol Clin Exp Res"},{"issue":"3\u20134","key":"860_CR241","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/J.1369-1600.2007.00094.X","volume":"13","author":"RJ Porter","year":"2008","unstructured":"Porter RJ, Sellman D, Joyce PR, Davies J, Frampton C. CLINICAL STUDY: prolactin response to fenfluramine in abstinent, alcohol-dependent patients. Addict Biol. 2008;13(3\u20134):380\u201385. https:\/\/doi.org\/10.1111\/J.1369-1600.2007.00094.X.","journal-title":"Addict Biol"},{"issue":"8\u20139","key":"860_CR242","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1007\/S007020170027","volume":"108","author":"HG Weijers","year":"2001","unstructured":"Weijers HG, Wiesbeck GA, Jakob F, B\u00f6ning J. Neuroendocrine responses to fenfluramine and its relationship to personality in alcoholism. J Neural Transm. 2001;108(8\u20139):1093\u2013105. https:\/\/doi.org\/10.1007\/S007020170027.","journal-title":"J Neural Transm"},{"issue":"36","key":"860_CR243","doi-asserted-by":"publisher","first-page":"6842","DOI":"10.1523\/JNEUROSCI.0733-20.2020","volume":"40","author":"S Khom","year":"2020","unstructured":"Khom S, Wolfe SA, Patel RR, Kirson D, Hedges DM, Varodayan FP, et al. Alcohol dependence and withdrawal impair serotonergic regulation of GABA transmission in the rat central nucleus of the amygdala. J Neurosci. 2020;40(36):6842\u201353. https:\/\/doi.org\/10.1523\/JNEUROSCI.0733-20.2020.","journal-title":"J Neurosci"},{"key":"860_CR244","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/J.NBD.2024.106590","volume":"199","author":"R Vlkolinsky","year":"2024","unstructured":"Vlkolinsky R, Khom S, Vozella V, Bajo M, Roberto M. Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats. Neurobiol Disease. 2024;199:199. https:\/\/doi.org\/10.1016\/J.NBD.2024.106590.","journal-title":"Neurobiol Disease"},{"issue":"6","key":"860_CR245","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1111\/J.1471-4159.2008.05733.X","volume":"107","author":"S Kela\u00ef","year":"2008","unstructured":"Kela\u00ef S, Renoir T, Chouchana L, Saurini F, Hanoun N, Hamon M, et al. Chronic voluntary ethanol intake hypersensitizes 5-HT 1A autoreceptors in C57BL\/6J mice. J Neurochem. 2008;107(6):1660\u201370. https:\/\/doi.org\/10.1111\/J.1471-4159.2008.05733.X.","journal-title":"J Neurochem"},{"issue":"9","key":"860_CR246","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1038\/NPP.2017.22","volume":"42","author":"S Nimitvilai","year":"2017","unstructured":"Nimitvilai S, Lopez MF, Mulholland PJ, Woodward JJ. Ethanol dependence abolishes monoamine and GIRK (Kir3) channel inhibition of orbitofrontal cortex excitability. Neuropsychopharmacology. 2017;42(9):1800\u201312. https:\/\/doi.org\/10.1038\/NPP.2017.22.","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"860_CR247","doi-asserted-by":"publisher","first-page":"41","DOI":"10.18773\/AUSTPRESCR.2015.015","volume":"38","author":"P Crowley","year":"2015","unstructured":"Crowley P. Long-term drug treatment of patients with alcohol dependence. Aust Prescr. 2015;38(2):41. https:\/\/doi.org\/10.18773\/AUSTPRESCR.2015.015.","journal-title":"Aust Prescr"},{"issue":"10","key":"860_CR248","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1080\/14656566.2021.1892641","volume":"22","author":"K Morley","year":"2021","unstructured":"Morley K, Perry C, Watt J, Hurzeler T, Leggio L, Lawrence A, et al. New approved and emerging pharmacological approaches to alcohol use disorder: a review of clinical studies. Expert Opin Pharmacother. 2021;22(10):1291\u2013303. https:\/\/doi.org\/10.1080\/14656566.2021.1892641.","journal-title":"Expert Opin Pharmacother"},{"key":"860_CR249","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1176\/AJP.153.2.281","volume":"153","author":"SS O\u2019Malley","year":"1996","unstructured":"O\u2019Malley SS, Jaffe AJ, Rode S, Rounsaville BJ. Experience of a \u201cslip\u201d among alcoholics treated with naltrexone or placebo. Am J Psychiatry. 1996;153:281\u201383. https:\/\/doi.org\/10.1176\/AJP.153.2.281.","journal-title":"Am J Psychiatry"},{"key":"860_CR250","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/7854_2023_452","volume":"66","author":"T Sharp","year":"2024","unstructured":"Sharp T, Collins H. Mechanisms of SSRI therapy and discontinuation. Curr Top Behav Neurosci. 2024;66:21\u201347. https:\/\/doi.org\/10.1007\/7854_2023_452.","journal-title":"Curr Top Behav Neurosci"},{"issue":"6","key":"860_CR251","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S0893-133X(02)00377-9","volume":"27","author":"S Koch","year":"2002","unstructured":"Koch S. R-fluoxetine increases extracellular DA, NE, as well as 5-HT in rat prefrontal cortex and hypothalamus an in vivo microdialysis and receptor binding study. Neuropsychopharmacology. 2002;27(6):949\u201359. https:\/\/doi.org\/10.1016\/S0893-133X(02)00377-9.","journal-title":"Neuropsychopharmacology"},{"issue":"s1","key":"860_CR252","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/J.1600-0773.1992.TB01631.X","volume":"71","author":"G Serra","year":"1992","unstructured":"Serra G, Collu M, D\u2019Aquila PS, Gessa GL. Role of the mesolimbic dopamine system in the mechanism of action of antidepressants. Pharmacol Toxicol. 1992;71(s1):72\u201385. https:\/\/doi.org\/10.1111\/J.1600-0773.1992.TB01631.X.","journal-title":"Pharmacol Toxicol"},{"issue":"2\u20133","key":"860_CR253","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0014-2999(97)00006-X","volume":"322","author":"M Collu","year":"1997","unstructured":"Collu M, Poggiu AS, Devoto P, Serra G. Behavioural sensitization of mesolimbic dopamine D2 receptors in chronic fluoxetine-treated rats. Eur J Pharmacol. 1997;322(2\u20133):123\u201327. https:\/\/doi.org\/10.1016\/S0014-2999(97)00006-X.","journal-title":"Eur J Pharmacol"},{"key":"860_CR254","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/978-1-4899-1678-5_13","volume":"7","author":"C Naranjo","year":"1989","unstructured":"Naranjo C, Sellers E. Serotonin uptake inhibitors attenuate ethanol intake in problem drinkers. Recent Dev Alcohol. 1989;7:255\u201366. https:\/\/doi.org\/10.1007\/978-1-4899-1678-5_13.","journal-title":"Recent Dev Alcohol"},{"key":"860_CR255","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/978-1-4899-1678-5_14","volume":"7","author":"DA Gorelick","year":"1989","unstructured":"Gorelick DA. Serotonin uptake blockers and the treatment of alcoholism. Recent Dev Alcohol. 1989;7:267\u201381. https:\/\/doi.org\/10.1007\/978-1-4899-1678-5_14.","journal-title":"Recent Dev Alcohol"},{"issue":"2","key":"860_CR256","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3109\/15622970009150572","volume":"1","author":"E Romeo","year":"2000","unstructured":"Romeo E, Pompili E, Di Michele F, Pace M, Rupprecht R, Bernardi G, et al. Effects of fluoxetine, Indomethacine and placebo on 3\u03b1, 5\u03b1 tetrahydroprogesterone (THP) plasma levels in uncomplicated alcohol withdrawal. World J Biol Psychiatry. 2000;1(2):101\u201304. https:\/\/doi.org\/10.3109\/15622970009150572.","journal-title":"World J Biol Psychiatry"},{"key":"860_CR257","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1176\/AJP.152.3.391","volume":"152","author":"HR Kranzler","year":"1995","unstructured":"Kranzler HR, Burleson JA, Korner P, Del Boca FK, Bohn MJ, Brown J, et al. Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics. Am J Psychiatry. 1995;152:391\u201397. https:\/\/doi.org\/10.1176\/AJP.152.3.391.","journal-title":"Am J Psychiatry"},{"issue":"7","key":"860_CR258","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1097\/01.ALC.0000130974.50563.04","volume":"28","author":"W Dundon","year":"2004","unstructured":"Dundon W, Lynch K, Pettinati H, Lipkin C. Treatment outcomes in type A and B alcohol dependence 6 months after serotonergic pharmacotherapy. Alcohol Clin Exp Res. 2004;28(7):1065\u201373. https:\/\/doi.org\/10.1097\/01.ALC.0000130974.50563.04.","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"860_CR259","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/J.1749-6632.2001.TB05799.X","volume":"932","author":"JR Cornelius","year":"2001","unstructured":"Cornelius JR, Salloum IM, Lynch K, Clark DB, John Manna J. Treating the substance-abusing suicidal patient. Ann New Y Acad Sci. 2001;932(1):78\u201393. https:\/\/doi.org\/10.1111\/J.1749-6632.2001.TB05799.X.","journal-title":"Ann New Y Acad Sci"},{"issue":"1","key":"860_CR260","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/01.JCP.0000194620.61868.35","volume":"26","author":"HR Kranzler","year":"2006","unstructured":"Kranzler HR, Mueller T, Cornelius J, Pettinati HM, Moak D, Martin PR, et al. Sertraline treatment of co-occurring alcohol dependence and major depression. J Clin Psychopharmacol. 2006;26(1):13\u201320. https:\/\/doi.org\/10.1097\/01.JCP.0000194620.61868.35.","journal-title":"J Clin Psychopharmacol"},{"issue":"6","key":"860_CR261","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1111\/ADB.12007","volume":"18","author":"HR Kranzler","year":"2013","unstructured":"Kranzler HR, Armeli S, Tennen H, Covault J. 5-HTTLPR genotype and daily negative mood moderate the effects of sertraline on drinking intensity. Addict Biol. 2013;18(6):1024\u201331. https:\/\/doi.org\/10.1111\/ADB.12007.","journal-title":"Addict Biol"},{"issue":"4","key":"860_CR262","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.jpsychires.2003.11.007","volume":"38","author":"IT Uzbay","year":"2004","unstructured":"Uzbay IT, Sa\u01e7 Lam E, Kayir H, \u00c7elik T, Beyazy\u00fcrek M. Effects of fluoxetine on ethanol withdrawal syndrome in rats. J Psychiatric Res. 2004;38(4):445\u201350. https:\/\/doi.org\/10.1016\/j.jpsychires.2003.11.007.","journal-title":"J Psychiatric Res"},{"issue":"7","key":"860_CR263","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1038\/npp.2011.37","volume":"36","author":"ES O\u2019Brien","year":"2011","unstructured":"O\u2019Brien ES, Legastelois R, Houchi H, Vilpoux C, Alaux-Cantin S, Pierrefiche O, et al. Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and\/or relapse in dependent rats. Neuropsychopharmacology. 2011;36(7):1518\u201330. https:\/\/doi.org\/10.1038\/npp.2011.37.","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"860_CR264","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1017\/S1461145713000217","volume":"16","author":"F Al\u00e9n","year":"2013","unstructured":"Al\u00e9n F, Orio L, Gorriti M\u00c1, De Heras RG, Ram\u00edrez-L\u00f3pez MT, Pozo M\u00c1, et al. Increased alcohol consumption in rats after subchronic antidepressant treatment. Int J Neuropsychopharmacol. 2013;16(8):1809\u201318. https:\/\/doi.org\/10.1017\/S1461145713000217.","journal-title":"Int J Neuropsychopharmacol"},{"key":"860_CR265","doi-asserted-by":"publisher","unstructured":"Su\u00e1rez J, Khom S, Al\u00e9n F, Natividad LA, Varodayan FP, Patel RR, et al. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addict Biol. 2020;25:25(5). https:\/\/doi.org\/10.1111\/adb.12813.","DOI":"10.1111\/adb.12813"},{"issue":"2","key":"860_CR266","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1124\/pr.115.011478","volume":"68","author":"DE Nichols","year":"2016","unstructured":"Nichols DE. Psychedelics. Pharmacol Rev. 2016;68(2):264. https:\/\/doi.org\/10.1124\/pr.115.011478.","journal-title":"Pharmacol Rev"},{"issue":"02","key":"860_CR267","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21926\/obm.neurobiol.2102102","volume":"5","author":"SC Rodan","year":"2021","unstructured":"Rodan SC, Aouad P, McGregor IS, Maguire S. Psilocybin as a novel pharmacotherapy for treatment-refractory anorexia nervosa. OBM Neurobiol. 2021;5(02):1\u201325. https:\/\/doi.org\/10.21926\/obm.neurobiol.2102102.","journal-title":"OBM Neurobiol"},{"issue":"3","key":"860_CR268","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/ijnp\/pyac074","volume":"26","author":"JJ Gattuso","year":"2023","unstructured":"Gattuso JJ, Perkins D, Ruffell S, Lawrence AJ, Hoyer D, Jacobson LH, et al. Default mode network modulation by psychedelics: a systematic review. Int J Neuropsychopharmacol. 2023;26(3):155\u201388. https:\/\/doi.org\/10.1093\/ijnp\/pyac074.","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"860_CR269","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41386-022-01389-z","volume":"48","author":"AE Calder","year":"2023","unstructured":"Calder AE, Hasler G. Towards an understanding of psychedelic-induced neuroplasticity. Neuropsychopharmacol. 2023;48(1):104. https:\/\/doi.org\/10.1038\/s41386-022-01389-z.","journal-title":"Neuropsychopharmacol"},{"issue":"1","key":"860_CR270","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3390\/psychoactives3010007","volume":"3","author":"FA Colosimo","year":"2024","unstructured":"Colosimo FA, Borsellino P, Krider RI, Marquez RE, Vida TA, et al. The clinical potential of Dimethyltryptamine: breakthroughs into the other side of mental illness, neurodegeneration, and consciousness. Psychoactives. 2024;3(1):93\u2013122. https:\/\/doi.org\/10.3390\/psychoactives3010007.","journal-title":"Psychoactives"},{"issue":"7","key":"860_CR271","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1177\/0269881112439253","volume":"26","author":"TS Krebs","year":"2012","unstructured":"Krebs TS, Johansen P-\u00d8. Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials. J Psychopharmacol. 2012;26(7):994\u20131002. https:\/\/doi.org\/10.1177\/0269881112439253.","journal-title":"J Psychopharmacol"},{"issue":"3","key":"860_CR272","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1177\/0269881114565144","volume":"29","author":"MP Bogenschutz","year":"2015","unstructured":"Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa P, Strassman RJ. Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol. 2015;29(3):289\u201399. https:\/\/doi.org\/10.1177\/0269881114565144.","journal-title":"J Psychopharmacol"},{"issue":"10","key":"860_CR273","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1001\/jamapsychiatry.2022.2096","volume":"79","author":"MP Bogenschutz","year":"2022","unstructured":"Bogenschutz MP, Ross S, Bhatt S, Baron T, Forcehimes AA, Laska E, et al. Percentage of heavy drinking days following psilocybin-assisted psychotherapy vs placebo in the treatment of adult patients with alcohol use disorder: a randomized clinical trial. JAMA Psychiatry. 2022;79(10):953\u201362. https:\/\/doi.org\/10.1001\/jamapsychiatry.2022.2096.","journal-title":"JAMA Psychiatry"},{"key":"860_CR274","doi-asserted-by":"publisher","unstructured":"Vanderijst L, Hever F, Buot A, Daur\u00e9 C, Benoit J, Hanak C, et al. Psilocybin-assisted therapy for severe alcohol use disorder: protocol for a double-blind, randomized, placebo-controlled, 7-month parallel-group phase II superiority trial. BMC Psychiatry. 2024;24:24(1). https:\/\/doi.org\/10.1186\/s12888-024-05502-y.","DOI":"10.1186\/s12888-024-05502-y"},{"issue":"6","key":"860_CR275","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/adb.13229","volume":"27","author":"J Calleja-Conde","year":"2022","unstructured":"Calleja-Conde J, Morales-Garc\u00eda JA, Echeverry-Alzate V, B\u00fchler KM, Gin\u00e9 E, L\u00f3pez-Moreno JA. Classic psychedelics and alcohol use disorders: a systematic review of human and animal studies. Addict Biol. 2022;27(6):27. https:\/\/doi.org\/10.1111\/adb.13229.","journal-title":"Addict Biol"},{"key":"860_CR276","doi-asserted-by":"publisher","first-page":"395965","DOI":"10.3389\/fphar.2018.00994","volume":"9","author":"K Alper","year":"2018","unstructured":"Alper K, Dong B, Shah R, Sershen H, Vinod KY. LSD administered as a single dose reduces alcohol consumption in C57BL\/6J mice. Front Pharmacol. 2018;9:395965. https:\/\/doi.org\/10.3389\/fphar.2018.00994.","journal-title":"Front Pharmacol"},{"key":"860_CR277","doi-asserted-by":"publisher","first-page":"1074633","DOI":"10.3389\/fphar.2022.1074633","volume":"13","author":"K Alper","year":"2023","unstructured":"Alper K, Cange J, Sah R, Schreiber-Gregory D, Sershen H, Vinod KY. Psilocybin sex-dependently reduces alcohol consumption in C57BL\/6J mice. Front Pharmacol. 2023;13:1074633. https:\/\/doi.org\/10.3389\/fphar.2022.1074633.","journal-title":"Front Pharmacol"},{"issue":"6","key":"860_CR278","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1007\/s00213-022-06104-w","volume":"239","author":"YA Serra","year":"2022","unstructured":"Serra YA, Barros-Santos T, Anjos-Santos A, Kisaki ND, Jovita-Farias C, Leite JPC, et al. Role of 5-HT2A receptors in the effects of ayahuasca on ethanol self-administration using a two-bottle choice paradigm in male mice. Psychopharmacology. 2022;239(6):1679\u201387. https:\/\/doi.org\/10.1007\/s00213-022-06104-w.","journal-title":"Psychopharmacology"},{"issue":"45","key":"860_CR279","doi-asserted-by":"publisher","first-page":"7472","DOI":"10.1523\/JNEUROSCI.1384-23.2023","volume":"43","author":"LP Cameron","year":"2023","unstructured":"Cameron LP, Benetatos J, Lewis V, Bonniwell EM, Jaster AM, Moliner R, et al. Beyond the 5-HT2A receptor: classic and nonclassic targets in psychedelic drug action. J Neurosci. 2023;43(45):7472\u201382. https:\/\/doi.org\/10.1523\/JNEUROSCI.1384-23.2023.","journal-title":"J Neurosci"},{"issue":"6","key":"860_CR280","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1007\/s43440-023-00539-4","volume":"75","author":"A Ws\u00f3\u0142","year":"2023","unstructured":"Ws\u00f3\u0142 A. Cardiovascular safety of psychedelic medicine: current status and future directions. Pharmacol Rep. 2023;75(6):1362\u201380. https:\/\/doi.org\/10.1007\/s43440-023-00539-4.","journal-title":"Pharmacol Rep"},{"issue":"5","key":"860_CR281","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/00004714-199610000-00003","volume":"16","author":"NJ Coupland","year":"1996","unstructured":"Coupland NJ, Bell CJ, Potokar JP. Serotonin reuptake inhibitor withdrawal. J Clin Psychopharmacol. 1996;16(5):356\u201362. https:\/\/doi.org\/10.1097\/00004714-199610000-00003.","journal-title":"J Clin Psychopharmacol"},{"issue":"5","key":"860_CR282","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1086\/503820","volume":"78","author":"FJ McMahon","year":"2006","unstructured":"McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, et al. Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet. 2006;78(5):804\u201314. https:\/\/doi.org\/10.1086\/503820.","journal-title":"Am J Hum Genet"}],"container-title":["Pharmacological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-026-00860-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43440-026-00860-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43440-026-00860-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:21:49Z","timestamp":1785856909000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43440-026-00860-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":282,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["860"],"URL":"https:\/\/doi.org\/10.1007\/s43440-026-00860-8","relation":{},"ISSN":["1734-1140","2299-5684"],"issn-type":[{"value":"1734-1140","type":"print"},{"value":"2299-5684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"31 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable","order":1,"name":"Ethics","label":"Ethics and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"AI tools (Grammarly, ChatGPT) were used solely for language editing to improve clarity and readability. The author reviewed and approved the final version and takes full responsibility for the content.","order":2,"name":"Ethics","label":"AI-assisted copy editing","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}