{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:41:34Z","timestamp":1780987294426,"version":"3.54.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22mk0101235"],"award-info":[{"award-number":["JP22mk0101235"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ther Innov Regul Sci"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s43441-022-00494-x","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T15:03:55Z","timestamp":1672931035000},"page":"603-610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy Endpoints in Phase II Clinical Trials for Meningioma: An Analysis of Recent Clinical Trials"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9953-8665","authenticated-orcid":false,"given":"Shinya","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narushi","family":"Sugii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyoshi","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"494_CR1","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1111\/cas.14967","volume":"112","author":"H Minami","year":"2021","unstructured":"Minami H, Kiyota N, Kimbara S, et al. Guidelines for clinical evaluation of anti-cancer drugs. Cancer Sci. 2021;112:2563\u201377.","journal-title":"Cancer Sci"},{"key":"494_CR2","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"EA Eisenhauer","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45:228\u201347.","journal-title":"Eur J Cancer"},{"key":"494_CR3","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.ejca.2006.01.026","volume":"42","author":"P Therasse","year":"2006","unstructured":"Therasse P, Eisenhauer EA, Verweij J. RECIST revisited: a review of validation studies on tumour assessment. Eur J Cancer. 2006;42:1031\u20139.","journal-title":"Eur J Cancer"},{"key":"494_CR4","first-page":"358","volume":"52","author":"S Watanabe","year":"2021","unstructured":"Watanabe S, Nonaka T, Maeda M, et al. Fact-finding research on efficacy endpoints in recent Phase II clinical trials targeting glioblastoma. Pharm Med Dev Regul Sci. 2021;52:358\u201367.","journal-title":"Pharm Med Dev Regul Sci"},{"key":"494_CR5","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P, et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol. 2021;23:1231\u201351.","journal-title":"Neuro Oncol"},{"key":"494_CR6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3171\/2014.7.JNS131644","volume":"122","author":"L Rogers","year":"2015","unstructured":"Rogers L, Barani I, Chamberlain M, et al. Meningiomas: knowledge base, treatment outcomes, and uncertainties A RANO review. J Neurosurg. 2015;122:4\u201323.","journal-title":"J Neurosurg"},{"key":"494_CR7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3171\/2010.1.JNS091114","volume":"113","author":"ME Sughrue","year":"2010","unstructured":"Sughrue ME, Sanai N, Shangari G, et al. Outcome and survival following primary and repeat surgery for World Health Organization Grade III meningiomas. J Neurosurg. 2010;113:202.","journal-title":"J Neurosurg"},{"key":"494_CR8","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.ijrobp.2019.11.028","volume":"106","author":"CL Rogers","year":"2020","unstructured":"Rogers CL, Won M, Vogelbaum MA, et al. High-risk meningioma: initial outcomes from NRG oncology\/RTOG 0539. Int J Radiat Oncol Biol Phys. 2020;106:790.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"494_CR9","first-page":"164","volume-title":"WHO classification of tumours of the central nervous system","author":"A Perry","year":"2007","unstructured":"Perry A, Louis DN, Scheithauer BW, et al. Meningiomas. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, editors., et al., WHO classification of tumours of the central nervous system. Lyon: IARC Press; 2007. p. 164."},{"key":"494_CR10","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1136\/jnnp.2007.121582","volume":"79","author":"SY Yang","year":"2008","unstructured":"Yang SY, Park CK, Park SH, et al. Atypical and anaplastic meningiomas: prognostic implications of clinicopathological features. J Neurol Neurosurg Psychiatry. 2008;79:574\u201380.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"494_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/neuonc\/noy137","volume":"21","author":"RY Huang","year":"2019","unstructured":"Huang RY, Bi WL, Weller M, et al. Proposed response assessment and endpoints for meningioma clinical trials: report from the response assessment in neuro-oncology working group. Neuro Oncol. 2019;21:26\u201336.","journal-title":"Neuro Oncol"},{"key":"494_CR12","first-page":"980","volume":"88","author":"MJ Shepard","year":"2021","unstructured":"Shepard MJ, Xu Z, Kearns K, et al. Stereotactic radiosurgery for atypical (World Health Organization II) and anaplastic (World Health Organization III) meningiomas: results from a multicenter. Int Cohort Study Neurosurg. 2021;88:980\u20138.","journal-title":"Int Cohort Study Neurosurg"},{"key":"494_CR13","doi-asserted-by":"publisher","first-page":"102082","DOI":"10.1016\/j.ctrv.2020.102082","volume":"90","author":"C Dittrich","year":"2020","unstructured":"Dittrich C. Basket trials: from tumour gnostic to tumour agnostic drug development. Cancer Treat Rev. 2020;90:102082.","journal-title":"Cancer Treat Rev"},{"key":"494_CR14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1212\/01.wnl.0000435744.57038.af","volume":"81","author":"E Dombi","year":"2013","unstructured":"Dombi E, Ardern-Holmes SL, Babovic-Vuksanovic D, et al. Recommendations for imaging tumor response in neurofibromatosis clinical trials. Neurology. 2013;81:33\u201340.","journal-title":"Neurology"},{"key":"494_CR15","volume-title":"Neuro-Oncology","author":"M Matsutani","year":"2016","unstructured":"Matsutani M. Neuro-Oncology. Japan: Kimpodo; 2016."}],"container-title":["Therapeutic Innovation &amp; Regulatory Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43441-022-00494-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43441-022-00494-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43441-022-00494-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T13:32:25Z","timestamp":1682515945000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43441-022-00494-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,5]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["494"],"URL":"https:\/\/doi.org\/10.1007\/s43441-022-00494-x","relation":{},"ISSN":["2168-4790","2168-4804"],"issn-type":[{"value":"2168-4790","type":"print"},{"value":"2168-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,5]]},"assertion":[{"value":"8 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}