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This development identifies the yeast as a perfect example for the relevance of the One Health concept for human well-being. Here, we compare the effectiveness of Photodynamic Inactivation (PDI) based on the economic and ecofriendly natural photosensitizer sodium\u2013magnesium\u2013chlorophyllin (Chl) to that of a synthetic chlorin e6 derivative carrying cationic moieties, B17-0024, suggesting both as alternative to common disinfectants against\n                    <jats:italic>C. auris.<\/jats:italic>\n                    Experiments were conducted on planktonic cells and\u2014for the very first time\u2014on dynamic biofilms using the CDC bioreactor. Treatment of planktonic cells with 50\u00a0\u00b5M Chl and blue light (395\u00a0nm, 7.5\u00a0J\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    , 15\u00a0min drug to light interval) achieved a 7 log\n                    <jats:sub>10<\/jats:sub>\n                    step reduction of viable\n                    <jats:italic>C. auris<\/jats:italic>\n                    . B17-0024 induced a more than 5 log\n                    <jats:sub>10<\/jats:sub>\n                    step photokilling at 10\u00a0\u00b5M. Illumination of the same concentrations with red light (600\u2013700\u00a0nm, 30\u00a0J\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) resulted in a relative inactivation of 7 log\n                    <jats:sub>10<\/jats:sub>\n                    steps for Chl and 6 log\n                    <jats:sub>10<\/jats:sub>\n                    steps for B17-0024. Dynamic biofilm samples were illuminated with 3.33-times higher radiant exposure (25\u00a0J\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    at 395\u00a0nm or 100\u00a0J\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    at 600\u2013700\u00a0nm). The antimicrobial effect of a 99.9% reduction of\n                    <jats:italic>C. auris<\/jats:italic>\n                    was exceeded with 10\u00a0\u00b5M B17-0024 and blue light illumination and with 50\u00a0\u00b5M Chl and B17-0024 activated by red light. Biofilms were completely eradicated when doubling the photosensitizer concentrations. Our results demonstrate that PDI based on Chl represents a rapid and effective tool to eliminate emerging pathogens even if resistant to conventional treatment. Due to its low costs and eco-friendliness PDI based on Chl may be applicable for disinfection of larger areas in hospitals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s43630-025-00768-x","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T13:15:25Z","timestamp":1755609325000},"page":"1393-1405","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chlorophyllin-based Photodynamic Inactivation against Candidozyma auris planktonic cells and dynamic biofilm"],"prefix":"10.1007","volume":"24","author":[{"given":"Annette","family":"Wimmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Jernej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristjan","family":"Plaetzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"768_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1348-0421.2008.00083.x","volume":"53","author":"K Satoh","year":"2009","unstructured":"Satoh, K., Makimura, K., Hasumi, Y., Nishiyama, Y., Uchida, K., & Yamaguchi, H. 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