{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:19:09Z","timestamp":1766067549186,"version":"3.48.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Photochem Photobiol Sci"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s43630-025-00820-w","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:52:32Z","timestamp":1764604352000},"page":"2153-2168","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photobiomodulation therapy enhances surfactant production in premature rat lungs: a non-invasive therapeutic strategy for neonatal respiratory distress syndromes"],"prefix":"10.1007","volume":"24","author":[{"given":"Halil \u0130brahim","family":"\u00d6zdemir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertu\u011frul","family":"\u00d6zkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metin","family":"Bilge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z\u00fcleyha \u00d6z\u00e7elik","family":"\u00c7etinel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu","family":"Bilge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cans\u0131n \u015eirin","family":"Tomruk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canberk","family":"Tomruk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice Elif","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayshan","family":"Ahadova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"\u00c7ekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur Selvi","family":"G\u00fcnel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7a\u011fla","family":"Kayaba\u015f\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demet","family":"Terek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Erol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahri Emrah","family":"Soylu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eenay","family":"\u015eanl\u0131er","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Yalaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cumhur","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130smail","family":"Oran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"820_CR1","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1146\/annurev.physiol.63.1.555","volume":"63","author":"TE Weaver","year":"2001","unstructured":"Weaver, T. E., & Conkright, J. J. (2001). Function of surfactant proteins B and C. Annual Reveiw of Physiology, 63, 555\u2009\u2013\u200978PMID: 11181967.","journal-title":"Annual Reveiw of Physiology"},{"issue":"1","key":"820_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/rr36","volume":"2","author":"H Fehrenbach","year":"2001","unstructured":"Fehrenbach, H. (2001). Alveolar epithelial type II cell: Defender of the alveolus revisited. Respiratory Research, 2(1), 33\u201346. https:\/\/doi.org\/10.1186\/rr36Epub 2001 Jan 15. PMID: 11686863; PMCID: PMC59567.","journal-title":"Respiratory Research"},{"issue":"1","key":"820_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","volume":"5","author":"MA Matthay","year":"2019","unstructured":"Matthay, M. A., Zemans, R. L., Zimmerman, G. A., Arabi, Y. M., Beitler, J. R., et al.  (2019).  Acute respiratory distress syndrome. Nature Reviews Disease Primers, 5(1), 18. https:\/\/doi.org\/10.1038\/s41572-019-0069-0PMID: 30872586; PMCID: PMC6709677.","journal-title":"Nature Reviews Disease Primers"},{"key":"820_CR4","doi-asserted-by":"publisher","DOI":"10.1117\/12.646294","author":"MR Hamblin","year":"2006","unstructured":"Hamblin, M. R., & Demidova, T. N. (2006). Mechanisms of low-level light therapy. SPIE. https:\/\/doi.org\/10.1117\/12.646294","journal-title":"SPIE"},{"issue":"3","key":"820_CR5","doi-asserted-by":"publisher","first-page":"7000417","DOI":"10.1109\/JSTQE.2016.2561201","volume":"22","author":"LF Freitas","year":"2016","unstructured":"Freitas, L. F., & Hamblin, M. R. (2016). Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE Journal of Selected Topics in Quantum Electronics, 22(3), 7000417. https:\/\/doi.org\/10.1109\/JSTQE.2016.2561201PMID: 28070154; PMCID: PMC5215870.","journal-title":"IEEE Journal of selected topics in quantum electronics"},{"issue":"1","key":"820_CR6","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1751-1097.2012.01214.x","volume":"89","author":"FM Lima","year":"2013","unstructured":"Lima, F. M., Albertini, R., Dantas, Y., Maia-Filho, A. L., de Loura Santana, C., Castro-Faria-Neto, H. C., Fran\u00e7a, C., Villaverde, A. B., & Aimbire, F. (2013). Low-level laser therapy restores the oxidative stress balance in acute lung injury induced by gut ischemia and reperfusion. Photochemistry and Photobiology, 89(1), 179\u2013188. https:\/\/doi.org\/10.1111\/j.1751-1097.2012.01214.xEpub 2012 Nov 19. PMID: 22882462.","journal-title":"Photochemistry and Photobiology"},{"issue":"7","key":"820_CR7","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1007\/s10103-014-1676-3","volume":"30","author":"R Torres-Silva","year":"2015","unstructured":"Torres-Silva, R., Lopes-Martins, R. A., Bjordal, J. M., Frigo, L., & Rahouadj, R. (2015). The low level laser therapy (LLLT) operating in 660 Nm reduce gene expression of inflammatory mediators in the experimental model of collagenase-induced rat tendinitis. Lasers in Medical Science, 30(7), 1985\u20131990. https:\/\/doi.org\/10.1007\/s10103-014-1676-3Epub 2014 Nov 8. PMID: 25380666.","journal-title":"Lasers in Medical Science"},{"key":"820_CR8","doi-asserted-by":"publisher","unstructured":"Brochetti, R. A., Leal, M. P., Rodrigues, R., da Palma, R. K., & de Oliveira, L. V. F., et al. (2017).  Photobiomodulation therapy improves both inflammatory and fibrotic parameters in experimental model of lung fibrosis in mice. Lasers in Medical Science, 32(8), 1825\u20131834. https:\/\/doi.org\/10.1007\/s10103-017-2281-z.Epub 2017 Jul 16. PMID: 28712048.","DOI":"10.1007\/s10103-017-2281-z"},{"key":"820_CR9","doi-asserted-by":"publisher","first-page":"155312","DOI":"10.1016\/j.cyto.2020.155312","volume":"137","author":"M Nejatifard","year":"2021","unstructured":"Nejatifard, M., Asefi, S., Jamali, R., Hamblin, M. R., & Fekrazad, R. (2021). Probable positive effects of the photobiomodulation as an adjunctive treatment in COVID-19: A systematic review. Cytokine, 137, 155312. https:\/\/doi.org\/10.1016\/j.cyto.2020.155312Epub 2020 Oct 12. PMID: 33128927; PMCID: PMC7550078.","journal-title":"Cytokine"},{"issue":"9","key":"820_CR10","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1007\/s43630-025-00784-x","volume":"24","author":"H\u0130 \u00d6zdemir","year":"2025","unstructured":"\u00d6zdemir, H. \u0130., Bilge, M., \u00d6zkan, E., G\u00fcnel, N. S., \u00d6zdemir, H. E., Ahadova, A., \u00c7ekin, A., \u00c7elebi, L. M. O., Kayaba\u015f\u0131, \u00c7., \u00c7etinel, Z. \u00d6., Bilge, D., Koylu, M., Tomruk, C. \u015e., Tomruk, C., \u015eanl\u0131er, \u015e., Terek, D., Erol, E., Soylu, F. E., Yalaz, M., Oran, \u0130., & G\u00fcnd\u00fcz, C. (2025). Effect of photobiomodulation therapy on surfactant production increase in human lung epithelial alveolar cells. Photochemical & Photobiological Sciences, 24(9), 1617\u20131632. https:\/\/doi.org\/10.1007\/s43630-025-00784-xEpub 2025 Sep 25. PMID: 40999280.","journal-title":"Photochemical & Photobiological Sciences"},{"issue":"12","key":"820_CR11","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1089\/pho.2011.9895","volume":"29","author":"PA Jenkins","year":"2011","unstructured":"Jenkins, P. A., & Carroll, J. D. (2011). How to report low-level laser therapy (LLLT)\/photomedicine dose and beam parameters in clinical and laboratory studies. Photomedicine and Laser Surgery, 29(12), 785\u2013787. https:\/\/doi.org\/10.1089\/pho.2011.9895","journal-title":"Photomedicine and Laser Surgery"},{"key":"820_CR12","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1258\/ebm.2012.012063","volume":"237","author":"NJ Prindeze","year":"2012","unstructured":"Prindeze, N. J., Moffatt, L. T., & Shupp, J. W. (2012). Mechanisms of action for light therapy: A review of molecular interactions. Experimental Biology and Medicine, 237, 1241\u20131248. https:\/\/doi.org\/10.1258\/ebm.2012.012063","journal-title":"Experimental Biology and Medicine"},{"key":"820_CR13","doi-asserted-by":"publisher","first-page":"58","DOI":"10.22037\/jlms.v5i2.2370","volume":"5","author":"S Farivar","year":"2014","unstructured":"Farivar, S., Malekshahabi, T., & Shiari, R. (2014). Biological effects of low level laser therapy. Journal of Lasers in Medical Sciences, 5, 58\u201362. https:\/\/doi.org\/10.22037\/jlms.v5i2.2370","journal-title":"Journal of Lasers in Medical Sciences"},{"key":"820_CR14","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1002\/ccr3.4000","volume":"9","author":"M Pelletier-Aouizerate","year":"2021","unstructured":"Pelletier-Aouizerate, M., & Zivic, Y. (2021). Early cases of acute infectious respiratory syndrome treated with photobiomodulation, diagnosis and intervention: Two case reports. Clinical Case Reports, 9, 2429\u20132437. https:\/\/doi.org\/10.1002\/ccr3.4000","journal-title":"Clinical Case Reports"},{"key":"820_CR15","doi-asserted-by":"publisher","first-page":"101711","DOI":"10.1016\/j.cocis.2023.101711","volume":"66","author":"M Isasi-Campillo","year":"2023","unstructured":"Isasi-Campillo, M., Losada-Oliva, P., P\u00e9rez-Gil, J., Olmeda, B., & Garc\u00eda-Ortega, L. (2023). Pulmonary surfactant-derived antiviral actions at the respiratory surface. Current Opinion in Colloid Ve Interface Science, 66, 101711. https:\/\/doi.org\/10.1016\/j.cocis.2023.101711","journal-title":"Current Opinion in Colloid Ve Interface Science"},{"issue":"2","key":"820_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.22037\/jlms.v5i2.2371","volume":"5","author":"FM Lima","year":"2014","unstructured":"Lima, F. M., Aimbire, F., Miranda, H., Vieira, R. P., & de Oliveira, A. P. (2014). Low-level laser therapy attenuates the myeloperoxidase activity and inflammatory mediator generation in lung inflammation induced by gut ischemia and reperfusion: A dose-response study. Journal of Lasers in Medical Sciences, 5(2), 63\u201370. https:\/\/doi.org\/10.22037\/jlms.v5i2.2371","journal-title":"Journal of Lasers in Medical Sciences"},{"key":"820_CR17","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1002\/jbio.201500278","volume":"9","author":"V Cury","year":"2016","unstructured":"Cury, V., de Lima, T. M., Prado, C. M., Pinheiro, N., Ariga, S. K., et al. (2016). Low level laser therapy reduces acute lung inflammation without impairing lung function. Journal of Biophotonics, 9, 1199\u20131207. https:\/\/doi.org\/10.1002\/jbio.201500278","journal-title":"Journal of Biophotonics"},{"key":"820_CR18","doi-asserted-by":"publisher","first-page":"43","DOI":"10.5978\/islsm.13-OR-07","volume":"22","author":"PK Min","year":"2013","unstructured":"Min, P. K., & Goo, B. L. (2013). 830 Nm light-emitting diode low level light therapy (LED-LLLT) enhances wound healing: A preliminary study. Laser Therapy, 22, 43\u201349. https:\/\/doi.org\/10.5978\/islsm.13-OR-07","journal-title":"Laser Therapy"},{"issue":"1","key":"820_CR19","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/phpp.12228","volume":"33","author":"A Yadav","year":"2017","unstructured":"Yadav, A., & Gupta, A. (2017). Noninvasive red and near-infrared wavelength-induced photobiomodulation: Promoting impaired cutaneous wound healing. Photodermatology Photoimmunology ve Photomedicine, 33(1), 4\u201313. https:\/\/doi.org\/10.1111\/phpp.12228","journal-title":"Photodermatology Photoimmunology Ve Photomedicine"},{"key":"820_CR20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.neures.2014.12.001","volume":"92","author":"F Reinhart","year":"2015","unstructured":"Reinhart, F., Massri, N. E., Darlot, F., Torres, N., Johnstone, D. M., et al. (2015). 810 Nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice. Neuroscience Research, 92, 86\u201390. https:\/\/doi.org\/10.1016\/j.neures.2014.12.001","journal-title":"Neuroscience Research"},{"key":"820_CR21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neures.2016.12.005","volume":"117","author":"F Reinhart","year":"2017","unstructured":"Reinhart, F., Massri, N. E., Torres, N., Chabrol, C., Molet, J., et al. (2017). The behavioural and neuroprotective outcomes when 670 Nm and 810 Nm near infrared light are applied together in MPTP-treated mice. Neuroscience Research, 117, 42\u201347. https:\/\/doi.org\/10.1016\/j.neures.2016.12.005","journal-title":"Neuroscience Research"},{"issue":"25","key":"820_CR22","doi-asserted-by":"publisher","first-page":"e2123564119","DOI":"10.1073\/pnas.2123564119","volume":"119","author":"G Kassab","year":"2022","unstructured":"Kassab, G., Diaz Tovar, J. S., Souza, L. M. P., Costa, R. K. M., Silva, R. S., Pimentel, A. S., Kurachi, C., & Bagnato, V. S. (2022). Lung surfactant negatively affects the photodynamic inactivation of bacteria-in vitro and molecular dynamic simulation analyses. Proceedings of the National Academy of Sciences U S A, 119(25), e2123564119. https:\/\/doi.org\/10.1073\/pnas.2123564119Epub 2022 Jun 13. PMID: 35696565; PMCID: PMC9231493.","journal-title":"Proceedings of the National Academy of Sciences U S A"}],"container-title":["Photochemical & Photobiological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43630-025-00820-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43630-025-00820-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43630-025-00820-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:11:56Z","timestamp":1766067116000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43630-025-00820-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["820"],"URL":"https:\/\/doi.org\/10.1007\/s43630-025-00820-w","relation":{},"ISSN":["1474-905X","1474-9092"],"issn-type":[{"type":"print","value":"1474-905X"},{"type":"electronic","value":"1474-9092"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"18 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Local Animal Experiments Ethics Committee of Ege University (Protocol No: 2021-077, dated 29.09.2021). No human participants were involved.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}