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These compounds were functionalized with 6-naphthoxy-2-sulfonic acid sodium salt groups. Given the limitations of conventional photodynamic therapy (PDT), we investigated the potential of sonophotodynamic therapy (SPDT), a dual-modality approach combining light and ultrasound, to enhance singlet oxygen (\u00b9O\n                    <jats:sub>2<\/jats:sub>\n                    ) production. Among the synthesized metallophthalocyanines, the zinc(II) complex\n                    <jats:bold>(2)<\/jats:bold>\n                    shows the highest \u00b9O\n                    <jats:sub>2<\/jats:sub>\n                    production in both organic and aqueous media under both photochemical and sonophotochemical conditions, showing promise for SPDT applications. Furthermore, the inhibitory effects of these complexes on acetylcholinesterase (AChE) and human carbonic anhydrase isoenzymes (hCA I and II), important targets for Alzheimer\u2019s disease, glaucoma, and epilepsy, were evaluated. The compounds showed strong inhibition with K\n                    <jats:sub>i<\/jats:sub>\n                    values ranging from 130.31\u2009\u00b1\u20096.18 to 157.47\u2009\u00b1\u20099.37 \u00b5M for hCA I (compared to AZA: 177.41\u2009\u00b1\u200911.40 \u00b5M), 99.18\u2009\u00b1\u20098.13 to 106.72\u2009\u00b1\u20098.50 \u00b5M for hCA II (compared to AZA: 143.51\u2009\u00b1\u20099.94 \u00b5M) and 0.31\u2009\u00b1\u20090.03 to 1.21\u2009\u00b1\u20090.01 \u00b5M for AChE (compared to TAC: 1.24\u2009\u00b1\u20090.21 \u00b5M). Molecular docking revealed strong binding affinities: In(III)-Pc\n                    <jats:bold>(4)<\/jats:bold>\n                    showed the highest affinity for AChE (BE: -26.96\u00a0kcal\/mol), while Ga(III)-Pc\n                    <jats:bold>(3)<\/jats:bold>\n                    preferentially bound to hCA I and II (BE: -13.90 and \u2212\u200915.39\u00a0kcal\/mol, respectively). These findings position the synthesized MPcs as multifunctional agents for SPDT and enzyme-targeted therapies.\n                  <\/jats:p>","DOI":"10.1007\/s43630-026-00866-4","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T13:28:05Z","timestamp":1771248485000},"page":"571-584","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Water-soluble phthalocyanines with non-peripheral naphthoxy-sulfonate substituents: computational docking, biological and sono-photochemical investigations"],"prefix":"10.1007","volume":"25","author":[{"given":"Arma\u011fan","family":"G\u00fcnsel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceren Can","family":"Karanl\u0131k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"G\u00fcnsel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba","family":"Taskin-Tok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet T.","family":"Bilgi\u00e7li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda Mehtap","family":"\u00d6zden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Erdo\u011fmu\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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