{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:09:13Z","timestamp":1793106553147,"version":"4.5.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["1241088"],"award-info":[{"award-number":["1241088"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["1251176"],"award-info":[{"award-number":["1251176"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Photochem Photobiol Sci"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s43630-026-00894-0","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T09:00:38Z","timestamp":1775725238000},"page":"951-963","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stabilization of 5-aminolevulinic acid by cucurbit[7]uril complex with enhanced fluorescence detection and photodynamic therapy of breast cancer in vitro and in a CAM model"],"prefix":"10.1007","volume":"25","author":[{"given":"Sof\u00eda P\u00e9rez","family":"del Pino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walther","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Guerra","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Z\u00fa\u00f1iga-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula S.","family":"Rivero-Jerez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-5897","authenticated-orcid":false,"given":"Hilde Harb","family":"Buzza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-7204","authenticated-orcid":false,"given":"Denis","family":"Fuentealba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"issue":"2","key":"894_CR1","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3390\/ijms25021023","volume":"25","author":"N Alvarez","year":"2024","unstructured":"Alvarez, N., & Sevilla, A. (2024). Current advances in photodynamic therapy (PDT) and the future potential of PDT-combinatorial cancer therapies. International Journal Of Molecular Sciences,  25(2), 1023-1045.","journal-title":"International Journal Of Molecular Sciences"},{"issue":"2","key":"894_CR2","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/php.13749","volume":"99","author":"N Mari\u00f1o-Ocampo","year":"2023","unstructured":"Mari\u00f1o-Ocampo, N., et al. (2023). Recent photosensitizer developments, delivery strategies and combination-based approaches for photodynamic therapy. Photochemistry and Photobiology, 99(2), 469\u2013497.","journal-title":"Photochemistry and Photobiology"},{"issue":"22","key":"894_CR3","doi-asserted-by":"publisher","first-page":"5398","DOI":"10.3390\/molecules25225398","volume":"25","author":"NJ Collier","year":"2020","unstructured":"Collier, N. J., & Rhodes, L. E. (2020). Photodynamic therapy for basal cell carcinoma: The clinical context for future research priorities. Molecules, 25(22), 5398.","journal-title":"Molecules"},{"issue":"5","key":"894_CR4","doi-asserted-by":"publisher","first-page":"e1560","DOI":"10.1002\/wnan.1560","volume":"11","author":"X Shi","year":"2019","unstructured":"Shi, X., et al. (2019). Recent advances in photodynamic therapy for cancer and infectious diseases. Wiley Interdisciplinary Reviews. Nanomedicine And Nanobiotechnology, 11(5), e1560.","journal-title":"Wiley Interdisciplinary Reviews. Nanomedicine And Nanobiotechnology"},{"issue":"2024","key":"894_CR5","doi-asserted-by":"publisher","first-page":"1310282","DOI":"10.3389\/fnins.2024.1310282","volume":"18","author":"A Gautheron","year":"2024","unstructured":"Gautheron, A. (2024). 5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: A review. Frontiers in Neuroscience, 18(2024), 1310282.","journal-title":"Frontiers in Neuroscience"},{"issue":"12","key":"894_CR6","doi-asserted-by":"publisher","first-page":"6478","DOI":"10.3390\/ijms23126478","volume":"23","author":"Y Harada","year":"2022","unstructured":"Harada, Y. (2022). 5-Aminolevulinic acid-induced protoporphyrin ix fluorescence imaging for tumor detection: Recent advances and challenges. International Journal of Molecular Sciences, 23(12), 6478.","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"894_CR7","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s11060-018-03079-7","volume":"141","author":"PA Valdes","year":"2019","unstructured":"Valdes, P. A., et al. (2019). 5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery. Journal of Neuro-Oncology, 141(3), 555\u2013565.","journal-title":"Journal of Neuro-Oncology"},{"issue":"8","key":"894_CR8","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/s41416-019-0516-4","volume":"121","author":"K McNicholas","year":"2019","unstructured":"McNicholas, K., MacGregor, M. N., & Gleadle, J. M. (2019). Order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid? British Journal of Cancer, 121(8), 631\u2013639.","journal-title":"British Journal of Cancer"},{"issue":"3","key":"894_CR9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3390\/ph14030229","volume":"14","author":"Y Shinoda","year":"2021","unstructured":"Shinoda, Y. (2021). Systematic review and meta-analysis of in vitro anti-human cancer experiments investigating the use of 5-aminolevulinic Acid (5-ALA) for photodynamic therapy. Pharmaceuticals, 14(3), 229.","journal-title":"Pharmaceuticals"},{"key":"894_CR10","doi-asserted-by":"crossref","unstructured":"Kitajima, Y. (2019). Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis. Scientific Reports, 9, 8666.","DOI":"10.1038\/s41598-019-44981-y"},{"key":"894_CR11","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.pdpdt.2017.04.012","volume":"19","author":"HH Buzz\u00e1","year":"2017","unstructured":"Buzz\u00e1, H. H., et al. (2017). Fluorescence analysis of a tumor model in the chorioallantoic membrane used for the evaluation of different photosensitizers for photodynamic therapy. Photodiagnosis and Photodynamic Therapy, 19, 78\u201383.","journal-title":"Photodiagnosis and Photodynamic Therapy"},{"issue":"2024","key":"894_CR12","doi-asserted-by":"publisher","first-page":"117132","DOI":"10.1016\/j.biopha.2024.117132","volume":"178","author":"N Guo","year":"2024","unstructured":"Guo, N., et al. (2024). 5-aminolevulinic acid photodynamic therapy for chronic wound infection in rats with diabetes. Biomedicine & Pharmacotherapy. 178(2024), 117132.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"894_CR13","doi-asserted-by":"crossref","unstructured":"Koumprentziotis, I. A., et al. (2024). Photodynamic therapy for the treatment of basal cell carcinoma: A comprehensive review of randomized controlled trials. Dermatology Practical & Conceptual. 14, 2.","DOI":"10.5826\/dpc.1402a105"},{"issue":"10","key":"894_CR14","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/lsm.23727","volume":"55","author":"LJ Yuan","year":"2023","unstructured":"Yuan, L. J., et al. (2023). Rational of topical photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) for treatment of endocervical canal low-grade squamous intraepithelial lesion with high-risk human papillomavirus infection. Lasers in Surgery and Medicine, 55(10), 880\u2013885.","journal-title":"Lasers in Surgery and Medicine"},{"issue":"3","key":"894_CR15","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1039\/b201027p","volume":"1","author":"CJ Kelty","year":"2002","unstructured":"Kelty, C. J., et al. (2002). The use of 5-aminolaevulinic acid as a photosensitiser in photodynamic therapy and photodiagnosis. Photochemical & Photobiological Sciences, 1(3), 158\u2013168.","journal-title":"Photochemical & Photobiological Sciences"},{"issue":"19","key":"894_CR16","doi-asserted-by":"publisher","first-page":"17607","DOI":"10.1007\/s00432-023-05429-z","volume":"149","author":"S Bhattacharya","year":"2023","unstructured":"Bhattacharya, S., et al. (2023). Nanoparticles drug delivery for 5-aminolevulinic acid (5-ALA) in photodynamic therapy (PDT) for multiple cancer treatment: A critical review on biosynthesis, detection, and therapeutic applications. Journal of Cancer Research and Clinical Oncology, 149(19), 17607\u201317634.","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"issue":"20","key":"894_CR17","doi-asserted-by":"publisher","first-page":"10671","DOI":"10.1021\/acsami.5b03087","volume":"7","author":"X Ma","year":"2015","unstructured":"Ma, X., Qu, Q., & Zhao, Y. (2015). Targeted delivery of 5-aminolevulinic acid by multifunctional hollow mesoporous silica nanoparticles for photodynamic skin cancer therapy. ACS Applied Materials and Interfaces, 7(20), 10671\u201310676.","journal-title":"ACS Applied Materials and Interfaces"},{"issue":"10","key":"894_CR18","first-page":"1","volume":"13","author":"A Babi\u010d","year":"2018","unstructured":"Babi\u010d, A. (2018). 5-Aminolevulinic acid-squalene nanoassemblies for tumor photodetection and therapy: In vitro studies. Nanoscale Research Letters, 13(10), 1-9.","journal-title":"Nanoscale Research Letters"},{"issue":"2024","key":"894_CR19","first-page":"104025","volume":"46","author":"F Akbarzadeh","year":"2015","unstructured":"Akbarzadeh, F., & Khoshgard, K. (2024). Enhancement of the effect of novel targeted 5-aminolevulinic acid conjugated bismuth oxide nanoparticles-based photodynamic therapy by simultaneous radiotherapy on KB cells. Photodiagnosis and Photodynamic Therapy, 46(2024), 104025.","journal-title":"Photodiagnosis and Photodynamic Therapy"},{"issue":"3","key":"894_CR20","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.ejpb.2005.01.014","volume":"60","author":"A Winkler","year":"2005","unstructured":"Winkler, A., & M\u00fcller-Goymann, C. C. (2005). The influence of topical formulations on the permeation of 5-aminolevulinic acid and its -butyl ester through excised human stratum corneum. European Journal of Pharmaceutics and Biopharmaceutics, 60(3), 427\u2013437.","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"issue":"3","key":"894_CR21","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.jconrel.2005.07.006","volume":"107","author":"C Valenta","year":"2005","unstructured":"Valenta, C., Auner, B. G., & Loibl, I. (2005). Skin permeation and stability studies of 5-aminolevulinic acid in a new gel and patch preparation. Journal of Controlled Release, 107(3), 495\u2013501.","journal-title":"Journal of Controlled Release"},{"issue":"1","key":"894_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1073274819856885","volume":"26","author":"HH Buzz\u00e1","year":"2019","unstructured":"Buzz\u00e1, H. H. (2019). Overall results for a national program of photodynamic therapy for basal cell carcinoma: A multicenter clinical study to bring new techniques to social health care. Cancer Control : Journal Of The Moffitt Cancer Center, 26(1), 1-12.","journal-title":"Cancer Control : Journal Of The Moffitt Cancer Center"},{"key":"894_CR23","doi-asserted-by":"publisher","first-page":"102465","DOI":"10.1016\/j.pdpdt.2021.102465","volume":"35","author":"HH Buzz\u00e1","year":"2021","unstructured":"Buzz\u00e1, H. H. (2021). HPV-induced condylomata acuminata treated by photodynamic therapy in comparison with trichloroacetic acid: A randomized clinical trial. Photodiagnosis and Photodynamic Therapy, 35, 102465.","journal-title":"Photodiagnosis and Photodynamic Therapy"},{"issue":"2025","key":"894_CR24","doi-asserted-by":"publisher","first-page":"104432","DOI":"10.1016\/j.pdpdt.2024.104432","volume":"51","author":"M Salmivuori","year":"2025","unstructured":"Salmivuori, M., et al. (2025). Long-term outcome of photodynamic therapy with hexyl aminolevulinate, 5-aminolevulinic acid nanoemulsion and methyl aminolevulinate for low-risk basal cell carcinomas. Photodiagnosis and Photodynamic Therapy, 51(2025), 104432.","journal-title":"Photodiagnosis and Photodynamic Therapy"},{"issue":"1","key":"894_CR25","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1365-2133.2008.08611.x","volume":"159","author":"JB Lee","year":"2008","unstructured":"Lee, J. B., et al. (2008). Relationship of protoporphyrin IX synthesis to photodynamic effects by 5-aminolaevulinic acid and its esters on various cell lines derived from the skin. British Journal of Dermatology, 159(1), 61\u201367.","journal-title":"British Journal of Dermatology"},{"issue":"2","key":"894_CR26","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0168-3659(03)00125-1","volume":"89","author":"FS De Rosa","year":"2003","unstructured":"De Rosa, F. S., et al. (2003). In vitro skin permeation and retention of 5-aminolevulinic acid ester derivatives for photodynamic therapy. Journal of Controlled Release, 89(2), 261\u2013269.","journal-title":"Journal of Controlled Release"},{"issue":"11","key":"894_CR27","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1039\/c7pp00203c","volume":"16","author":"W Zhu","year":"2017","unstructured":"Zhu, W., et al. (2017). Synthesis and evaluation of new 5-aminolevulinic acid derivatives as prodrugs of protoporphyrin for photodynamic therapy. Photochemical & Photobiological Sciences, 16(11), 1623\u20131630.","journal-title":"Photochemical & Photobiological Sciences"},{"key":"894_CR28","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/978-1-60761-697-9_7","volume":"635","author":"A Juzeniene","year":"2010","unstructured":"Juzeniene, A., Juzenas, P., & Moan, J. (2010). Application of 5-aminolevulinic acid and its derivatives for photodynamic therapy in vitro and in vivo. Photodynamic Therapy: Methods and Protocols, 635, 97\u2013106.","journal-title":"Photodynamic Therapy: Methods and Protocols"},{"issue":"1","key":"894_CR29","first-page":"150","volume":"67","author":"J Kloek","year":"1998","unstructured":"Kloek, J., Akkermans, W., & van Henegouwen, G. M. J. B. (1998). Derivatives of 5-aminolevulinic acid for photodynamic therapy: Enzymatic conversion into protoporphyrin. Photochemistry and Photobiology, 67(1), 150\u2013154.","journal-title":"Photochemistry and Photobiology"},{"issue":"2024","key":"894_CR30","doi-asserted-by":"publisher","first-page":"117726","DOI":"10.1016\/j.bmc.2024.117726","volume":"105","author":"J Zhang","year":"2024","unstructured":"Zhang, J., et al. (2024). Photodynamic anticancer activity evaluation of novel 5-aminolevulinic acid and 3-hydroxypyridinone conjugates. Bioorganic and Medicinal Chemistry. 105(2024), 117726.","journal-title":"Bioorganic and Medicinal Chemistry"},{"issue":"2021","key":"894_CR31","doi-asserted-by":"publisher","first-page":"112107","DOI":"10.1016\/j.jphotobiol.2020.112107","volume":"215","author":"K Li","year":"2021","unstructured":"Li, K. (2021). Dual-targeted 5-aminolevulinic acid derivatives with glutathione depletion function for enhanced photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology, 215(2021), 112107.","journal-title":"Journal of Photochemistry and Photobiology B: Biology"},{"issue":"1","key":"894_CR32","first-page":"15","volume":"61","author":"M Kaliszewski","year":"2004","unstructured":"Kaliszewski, M., et al. (2004). The stability of 5-aminolevulinic acid and its ester derivatives. Acta Poloniae Pharmaceutica, 61(1), 15\u201319.","journal-title":"Acta Poloniae Pharmaceutica"},{"issue":"11","key":"894_CR33","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1039\/c8pp00362a","volume":"17","author":"KM Tewari","year":"2018","unstructured":"Tewari, K. M., & Eggleston, I. M. (2018). Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis. Photochemical & Photobiological Sciences, 17(11), 1553\u20131572.","journal-title":"Photochemical & Photobiological Sciences"},{"issue":"11","key":"894_CR34","doi-asserted-by":"publisher","first-page":"5593","DOI":"10.1021\/acs.molpharmaceut.3c00494","volume":"20","author":"A Gaballo","year":"2023","unstructured":"Gaballo, A., et al. (2023). Enhanced delivery of 5-aminolevulinic acid by lecithin invasomes in 3D melanoma cancer model. Molecular Pharmaceutics, 20(11), 5593\u20135606.","journal-title":"Molecular Pharmaceutics"},{"issue":"4","key":"894_CR35","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1562\/2004-08-23-IR-283R1.1","volume":"81","author":"RF Donnelly","year":"2005","unstructured":"Donnelly, R. F., McCarron, P. A., & Woolfson, A. D. (2005). Drug delivery of aminolevulinic acid from topical formulations intended for photodynamic therapy. Photochemistry and Photobiology, 81(4), 750\u2013767.","journal-title":"Photochemistry and Photobiology"},{"issue":"2022","key":"894_CR36","doi-asserted-by":"publisher","first-page":"103933","DOI":"10.1016\/j.jddst.2022.103933","volume":"78","author":"CP Zhang","year":"2022","unstructured":"Zhang, C. P. (2022). Advances in 5-aminoketovaleric acid(5-ALA) nanoparticle delivery system based on cancer photodynamic therapy. Journal of Drug Delivery Science and Technology, 78(2022), 103933.","journal-title":"Journal of Drug Delivery Science and Technology"},{"issue":"2011","key":"894_CR37","first-page":"693","volume":"6","author":"LW Zhang","year":"2005","unstructured":"Zhang, L. W. (2011). Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil-in-water and water-in-oil nanoemulsions. International Journal of Nanomedicine, 6(2011), 693-704.","journal-title":"International Journal of Nanomedicine"},{"issue":"2023","key":"894_CR38","doi-asserted-by":"publisher","first-page":"1137707","DOI":"10.3389\/fphar.2023.1137707","volume":"14","author":"L Lou","year":"2023","unstructured":"Lou, L. (2023). Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology. Frontiers in Pharmacology, 14(2023), 1137707.","journal-title":"Frontiers in Pharmacology"},{"issue":"16","key":"894_CR39","doi-asserted-by":"publisher","first-page":"3828","DOI":"10.3390\/molecules29163828","volume":"29","author":"YR Yang","year":"2024","unstructured":"Yang, Y. R. (2024). Macrocycle-based supramolecular drug delivery systems: A concise review. Molecules, 29(16), 3828.","journal-title":"Molecules"},{"issue":"2023","key":"894_CR40","doi-asserted-by":"publisher","first-page":"133126","DOI":"10.1016\/j.snb.2022.133126","volume":"378","author":"R Cen","year":"2023","unstructured":"Cen, R. (2023). A double-cavity nor-seco-cucurbit[10]uril-based fluorescent probe for detection of ClO- and its application in cell imaging. Sensors and Actuators B-Chemical, 378(2023), 133126.","journal-title":"Sensors and Actuators B-Chemica"},{"issue":"35","key":"894_CR41","doi-asserted-by":"publisher","first-page":"e202207209","DOI":"10.1002\/anie.202207209","volume":"61","author":"M Liu","year":"2022","unstructured":"Liu, M. (2022). Double-Cavity -Nor-Seco- Cucurbit[10]uril Enables Efficient and Rapid Separation of Pyridine from Mixtures of Toluene, Benzene, and Pyridine. Angewandte Chemie-International Edition, 61(35), e202207209.","journal-title":"Angewandte Chemie-International Edition"},{"issue":"6","key":"894_CR42","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1039\/B814897J","volume":"2009","author":"L Isaacs","year":"2009","unstructured":"Isaacs, L. (2009). Cucurbit[n]urils: from mechanism to structure and function. Chemical Communications, 2009(6):619\u2013629.","journal-title":"Chemical Communications"},{"key":"894_CR43","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1039\/b9pp00041k","volume":"8","author":"P Montes-Navajas","year":"2009","unstructured":"Montes-Navajas, P., et al. (2009). Cucurbituril complexes cross the cell membrane. Photochemical & Photobiological Sciences, 8, 1743\u20131747.","journal-title":"Photochemical & Photobiological Sciences"},{"key":"894_CR44","doi-asserted-by":"crossref","unstructured":"Saleh, N., Ghosh, I., & Nau, W. M. (2013). Cucurbiturils in drug delivery and for biomedical applications. In:  Schneider H.-J.,( Ed) Supramolecular systems in biomedical fields. Royal Society of Chemistry. pp. 164\u2013212.","DOI":"10.1039\/9781849737821-00164"},{"issue":"22","key":"894_CR45","doi-asserted-by":"publisher","first-page":"12320","DOI":"10.1021\/acs.chemrev.5b00341","volume":"115","author":"SJ Barrow","year":"2015","unstructured":"Barrow, S. J., et al. (2015). Cucurbituril-based molecular recognition. Chemical Reviews, 115(22), 12320\u201312406.","journal-title":"Chemical Reviews"},{"issue":"9","key":"894_CR46","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1021\/jacsau.3c00273","volume":"3","author":"H Yin","year":"2023","unstructured":"Yin, H., et al. (2023). Challenges and opportunities of functionalized cucurbiturils for biomedical applications. Jacs Au, 3(9), 2356\u20132377.","journal-title":"Jacs Au"},{"issue":"24","key":"894_CR47","doi-asserted-by":"publisher","first-page":"10275","DOI":"10.1021\/jo2018312","volume":"76","author":"S Yi","year":"2011","unstructured":"Yi, S., & Kaifer, A. E. (2011). Determination of the purity of Cucurbit[n]uril (n\u2009=\u20097, 8) host samples. Journal of Organic Chemistry, 76(24), 10275\u201310278.","journal-title":"Journal of Organic Chemistry"},{"key":"894_CR48","doi-asserted-by":"crossref","unstructured":"Frisch, M. J. (2016). Gaussian 16 Rev. C.01.","DOI":"10.5965\/1984723816322015001"},{"issue":"7","key":"894_CR49","doi-asserted-by":"publisher","first-page":"5648","DOI":"10.1063\/1.464913","volume":"98","author":"AD Becke","year":"1993","unstructured":"Becke, A. D. (1993). Density-functional thermochemistry. III. The role of exact exchange. The Journal of Chemical Physics, 98(7), 5648\u20135652.","journal-title":"The Journal of Chemical Physics"},{"issue":"2","key":"894_CR50","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","volume":"37","author":"C Lee","year":"1988","unstructured":"Lee, C., Yang, W., & Parr, R. G. (1988). Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Physical Review B, 37(2), 785\u2013789.","journal-title":"Physical Review B"},{"issue":"4","key":"894_CR51","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1063\/1.455064","volume":"89","author":"GA Petersson","year":"1988","unstructured":"Petersson, G. A., et al. (1988). A complete basis set model chemistry. I. The total energies of closed-shell atoms and hydrides of the first\u2010row elements. The Journal of Chemical Physics, 89(4), 2193\u20132218.","journal-title":"The Journal of Chemical Physics"},{"issue":"9","key":"894_CR52","doi-asserted-by":"publisher","first-page":"6081","DOI":"10.1063\/1.460447","volume":"94","author":"GA Petersson","year":"1991","unstructured":"Petersson, G. A., & Al-Laham, M. A. (1991). A complete basis set model chemistry. II. Open\u2010shell systems and the total energies of the first\u2010row atoms. The Journal of Chemical Physics, 94(9), 6081\u20136090.","journal-title":"The Journal of Chemical Physics"},{"issue":"6","key":"894_CR53","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1002\/jcc.10189","volume":"24","author":"M Cossi","year":"2003","unstructured":"Cossi, M., et al. (2003). Energies, structures, and electronic properties of molecules in solution with the C-PCM solvation model. Journal of Computational Chemistry, 24(6), 669\u2013681.","journal-title":"Journal of Computational Chemistry"},{"issue":"1","key":"894_CR54","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65(1), 55\u201363.","journal-title":"Journal of Immunological Methods"},{"issue":"1","key":"894_CR55","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jphotobiol.2011.01.012","volume":"103","author":"MA Munoz","year":"2011","unstructured":"Munoz, M. A., et al. (2011). Different cell death mechanisms are induced by a hydrophobic flavin in human tumor cells after visible light irradiation. Journal Of Photochemistry And Photobiology B, 103(1), 57\u201367.","journal-title":"Journal Of Photochemistry And Photobiology B"},{"key":"894_CR56","doi-asserted-by":"publisher","first-page":"115388","DOI":"10.1016\/j.jphotochem.2023.115388","volume":"449","author":"S Day","year":"2024","unstructured":"Day, S., et al. (2024). Supramolecular complex of tetracationic porphyrin with acyclic cucurbituril-like container induces quantitative singlet oxygen generation. Phototoxicity studies in vitro in MCF-7 human breast cancer cells. Journal of Photochemistry and Photobiology A: Chemistry, 449, 115388.","journal-title":"Journal of Photochemistry and Photobiology A: Chemistry"},{"issue":"2","key":"894_CR57","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1039\/C4CS00273C","volume":"44","author":"KI Assaf","year":"2015","unstructured":"Assaf, K. I., & Nau, W. M. (2015). Cucurbiturils: from synthesis to high-affinity binding and catalysis. Chemical Society Reviews, 44(2), 394\u2013418.","journal-title":"Chemical Society Reviews"},{"issue":"37","key":"894_CR58","doi-asserted-by":"publisher","first-page":"15318","DOI":"10.1021\/ja303309e","volume":"134","author":"F Biedermann","year":"2012","unstructured":"Biedermann, F., et al. (2012). Release of high-energy water as an essential driving force for the high-affinity binding of Cucurbit[ ]urils. Journal of the American Chemical Society, 134(37), 15318\u201315323.","journal-title":"Journal of the American Chemical Society"},{"issue":"10","key":"894_CR59","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1002\/1520-6017(200010)89:10<1335::AID-JPS11>3.0.CO;2-#","volume":"89","author":"A Bunke","year":"2000","unstructured":"Bunke, A., et al. (2000). Degradation mechanism and stability of 5-aminolevulinic acid. Journal of Pharmaceutical Sciences, 89(10), 1335\u20131341.","journal-title":"Journal of Pharmaceutical Sciences"},{"issue":"9","key":"894_CR60","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1039\/C7CS00095B","volume":"46","author":"J Murray","year":"2017","unstructured":"Murray, J., et al. (2017). The aqueous supramolecular chemistry of cucurbit[n]urils, pillar[n]arenes and deep-cavity cavitands. Chemical Society Reviews, 46(9), 2479\u20132496.","journal-title":"Chemical Society Reviews"},{"key":"894_CR61","doi-asserted-by":"publisher","first-page":"104411","DOI":"10.1016\/j.pdpdt.2024.104411","volume":"50","author":"M Priyadarshini","year":"2024","unstructured":"Priyadarshini, M., & Raj, N. A. N. (2024). Green synthesis and in vitro photodynamic efficacy of hypericin: Cytotoxicity assessment on MCF-7 breast cancer cells. Photodiagnosis and Photodynamic Therapy, 50, 104411.","journal-title":"Photodiagnosis and Photodynamic Therapy"},{"issue":"5","key":"894_CR62","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1111\/j.1751-1097.2009.00558.x","volume":"85","author":"ME Rodriguez","year":"2009","unstructured":"Rodriguez, M. E., et al. (2009). Structural factors and mechanisms underlying the improved photodynamic cell killing with silicon phthalocyanine photosensitizers directed to lysosomes versus mitochondria. Photochemistry and Photobiology, 85(5), 1189\u20131200.","journal-title":"Photochemistry and Photobiology"},{"key":"894_CR63","doi-asserted-by":"publisher","first-page":"104700","DOI":"10.1016\/j.pdpdt.2025.104700","volume":"54","author":"D Kessel","year":"2025","unstructured":"Kessel, D. (2025). Pitfalls and other issues with the MTT assay. Photodiagnosis and Photodynamic Therapy, 54, 104700.","journal-title":"Photodiagnosis and Photodynamic Therapy"},{"issue":"1","key":"894_CR64","doi-asserted-by":"publisher","first-page":"F9","DOI":"10.1016\/S1761-676X(09)70028-8","volume":"19","author":"D Vordos","year":"2009","unstructured":"Vordos, D., & Ploussard, G. (2009). Fluorescent cystoscopy for superficial tumors of the bladder: the contribution of hexaminolevulinate (Hexvix\u00ae) and a photodynamic diagnosis. Progres En Urologie, 19(1), F9\u2013F14.","journal-title":"Progres En Urologie"},{"issue":"29","key":"894_CR65","doi-asserted-by":"publisher","first-page":"8769","DOI":"10.3748\/wjg.v21.i29.8769","volume":"21","author":"T Namikawa","year":"2015","unstructured":"Namikawa, T., et al. (2015). Clinical applications of 5-aminolevulinic acid-mediated fluorescence for gastric cancer. World Journal of Gastroenterology, 21(29), 8769\u20138775.","journal-title":"World Journal of Gastroenterology"}],"container-title":["Photochemical &amp; Photobiological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43630-026-00894-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43630-026-00894-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43630-026-00894-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:08:50Z","timestamp":1778598530000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43630-026-00894-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["894"],"URL":"https:\/\/doi.org\/10.1007\/s43630-026-00894-0","relation":{},"ISSN":["1474-905X","1474-9092"],"issn-type":[{"value":"1474-905X","type":"print"},{"value":"1474-9092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]},"assertion":[{"value":"7 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}