{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:57:45Z","timestamp":1781513865120,"version":"3.54.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Convergence Grant, UT Dallas"},{"name":"Jonsson School Research Initiative, UT Dallas"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00CA215301"],"award-info":[{"award-number":["R00CA215301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Foundation","award":["2326628"],"award-info":[{"award-number":["2326628"]}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP240498"],"award-info":[{"award-number":["RP240498"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Photochem Photobiol Sci"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s43630-026-00909-w","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:00:17Z","timestamp":1778576417000},"page":"1189-1203","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The clinical ionizable lipid SM-102 enhances photochemical immunogenic cell death by verteporfin-conjugated liposomes and improves survival in vivo"],"prefix":"10.1007","volume":"25","author":[{"given":"Nimit","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell Bortei","family":"Quaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavana","family":"Sudula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarati","family":"Upreti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashritha","family":"Malkoochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taksheel Rao","family":"Aileni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Karambelkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arden","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doha","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghana Sree","family":"Vadlamudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth Reddy","family":"Soma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline N.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf A.","family":"Brekken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girgis","family":"Obaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"909_CR1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nrc3380","volume":"12","author":"DV Krysko","year":"2012","unstructured":"Krysko, D. V., Garg, A. D., Kaczmarek, A., Krysko, O., Agostinis, P., & Vandenabeele, P. (2012). Immunogenic cell death and DAMPs in cancer therapy. Nature Reviews Cancer, 12, 860\u2013875.","journal-title":"Nature Reviews Cancer"},{"key":"909_CR2","doi-asserted-by":"publisher","unstructured":"Kristian, P., & Mladen, S. Enhancing antitumour immunity with photodynamic therapy. Photochemical & Photobiological Sciences, https:\/\/doi.org\/10.1007\/s43630-025-00690-2","DOI":"10.1007\/s43630-025-00690-2"},{"key":"909_CR3","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/php.13173","volume":"95","author":"S Nath","year":"2019","unstructured":"Nath, S., Obaid, G., & Hasan, T. (2019). The course of immune stimulation by photodynamic therapy: Bridging fundamentals of photochemically induced immunogenic cell death to the enrichment of T-Cell repertoire. Photochemistry and Photobiology, 95, 1288\u20131305.","journal-title":"Photochemistry And Photobiology"},{"key":"909_CR4","doi-asserted-by":"crossref","unstructured":"Obaid, G., Celli, J. P., Broekgaarden, M., Bulin, A. L., Uusimaa, P., Pogue, B., Hasan, T., & Huang, H. C. (2024). Engineering photodynamics for treatment, priming and imaging. Nature Reviews Bioengineering, 1\u201318.","DOI":"10.1038\/s44222-024-00196-z"},{"key":"909_CR5","doi-asserted-by":"crossref","unstructured":"Bhandari, C., Moffat, A., Shah, N., Khan, A., Quaye, M., Fakhry, J., Soma, S., Nguyen, A., Eroy, M., Malkoochi, A., Brekken, R., Hasan, T., Ferruzzi, J., & Obaid, G. (2024). PD-L1 Immune Checkpoint Targeted Photoactivable Liposomes (iTPALs) prime the stroma of pancreatic tumors and promote self\u2010delivery. Advanced Healthcare Materials, 1\u201326.","DOI":"10.1002\/adhm.202304340"},{"key":"909_CR6","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1515\/nanoph-2021-0191","volume":"10","author":"M Guirguis","year":"2021","unstructured":"Guirguis, M., Bhandari, C., Li, J., Eroy, M., Prajapati, S., Margolis, R., Shrivastava, N., Hoyt, K., Hasan, T., & Obaid, G. (2021). Membrane composition is a functional determinant of NIR-activable liposomes in orthotopic head and neck cancer. Nanophotonics, 10, 3169\u20133185.","journal-title":"Nanophotonics"},{"key":"909_CR7","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/php.13002","volume":"95","author":"G Obaid","year":"2019","unstructured":"Obaid, G., Jin, W., Bano, S., Kessel, D., & Hasan, T. (2019). Nanolipid formulations of benzoporphyrin derivative: Exploring the Dependence of nanoconstruct photophysics and photochemistry on their therapeutic index in ovarian cancer cells. Photochemistry and Photobiology, 95, 364\u2013377.","journal-title":"Photochemistry And Photobiology"},{"key":"909_CR8","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.1021\/acsabm.4c00316","volume":"7","author":"N Shah","year":"2024","unstructured":"Shah, N., Soma, S. R., Quaye, M. B., Mahmoud, D., Ahmed, S., Malkoochi, A., Obaid, G., & Physiochemical, A. (2024). In Vitro, and In Vivo Comparative Analysis of Verteporfin-Lipid Conjugate Formulations: Solid Lipid Nanoparticles and Liposomes. ACS Applied Bio Materials, 7, 4427\u20134441.","journal-title":"ACS Appl Bio Mater"},{"key":"909_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202500290","author":"N Shah","year":"2025","unstructured":"Shah, N., Quaye, M. B., Soma, S. R., Vadlamudi, M. S., Mahmoud, D., Malkoochi, A., Aileni, T. R., Bhandari, C., Karambelkar, K., Hasan, T., Korbelik, M., Fei, B., Song, X., & Obaid, G. (2025). Fine-tuning photochemical immunogenic cell death by a panel of Vertepor fi n-Lipid nanoparticles: A data-driven approach. Small Science. https:\/\/doi.org\/10.1002\/smsc.202500290","journal-title":"Small Science"},{"key":"909_CR10","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/php.13066","volume":"95","author":"I Rizvi","year":"2019","unstructured":"Rizvi, I., Nath, S., Obaid, G., Ruhi, M. K., Moore, K., Bano, S., Kessel, D., & Hasan, T. (2019). A Combination of Visudyne and a Lipid-anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer. Photochemistry and Photobiology, 95, 419\u2013429.","journal-title":"Photochemistry And Photobiology"},{"key":"909_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/advs.202104594","volume":"9","author":"G Obaid","year":"2022","unstructured":"Obaid, G., Bano, S., Thomsen, H., Callaghan, S., Shah, N., Swain, J. W. R., Jin, W., Ding, X., Cameron, C. G., McFarland, S. A., Wu, J., Vangel, M., Stoilova-McPhie, S., Zhao, J., Mino-Kenudson, M., Lin, C., & Hasan, T. (2022). Remediating desmoplasia with EGFR-targeted photoactivable multi-inhibitor liposomes doubles overall survival in pancreatic cancer. Advanced Science, 9, 1\u201317.","journal-title":"Advanced Science"},{"key":"909_CR12","doi-asserted-by":"crossref","unstructured":"Bhandari, C., Moffat, A., Fakhry, J., Malkoochi, A., Nguyen, A., Trinh, B., Hoyt, K., Story, M. D., Hasan, T., & Obaid, G. (2023). A single photodynamic priming protocol augments delivery of \u237a-PD-L1 mAbs and induces immunogenic cell death in head and neck tumors*. Photochem Photobiol, 1\u201312.","DOI":"10.1111\/php.13865"},{"key":"909_CR13","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1515\/nanoph-2021-0304","volume":"10","author":"P De Silva","year":"2021","unstructured":"De Silva, P., Bano, S., Pogue, B. W., Wang, K. K., Maytin, E. V., & Hasan, T. (2021). Photodynamic priming with triple-receptor targeted nanoconjugates that trigger T cell-mediated immune responses in a 3D in vitro heterocellular model of pancreatic cancer. Nanophotonics, 10, 3199\u20133214.","journal-title":"Nanophotonics"},{"key":"909_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40425-019-0826-3","volume":"7","author":"VD Turubanova","year":"2019","unstructured":"Turubanova, V. D., Balalaeva, I. V., Mishchenko, T. A., Catanzaro, E., Alzeibak, R., Peskova, N. N., Efimova, I., Bachert, C., Mitroshina, E. V., Krysko, O., Vedunova, M. V., & Krysko, D. V. (2019). Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine. Journal for Immunotherapy of Cancer, 7, 1\u201313.","journal-title":"Journal For Immunotherapy Of Cancer"},{"key":"909_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215350","author":"M Warszy\u0144ska","year":"2023","unstructured":"Warszy\u0144ska, M., Repetowski, P., & D\u0105browski, J. M. (2023). Photodynamic therapy combined with immunotherapy: Recent advances and future research directions. Coordination Chemistry Reviews. https:\/\/doi.org\/10.1016\/j.ccr.2023.215350","journal-title":"Coord Chem Rev"},{"key":"909_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1375767","author":"J Thiruppathi","year":"2024","unstructured":"Thiruppathi, J., Vijayan, V., Park, I. K., Lee, S. E., & Rhee, J. H. (2024). Enhancing cancer immunotherapy with photodynamic therapy and nanoparticle: making tumor microenvironment hotter to make immunotherapeutic work better. Frontiers in Immunology. https:\/\/doi.org\/10.3389\/fimmu.2024.1375767","journal-title":"Front Immunol"},{"key":"909_CR17","first-page":"1","volume":"15","author":"KY Li","year":"2024","unstructured":"Li, K. Y., Lowy, A. M., & Fanta, P. (2024). Quantification of PD-L1 expression and tumor mutational burden in biologically distinct advanced pancreatic cancers responding to pembrolizumab: Case reports. Frontiers in Immunology, 15, 1\u20136.","journal-title":"Frontiers In Immunology"},{"key":"909_CR18","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13045-024-01561-6","volume":"17","author":"P Farhangnia","year":"2024","unstructured":"Farhangnia, P., Khorramdelazad, H., Nickho, H., & Delbandi, A. A. (2024). Current and future immunotherapeutic approaches in pancreatic cancer treatment. Journal of Hematology & Oncology, 17, 40.","journal-title":"Journal Of Hematology & Oncology"},{"key":"909_CR19","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s41698-024-00681-z","volume":"8","author":"Y Ju","year":"2024","unstructured":"Ju, Y., Xu, D., Liao, M., Sun, Y., Bao, W., Yao, F., & Ma, L. (2024). Barriers and opportunities in pancreatic cancer immunotherapy. NPJ Precision Oncology, 8, 199.","journal-title":"NPJ Precis Oncol"},{"key":"909_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12032-025-02605-8","volume":"42","author":"L Das","year":"2025","unstructured":"Das, L., & Das, S. (2025). A comprehensive insights of cancer immunotherapy resistance. Medical Oncology, 42, 1\u201313.","journal-title":"Medical Oncology"},{"key":"909_CR21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","volume":"20","author":"MJ Mitchell","year":"2021","unstructured":"Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021). Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery, 20, 101\u2013124.","journal-title":"Nature Reviews. Drug Discovery"},{"key":"909_CR22","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41467-021-27493-0","volume":"12","author":"X Han","year":"2021","unstructured":"Han, X., Zhang, H., Butowska, K., Swingle, K. L., Alameh, M. G., Weissman, D., & Mitchell, M. J. (2021). An ionizable lipid toolbox for RNA delivery. Nature Communications, 12, 8\u201313.","journal-title":"Nature Communications"},{"key":"909_CR23","doi-asserted-by":"publisher","first-page":"119341","DOI":"10.1016\/j.biomaterials.2019.119341","volume":"218","author":"S Ghosh","year":"2019","unstructured":"Ghosh, S., Carter, K. A., & Lovell, J. F. (2019). Liposomal formulations of photosensitizers. Biomaterials, 218, 119341.","journal-title":"Biomaterials"},{"key":"909_CR24","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","volume":"6","author":"X Hou","year":"2021","unstructured":"Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021). Lipid nanoparticles for mRNA delivery. Nature Reviews Materials, 6, 1078\u20131094.","journal-title":"Nat Rev Mater"},{"key":"909_CR25","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nmat2986","volume":"10","author":"JF Lovell","year":"2011","unstructured":"Lovell, J. F., Jin, C. S., Huynh, E., Jin, H., Kim, C., Rubinstein, J. L., Chan, W. C. W., Cao, W., Wang, L. V., & Zheng, G. (2011). Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents. Nature Materials, 10, 324\u2013332.","journal-title":"Nature Materials"},{"key":"909_CR26","doi-asserted-by":"publisher","first-page":"7573","DOI":"10.1021\/acs.nanolett.9b00859","volume":"19","author":"G Obaid","year":"2019","unstructured":"Obaid, G., Bano, S., Mallidi, S., Broekgaarden, M., Kuriakose, J., Silber, Z., Bulin, A. L., Wang, Y., Mai, Z., Jin, W., Simeone, D., & Hasan, T. (2019). Impacting pancreatic cancer therapy in heterotypic in vitro organoids and in vivo tumors with specificity-tuned, NIR-activable photoimmunonanoconjugates: Towards conquering desmoplasia? Nano Letters, 19, 7573\u20137587.","journal-title":"Nano Letters"},{"key":"909_CR27","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.3390\/jcm9082390","volume":"9","author":"S Bano","year":"2020","unstructured":"Bano, S., Obaid, G., Swain, J. W. R., Yamada, M., Pogue, B. W., Wang, K., & Hasan, T. (2020). NIR photodynamic destruction of PDAC and HNSCC nodules using triple-receptor-targeted photoimmuno-nanoconjugates: Targeting heterogeneity in cancer. Journal of Clinical Medicine, 9, 2390.","journal-title":"J Clin Med"},{"key":"909_CR28","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.ccell.2022.04.011","volume":"40","author":"H Huang","year":"2022","unstructured":"Huang, H., Wang, Z., Zhang, Y., Pradhan, R. N., Ganguly, D., Chandra, R., Murimwa, G., Wright, S., Gu, X., Maddipati, R., M\u00fcller, S., Turley, S. J., & Brekken, R. A. (2022). Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer. Cancer Cell, 40, 656\u2013673e7.","journal-title":"Cancer Cell"},{"key":"909_CR29","doi-asserted-by":"publisher","unstructured":"Berger, M., Degey, M., Leblond Chain, J., Maquoi, E., Evrard, B., Lechanteur, A., & Piel, G. Effect of PEG anchor and serum on lipid nanoparticles: Development of a nanoparticles tracking method, Pharmaceutics, https:\/\/doi.org\/10.3390\/pharmaceutics15020597","DOI":"10.3390\/pharmaceutics15020597"},{"key":"909_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fchem.2020.589959","volume":"8","author":"ML Guevara","year":"2020","unstructured":"Guevara, M. L., Persano, F., & Persano, S. (2020). Advances in lipid nanoparticles for mRNA-based cancer immunotherapy. Frontiers In Chemistry, 8, 1\u201317.","journal-title":"Frontiers In Chemistry"},{"key":"909_CR31","first-page":"1","volume":"27","author":"C Zhang","year":"2022","unstructured":"Zhang, C., Ma, Y., Zhang, J., Kuo, J. C. T., Zhang, Z., Xie, H., Zhu, J., & Liu, T. (2022). Modification of lipid-based nanoparticles: An efficient delivery system for nucleic acid-based immunotherapy. Molecules, 27, 1\u201329.","journal-title":"Molecules"},{"key":"909_CR32","doi-asserted-by":"publisher","unstructured":"Kamiya, M., Matsumoto, M., Yamashita, K., Izumi, T., Kawaguchi, M., Mizukami, S., Tsurumaru, M., Mukai, H., & Kawakami, S. Stability study of mRNA-Lipid nanoparticles exposed to various conditions based on the evaluation between physicochemical properties and their relation with protein expression ability, Pharmaceutics, https:\/\/doi.org\/10.3390\/pharmaceutics14112357","DOI":"10.3390\/pharmaceutics14112357"},{"key":"909_CR33","doi-asserted-by":"publisher","first-page":"4787","DOI":"10.1021\/acsnano.8b01516","volume":"12","author":"JA Kulkarni","year":"2018","unstructured":"Kulkarni, J. A., Darjuan, M. M., Mercer, J. E., Chen, S., Van Der Meel, R., Thewalt, J. L., Tam, Y. Y. C., & Cullis, P. R. (2018). On the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA. Acs Nano, 12, 4787\u20134795.","journal-title":"Acs Nano"},{"key":"909_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/adma.202103978","volume":"33","author":"Y Wan","year":"2021","unstructured":"Wan, Y., Fu, L. H., Li, C., Lin, J., & Huang, P. (2021). Conquering the hypoxia limitation for photodynamic therapy. Advanced Materials, 33, 1\u201336.","journal-title":"Advanced Materials"},{"key":"909_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom12010081","volume":"12","author":"L Hong","year":"2022","unstructured":"Hong, L., Li, J., Luo, Y., Guo, T., Zhang, C., Ou, S., Long, Y., & Hu, Z. (2022). Recent advances in strategies for addressing hypoxia in tumor photodynamic therapy. Biomolecules, 12, 1\u201325.","journal-title":"Biomolecules"},{"key":"909_CR36","doi-asserted-by":"publisher","first-page":"9784","DOI":"10.1039\/D0SC03008B","volume":"11","author":"JA Roque","year":"2020","unstructured":"Roque, J. A., Barrett, P. C., Cole, H. D., Lifshits, L. M., Shi, G., Monro, S., Von Dohlen, D., Kim, S., Russo, N., Deep, G., Cameron, C. G., Alberto, M. E., & McFarland, S. A. (2020). Breaking the barrier: An osmium photosensitizer with unprecedented hypoxic phototoxicity for real world photodynamic therapy. Chemical Science, 11, 9784\u20139806.","journal-title":"Chemical Science"},{"key":"909_CR37","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1039\/C9CS00129H","volume":"49","author":"PC Lo","year":"2020","unstructured":"Lo, P. C., Rodr\u00edguez-Morgade, M. S., Pandey, R. K., Ng, D. K. P., Torres, T., & Dumoulin, F. (2020). The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer. Chemical Society Reviews, 49, 1041\u20131056.","journal-title":"Chemical Society Reviews"},{"key":"909_CR38","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jconrel.2011.08.019","volume":"156","author":"H Ding","year":"2011","unstructured":"Ding, H., Yu, H., Dong, Y., Tian, R., Huang, G., Boothman, D. A., Sumer, B. D., & Gao, J. (2011). Photoactivation switch from type II to type i reactions by electron-rich micelles for improved photodynamic therapy of cancer cells under hypoxia. Journal of Controlled Release, 156, 276\u2013280.","journal-title":"Journal of Controlled Release"},{"key":"909_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-022-29862-9","volume":"13","author":"J An","year":"2022","unstructured":"An, J., Tang, S., Hong, G., Chen, W., Chen, M., Song, J., Li, Z., Peng, X., Song, F., & Zheng, W. H. (2022). An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers. Nature Communications, 13, 1\u201310.","journal-title":"Nature Communications"},{"key":"909_CR40","first-page":"1","volume":"14","author":"S Shao","year":"2024","unstructured":"Shao, S., Delk, N. A., & Jones, C. N. (2024). A microphysiological system reveals neutrophil contact-dependent attenuation of pancreatic tumor progression by CXCR2 inhibition-based immunotherapy. Scientific Reports, 14, 1\u201316.","journal-title":"Scientific Reports"},{"key":"909_CR41","unstructured":"Shuo, S., Duncko, D., & Jones, N. C. Behaviorome profiling of anti-tumor and pro-tumor human neutrophil subtypes in a microphysiological system. Lab Chip."},{"key":"909_CR42","doi-asserted-by":"publisher","first-page":"e129212","DOI":"10.1172\/jci.insight.129212","volume":"4","author":"AN Hosein","year":"2019","unstructured":"Hosein, A. N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E., Verma, U., & Brekken, R. A. (2019). Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution. JCI Insight, 4, e129212.","journal-title":"JCI Insight"},{"key":"909_CR43","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/s41590-022-01160-y","volume":"23","author":"S Tahtinen","year":"2022","unstructured":"Tahtinen, S., Tong, A. J., Himmels, P., Oh, J., Paler-Martinez, A., Kim, L., Wichner, S., Oei, Y., McCarron, M. J., Freund, E. C., Amir, Z. A., de la Cruz, C. C., Haley, B., Blanchette, C., Schartner, J. M., Ye, W., Yadav, M., Sahin, U., Delamarre, L., & Mellman, I. (2022). IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines. Nature Immunology, 23, 532\u2013542.","journal-title":"Nature Immunology"},{"key":"909_CR44","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1038\/s12276-023-01086-x","volume":"55","author":"Y Lee","year":"2023","unstructured":"Lee, Y., Jeong, M., Park, J., Jung, H., & Lee, H. (2023). Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics. Experimental & Molecular Medicine, 55, 2085\u20132096.","journal-title":"Experimental & Molecular Medicine"}],"container-title":["Photochemical & Photobiological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43630-026-00909-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43630-026-00909-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43630-026-00909-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:40:51Z","timestamp":1781512851000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43630-026-00909-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["909"],"URL":"https:\/\/doi.org\/10.1007\/s43630-026-00909-w","relation":{},"ISSN":["1474-905X","1474-9092"],"issn-type":[{"value":"1474-905X","type":"print"},{"value":"1474-9092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]},"assertion":[{"value":"28 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}