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Ultraviolet (UV) radiation exposure has been proposed as a potential modifiable environmental factor influencing blood pressure regulation. While traditionally associated with vitamin D synthesis, emerging evidence suggests alternative mechanisms, including nitric oxide (NO) mobilization, may play a significant role.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically review the available evidence on effects of UV exposure on blood pressure, with a focus on hypertension in human populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Electronic databases were searched for studies investigating the impact of UV exposure (UVA and\/or UVB) on blood pressure. Eligible studies included randomized controlled trials (RCTs), clinical trials, and observational studies involving human participants. Data extraction and risk of bias assessment were performed independently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 14 studies were included in the final analysis. The majority demonstrated that UV exposure, particularly UVA, was associated with a reduction in blood pressure. Several studies suggested that this effect is mediated through NO release from cutaneous stores, independent of vitamin D pathways. However, findings were heterogeneous, with studies reporting no significant effects, likely due to differences in study design, population characteristics, and exposure protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UV exposure, especially UVA, demonstrates a blood pressure-lowering effect, potentially mediated by NO-related mechanisms. However, clinical translation requires a balanced quantitative risk-benefit assessment that considers potential cardiovascular benefits, all-cause mortality-related evidence, and dermatological risks. Further large-scale and well-designed RCTs with standardized exposure protocols and long-term safety follow-up are required before UV-based interventions can be recommended for cardiovascular prevention or hypertension management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s43630-026-00970-5","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:51:40Z","timestamp":1786956700000},"page":"2037-2046","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of ultraviolet light exposure on blood pressure: a systematic review"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2747-165X","authenticated-orcid":false,"given":"Pirus","family":"Ghadjar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Syzonenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia Lucia","family":"Strzebinczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz V.","family":"Scharr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Piazena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"4","key":"970_CR1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","volume":"16","author":"KT Mills","year":"2020","unstructured":"Mills, K. 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