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Dr. Vimal H. Prajapati has been an advisor, consultant, and\/or speaker for AbbVie, Actelion, Amgen, Apogee Therapeutics, Aralez, Arcutis, Aspen, Bausch Health, BioScript Solutions, Boehringer Ingelheim, Bristol Myers Squibb, Canadian Psoriasis Network, Celgene, Cipher, Concert, CorEvitas, Eczema Society of Canada, Eli Lilly, Galderma, GlaxoSmithKline, Homeocan, Incyte, Jamp Pharma, J&J Innovative Medicine, Janssen, Johnson & Johnson, LEO Pharma, Medexus, Novartis, Organon, Pediapharm, Pfizer, Sanofi Genzyme, Sun Pharma, Tribute, UCB, and Valeant. Dr. Vimal H. Prajapati has been an investigator for AbbVie, AnaptysBio, Arcutis, Arena, Asana, Bausch Health, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Concert, CorEvitas, Dermavant, Dermira, Eli Lilly, Galderma, Incyte, Janssen, LEO Pharma, Meiji Pharma, Nektar Therapeutics, Nimbus Lakshmi, Novartis, Pfizer, RAPT Therapeutics, Regeneron, Reistone, Sanofi Genzyme, Sun Pharma, Takeda, and UCB. Dr. Vimal H. Prajapati has received grants from AbbVie, Bausch Health, Janssen, LEO Pharma, Novartis, and Sanofi Genzyme. Dr. Eric Mutter has received payment\/honoraria from Boehringer Ingelheim for educational events\/meetings\/travel. Dr. Melinda Gooderham has been an advisor, consultant, speaker, and\/or investigator for Abbvie, Akros Pharma, Amgen, AnaptysBio, Arcutis Pharmaceuticals, Aristea Therapeutics, Asana Bio Sciences, Aslan Pharmaceuticals, Attovia Therapeutics, Bausch Health, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Coherus Biosciences, Dermavant, Dermira, Eli Lilly, Galderma, GlaxoSmithKline, Incyte Biosciences, Janssen, Kyowa Kirin, LEO pharma, MedImmune, Meiji Seika, Merck, Moonlake Immunotherapeutics, Nimbus Therapeutics, Novartis, Pfizer, Regeneron, Sanofi Genzyme, Sun Pharma, Tarsus, UCB, and Ventyx. None of the authors have received payment to promote spesolimab or to be involved with this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Photographs were provided by Dr. Melinda Gooderham (Fig.\u00a0B) and Dr. Jensen Yeung (Fig.\u00a0C) with patient consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}