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The photosynthetic autotroph <jats:italic>Synechocystis<\/jats:italic> sp. PCC 6803 is frequently used as an indicator organism for water pollution and a cell factory for high-value biochemical production in synthetic biology. During its growth, this organism often encounters various abiotic stresses, including oxidative, salt, and antibiotic stress. In this study, we conducted transcriptomic analysis on both \u0394<jats:italic>zur<\/jats:italic> mutant and wild-type (WT) strains to identify potential Zur-regulated genes in <jats:italic>Synechocystis<\/jats:italic> sp. PCC 6803. These genes primarily participate in multiple pathways such as inorganic ion transport, carbohydrate transport, energy production and conversion, and cell motility. Zur not only controls zinc ion homeostasis within the cell but also influences the iron balance by directly regulating the expression of the <jats:italic>fur<\/jats:italic> gene. In terms of motility, Zur regulates the expression of bacterial pili gene cluster and other motility-related genes, thereby affecting the twitching motility of <jats:italic>Synechocystis<\/jats:italic> sp. PCC 6803. Furthermore, Zur plays a crucial role in promoting biofilm formation and enhancing resistance to salt, oxidative, and antibiotic stresses by modulating relative gene expression. In conclusion, as a global transcriptional regulator, Zur plays pivotal roles in metal ion homeostasis, motility, and resistance to multiple stresses in <jats:italic>Synechocystis<\/jats:italic> sp. PCC 6803. This study illustrates the Zur regulons in <jats:italic>Synechocystis<\/jats:italic> sp. PCC 6803, and underscores the importance of Zur in enhancing the environmental adaptability of cyanobacteria.<\/jats:p>","DOI":"10.1007\/s44154-025-00224-x","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T08:17:52Z","timestamp":1746605872000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Functional investigation of Zur in metal ion homeostasis, motility and multiple stresses resistance in cyanobacteria Synechocystis sp. PCC 6803"],"prefix":"10.1007","volume":"5","author":[{"given":"Han","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoru","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2489-7639","authenticated-orcid":false,"given":"Yantao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"224_CR1","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1111\/j.1365-2958.2006.05065.x","volume":"59","author":"BE Ahn","year":"2006","unstructured":"Ahn BE, Cha J, Lee EJ, Han AR, Thompson CJ, Roe JH (2006) Nur, a nickel-responsive regulator of the Fur family, regulates superoxide dismutases and nickel transport in Streptomyces coelicolor. 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