{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:30:18Z","timestamp":1786501818762,"version":"build-2736575974"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2023YFD1301400"],"award-info":[{"award-number":["2023YFD1301400"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2025LHT-04"],"award-info":[{"award-number":["2025LHT-04"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2025SFTG-02"],"award-info":[{"award-number":["2025SFTG-02"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2025JCQY004"],"award-info":[{"award-number":["2025JCQY004"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stress Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s44154-026-00329-x","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:26:26Z","timestamp":1786501586000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary supplementation of Acer truncatum leaf extract alleviates oxidative-stress induced impairment of ovarian function in laying hens via Nrf2-mediated antioxidant defense and VEGF-mediated angiogenesis"],"prefix":"10.1007","volume":"6","author":[{"given":"Kailong","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"issue":"2","key":"329_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13020158","volume":"13","author":"M Bertozzi-Matheus","year":"2024","unstructured":"Bertozzi-Matheus M, Bueno-Pereira TO, Nunes PR, Sandrim VC (2024) EGCG, a green tea compound, increases NO production and has antioxidant action in a static and shear stress in vitro model of preeclampsia. Antioxidants (Basel) 13(2):158. https:\/\/doi.org\/10.3390\/antiox13020158","journal-title":"Antioxidants (Basel)"},{"issue":"9","key":"329_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2024.104060","volume":"103","author":"R Bi","year":"2024","unstructured":"Bi R, Yang M, Liu X, Guo F, Hu Z, Huang J, Abbas W, Xu T, Liu W, Wang Z (2024) Effects of chlorogenic acid on productive and reproductive performances, egg quality, antioxidant functions, and intestinal microenvironment in aged breeder laying hens. Poult Sci 103(9):104060. https:\/\/doi.org\/10.1016\/j.psj.2024.104060","journal-title":"Poult Sci"},{"issue":"1","key":"329_CR3","doi-asserted-by":"publisher","DOI":"10.1080\/10495398.2025.2463995","volume":"36","author":"I Brouklogiannis","year":"2025","unstructured":"Brouklogiannis I, Mountzouris KC (2025) Nutrigenomic evidence of phytogenic cytoprotective functions in the ovary and liver provides mechanistic support for improved laying hen performance. Anim Biotechnol 36(1):2463995. https:\/\/doi.org\/10.1080\/10495398.2025.2463995","journal-title":"Anim Biotechnol"},{"key":"329_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172418","volume":"856","author":"J Chen","year":"2019","unstructured":"Chen J, Zhang X, Liu X, Zhang C, Shang W, Xue J, Chen R, Xing Y, Song D, Xu R (2019) Ginsenoside Rg1 promotes cerebral angiogenesis via the PI3k\/Akt\/mTOR signaling pathway in ischemic mice. Eur J Pharmacol 856:172418. https:\/\/doi.org\/10.1016\/j.ejphar.2019.172418","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"329_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.101938","volume":"101","author":"H Chen","year":"2022","unstructured":"Chen H, Chen X, Ping Z, Jiang X, Ge M, Ma J, Yu W (2022) Promotion effect of Angelica sinensis extract on angiogenesis of chicken preovulatory follicles in vitro. Poult Sci 101(7):101938. https:\/\/doi.org\/10.1016\/j.psj.2022.101938","journal-title":"Poult Sci"},{"issue":"3","key":"329_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.102430","volume":"102","author":"H Chen","year":"2023","unstructured":"Chen H, Chen X, Ping Z, Fang L, Jiang X, Ge M, Ma J, Yu W (2023) Ligusticum chuanxiong promotes the angiogenesis of preovulatory follicles (F1\u2013F3) in late-phase laying hens. Poult Sci 102(3):102430. https:\/\/doi.org\/10.1016\/j.psj.2022.102430","journal-title":"Poult Sci"},{"issue":"Pt 1","key":"329_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.118811","volume":"252","author":"J Chen","year":"2024","unstructured":"Chen J, Wei Y, Zhou J, Cao X, Yuan R, Lu Y, Guo Y, Shao X, Sun W, Jia M, Chen X (2024a) Tributyltin-induced oxidative stress causes developmental damage in the cardiovascular system of zebrafish (Danio rerio). Environ Res 252(Pt 1):118811. https:\/\/doi.org\/10.1016\/j.envres.2024.118811","journal-title":"Environ Res"},{"key":"329_CR8","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.2147\/IJN.S449290","volume":"19","author":"T Chen","year":"2024","unstructured":"Chen T, Wu Z, Hou Q, Mei Y, Yang K, Xu J, Wang L (2024b) The dual angiogenesis effects via Nrf2\/HO-1 signaling pathway of melatonin nanocomposite scaffold on promoting diabetic bone defect repair. Int J Nanomedicine 19:2709\u20132732. https:\/\/doi.org\/10.2147\/IJN.S449290","journal-title":"Int J Nanomedicine"},{"issue":"11","key":"329_CR9","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.5713\/ab.20.0791","volume":"34","author":"S Cheng","year":"2021","unstructured":"Cheng S, Li X, Wang J, Wu Y, Li P, Pi J (2021) The effect of light on follicular development in laying hens. Anim Biosci 34(11):1766\u20131775. https:\/\/doi.org\/10.5713\/ab.20.0791","journal-title":"Anim Biosci"},{"issue":"1","key":"329_CR10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s12551-016-0244-4","volume":"9","author":"P Deshmukh","year":"2017","unstructured":"Deshmukh P, Unni S, Krishnappa G, Padmanabhan B (2017) The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophys Rev 9(1):41\u201356. https:\/\/doi.org\/10.1007\/s12551-016-0244-4","journal-title":"Biophys Rev"},{"issue":"6","key":"329_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.101886","volume":"101","author":"X Ding","year":"2022","unstructured":"Ding X, Cai C, Jia R, Bai S, Zeng Q, Mao X, Xu S, Zhang K, Wang J (2022) Dietary resveratrol improved production performance, egg quality, and intestinal health of laying hens under oxidative stress. Poult Sci 101(6):101886. https:\/\/doi.org\/10.1016\/j.psj.2022.101886","journal-title":"Poult Sci"},{"issue":"1","key":"329_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-03890-z","volume":"15","author":"R Dubey","year":"2025","unstructured":"Dubey R, Garg SS, Khurana N, Prabhakar PK, Gupta J (2025) Sinapic acid accelerates diabetic wound healing by promoting angiogenesis and reducing oxidative stress. Sci Rep 15(1):33796. https:\/\/doi.org\/10.1038\/s41598-025-03890-z","journal-title":"Sci Rep"},{"issue":"49","key":"329_CR13","doi-asserted-by":"publisher","first-page":"46851","DOI":"10.1021\/acsomega.3c06450","volume":"8","author":"J Ekowati","year":"2023","unstructured":"Ekowati J, Tejo BA, Maulana S, Kusuma WA, Fatriani R, Ramadhanti NS, Norhayati N, Nofianti KA, Sulistyowaty MI, Zubair MS, Yamauchi T, Hamid IS (2023) Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-\u03b1 convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach. ACS Omega 8(49):46851\u201346868. https:\/\/doi.org\/10.1021\/acsomega.3c06450","journal-title":"ACS Omega"},{"key":"329_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1068849","volume":"14","author":"Y Fan","year":"2023","unstructured":"Fan Y, Gu R, Zhang R, Wang M, Xu H, Wang M, Long C (2023) Protective effects of extracts from Acer truncatum leaves on SLS-induced HaCaT cells. Front Pharmacol 14:1068849. https:\/\/doi.org\/10.3389\/fphar.2023.1068849","journal-title":"Front Pharmacol"},{"issue":"2","key":"329_CR15","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1080\/17512433.2021.1878877","volume":"14","author":"J Feng","year":"2021","unstructured":"Feng J, Liu L, Yao F, Zhou D, He Y, Wang J (2021) The protective effect of tanshinone IIa on endothelial cells: a generalist among clinical therapeutics. Expert Rev Clin Pharmacol 14(2):239\u2013248. https:\/\/doi.org\/10.1080\/17512433.2021.1878877","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"1","key":"329_CR16","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s44154-025-00243-8","volume":"5","author":"J Gao","year":"2025","unstructured":"Gao J, Ren H, Wu X, Zou C, He B, Ma W (2025) Dietary glycerol monolaurate mitigates heat stress-induced disruption of intestinal homeostasis and hepatic lipid metabolism in laying hens. Stress Biol 5(1):49. https:\/\/doi.org\/10.1007\/s44154-025-00243-8","journal-title":"Stress Biol"},{"issue":"20","key":"329_CR17","doi-asserted-by":"publisher","first-page":"10228","DOI":"10.1093\/nar\/gks827","volume":"40","author":"Y Hirotsu","year":"2012","unstructured":"Hirotsu Y, Katsuoka F, Funayama R, Nagashima T, Nishida Y, Nakayama K, Engel JD, Yamamoto M (2012) Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks. Nucleic Acids Res 40(20):10228\u201310239. https:\/\/doi.org\/10.1093\/nar\/gks827","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"329_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-025-12236-y","volume":"26","author":"F Hu","year":"2025","unstructured":"Hu F, Xu T, Huang S, Liu X, Wu L, Zhang H, Niu X, Wang J, Ran X (2025) The systemic wrinkled skin phenotype involves aberrant expression and variation of genes related to the oxidative stress and extracellular matrix in Xiang pigs. BMC Genomics 26(1):1034. https:\/\/doi.org\/10.1186\/s12864-025-12236-y","journal-title":"BMC Genomics"},{"issue":"9","key":"329_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14091045","volume":"14","author":"W Huang","year":"2025","unstructured":"Huang W, Lv Y, Zou C, Ge C, Zhan S, Shen X, Lin G, Yu D, Liu B (2025) Mangosteen pericarp extract mitigates diquat-induced hepatic oxidative stress by NRF2\/HO-1 activation, intestinal barrier integrity restoration, and gut microbiota modulation. Antioxidants (Basel) 14(9):1045. https:\/\/doi.org\/10.3390\/antiox14091045","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"329_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2020.12.011","volume":"100","author":"AM Humam","year":"2021","unstructured":"Humam AM, Loh TC, Foo HL, Izuddin WI, Zulkifli I, Samsudin AA, Mustapha NM (2021) Supplementation of postbiotic RI11 improves antioxidant enzyme activity, upregulated gut barrier genes, and reduced cytokine, acute phase protein, and heat shock protein 70 gene expression levels in heat-stressed broilers. Poult Sci 100(3):100908. https:\/\/doi.org\/10.1016\/j.psj.2020.12.011","journal-title":"Poult Sci"},{"issue":"2","key":"329_CR21","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1021\/acsnano.4c03214","volume":"19","author":"K Jain","year":"2025","unstructured":"Jain K, Kishan K, Minhaj RF, Kanchanawong P, Sheetz MP, Changede R (2025) Immobile integrin signaling transit and relay nodes organize mechanosignaling through force-dependent phosphorylation in focal adhesions. ACS Nano 19(2):2070\u20132088. https:\/\/doi.org\/10.1021\/acsnano.4c03214","journal-title":"ACS Nano"},{"issue":"1","key":"329_CR22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s40104-025-01263-0","volume":"16","author":"A Jiang","year":"2025","unstructured":"Jiang A, Li J, Wang L, Liu Y, Wu Z, Wang H, Wu S, Bao W (2025a) HIF1a regulates follicular atresia through o-GlcNAcylation-mediated VEZF1\/ET-1\/FOXO1\/BAX signaling in porcine granulosa cells. J Anim Sci Biotechnol 16(1):127. https:\/\/doi.org\/10.1186\/s40104-025-01263-0","journal-title":"J Anim Sci Biotechnol"},{"issue":"9","key":"329_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2025.105438","volume":"104","author":"H Jiang","year":"2025","unstructured":"Jiang H, Zhao M, Chen B, Yang X, Wu F, Han S, Liu S (2025b) Effects of chlorogenic acid and its isomers on growth performance and antioxidant function of broilers: a meta-analysis. Poult Sci 104(9):105438. https:\/\/doi.org\/10.1016\/j.psj.2025.105438","journal-title":"Poult Sci"},{"issue":"Pt B","key":"329_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120660","volume":"355","author":"G Jiang","year":"2026","unstructured":"Jiang G, Pan H, Gu L, Cheng T, Zhu B, Wang X, Yu J, Zhu F, Lin M, Hu J, Wang X (2026) Chrysanthemum morifolium extract attenuates pathological angiogenesis of age-related macular degeneration via VEGF and Nrf2 pathway modulation. J Ethnopharmacol 355(Pt B):120660. https:\/\/doi.org\/10.1016\/j.jep.2025.120660","journal-title":"J Ethnopharmacol"},{"issue":"14","key":"329_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147434","volume":"22","author":"NC Karunatilleke","year":"2021","unstructured":"Karunatilleke NC, Fast CS, Ngo V, Brickenden A, Duennwald ML, Konermann L, Choy WY (2021) Nrf2, the major regulator of the cellular oxidative stress response, is partially disordered. Int J Mol Sci 22(14):7434. https:\/\/doi.org\/10.3390\/ijms22147434","journal-title":"Int J Mol Sci"},{"issue":"50","key":"329_CR26","doi-asserted-by":"publisher","first-page":"42863","DOI":"10.1074\/jbc.M111.286880","volume":"286","author":"N Kweider","year":"2011","unstructured":"Kweider N, Fragoulis A, Rosen C, Pecks U, Rath W, Pufe T, Wruck CJ (2011) Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (nrf2): implications for preeclampsia. J Biol Chem 286(50):42863\u201342872. https:\/\/doi.org\/10.1074\/jbc.M111.286880","journal-title":"J Biol Chem"},{"key":"329_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.591672","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Li C, Li Q, Li G, Li W, Li H, Kang X, Tian Y (2020) Novel regulatory factors in the hypothalamic-pituitary-ovarian axis of hens at four developmental stages. Front Genet 11:591672. https:\/\/doi.org\/10.3389\/fgene.2020.591672","journal-title":"Front Genet"},{"issue":"41","key":"329_CR28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2213026119","volume":"119","author":"S Li","year":"2022","unstructured":"Li S, Bhandary B, Gu X, DeFalco T (2022) Perivascular cells support folliculogenesis in the developing ovary. Proc Natl Acad Sci U S A 119(41):e2213026119. https:\/\/doi.org\/10.1073\/pnas.2213026119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"329_CR29","doi-asserted-by":"publisher","DOI":"10.1177\/20417314241268917","volume":"15","author":"D Li","year":"2024","unstructured":"Li D, Li Y, Lv D, Deng T, Zeng X, You L, Pang Q, Li Y, Zhu B (2024a) Enhanced interaction between genome-edited mesenchymal stem cells and platelets improves wound healing in mice. J Tissue Eng 15:20417314241268917. https:\/\/doi.org\/10.1177\/20417314241268917","journal-title":"J Tissue Eng"},{"issue":"1","key":"329_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-67557-x","volume":"14","author":"F Li","year":"2024","unstructured":"Li F, Zhu F, Wang S, Hu H, Zhang D, He Z, Chen J, Li X, Cheng L, Zhong F (2024b) Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2\/ARE pathway. Sci Rep 14(1):17318. https:\/\/doi.org\/10.1038\/s41598-024-67557-x","journal-title":"Sci Rep"},{"issue":"10","key":"329_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2025.105461","volume":"104","author":"X Li","year":"2025","unstructured":"Li X, Zhou H, Luo W, Luo X, Zhang X, Mei Z, Gong Y (2025a) Comparative transcriptome analysis reveals involvement of FOXL2 in regulation of ovulation cycle in chicken. Poult Sci 104(10):105461. https:\/\/doi.org\/10.1016\/j.psj.2025.105461","journal-title":"Poult Sci"},{"key":"329_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2025.110400","volume":"768","author":"Y Li","year":"2025","unstructured":"Li Y, Zhang L, Zhang Q, Zhang Y, Pan S, Zhao H, Zhang L (2025b) HSPB1 suppresses oxLDL-induced vascular smooth muscle cell ferroptosis by inhibiting DPP4. Arch Biochem Biophys 768:110400. https:\/\/doi.org\/10.1016\/j.abb.2025.110400","journal-title":"Arch Biochem Biophys"},{"issue":"5","key":"329_CR33","doi-asserted-by":"publisher","first-page":"166","DOI":"10.17221\/65\/2024-VETMED","volume":"70","author":"F Liao","year":"2025","unstructured":"Liao F, He J (2025) Antibacterial activity and compositional analysis of Acer truncatum Bunge leaf extract against Staphylococcus aureus. Vet Med (Praha) 70(5):166\u2013176. https:\/\/doi.org\/10.17221\/65\/2024-VETMED","journal-title":"Vet Med (Praha)"},{"issue":"10","key":"329_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2023.102951","volume":"102","author":"J Liu","year":"2023","unstructured":"Liu J, Liang S, Qin K, Jia B, Ren Z, Yang X, Yang X (2023) Acer truncatum leaves extract modulates gut microbiota, improves antioxidant capacity, and alleviates lipopolysaccharide-induced inflammation in broilers. Poult Sci 102(10):102951. https:\/\/doi.org\/10.1016\/j.psj.2023.102951","journal-title":"Poult Sci"},{"issue":"17","key":"329_CR35","doi-asserted-by":"publisher","first-page":"10230","DOI":"10.1021\/acs.jafc.4c12371","volume":"73","author":"C Liu","year":"2025","unstructured":"Liu C, Shen J, Niu G, Khusbu K, Wang Z, Liu X, Bi Y (2025a) Lycopene protects corneal endothelial cells from oxidative stress by regulating the p62-autophagy-keap1\/nrf2 pathway. J Agric Food Chem 73(17):10230\u201310245. https:\/\/doi.org\/10.1021\/acs.jafc.4c12371","journal-title":"J Agric Food Chem"},{"issue":"1","key":"329_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-17390-7","volume":"15","author":"F Liu","year":"2025","unstructured":"Liu F, Zhang Y, Zhang L, Feng W, Zhao Y, Wei J, Zhu X, Zhao S (2025b) Aqueous extract of Acer truncatum leaves retards Drosophila melanogaster senescence by regulating amino acid metabolism and gut microbiota. Sci Rep 15(1):34409. https:\/\/doi.org\/10.1038\/s41598-025-17390-7","journal-title":"Sci Rep"},{"issue":"1","key":"329_CR37","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1186\/s12967-025-06973-7","volume":"23","author":"X Liu","year":"2025","unstructured":"Liu X, Liu X, Luo S, Chen D, Lin J, Xiong M, Yang L, Li K, Sun D, Wei L, Luo S, Wang Y (2025c) Quercetin promotes angiogenesis and protects the blood-spinal cord barrier structure after spinal cord injury by targeting the PI3k\/akt signaling pathway. J Transl Med 23(1):958. https:\/\/doi.org\/10.1186\/s12967-025-06973-7","journal-title":"J Transl Med"},{"key":"329_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.135873","volume":"417","author":"T Long","year":"2023","unstructured":"Long T, Gu R, Linghu C, Long J, Kennelly EJ, Long C (2023) UPLC-QTOF-MS-based metabolomics and chemometrics studies of geographically diverse Acer truncatum leaves: a traditional herbal tea in northern China. Food Chem 417:135873. https:\/\/doi.org\/10.1016\/j.foodchem.2023.135873","journal-title":"Food Chem"},{"issue":"1","key":"329_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2023.103250","volume":"103","author":"Y Ma","year":"2024","unstructured":"Ma Y, Cheng B, Zhou S, Wang Y, Jing Y, Leng L, Wang S, Li Y, Luan P, Cao Z, Li H (2024) Comparative analyses of laying performance and follicular development characteristics between fat and lean broiler lines. Poult Sci 103(1):103250. https:\/\/doi.org\/10.1016\/j.psj.2023.103250","journal-title":"Poult Sci"},{"issue":"1","key":"329_CR40","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41467-024-55509-y","volume":"16","author":"L Mu","year":"2025","unstructured":"Mu L, Wang G, Yang X, Liang J, Tong H, Li L, Geng K, Bo Y, Hu X, Yang R, Xu X, Zhang Y, Zhang H (2025) Physiological premature aging of ovarian blood vessels leads to decline in fertility in middle-aged mice. Nat Commun 16(1):72. https:\/\/doi.org\/10.1038\/s41467-024-55509-y","journal-title":"Nat Commun"},{"issue":"1","key":"329_CR41","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12428","volume":"21","author":"A Nishigaki","year":"2022","unstructured":"Nishigaki A, Tsubokura H, Tsuzuki-Nakao T, Okada H (2022) Hypoxia: role of SIRT1 and the protective effect of resveratrol in ovarian function. Reprod Med Biol 21(1):e12428. https:\/\/doi.org\/10.1002\/rmb2.12428","journal-title":"Reprod Med Biol"},{"issue":"5","key":"329_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202400814","volume":"69","author":"F Qian","year":"2025","unstructured":"Qian F, Zhu Z, Luo C, Qi R, Wei L, Bo L, Jiang W, Mao C (2025) Chlorogenic acid ameliorates chronic unpredictable stress-induced diminished ovarian reserve through ovarian renin-angiotensin system. Mol Nutr Food Res 69(5):e202400814. https:\/\/doi.org\/10.1002\/mnfr.202400814","journal-title":"Mol Nutr Food Res"},{"issue":"12","key":"329_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0315437","volume":"19","author":"L Qiu","year":"2024","unstructured":"Qiu L, Ma Z, Li J, Wu Z, Dai L, Long R, Hu L, Sun J, Hu M, Li Y (2024) Development of a spontaneous model of renal interstitial fibrosis in NOD\/SCID mice: aging-induced pathogenesis. PLoS ONE 19(12):e0315437. https:\/\/doi.org\/10.1371\/journal.pone.0315437","journal-title":"PLoS ONE"},{"issue":"8","key":"329_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2024.103893","volume":"103","author":"M Ru","year":"2024","unstructured":"Ru M, Liang H, Ruan J, Haji RA, Cui Y, Yin C, Wei Q, Huang J (2024) Chicken ovarian follicular atresia: interaction network at organic, cellular, and molecular levels. Poult Sci 103(8):103893. https:\/\/doi.org\/10.1016\/j.psj.2024.103893","journal-title":"Poult Sci"},{"key":"329_CR45","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40104-025-01350-2","volume":"17","author":"Y Shen","year":"2026","unstructured":"Shen Y, Chen J, Xiao Y, Shi S (2026) Dietary glucuronolactone alleviates hepatic lipid accumulation via the enterohepatic axis in laying hens. J Anim Sci Biotechnol 17:38. https:\/\/doi.org\/10.1186\/s40104-025-01350-2","journal-title":"J Anim Sci Biotechnol"},{"issue":"13","key":"329_CR46","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.18632\/aging.204831","volume":"15","author":"P Shi","year":"2023","unstructured":"Shi P, Gao J, Zhao S, Xia W, Li J, Tao C (2023) Treatment of porcine ovarian follicles with tert-butyl hydroperoxide as an ovarian senescence model in vitro. Aging (Albany NY) 15(13):6212\u20136224. https:\/\/doi.org\/10.18632\/aging.204831","journal-title":"Aging (Albany NY)"},{"issue":"5","key":"329_CR47","doi-asserted-by":"publisher","first-page":"848","DOI":"10.3390\/ani16050848","volume":"16","author":"S Sookying","year":"2026","unstructured":"Sookying S, Panprommin D, Pook-In G, Pardubyew P, Kaeothep T, Nakwong T, Panase P (2026) Phytochemical profiling, antioxidant and antibacterial activities of Persicaria odorata ethanolic leaf extract and evaluation of growth performance, disease resistance, and gene expression in Labeo chrysophekadion (Bleeker, 1849). Animals (Basel) 16(5):848. https:\/\/doi.org\/10.3390\/ani16050848","journal-title":"Animals (Basel)"},{"issue":"18","key":"329_CR48","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.3390\/ani12182465","volume":"12","author":"W Tao","year":"2022","unstructured":"Tao W, Jin F, Fan Q, Zhao N, Wang G, Du E, Chen F, Guo W, Huang S, Chen M, Wei J (2022) Effects of chitosan oligosaccharide on production performance, egg quality and ovarian function in laying hens with fatty liver syndrome. Animals (Basel) 12(18):2465. https:\/\/doi.org\/10.3390\/ani12182465","journal-title":"Animals (Basel)"},{"issue":"1","key":"329_CR49","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13048-016-0293-0","volume":"9","author":"AB Tino","year":"2016","unstructured":"Tino AB, Chitcholtan K, Sykes PH, Garrill A (2016) Resveratrol and acetyl-resveratrol modulate activity of VEGF and IL-8 in ovarian cancer cell aggregates via attenuation of the NF-\u03bab protein. J Ovarian Res 9(1):84. https:\/\/doi.org\/10.1186\/s13048-016-0293-0","journal-title":"J Ovarian Res"},{"issue":"1","key":"329_CR50","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s11886-025-02235-6","volume":"27","author":"SI Travisano","year":"2025","unstructured":"Travisano SI, Lien C (2025) Cardiac regeneration and repair in zebrafish and mammalian models. Curr Cardiol Rep 27(1):95. https:\/\/doi.org\/10.1007\/s11886-025-02235-6","journal-title":"Curr Cardiol Rep"},{"issue":"1","key":"329_CR51","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1620\/tjem.253.69","volume":"253","author":"A Tubsakul","year":"2021","unstructured":"Tubsakul A, Sangartit W, Pakdeechote P, Kukongviriyapan V, Apaijit K, Kukongviriyapan U (2021) Curcumin mitigates hypertension, endothelial dysfunction and oxidative stress in rats with chronic exposure to lead and cadmium. Tohoku J Exp Med 253(1):69\u201376. https:\/\/doi.org\/10.1620\/tjem.253.69","journal-title":"Tohoku J Exp Med"},{"issue":"9","key":"329_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091422","volume":"10","author":"J Wang","year":"2021","unstructured":"Wang J, Jia R, Gong H, Celi P, Zhuo Y, Ding X, Bai S, Zeng Q, Yin H, Xu S, Liu J, Mao X, Zhang K (2021a) The effect of oxidative stress on the chicken ovary: involvement of microbiota and melatonin interventions. Antioxidants (Basel) 10(9):1422. https:\/\/doi.org\/10.3390\/antiox10091422","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"329_CR53","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1530\/JME-21-0095","volume":"67","author":"L Wang","year":"2021","unstructured":"Wang L, He W, Xu X, Qi L, Lv B, Qin J, Xue Z, Xue J (2021b) Pathological changes and oxidative stress of the HPG axis in hypothyroid rat. J Mol Endocrinol 67(3):107\u2013119. https:\/\/doi.org\/10.1530\/JME-21-0095","journal-title":"J Mol Endocrinol"},{"key":"329_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.911381","volume":"13","author":"J Wang","year":"2022","unstructured":"Wang J, Jia R, Celi P, Zhuo Y, Ding X, Zeng Q, Bai S, Xu S, Yin H, Lv L, Zhang K (2022) Resveratrol alleviating the ovarian function under oxidative stress by alternating microbiota related tryptophan-kynurenine pathway. Front Immunol 13:911381. https:\/\/doi.org\/10.3389\/fimmu.2022.911381","journal-title":"Front Immunol"},{"issue":"1","key":"329_CR55","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s13048-023-01272-5","volume":"16","author":"J Wang","year":"2023","unstructured":"Wang J, Zhao X, Luo R, Xia D, Liu Y, Shen T, Liang Y (2023) The causal association between systemic inflammatory regulators and primary ovarian insufficiency: a bidirectional mendelian randomization study. J Ovarian Res 16(1):191. https:\/\/doi.org\/10.1186\/s13048-023-01272-5","journal-title":"J Ovarian Res"},{"issue":"8","key":"329_CR56","doi-asserted-by":"publisher","first-page":"935","DOI":"10.3390\/antiox13080935","volume":"13","author":"X Wang","year":"2024","unstructured":"Wang X, Yuan Q, Xiao Y, Cai X, Yang Z, Zeng W, Mi Y, Zhang C (2024) Pterostilbene, a resveratrol derivative, improves ovary function by upregulating antioxidant defenses in the aging chickens via increased SIRT1\/nrf2 expression. Antioxidants (Basel) 13(8):935. https:\/\/doi.org\/10.3390\/antiox13080935","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"329_CR57","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41514-025-00216-1","volume":"11","author":"G Wang","year":"2025","unstructured":"Wang G, Yang R, Zhang H (2025) Ovarian vascular aging: a hidden driver of mid-age female fertility decline. NPJ Aging 11(1):24. https:\/\/doi.org\/10.1038\/s41514-025-00216-1","journal-title":"NPJ Aging"},{"issue":"1","key":"329_CR58","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s13287-022-02989-8","volume":"13","author":"W Xu","year":"2022","unstructured":"Xu W, Wu C, Zhu X, Wu J, Zhang Z, Wei Z, Cao Y, Zhou P, Wang J (2022a) UC-MSCs promote frozen-thawed ovaries angiogenesis via activation of the wnt\/\u03b2-catenin pathway in vitro ovarian culture system. Stem Cell Res Ther 13(1):296. https:\/\/doi.org\/10.1186\/s13287-022-02989-8","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"329_CR59","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi8683","volume":"8","author":"X Xu","year":"2022","unstructured":"Xu X, Mu L, Li L, Liang J, Zhang S, Jia L, Yang X, Dai Y, Zhang J, Wang Y, Niu S, Xia G, Yang Y, Zhang Y, Cao Y, Zhang H (2022b) Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging. Sci Adv 8(2):eabi8683. https:\/\/doi.org\/10.1126\/sciadv.abi8683","journal-title":"Sci Adv"},{"issue":"10","key":"329_CR60","doi-asserted-by":"publisher","first-page":"11983","DOI":"10.1002\/cam4.5873","volume":"12","author":"X Xu","year":"2023","unstructured":"Xu X, Shen L, Li W, Liu X, Yang P, Cai J (2023) ITGA5 promotes tumor angiogenesis in cervical cancer. Cancer Med 12(10):11983\u201311999. https:\/\/doi.org\/10.1002\/cam4.5873","journal-title":"Cancer Med"},{"issue":"10","key":"329_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2025.105613","volume":"104","author":"Y Xu","year":"2025","unstructured":"Xu Y, Xu K, Wang L, Zhu L, Long C, Lin Z, Dou J, Wang X, Qi X, Chen L, Sheng X (2025) Comparative morphological and lipidomic profiling of abdominal adipose tissue in Beijing you chickens at different ages and Ross 308 broilers. Poult Sci 104(10):105613. https:\/\/doi.org\/10.1016\/j.psj.2025.105613","journal-title":"Poult Sci"},{"issue":"7","key":"329_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071007","volume":"10","author":"Q Yan","year":"2021","unstructured":"Yan Q, Mao Z, Hong J, Gao K, Niimi M, Mitsui T, Yao J (2021) Tanshinone IIA stimulates cystathionine \u03b3-lyase expression and protects endothelial cells from oxidative injury. Antioxidants (Basel) 10(7):1007. https:\/\/doi.org\/10.3390\/antiox10071007","journal-title":"Antioxidants (Basel)"},{"key":"329_CR63","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-026-01035-2","author":"J Yang","year":"2026","unstructured":"Yang J, Qin K, Wang Q, Guo W, Yang X (2026) Gut commensal Parabacteroides goldsteinii-derived CDCA mediates FXR signalling to improve mucosal barrier function. NPJ Biofilms Microbiomes. https:\/\/doi.org\/10.1038\/s41522-026-01035-2","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"7","key":"329_CR64","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70638","volume":"13","author":"F Zahedi","year":"2025","unstructured":"Zahedi F, Kowsar R, Khodabandeh Z, Dara M, Alaee S (2025) Protective effects of gallic acid against lead acetate- induced toxicity in mice ovary: focus on apoptosis, inflammation, and folliculogenesis. Food Sci Nutr 13(7):e70638. https:\/\/doi.org\/10.1002\/fsn3.70638","journal-title":"Food Sci Nutr"},{"issue":"5","key":"329_CR65","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.3892\/etm.2021.10631","volume":"22","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Mao X, Cao A, Chu S, Li Z, Wang Y, Peng W, Wang L, Wang H (2021) Astragaloside IV prevents endothelial dysfunction by improving oxidative stress in streptozotocin-induced diabetic mouse aortas. Exp Ther Med 22(5):1197. https:\/\/doi.org\/10.3892\/etm.2021.10631","journal-title":"Exp Ther Med"},{"issue":"7","key":"329_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2024.103795","volume":"103","author":"T Zhang","year":"2024","unstructured":"Zhang T, Bai S, Ding X, Zeng Q, Xuan Y, Xu S, Mao X, Peng H, Zhang K, Wang J (2024) Pu-erh tea theabrownin improves the ovarian function and gut microbiota in laying hens. Poult Sci 103(7):103795. https:\/\/doi.org\/10.1016\/j.psj.2024.103795","journal-title":"Poult Sci"},{"issue":"1","key":"329_CR67","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3390\/genes14010141","volume":"14","author":"J Zhao","year":"2023","unstructured":"Zhao J, Pan H, Liu Y, He Y, Shi H, Ge C (2023) Interacting networks of the hypothalamic-pituitary-ovarian axis regulate layer hens performance. Genes (Basel) 14(1):141. https:\/\/doi.org\/10.3390\/genes14010141","journal-title":"Genes (Basel)"},{"issue":"3","key":"329_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2024.103914","volume":"49","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Wang J, Qin W, Hu Q, Li J, Qin R, Ma N, Zheng F, Tian W, Jiang J, Huang J, Qin A (2024) Dehydroepiandrosterone promotes ovarian angiogenesis and improves ovarian function in a rat model of premature ovarian insufficiency by up-regulating HIF-1\u03b1\/VEGF signalling. Reprod Biomed Online 49(3):103914. https:\/\/doi.org\/10.1016\/j.rbmo.2024.103914","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"329_CR69","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-025-22231-3","volume":"25","author":"H Zhou","year":"2025","unstructured":"Zhou H, Mao Y, Ye M, Zuo Z (2025) Exploring the nonlinear association between cardiometabolic index and hypertension in U.S. Adults: an NHANES-based study. BMC Public Health 25(1):1092. https:\/\/doi.org\/10.1186\/s12889-025-22231-3","journal-title":"BMC Public Health"}],"container-title":["Stress Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44154-026-00329-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44154-026-00329-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44154-026-00329-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:26:27Z","timestamp":1786501587000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44154-026-00329-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["329"],"URL":"https:\/\/doi.org\/10.1007\/s44154-026-00329-x","relation":{},"ISSN":["2097-4418","2731-0450"],"issn-type":[{"value":"2097-4418","type":"print"},{"value":"2731-0450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"19 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The protocol for the experimental animal procedures was approved by the Institutional Animal Care and Use Committee of Northwest A&F University (Permit Number: NWAFAC 1008). All efforts were made to provide a suitable habitat for laboratory animals.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agree to publish.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"60"}}