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This study aimed to investigate the impact of lycopene (Ly) on systemic inflammation, oxidative stress, and dysbiosis in mice exposed to T-2 toxin. A total of 20 male BALB\/c mice (6\u00a0weeks old, weighing 23.5\u2009\u00b1\u20090.32\u00a0g) randomly divided into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095): Control (Cont), Ly, T-2, and T-2\u2009+\u2009Ly groups. Findings revealed that Ly enhanced the body weight, feedd, and water intake that have been reduced by T-2. Ly increased the villus height (VH) and VH: crypt depth (CD) and decreased CD and villus width (VW) in ileum compared to the T-2 group. In alpha diversity,\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    and\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    were the most prevalent in Cont group;\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    , and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    , were the most prevalent in T-2 group;\n                    <jats:italic>Candidatus-Arthromitus<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    were the most prevalent in T-2\u2009+\u2009Ly group. Moreover, T-2 mice had significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) greater levels of interleukin-1 beta (IL-1\u03b2), interferon gamma (IFN-\u03b3), Interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-\u03b1) than Cont, while the Ly significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) lowered their concentration. The T-2 mice had significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) higher levels of reactive oxygen species (ROS) and malondialdehyde (MDA), while their catalase (CAT),, glutathione (GSH), adenosine triphosphate (ATP), and superoxide dismutase 1(SOD1) activities were significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) lower than Cont. Ly significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) restored their concentration. Moreover, there was a significant reduction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) of hexanoic, butyric, acetic, pentanoic, and Heptanoic acids in the T-2 mice compared to Cont. In contrast, treatment with Ly was found to significantly restore their levels compared to T-2 group. We conclude that Ly administration in the context of T-2\u2013induced toxicity may help attenuate systemic oxidative stress and inflammation, possibly through modulation of gut microbiota and fecal short-chain fatty acids (SCFAs).\n                  <\/jats:p>","DOI":"10.1007\/s44154-026-00331-3","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:55:54Z","timestamp":1789030554000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lycopene mitigates T-2 toxin-induced systemic inflammation and oxidative stress in association with gut microbiota and SCFAs regulation in mice"],"prefix":"10.1007","volume":"6","author":[{"given":"Saber Y.","family":"Adam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Ennab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuipeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkareem A.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Osman Abdalrahem","family":"Essa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosameldeen Mohamed","family":"Husien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-5292","authenticated-orcid":false,"given":"Demin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"331_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-024-01273-1","author":"A Acharya","year":"2024","unstructured":"Acharya A, Shetty PK, Sonkusare S, Padmanabha Ganeshkodi R, Padarthi Chitrabanu S, Acharya R, Somanatha H, Derappajjanamane D, Kumari Nalilu S (2024) Short-chain fatty acids ameliorates lipid profile, oxidative stress and inflammation in letrozole induced polycystic ovary syndrome rat model. 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