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In this study, FgMetR was identified as a putative binding partner of Fgk3, the\n                    <jats:italic>Fusarium graminearum<\/jats:italic>\n                    ortholog of Gsk3, although the specific functions of both proteins remain uncharacterized. Notably, the physical interaction between FgMetR and Fgk3 was confirmed via yeast two-hybrid (Y2H) assays, and both proteins were shown to co-localize within the nucleus. FgMetR was vital for mycelial growth, conidia development, deoxynivalenol (DON) production, oxidative stress response, and pathogenicity in\n                    <jats:italic>F. graminearum<\/jats:italic>\n                    . RNA-seq showed the Fgk3 and FgMetR co-regulated ABC transporters pathway and secondary metabolite biosynthesis. This study identified FgMetR as a new interacting protein of Fgk3, and demonstrated its crucial role in the growth, conidiation, DON production, and virulence of\n                    <jats:italic>F. graminearum<\/jats:italic>\n                    . It advanced the understanding of Fgk3 function in filamentous fungi and provided a theoretical basis for preventing Fusarium-related diseases.\n                  <\/jats:p>","DOI":"10.1007\/s44154-026-00342-0","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:48:09Z","timestamp":1789379289000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fgk3 interacts with FgMetR to regulate mycelial growth, conidia development, DON production, and pathogenicity in Fusarium graminearum"],"prefix":"10.1007","volume":"6","author":[{"given":"Min","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wende","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"342_CR1","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.pharmthera.2014.11.016","volume":"148","author":"E Beurel","year":"2015","unstructured":"Beurel E, Grieco SF, Jope RS (2015) Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. 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