{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:21:29Z","timestamp":1789464089016,"version":"build-2803163510"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stress Biology"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inducible gene expression is generally thought to be activated when transcription factors bind to promoter cis-elements, thereby recruiting the general transcriptional machinery to initiate gene transcription. However, the mechanisms that repress inducible genes under non-inducing conditions remain poorly understood. In this study, we identified a novel mutant,\n                    <jats:italic>shi6<\/jats:italic>\n                    , which exhibits slow growth, a dwarf phenotype, and elevated expression of a luciferase (LUC) reporter gene driven by a salt-inducible promoter. The\n                    <jats:italic>shi6<\/jats:italic>\n                    mutant also displayed increased sensitivity to abscisic acid (ABA), NaCl, and methyl jasmonate. Map-based cloning revealed that\n                    <jats:italic>SHI6<\/jats:italic>\n                    encodes the RNA helicase BRR2a, a core component required for pre-mRNA splicing and essential for plant embryogenesis. As expected, SHI6\/BRR2a was required for the proper splicing of stress-inducible genes. Unexpectedly, SHI6\/BRR2a also exhibited transcriptional activation activity in both yeast and Arabidopsis, suggesting that it associates with the transcriptional machinery and participates in gene transcription. Together, our findings demonstrate that SHI6\/BRR2a is a dual-function protein that plays essential roles in both pre-mRNA splicing and the repression of stress-inducible genes under non-inducing conditions.\n                  <\/jats:p>","DOI":"10.1007\/s44154-026-00345-x","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:15:50Z","timestamp":1789460150000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The splicing factor BRR2a functions as a repressor of stress-inducible genes"],"prefix":"10.1007","volume":"6","author":[{"given":"Jianfei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangshing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3817-9774","authenticated-orcid":false,"given":"Huazhong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"345_CR1","doi-asserted-by":"publisher","first-page":"3362","DOI":"10.1080\/15384101.2016.1249549","volume":"15","author":"E Absmeier","year":"2016","unstructured":"Absmeier E, Santos KF, Wahl MC (2016) Functions and regulation of the Brr2 RNA helicase during splicing. 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