{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:21:01Z","timestamp":1783441261548,"version":"3.54.6"},"reference-count":238,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["I 4854"],"award-info":[{"award-number":["I 4854"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Ment Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adverse influences during pregnancy are associated with a range of unfavorable outcomes for the developing offspring. Maternal psychosocial stress, exposure to infections and nutritional imbalances are known risk factors for neurodevelopmental derangements and according psychiatric and neurological manifestations later in offspring life. In this context, the maternal immune activation (MIA) model has been extensively used in preclinical research to study how stimulation of the maternal immune system during gestation derails the tightly coordinated sequence of fetal neurodevelopment. The ensuing consequence of MIA for offspring brain structure and function are majorly manifested in behavioral and cognitive abnormalities, phenotypically presenting during the periods of adolescence and adulthood. These observations have been interpreted within the framework of the \u201cdouble-hit-hypothesis\u201d suggesting that an elevated risk for neurodevelopmental disorders results from an individual being subjected to two adverse environmental influences at distinct periods of life, jointly leading to the emergence of pathology. The early postnatal period, during which the caregiving parent is the major determinant of the newborn\u00b4s environment, constitutes a window of vulnerability to external stimuli. Considering that MIA not only affects the developing fetus, but also impinges on the mother\u00b4s brain, which is in a state of heightened malleability during pregnancy, the impact of MIA on maternal brain function and behavior postpartum may importantly contribute to the detrimental consequences for her progeny. Here we review current information on the interaction between the prenatal and postnatal maternal environments in the modulation of offspring development and their relevance for the pathophysiology of the MIA model.<\/jats:p>","DOI":"10.1007\/s44192-023-00042-5","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:02:56Z","timestamp":1692705776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Interaction of the pre- and postnatal environment in the maternal immune activation model"],"prefix":"10.1007","volume":"3","author":[{"given":"Anna","family":"Gundacker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cuenca Rico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stoehrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina E.","family":"Tillmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Weber-Stadlbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela D.","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"42_CR1","first-page":"11994","volume-title":"International encyclopedia of the social & behavioral sciences","author":"LP Lipsitt","year":"2015","unstructured":"Lipsitt LP, Rovee-Collier C. Prenatal and infant development: overview. In: Smelser J, Baltes PB, editors. International encyclopedia of the social & behavioral sciences. Oxford: Pergamon; 2001. p. 11994\u20137."},{"key":"42_CR2","doi-asserted-by":"publisher","DOI":"10.1891\/9780826139146.0001","author":"C Kenner","year":"2019","unstructured":"Kenner C, Altimier LB, Boykova MV. Fetal development: environmental influences and critical periods. Compr Neonatal Nurs Care. 2019. https:\/\/doi.org\/10.1891\/9780826139146.0001.","journal-title":"Compr Neonatal Nurs Care"},{"key":"42_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.PNEUROBIO.2013.04.001","volume":"106\u2013107","author":"BD Semple","year":"2013","unstructured":"Semple BD, Blomgren K, Gimlin K, et al. Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species. Prog Neurobiol. 2013;106\u2013107:1\u201316. https:\/\/doi.org\/10.1016\/J.PNEUROBIO.2013.04.001.","journal-title":"Prog Neurobiol"},{"issue":"2","key":"42_CR4","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/35081509","volume":"27","author":"MH Johnson","year":"2001","unstructured":"Johnson MH. Functional brain development in humans. Nat Rev Neurosci. 2001;27(2):475\u201383. https:\/\/doi.org\/10.1038\/35081509.","journal-title":"Nat Rev Neurosci"},{"key":"42_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0149-7634(03)00005-8","volume":"27","author":"SL Andersen","year":"2003","unstructured":"Andersen SL. Trajectories of brain development: Point of vulnerability or window of opportunity? Neurosci Biobehav Rev. 2003;27:3\u201318. https:\/\/doi.org\/10.1016\/S0149-7634(03)00005-8.","journal-title":"Neurosci Biobehav Rev"},{"key":"42_CR6","doi-asserted-by":"publisher","first-page":"14098","DOI":"10.5812\/IJEM.14098","volume":"12","author":"O Tkachenko","year":"2014","unstructured":"Tkachenko O, Shchekochikhin D, Schrier RW. Hormones and hemodynamics in pregnancy. Int J Endocrinol Metab. 2014;12:14098. https:\/\/doi.org\/10.5812\/IJEM.14098.","journal-title":"Int J Endocrinol Metab"},{"key":"42_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41574-023-00871-y","volume":"2023","author":"R Haddad-T\u00f3volli","year":"2023","unstructured":"Haddad-T\u00f3volli R, Claret M. Metabolic and feeding adjustments during pregnancy. Nat Rev Endocrinol. 2023;2023:1\u201317. https:\/\/doi.org\/10.1038\/s41574-023-00871-y.","journal-title":"Nat Rev Endocrinol"},{"key":"42_CR8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/B978-0-444-64239-4.00002-3","volume":"171","author":"DR Grattan","year":"2020","unstructured":"Grattan DR, Ladyman SR. Neurophysiological and cognitive changes in pregnancy. Handb Clin Neurol. 2020;171:25\u201355. https:\/\/doi.org\/10.1016\/B978-0-444-64239-4.00002-3.","journal-title":"Handb Clin Neurol"},{"key":"42_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.06.007","volume-title":"Becoming a mother-circuit plasticity underlying maternal behavior","author":"YM Elyada","year":"2015","unstructured":"Elyada YM, Mizrahi A. Becoming a mother-circuit plasticity underlying maternal behavior. Amsterdam: Elsevier Ltd.; 2015."},{"key":"42_CR10","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/J.TINS.2015.04.004","volume":"38","author":"R Feldman","year":"2015","unstructured":"Feldman R. The adaptive human parental brain: implications for children\u2019s social development. Trends Neurosci. 2015;38:387\u201399. https:\/\/doi.org\/10.1016\/J.TINS.2015.04.004.","journal-title":"Trends Neurosci"},{"key":"42_CR11","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1177\/1073858406296401","volume":"13","author":"U Meyer","year":"2007","unstructured":"Meyer U, Yee BK, Feldon J. The neurodevelopmental impact of prenatal infections at different times of pregnancy: the earlier the worse? Neurosci. 2007;13:241\u201356. https:\/\/doi.org\/10.1177\/1073858406296401.","journal-title":"Neurosci"},{"key":"42_CR12","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/mp.2017.15","volume":"23","author":"MV Lombardo","year":"2018","unstructured":"Lombardo MV, Moon HM, Su J, et al. Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder. Mol Psychiatry. 2018;23:1001\u201313. https:\/\/doi.org\/10.1038\/mp.2017.15.","journal-title":"Mol Psychiatry"},{"key":"42_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2018.12.002","volume-title":"Brain changes in a maternal immune activation model of neurodevelopmental brain disorders","author":"L Bergdolt","year":"2019","unstructured":"Bergdolt L, Dunaevsky A. Brain changes in a maternal immune activation model of neurodevelopmental brain disorders. Oxford: Pergamon; 2019."},{"key":"42_CR14","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/s41582-021-00530-8","volume":"17","author":"VX Han","year":"2021","unstructured":"Han VX, Patel S, Jones HF, Dale RC. Maternal immune activation and neuroinflammation in human neurodevelopmental disorders. Nat Rev Neurol. 2021;17:564\u201379. https:\/\/doi.org\/10.1038\/s41582-021-00530-8.","journal-title":"Nat Rev Neurol"},{"key":"42_CR15","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00221-006-0419-5","volume":"173","author":"U Meyer","year":"2006","unstructured":"Meyer U, Schwendener S, Feldon J, Yee BK. Prenatal and postnatal maternal contributions in the infection model of schizophrenia. Exp Brain Res. 2006;173:243\u201357. https:\/\/doi.org\/10.1007\/s00221-006-0419-5.","journal-title":"Exp Brain Res"},{"key":"42_CR16","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.pharmthera.2015.01.001","volume":"149","author":"S Reisinger","year":"2015","unstructured":"Reisinger S, Khan D, Kong E, et al. The Poly(I:C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery. Pharmacol Ther. 2015;149:213\u201326. https:\/\/doi.org\/10.1016\/j.pharmthera.2015.01.001.","journal-title":"Pharmacol Ther"},{"key":"42_CR17","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1093\/JPIDS\/PIU050","volume":"3","author":"SH James","year":"2014","unstructured":"James SH, Sheffield JS, Kimberlin DW. Mother-to-child transmission of herpes simplex virus. J Pediatric Infect Dis Soc. 2014;3:S19. https:\/\/doi.org\/10.1093\/JPIDS\/PIU050.","journal-title":"J Pediatric Infect Dis Soc"},{"key":"42_CR18","doi-asserted-by":"publisher","first-page":"6808","DOI":"10.1128\/JVI.74.15.6808-6820.2000","volume":"74","author":"S Fisher","year":"2000","unstructured":"Fisher S, Genbacev O, Maidji E, Pereira L. Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis. J Virol. 2000;74:6808. https:\/\/doi.org\/10.1128\/JVI.74.15.6808-6820.2000.","journal-title":"J Virol"},{"key":"42_CR19","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jcv.2005.09.007","volume":"35","author":"JQ Andrade","year":"2006","unstructured":"Andrade JQ, Bunduki V, Curti SP, et al. Rubella in pregnancy: intrauterine transmission and perinatal outcome during a Brazilian epidemic. J Clin Virol. 2006;35:285\u201391. https:\/\/doi.org\/10.1016\/j.jcv.2005.09.007.","journal-title":"J Clin Virol"},{"key":"42_CR20","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1128\/IAI.05899-11","volume":"80","author":"JR Robbins","year":"2012","unstructured":"Robbins JR, Zeldovich VB, Poukchanski A, et al. Tissue barriers of the human placenta to infection with Toxoplasma gondii. Infect Immun. 2012;80:418. https:\/\/doi.org\/10.1128\/IAI.05899-11.","journal-title":"Infect Immun"},{"key":"42_CR21","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3389\/fimmu.2020.00175","volume":"11","author":"FME Teixeira","year":"2020","unstructured":"Teixeira FME, Pietrobon AJ, de Oliveira LM, et al. Maternal-fetal interplay in Zika virus infection and adverse perinatal outcomes. Front Immunol. 2020;11:175. https:\/\/doi.org\/10.3389\/fimmu.2020.00175.","journal-title":"Front Immunol"},{"key":"42_CR22","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat6114","author":"SE Ander","year":"2019","unstructured":"Ander SE, Diamond MS, Coyne CB. Immune responses at the maternal-fetal interface. Sci Immunol. 2019. https:\/\/doi.org\/10.1126\/sciimmunol.aat6114.","journal-title":"Sci Immunol"},{"key":"42_CR23","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1097\/00004872-199212000-00004","volume":"10","author":"DJP Barker","year":"1992","unstructured":"Barker DJP. The fetal origins of adult hypertension. J Hypertens. 1992;10:S39-44. https:\/\/doi.org\/10.1097\/00004872-199212000-00004.","journal-title":"J Hypertens"},{"key":"42_CR24","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1476-069X-11-42","volume":"11","author":"R Barouki","year":"2012","unstructured":"Barouki R, Gluckman PD, Grandjean P, et al. Developmental origins of non-communicable disease: implications for research and public health. Environ Heal. 2012;11:42. https:\/\/doi.org\/10.1186\/1476-069X-11-42.","journal-title":"Environ Heal"},{"key":"42_CR25","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1079\/PNS2001111","volume":"60","author":"SC Langley-Evans","year":"2001","unstructured":"Langley-Evans SC. Fetal programming of cardiovascular function through exposure to maternal undernutrition. Proc Nutr Soc. 2001;60:505\u201313. https:\/\/doi.org\/10.1079\/PNS2001111.","journal-title":"Proc Nutr Soc"},{"key":"42_CR26","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/S0024-3205(96)00611-X","volume":"60","author":"SC Langley-Evans","year":"1997","unstructured":"Langley-Evans SC. Intrauterine programming of hypertension by glucocorticoids. Life Sci. 1997;60:1213\u201321. https:\/\/doi.org\/10.1016\/S0024-3205(96)00611-X.","journal-title":"Life Sci"},{"key":"42_CR27","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1161\/01.HYP.27.6.1200","volume":"27","author":"RS Lindsay","year":"1996","unstructured":"Lindsay RS, Lindsay RM, Edwards CRW, Seckl JR. Inhibition of 11-beta-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring. Hypertens. 1996;27:1200\u20134. https:\/\/doi.org\/10.1161\/01.HYP.27.6.1200.","journal-title":"Hypertens"},{"key":"42_CR28","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1046\/j.1460-9568.2000.00958.x","volume":"12","author":"LAM Welberg","year":"2000","unstructured":"Welberg LAM, Seckl JR, Holmes MC. Inhibition of 11\u03b2-hydroxysteroid dehydrogenase, the foetoplacental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. Eur J Neurosci. 2000;12:1047\u201354. https:\/\/doi.org\/10.1046\/j.1460-9568.2000.00958.x.","journal-title":"Eur J Neurosci"},{"key":"42_CR29","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1210\/ENDO.142.7.8238","volume":"142","author":"C Bertram","year":"2001","unstructured":"Bertram C, Trowern AR, Copin N, et al. The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11beta-hydroxysteroid dehydrogenase: potential molecular mechanisms underlying the programming of hypertension in utero. Endocrinology. 2001;142:2841\u201353. https:\/\/doi.org\/10.1210\/ENDO.142.7.8238.","journal-title":"Endocrinology"},{"key":"42_CR30","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1203\/01.PDR.0000127012.37315.36","volume":"55","author":"P Pladys","year":"2004","unstructured":"Pladys P, Lahaie I, Cambonie G, et al. Role of brain and peripheral angiotensin ii in hypertension and altered arterial baroreflex programmed during fetal life in rat. Pediatr Res. 2004;55:1042\u20139. https:\/\/doi.org\/10.1203\/01.PDR.0000127012.37315.36.","journal-title":"Pediatr Res"},{"key":"42_CR31","first-page":"175","volume-title":"Progress in molecular biology and translational science","author":"C Liu","year":"2018","unstructured":"Liu C, Jiao C, Wang K, Yuan N. DNA methylation and psychiatric disorders. In: Grayson DR, editor. Progress in molecular biology and translational science. Amsterdam: Elsevier Inc.; 2018. p. 175\u2013232."},{"key":"42_CR32","first-page":"6","volume":"35","author":"S Zakhari","year":"2012","unstructured":"Zakhari S. Alcohol metabolism and epigenetics changes. Alcohol Res Curr Rev. 2012;35:6\u201316.","journal-title":"Alcohol Res Curr Rev"},{"issue":"12","key":"42_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-022-01785-5","volume":"121","author":"SP Zoubovsky","year":"2022","unstructured":"Zoubovsky SP, Williams MT, Hoseus S, et al. Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment. Transl Psychiatry. 2022;121(12):1\u201310. https:\/\/doi.org\/10.1038\/s41398-022-01785-5.","journal-title":"Transl Psychiatry"},{"issue":"47","key":"42_CR34","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1203\/00006450-200002000-00011","volume":"472","author":"P Franco","year":"2000","unstructured":"Franco P, Chabanski S, Szliwowski H, et al. Influence of maternal smoking on autonomic nervous system in healthy infants. Pediatr Res. 2000;472(47):215\u2013215. https:\/\/doi.org\/10.1203\/00006450-200002000-00011.","journal-title":"Pediatr Res"},{"key":"42_CR35","doi-asserted-by":"publisher","first-page":"455","DOI":"10.4088\/PCC.v09n0608","volume":"9","author":"CG Bhuvaneswar","year":"2007","unstructured":"Bhuvaneswar CG, Chang G, Epstein LA, Stern TA. Alcohol use during pregnancy: Prevalence and impact. Prim Care Companion J Clin Psychiatry. 2007;9:455\u201360. https:\/\/doi.org\/10.4088\/PCC.v09n0608.","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"42_CR36","first-page":"331","volume":"37","author":"FT Crews","year":"2015","unstructured":"Crews FT, Sarkar DK, Qin L, et al. Neuroimmune function and the consequences of alcohol exposure. Alcohol Res Curr Rev. 2015;37:331\u201351.","journal-title":"Alcohol Res Curr Rev"},{"key":"42_CR37","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/nn.2436","volume":"12","author":"C Murgatroyd","year":"2009","unstructured":"Murgatroyd C, Patchev AV, Wu Y, et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci. 2009;12:1559\u201366. https:\/\/doi.org\/10.1038\/nn.2436.","journal-title":"Nat Neurosci"},{"key":"42_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01744-y","author":"H DeRosa","year":"2022","unstructured":"DeRosa H, Caradonna SG, Tran H, et al. Got milk? Maternal immune activation during the mid-lactational period affects nutritional milk quality and adolescent offspring sensory processing in male and female rats. Mol Psychiatry. 2022. https:\/\/doi.org\/10.1038\/s41380-022-01744-y.","journal-title":"Mol Psychiatry"},{"key":"42_CR39","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.pnpbp.2017.12.016","volume":"83","author":"X Yan","year":"2018","unstructured":"Yan X, Zhao X, Li J, et al. Effects of early-life malnutrition on neurodevelopment and neuropsychiatric disorders and the potential mechanisms. Prog Neuro-Psychopharmacol Biol Psychiatry. 2018;83:64\u201375. https:\/\/doi.org\/10.1016\/j.pnpbp.2017.12.016.","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"42_CR40","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/0002-9378(80)90249-5","volume":"138","author":"I Thaler","year":"1980","unstructured":"Thaler I, Goodman JDS, Dawes GS. Effects of maternal cigarette smoking on fetal breathing and fetal movements. Am J Obstet Gynecol. 1980;138:282\u20137. https:\/\/doi.org\/10.1016\/0002-9378(80)90249-5.","journal-title":"Am J Obstet Gynecol"},{"key":"42_CR41","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/0002-9378(84)90156-X","volume":"149","author":"M Mochizuki","year":"1984","unstructured":"Mochizuki M, Maruo T, Masuko K, Ohtsu T. Effects of smoking on fetoplacental-maternal system during pregnancy. Am J Obstet Gynecol. 1984;149:413\u201320. https:\/\/doi.org\/10.1016\/0002-9378(84)90156-X.","journal-title":"Am J Obstet Gynecol"},{"key":"42_CR42","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1055\/S-2007-994787","volume":"9","author":"P Arbeille","year":"1992","unstructured":"Arbeille P, Bosc M, Vaillant TF. Nicotine-induced changes in the cerebral circulation in ovine fetuses. Am J Perinatol. 1992;9:270\u20134. https:\/\/doi.org\/10.1055\/S-2007-994787.","journal-title":"Am J Perinatol"},{"key":"42_CR43","doi-asserted-by":"publisher","first-page":"506","DOI":"10.5468\/ogs.2017.60.6.506","volume":"60","author":"EJ Kwon","year":"2017","unstructured":"Kwon EJ, Kim YJ. What is fetal programming?: a lifetime health is under the control of in utero health. Obstet Gynecol Sci. 2017;60:506. https:\/\/doi.org\/10.5468\/ogs.2017.60.6.506.","journal-title":"Obstet Gynecol Sci"},{"key":"42_CR44","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0022-3956(99)00039-4","volume":"33","author":"TA Bayer","year":"1999","unstructured":"Bayer TA, Falkai P, Maier W. Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the \u201cTwo hit hypothesis.\u201d J Psychiatr Res. 1999;33:543\u20138. https:\/\/doi.org\/10.1016\/S0022-3956(99)00039-4.","journal-title":"J Psychiatr Res"},{"key":"42_CR45","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.expneurol.2014.01.023","volume":"259","author":"JE Catuzzi","year":"2014","unstructured":"Catuzzi JE, Beck KD. Anxiety vulnerability in women: a two-hit hypothesis. Exp Neurol. 2014;259:75\u201380. https:\/\/doi.org\/10.1016\/j.expneurol.2014.01.023.","journal-title":"Exp Neurol"},{"key":"42_CR46","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1126\/science.aag3194","volume":"353","author":"ML Estes","year":"2016","unstructured":"Estes ML, McAllister AK. Maternal immune activation: implications for neuropsychiatric disorders. Science. 2016;353:772\u20137. https:\/\/doi.org\/10.1126\/science.aag3194.","journal-title":"Science"},{"key":"42_CR47","doi-asserted-by":"publisher","first-page":"F513","DOI":"10.1136\/ADC.2005.091405","volume":"92","author":"PM Dunn","year":"2007","unstructured":"Dunn PM. Perinatal lessons from the past: Sir Norman Gregg, ChM, MC, of Sydney (1892\u20131966) and rubella embryopathy. Arch Dis Child Fetal Neonatal Ed. 2007;92:F513. https:\/\/doi.org\/10.1136\/ADC.2005.091405.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"42_CR48","doi-asserted-by":"publisher","first-page":"552.e1","DOI":"10.1016\/j.ajog.2010.06.002","volume":"203","author":"A Berr\u00e9bi","year":"2010","unstructured":"Berr\u00e9bi A, Assouline C, Bessi\u00e8res MH, et al. Long-term outcome of children with congenital toxoplasmosis. Am J Obstet Gynecol. 2010;203:552.e1-552.e6. https:\/\/doi.org\/10.1016\/j.ajog.2010.06.002.","journal-title":"Am J Obstet Gynecol"},{"key":"42_CR49","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1136\/BJO.79.6.581","volume":"79","author":"C Meenken","year":"1995","unstructured":"Meenken C, Assies J, Van Nieuwenhuizen O, et al. Long term ocular and neurological involvement in severe congenital toxoplasmosis. Br J Ophthalmol. 1995;79:581\u20134. https:\/\/doi.org\/10.1136\/BJO.79.6.581.","journal-title":"Br J Ophthalmol"},{"key":"42_CR50","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1515\/jpem.2002.15.9.1487","volume":"15","author":"N Setian","year":"2002","unstructured":"Setian N, Andrade RSF, Kuperman H, et al. Precocious puberty: an endocrine manifestation on congenital toxoplasmosis. J Pediatr Endocrinol Metab. 2002;15:1487\u201390. https:\/\/doi.org\/10.1515\/jpem.2002.15.9.1487.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"42_CR51","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1542\/peds.82.2.181","volume":"82","author":"JL Sever","year":"1988","unstructured":"Sever JL, Ellenberg JH, Ley AC, et al. Toxoplasmosis: maternal and pediatric findings in 23,000 pregnancies. Pediatrics. 1988;82:181\u201392. https:\/\/doi.org\/10.1542\/peds.82.2.181.","journal-title":"Pediatrics"},{"key":"42_CR52","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1176\/APPI.AJP.157.3.438","volume":"157","author":"AS Brown","year":"2000","unstructured":"Brown AS, Cohen P, Greenwald S, Susser E. Nonaffective psychosis after prenatal exposure to rubella. Am J Psychiatry. 2000;157:438\u201343. https:\/\/doi.org\/10.1176\/APPI.AJP.157.3.438.","journal-title":"Am J Psychiatry"},{"key":"42_CR53","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0006-3223(01)01068-X","volume":"49","author":"AS Brown","year":"2001","unstructured":"Brown AS, Cohen P, Harkavy-Friedman J, et al. Prenatal rubella, premorbid abnormalities, and adult schizophrenia. Biol Psychiatry. 2001;49:473\u201386. https:\/\/doi.org\/10.1016\/S0006-3223(01)01068-X.","journal-title":"Biol Psychiatry"},{"key":"42_CR54","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1523\/jneurosci.23-01-00297.2003","volume":"23","author":"L Shi","year":"2003","unstructured":"Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci. 2003;23:297\u2013302. https:\/\/doi.org\/10.1523\/jneurosci.23-01-00297.2003.","journal-title":"J Neurosci"},{"key":"42_CR55","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/SYN.20162","volume":"57","author":"SH Fatemi","year":"2005","unstructured":"Fatemi SH, Pearce DA, Brooks AI, Sidwell RW. Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: a potential animal model for schizophrenia and autism. Synapse. 2005;57:91\u20139. https:\/\/doi.org\/10.1002\/SYN.20162.","journal-title":"Synapse"},{"key":"42_CR56","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/ACPS.13295","volume":"143","author":"A Tanskanen","year":"2021","unstructured":"Tanskanen A, Taipale H, Cannon M, et al. Incidence of schizophrenia and influence of prenatal and infant exposure to viral infectious diseases. Acta Psychiatr Scand. 2021;143:487\u201394. https:\/\/doi.org\/10.1111\/ACPS.13295.","journal-title":"Acta Psychiatr Scand"},{"key":"42_CR57","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1192\/BJP.160.4.461","volume":"160","author":"PC Sham","year":"1992","unstructured":"Sham PC, O\u2019Callaghan E, Takei N, et al. Schizophrenia following pre-natal exposure to influenza epidemics between 1939 and 1960. Br J Psychiatry. 1992;160:461\u20136. https:\/\/doi.org\/10.1192\/BJP.160.4.461.","journal-title":"Br J Psychiatry"},{"key":"42_CR58","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1001\/ARCHPSYC.1990.01810210077012","volume":"47","author":"CE Barr","year":"1990","unstructured":"Barr CE, Mednick SA, Munk Jorgensen P. Exposure to influenza epidemics during gestation and adult schizophrenia: a 40-year study. Arch Gen Psychiatry. 1990;47:869\u201374. https:\/\/doi.org\/10.1001\/ARCHPSYC.1990.01810210077012.","journal-title":"Arch Gen Psychiatry"},{"key":"42_CR59","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1001\/ARCHPEDI.1965.02090030415009","volume":"110","author":"JL Sever","year":"1965","unstructured":"Sever JL, Nelson KB, Gilkeson MR. Rubella epidemic, 1964: effect on 6,000 pregnancies. Am J Dis Child. 1965;110:395\u2013407. https:\/\/doi.org\/10.1001\/ARCHPEDI.1965.02090030415009.","journal-title":"Am J Dis Child"},{"key":"42_CR60","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1136\/BMJ.2.5475.1401","volume":"2","author":"JM Lindquist","year":"1965","unstructured":"Lindquist JM, Plotkin SA, Shaw L, et al. Congenital rubella syndrome as a systemic infection: studies of affected infants born in Philadelphia, U.S.A. Br Med J. 1965;2:1401\u20135. https:\/\/doi.org\/10.1136\/BMJ.2.5475.1401.","journal-title":"Br Med J"},{"key":"42_CR61","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1001\/jamapsychiatry.2019.0029","volume":"76","author":"BJSS Al-Haddad","year":"2019","unstructured":"Al-Haddad BJSS, Jacobsson B, Chabra S, et al. Long-term risk of neuropsychiatric disease after exposure to infection in utero. JAMA Psychiat. 2019;76:594. https:\/\/doi.org\/10.1001\/jamapsychiatry.2019.0029.","journal-title":"JAMA Psychiat"},{"key":"42_CR62","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s11126-020-09843-1","volume":"92","author":"ZA Oskovi-Kaplan","year":"2021","unstructured":"Oskovi-Kaplan ZA, Buyuk GN, Ozgu-Erdinc AS, et al. The effect of COVID-19 pandemic and social restrictions on depression rates and maternal attachment in immediate postpartum women: a preliminary study. Psychiatr Q. 2021;92:675\u201382. https:\/\/doi.org\/10.1007\/s11126-020-09843-1.","journal-title":"Psychiatr Q"},{"key":"42_CR63","doi-asserted-by":"publisher","first-page":"E2238941","DOI":"10.1001\/jamanetworkopen.2022.38941","volume":"5","author":"K Hessami","year":"2022","unstructured":"Hessami K, Norooznezhad AH, Monteiro S, et al. COVID-19 pandemic and infant neurodevelopmental impairment: a systematic review and meta-analysis. JAMA Netw Open. 2022;5:E2238941. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.38941.","journal-title":"JAMA Netw Open"},{"key":"42_CR64","doi-asserted-by":"publisher","first-page":"E2215787","DOI":"10.1001\/jamanetworkopen.2022.15787","volume":"5","author":"AG Edlow","year":"2022","unstructured":"Edlow AG, Castro VM, Shook LL, et al. Neurodevelopmental outcomes at 1 year in infants of mothers who tested positive for SARS-CoV-2 during pregnancy. JAMA Netw Open. 2022;5:E2215787. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.15787.","journal-title":"JAMA Netw Open"},{"key":"42_CR65","doi-asserted-by":"publisher","first-page":"101427","DOI":"10.1016\/j.siny.2023.101427","volume":"28","author":"AC Brum","year":"2023","unstructured":"Brum AC, Vain NE. Impact of perinatal COVID on fetal and neonatal brain and neurodevelopmental outcomes. Semin Fetal Neonatal Med. 2023;28:101427. https:\/\/doi.org\/10.1016\/j.siny.2023.101427.","journal-title":"Semin Fetal Neonatal Med"},{"key":"42_CR66","doi-asserted-by":"publisher","first-page":"R99","DOI":"10.1152\/ajpregu.00087.2021","volume":"322","author":"M Bao","year":"2022","unstructured":"Bao M, Hofsink N, Pl\u00f6sch T. LPS versus Poly I: C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring. Am J Physiol Integr Comp Physiol. 2022;322:R99\u2013111. https:\/\/doi.org\/10.1152\/ajpregu.00087.2021.","journal-title":"Am J Physiol Integr Comp Physiol"},{"key":"42_CR67","doi-asserted-by":"publisher","first-page":"4097","DOI":"10.3390\/IJMS21114097","volume":"21","author":"M Cie\u015blik","year":"2020","unstructured":"Cie\u015blik M, G\u0105ssowska-Dobrowolska M, J\u0119\u015bko H, et al. Maternal immune activation induces neuroinflammation and cortical synaptic deficits in the adolescent rat offspring. Int J Mol Sci. 2020;21:4097. https:\/\/doi.org\/10.3390\/IJMS21114097.","journal-title":"Int J Mol Sci"},{"key":"42_CR68","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.bbi.2005.11.003","volume":"20","author":"U Meyer","year":"2006","unstructured":"Meyer U, Feldon J, Schedlowski M, Yee BK. Immunological stress at the maternal-foetal interface: a link between neurodevelopment and adult psychopathology. Brain Behav Immun. 2006;20:378\u201388. https:\/\/doi.org\/10.1016\/j.bbi.2005.11.003.","journal-title":"Brain Behav Immun"},{"key":"42_CR69","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.semcdb.2019.06.006","volume":"97","author":"DD Pollak","year":"2020","unstructured":"Pollak DD, Weber-Stadlbauer U. Transgenerational consequences of maternal immune activation. Semin Cell Dev Biol. 2020;97:181\u20138. https:\/\/doi.org\/10.1016\/j.semcdb.2019.06.006.","journal-title":"Semin Cell Dev Biol"},{"key":"42_CR70","doi-asserted-by":"publisher","first-page":"e16638","DOI":"10.1371\/JOURNAL.PONE.0016638","volume":"6","author":"MY Deng","year":"2011","unstructured":"Deng MY, Lam S, Meyer U, et al. Frontal-subcortical protein expression following prenatal exposure to maternal inflammation. PLoS ONE. 2011;6:e16638. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0016638.","journal-title":"PLoS ONE"},{"key":"42_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/J.YNSTR.2023.100538","author":"H DeRosa","year":"2023","unstructured":"DeRosa H, Smith A, Geist L, et al. Maternal immune activation alters placental histone-3 lysine-9 tri-methylation, offspring sensorimotor processing, and hypothalamic transposable element expression in a sex-specific manner. Neurobiol Stress. 2023. https:\/\/doi.org\/10.1016\/J.YNSTR.2023.100538.","journal-title":"Neurobiol Stress"},{"key":"42_CR72","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/j.neuropharm.2011.01.009","volume":"62","author":"U Meyer","year":"2012","unstructured":"Meyer U, Feldon J. To poly(I:C) or not to poly(I:C): advancing preclinical schizophrenia research through the use of prenatal immune activation models. Neuropharmacology. 2012;62:1308\u201321. https:\/\/doi.org\/10.1016\/j.neuropharm.2011.01.009.","journal-title":"Neuropharmacology"},{"key":"42_CR73","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/imr.13125","volume":"311","author":"AM Otero","year":"2022","unstructured":"Otero AM, Antonson AM. At the crux of maternal immune activation: viruses, microglia, microbes, and IL-17A. Immunol Rev. 2022;311:205\u201323. https:\/\/doi.org\/10.1111\/imr.13125.","journal-title":"Immunol Rev"},{"key":"42_CR74","doi-asserted-by":"publisher","first-page":"688","DOI":"10.2174\/1570159X14666151215095359","volume":"14","author":"M Ronovsky","year":"2016","unstructured":"Ronovsky M, Berger S, Molz B, et al. Animal models of maternal immune activation in depression research. Curr Neuropharmacol. 2016;14:688\u2013704. https:\/\/doi.org\/10.2174\/1570159X14666151215095359.","journal-title":"Curr Neuropharmacol"},{"key":"42_CR75","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41386-018-0185-7","volume":"44","author":"AC Kentner","year":"2019","unstructured":"Kentner AC, Bilbo SD, Brown AS, et al. Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model. Neuropsychopharmacology. 2019;44:245\u201358. https:\/\/doi.org\/10.1038\/s41386-018-0185-7.","journal-title":"Neuropsychopharmacology"},{"key":"42_CR76","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.biopsych.2013.07.011","volume":"75","author":"U Meyer","year":"2014","unstructured":"Meyer U. Prenatal poly(I:C) exposure and other developmental immune activation models in rodent systems. Biol Psychiatry. 2014;75:307\u201315. https:\/\/doi.org\/10.1016\/j.biopsych.2013.07.011.","journal-title":"Biol Psychiatry"},{"key":"42_CR77","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.neubiorev.2020.04.012","volume":"113","author":"FL Haddad","year":"2020","unstructured":"Haddad FL, Patel SV, Schmid S. Maternal immune activation by poly I: C as a preclinical model for neurodevelopmental disorders: a focus on autism and schizophrenia. Neurosci Biobehav Rev. 2020;113:546\u201367.","journal-title":"Neurosci Biobehav Rev"},{"key":"42_CR78","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.tins.2019.08.001","volume":"42","author":"U Meyer","year":"2019","unstructured":"Meyer U. Neurodevelopmental resilience and susceptibility to maternal immune activation. Trends Neurosci. 2019;42:793\u2013806. https:\/\/doi.org\/10.1016\/j.tins.2019.08.001.","journal-title":"Trends Neurosci"},{"key":"42_CR79","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1126\/SCIENCE.AAD0314","volume":"351","author":"GB Choi","year":"2016","unstructured":"Choi GB, Yim YS, Wong H, et al. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016;351:933\u20139. https:\/\/doi.org\/10.1126\/SCIENCE.AAD0314.","journal-title":"Science"},{"key":"42_CR80","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/S41586-019-1843-6","volume":"577","author":"MD Reed","year":"2020","unstructured":"Reed MD, Yim YS, Wimmer RD, et al. IL-17a promotes sociability in mouse models of neurodevelopmental disorders. Nature. 2020;577:249\u201353. https:\/\/doi.org\/10.1038\/S41586-019-1843-6.","journal-title":"Nature"},{"key":"42_CR81","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/NATURE23910","volume":"549","author":"S Kim","year":"2017","unstructured":"Kim S, Kim H, Yim YS, et al. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature. 2017;549:528\u201332. https:\/\/doi.org\/10.1038\/NATURE23910.","journal-title":"Nature"},{"issue":"6","key":"42_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep29885","volume":"61","author":"X Zhu","year":"2016","unstructured":"Zhu X, Levasseur PR, Michaelis KA, et al. A distinct brain pathway links viral RNA exposure to sickness behavior. Sci Rep. 2016;61(6):1\u201315. https:\/\/doi.org\/10.1038\/srep29885.","journal-title":"Sci Rep"},{"key":"42_CR83","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nature08365","volume":"461","author":"D Reich","year":"2009","unstructured":"Reich D, Thangaraj K, Patterson N, et al. Reconstructing Indian population history. Nature. 2009;461:489\u201394. https:\/\/doi.org\/10.1038\/nature08365.","journal-title":"Nature"},{"key":"42_CR84","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000348384","volume":"74","author":"CHD Fall","year":"2013","unstructured":"Fall CHD. Fetal malnutrition and long-term outcomes. Nestle Nutr Inst Workshop Ser. 2013;74:11\u201325.","journal-title":"Nestle Nutr Inst Workshop Ser"},{"key":"42_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13229-017-0125-0","volume":"8","author":"S Vuillermot","year":"2017","unstructured":"Vuillermot S, Luan W, Meyer U, Eyles D. Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. Mol Autism. 2017;8:1\u201313. https:\/\/doi.org\/10.1186\/s13229-017-0125-0.","journal-title":"Mol Autism"},{"key":"42_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-28090-w","volume":"8","author":"W Luan","year":"2018","unstructured":"Luan W, Hammond LA, Vuillermot S, et al. Maternal vitamin D prevents abnormal dopaminergic development and function in a mouse model of prenatal immune activation. Sci Rep. 2018;8:1\u201312. https:\/\/doi.org\/10.1038\/s41598-018-28090-w.","journal-title":"Sci Rep"},{"key":"42_CR87","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/J.BBR.2007.04.016","volume":"181","author":"ME Fortier","year":"2007","unstructured":"Fortier ME, Luheshi GN, Boksa P. Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancy. Behav Brain Res. 2007;181:270\u20137. https:\/\/doi.org\/10.1016\/J.BBR.2007.04.016.","journal-title":"Behav Brain Res"},{"key":"42_CR88","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.bbi.2014.06.013","volume":"42","author":"S Missault","year":"2014","unstructured":"Missault S, Van den Eynde K, Vanden Berghe W, et al. The risk for behavioural deficits is determined by the maternal immune response to prenatal immune challenge in a neurodevelopmental model. Brain Behav Immun. 2014;42:138\u201346. https:\/\/doi.org\/10.1016\/j.bbi.2014.06.013.","journal-title":"Brain Behav Immun"},{"key":"42_CR89","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.biopsych.2021.03.017","volume":"90","author":"E Guma","year":"2021","unstructured":"Guma E, do Bordignon PC, Devenyi GA, et al. Early or late gestational exposure to maternal immune activation alters neurodevelopmental trajectories in mice: an integrated neuroimaging, behavioral, and transcriptional study. Biol Psychiatry. 2021;90:328\u201341. https:\/\/doi.org\/10.1016\/j.biopsych.2021.03.017.","journal-title":"Biol Psychiatry"},{"key":"42_CR90","doi-asserted-by":"publisher","first-page":"4752","DOI":"10.1523\/JNEUROSCI.0099-06.2006","volume":"26","author":"U Meyer","year":"2006","unstructured":"Meyer U, Nyffeler M, Engler A, et al. The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J Neurosci. 2006;26:4752\u201362. https:\/\/doi.org\/10.1523\/JNEUROSCI.0099-06.2006.","journal-title":"J Neurosci"},{"issue":"4","key":"42_CR91","doi-asserted-by":"publisher","first-page":"e363","DOI":"10.1038\/tp.2013.132","volume":"42","author":"D Khan","year":"2014","unstructured":"Khan D, Fernando P, Cicvaric A, et al. Long-term effects of maternal immune activation on depression-like behavior in the mouse. Transl Psychiatry. 2014;42(4):e363\u2013e363. https:\/\/doi.org\/10.1038\/tp.2013.132.","journal-title":"Transl Psychiatry"},{"key":"42_CR92","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.biopsych.2005.07.031","volume":"59","author":"K Ozawa","year":"2006","unstructured":"Ozawa K, Hashimoto K, Kishimoto T, et al. Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia. Biol Psychiatry. 2006;59:546\u201354. https:\/\/doi.org\/10.1016\/j.biopsych.2005.07.031.","journal-title":"Biol Psychiatry"},{"key":"42_CR93","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.bbi.2013.12.003","volume":"37","author":"S Babri","year":"2014","unstructured":"Babri S, Doosti M-H, Salari A-A. Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring. Brain Behav Immun. 2014;37:164\u201376. https:\/\/doi.org\/10.1016\/j.bbi.2013.12.003.","journal-title":"Brain Behav Immun"},{"key":"42_CR94","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbi.2018.09.005","volume":"75","author":"KN Murray","year":"2019","unstructured":"Murray KN, Edye ME, Manca M, et al. Evolution of a maternal immune activation (mIA) model in rats: early developmental effects. Brain Behav Immun. 2019;75:48\u201359. https:\/\/doi.org\/10.1016\/j.bbi.2018.09.005.","journal-title":"Brain Behav Immun"},{"key":"42_CR95","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.biopsych.2016.10.020","volume":"81","author":"M Careaga","year":"2017","unstructured":"Careaga M, Murai T, Bauman MD. Maternal immune activation and autism spectrum disorder: from rodents to nonhuman and human primates. Biol Psychiatry. 2017;81:391\u2013401. https:\/\/doi.org\/10.1016\/j.biopsych.2016.10.020.","journal-title":"Biol Psychiatry"},{"key":"42_CR96","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.bbi.2016.10.016","volume":"63","author":"M Ronovsky","year":"2017","unstructured":"Ronovsky M, Berger S, Zambon A, et al. Maternal immune activation transgenerationally modulates maternal care and offspring depression-like behavior. Brain Behav Immun. 2017;63:127\u201336. https:\/\/doi.org\/10.1016\/j.bbi.2016.10.016.","journal-title":"Brain Behav Immun"},{"key":"42_CR97","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.bbi.2013.07.006","volume":"33","author":"J Richetto","year":"2013","unstructured":"Richetto J, Calabrese F, Meyer U, Riva MA. Prenatal versus postnatal maternal factors in the development of infection-induced working memory impairments in mice. Brain Behav Immun. 2013;33:190\u2013200. https:\/\/doi.org\/10.1016\/j.bbi.2013.07.006.","journal-title":"Brain Behav Immun"},{"key":"42_CR98","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1126\/science.1228261","volume":"339","author":"S Giovanoli","year":"2013","unstructured":"Giovanoli S, Engler H, Engler A, et al. Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science. 2013;339:1100\u20132. https:\/\/doi.org\/10.1126\/science.1228261.","journal-title":"Science"},{"key":"42_CR99","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.bbi.2018.02.008","volume":"70","author":"S Berger","year":"2018","unstructured":"Berger S, Ronovsky M, Horvath O, et al. Impact of maternal immune activation on maternal care behavior, offspring emotionality and intergenerational transmission in C3H\/He mice. Brain Behav Immun. 2018;70:131\u201340. https:\/\/doi.org\/10.1016\/j.bbi.2018.02.008.","journal-title":"Brain Behav Immun"},{"key":"42_CR100","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.psyneuen.2012.01.005","volume":"37","author":"AK Walker","year":"2012","unstructured":"Walker AK, Hawkins G, Sominsky L, Hodgson DM. Transgenerational transmission of anxiety induced by neonatal exposure to lipopolysaccharide: implications for male and female germ lines. Psychoneuroendocrinology. 2012;37:1320\u201335. https:\/\/doi.org\/10.1016\/j.psyneuen.2012.01.005.","journal-title":"Psychoneuroendocrinology"},{"key":"42_CR101","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuroscience.2014.06.028","volume":"277","author":"C O\u2019Leary","year":"2014","unstructured":"O\u2019Leary C, Desbonnet L, Clarke N, et al. Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1. Neuroscience. 2014;277:294\u2013305. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.06.028.","journal-title":"Neuroscience"},{"key":"42_CR102","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41398-021-01361-3","volume":"11","author":"LA Quagliato","year":"2021","unstructured":"Quagliato LA, de Matos U, Nardi AE. Maternal immune activation generates anxiety in offspring: a translational meta-analysis. Transl Psychiatry. 2021;11:4\u20139. https:\/\/doi.org\/10.1038\/s41398-021-01361-3.","journal-title":"Transl Psychiatry"},{"key":"42_CR103","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.bbi.2019.04.019","volume":"80","author":"FS Mueller","year":"2019","unstructured":"Mueller FS, Richetto J, Hayes LN, et al. Influence of poly (I: C ) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation. Brain Behav Immun. 2019;80:406\u201318. https:\/\/doi.org\/10.1016\/j.bbi.2019.04.019.","journal-title":"Brain Behav Immun"},{"key":"42_CR104","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.bbi.2020.04.061","volume":"88","author":"ML Estes","year":"2020","unstructured":"Estes ML, Prendergast K, MacMahon JA, et al. Baseline immunoreactivity before pregnancy and poly(I:C) dose combine to dictate susceptibility and resilience of offspring to maternal immune activation. Brain Behav Immun. 2020;88:619\u201330. https:\/\/doi.org\/10.1016\/j.bbi.2020.04.061.","journal-title":"Brain Behav Immun"},{"key":"42_CR105","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1002\/DNEU.22043","volume":"72","author":"L Harvey","year":"2012","unstructured":"Harvey L, Boksa P. Prenatal and postnatal animal models of immune activation: relevance to a range of neurodevelopmental disorders. Dev Neurobiol. 2012;72:1335\u201348. https:\/\/doi.org\/10.1002\/DNEU.22043.","journal-title":"Dev Neurobiol"},{"key":"42_CR106","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1203\/PDR.0b013e318212c196","volume":"69","author":"U Meyer","year":"2011","unstructured":"Meyer U, Feldon J, Dammann O. Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation? Pediatr Res. 2011;69:26\u201333. https:\/\/doi.org\/10.1203\/PDR.0b013e318212c196.","journal-title":"Pediatr Res"},{"key":"42_CR107","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ynstr.2016.02.007","volume":"4","author":"SN Reisinger","year":"2016","unstructured":"Reisinger SN, Kong E, Khan D, et al. Maternal immune activation epigenetically regulates hippocampal serotonin transporter levels. Neurobiol Stress. 2016;4:34\u201343. https:\/\/doi.org\/10.1016\/j.ynstr.2016.02.007.","journal-title":"Neurobiol Stress"},{"key":"42_CR108","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/J.BBI.2018.05.005","volume":"75","author":"R Glass","year":"2019","unstructured":"Glass R, Norton S, Fox N, Kusnecov AW. Maternal immune activation with staphylococcal enterotoxin A produces unique behavioral changes in C57BL\/6 mouse offspring. Brain Behav Immun. 2019;75:12\u201325. https:\/\/doi.org\/10.1016\/J.BBI.2018.05.005.","journal-title":"Brain Behav Immun"},{"key":"42_CR109","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/ANA.23898","volume":"74","author":"E Pineda","year":"2013","unstructured":"Pineda E, Shin D, You SJ, et al. Maternal immune activation promotes hippocampal kindling epileptogenesis in mice. Ann Neurol. 2013;74:11\u20139. https:\/\/doi.org\/10.1002\/ANA.23898.","journal-title":"Ann Neurol"},{"key":"42_CR110","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.09.011","author":"S Kreitz","year":"2019","unstructured":"Kreitz S, Zambon A, Ronovsky M, et al. Maternal immune activation during pregnancy impacts on brain structure and function in the adult offspring. Brain Behav Immun. 2019. https:\/\/doi.org\/10.1016\/j.bbi.2019.09.011.","journal-title":"Brain Behav Immun"},{"key":"42_CR111","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.bbi.2007.09.012","volume":"22","author":"U Meyer","year":"2008","unstructured":"Meyer U, Nyffeler M, Yee BK, et al. Adult brain and behavioral pathological markers of prenatal immune challenge during early\/middle and late fetal development in mice. Brain Behav Immun. 2008;22:469\u201386. https:\/\/doi.org\/10.1016\/j.bbi.2007.09.012.","journal-title":"Brain Behav Immun"},{"key":"42_CR112","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1038\/npp.2010.129","volume":"35","author":"BK Bitanihirwe","year":"2010","unstructured":"Bitanihirwe BK, Peleg-Raibstein D, Mouttet F, et al. Late prenatal immune activation in mice leads to behavioral and neurochemical abnormalities relevant to the negative symptoms of schizophrenia. Neuropsychopharmacology. 2010;35:2462\u201378. https:\/\/doi.org\/10.1038\/npp.2010.129.","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"42_CR113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-022-02065-y","volume":"121","author":"AM Henricks","year":"2022","unstructured":"Henricks AM, Sullivan EDK, Dwiel LL, et al. Maternal immune activation and adolescent alcohol exposure increase alcohol drinking and disrupt cortical-striatal-hippocampal oscillations in adult offspring. Transl Psychiatry. 2022;121(12):1\u20138. https:\/\/doi.org\/10.1038\/s41398-022-02065-y.","journal-title":"Transl Psychiatry"},{"issue":"12","key":"42_CR114","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-022-02149-9","volume":"121","author":"AM Tartaglione","year":"2022","unstructured":"Tartaglione AM, Villani A, Ajmone-Cat MA, et al. Maternal immune activation induces autism-like changes in behavior, neuroinflammatory profile and gut microbiota in mouse offspring of both sexes. Transl Psychiatry. 2022;121(12):1\u201310. https:\/\/doi.org\/10.1038\/s41398-022-02149-9.","journal-title":"Transl Psychiatry"},{"issue":"24","key":"42_CR115","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41593-020-00762-9","volume":"242","author":"BT Kalish","year":"2020","unstructured":"Kalish BT, Kim E, Finander B, et al. Maternal immune activation in mice disrupts proteostasis in the fetal brain. Nat Neurosci. 2020;242(24):204\u201313. https:\/\/doi.org\/10.1038\/s41593-020-00762-9.","journal-title":"Nat Neurosci"},{"key":"42_CR116","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41386-020-00855-w","volume":"46","author":"U Weber-Stadlbauer","year":"2021","unstructured":"Weber-Stadlbauer U, Richetto J, Zwamborn RAJ, et al. Transgenerational modification of dopaminergic dysfunctions induced by maternal immune activation. Neuropsychopharmacology. 2020;46:404\u201312. https:\/\/doi.org\/10.1038\/s41386-020-00855-w.","journal-title":"Neuropsychopharmacology"},{"key":"42_CR117","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/J.BBI.2008.07.012","volume":"23","author":"L Shi","year":"2009","unstructured":"Shi L, Smith SEP, Malkova N, et al. Activation of the maternal immune system alters cerebellar development in the offspring. Brain Behav Immun. 2009;23:116\u201323. https:\/\/doi.org\/10.1016\/J.BBI.2008.07.012.","journal-title":"Brain Behav Immun"},{"key":"42_CR118","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/jne.12175","volume":"26","author":"S Maccari","year":"2014","unstructured":"Maccari S, Krugers HJ, Morley-Fletcher S, et al. The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations. J Neuroendocrinol. 2014;26:707\u201323. https:\/\/doi.org\/10.1111\/jne.12175.","journal-title":"J Neuroendocrinol"},{"key":"42_CR119","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.yfrne.2008.03.003","volume":"29","author":"FA Champagne","year":"2008","unstructured":"Champagne FA. Epigenetic mechanisms and the transgenerational effects of maternal care. Front Neuroendocrinol. 2008;29:386\u201397. https:\/\/doi.org\/10.1016\/j.yfrne.2008.03.003.","journal-title":"Front Neuroendocrinol"},{"key":"42_CR120","doi-asserted-by":"publisher","first-page":"e434","DOI":"10.1038\/tp.2014.80","volume":"4","author":"P Basil","year":"2014","unstructured":"Basil P, Li Q, Dempster EL, et al. Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Transl Psychiatry. 2014;4:e434\u2013e434. https:\/\/doi.org\/10.1038\/tp.2014.80.","journal-title":"Transl Psychiatry"},{"key":"42_CR121","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.biopsych.2022.04.018","volume":"92","author":"K Girdhar","year":"2022","unstructured":"Girdhar K, Rahman S, Dong P, et al. The neuroepigenome: implications of chemical and physical modifications of genomic DNA in schizophrenia. Biol Psychiatry. 2022;92:443\u20139. https:\/\/doi.org\/10.1016\/j.biopsych.2022.04.018.","journal-title":"Biol Psychiatry"},{"key":"42_CR122","doi-asserted-by":"publisher","first-page":"771","DOI":"10.2174\/1568026616666160414124628","volume":"17","author":"N Karpova","year":"2017","unstructured":"Karpova N, Sales A, Joca S. Epigenetic basis of neuronal and synaptic plasticity. Curr Top Med Chem. 2017;17:771\u201393. https:\/\/doi.org\/10.2174\/1568026616666160414124628.","journal-title":"Curr Top Med Chem"},{"key":"42_CR123","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/J.PSC.2009.12.003","volume":"33","author":"PV Gejman","year":"2010","unstructured":"Gejman PV, Sanders AR, Duan J. The role of genetics in the etiology of schizophrenia. Psychiatr Clin. 2010;33:35\u201366. https:\/\/doi.org\/10.1016\/J.PSC.2009.12.003.","journal-title":"Psychiatr Clin"},{"issue":"12","key":"42_CR124","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/nrn.2017.125","volume":"18","author":"R Birnbaum","year":"2017","unstructured":"Birnbaum R, Weinberger DR. Genetic insights into the neurodevelopmental origins of schizophrenia. Nat Rev Neurosci. 2017;18(12):727\u201340. https:\/\/doi.org\/10.1038\/nrn.2017.125.","journal-title":"Nat Rev Neurosci"},{"issue":"26","key":"42_CR125","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/s41380-019-0434-0","volume":"263","author":"TD Purves-Tyson","year":"2019","unstructured":"Purves-Tyson TD, Weber-Stadlbauer U, Richetto J, et al. Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation. Mol Psychiatry. 2019;263(26):849\u201363. https:\/\/doi.org\/10.1038\/s41380-019-0434-0.","journal-title":"Mol Psychiatry"},{"key":"42_CR126","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01917-9","author":"JM LaSalle","year":"2023","unstructured":"LaSalle JM. Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder. Mol Psychiatry. 2023. https:\/\/doi.org\/10.1038\/s41380-022-01917-9.","journal-title":"Mol Psychiatry"},{"key":"42_CR127","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1741-7015-7-62","volume":"7","author":"SG Gregory","year":"2009","unstructured":"Gregory SG, Connelly JJ, Towers AJ, et al. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med. 2009;7:1\u201313. https:\/\/doi.org\/10.1186\/1741-7015-7-62.","journal-title":"BMC Med"},{"key":"42_CR128","doi-asserted-by":"publisher","first-page":"R138","DOI":"10.1093\/hmg\/ddl213","volume":"15","author":"NC Schanen","year":"2006","unstructured":"Schanen NC. Epigenetics of autism spectrum disorders. Hum Mol Genet. 2006;15:R138\u201350. https:\/\/doi.org\/10.1093\/hmg\/ddl213.","journal-title":"Hum Mol Genet"},{"key":"42_CR129","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.brainresbull.2011.08.015","volume":"87","author":"M Enayati","year":"2012","unstructured":"Enayati M, Solati J, Hosseini M-H, et al. Maternal infection during late pregnancy increases anxiety- and depression-like behaviors with increasing age in male offspring. Brain Res Bull. 2012;87:295\u2013302. https:\/\/doi.org\/10.1016\/j.brainresbull.2011.08.015.","journal-title":"Brain Res Bull"},{"key":"42_CR130","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/J.BBR.2013.10.034","volume":"259","author":"YL Lin","year":"2014","unstructured":"Lin YL, Wang S. Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats. Behav Brain Res. 2014;259:24\u201334. https:\/\/doi.org\/10.1016\/J.BBR.2013.10.034.","journal-title":"Behav Brain Res"},{"key":"42_CR131","doi-asserted-by":"publisher","first-page":"e822","DOI":"10.1038\/TP.2016.91","volume":"6","author":"SE Gilman","year":"2016","unstructured":"Gilman SE, Cherkerzian S, Buka SL, et al. Prenatal immune programming of the sex-dependent risk for major depression. Transl Psychiatry. 2016;6:e822\u2013e822. https:\/\/doi.org\/10.1038\/TP.2016.91.","journal-title":"Transl Psychiatry"},{"key":"42_CR132","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/mp.2016.41","volume":"22","author":"U Weber-Stadlbauer","year":"2017","unstructured":"Weber-Stadlbauer U, Richetto J, Labouesse MA, et al. Transgenerational transmission and modification of pathological traits induced by prenatal immune activation. Mol Psychiatry. 2017;22:102\u201312. https:\/\/doi.org\/10.1038\/mp.2016.41.","journal-title":"Mol Psychiatry"},{"issue":"16","key":"42_CR133","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/nrg3964","volume":"1611","author":"J Bohacek","year":"2015","unstructured":"Bohacek J, Mansuy IM. Molecular insights into transgenerational non-genetic inheritance of acquired behaviours. Nat Rev Genet. 2015;1611(16):641\u201352. https:\/\/doi.org\/10.1038\/nrg3964.","journal-title":"Nat Rev Genet"},{"key":"42_CR134","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/J.TRSL.2014.02.003","volume":"165","author":"EE Nilsson","year":"2015","unstructured":"Nilsson EE, Skinner MK. Environmentally induced epigenetic transgenerational inheritance of disease susceptibility. Transl Res. 2015;165:12\u20137. https:\/\/doi.org\/10.1016\/J.TRSL.2014.02.003.","journal-title":"Transl Res"},{"issue":"41","key":"42_CR135","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1038\/npp.2016.87","volume":"4111","author":"K Gapp","year":"2016","unstructured":"Gapp K, Bohacek J, Grossmann J, et al. Potential of environmental enrichment to prevent transgenerational effects of paternal trauma. Neuropsychopharmacol. 2016;4111(41):2749\u201358. https:\/\/doi.org\/10.1038\/npp.2016.87.","journal-title":"Neuropsychopharmacol"},{"issue":"16","key":"42_CR136","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nrn3818","volume":"166","author":"TL Bale","year":"2015","unstructured":"Bale TL. Epigenetic and transgenerational reprogramming of brain development. Nat Rev Neurosci. 2015;166(16):332\u201344. https:\/\/doi.org\/10.1038\/nrn3818.","journal-title":"Nat Rev Neurosci"},{"key":"42_CR137","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.biopsych.2016.08.010","volume":"81","author":"J Richetto","year":"2017","unstructured":"Richetto J, Massart R, Weber-Stadlbauer U, et al. Genome-wide DNA methylation changes in a mouse model of infection-mediated neurodevelopmental disorders. Biol Psychiatry. 2017;81:265\u201376. https:\/\/doi.org\/10.1016\/j.biopsych.2016.08.010.","journal-title":"Biol Psychiatry"},{"key":"42_CR138","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/J.SCHRES.2012.06.037","volume":"140","author":"CM Connor","year":"2012","unstructured":"Connor CM, Dincer A, Straubhaar J, et al. Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome. Schizophr Res. 2012;140:175\u201384. https:\/\/doi.org\/10.1016\/J.SCHRES.2012.06.037.","journal-title":"Schizophr Res"},{"issue":"4","key":"42_CR139","doi-asserted-by":"publisher","first-page":"e452","DOI":"10.1038\/tp.2014.99","volume":"49","author":"SL Hollins","year":"2014","unstructured":"Hollins SL, Zavitsanou K, Walker FR, Cairns MJ. Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure. Transl Psychiatry. 2014;49(4):e452\u2013e452. https:\/\/doi.org\/10.1038\/tp.2014.99.","journal-title":"Transl Psychiatry"},{"issue":"11","key":"42_CR140","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-19048-6","volume":"111","author":"H Tsivion-Visbord","year":"2020","unstructured":"Tsivion-Visbord H, Kopel E, Feiglin A, et al. Increased RNA editing in maternal immune activation model of neurodevelopmental disease. Nat Commun. 2020;111(11):1\u201313. https:\/\/doi.org\/10.1038\/s41467-020-19048-6.","journal-title":"Nat Commun"},{"issue":"2","key":"42_CR141","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1038\/tp.2012.24","volume":"24","author":"KA Garbett","year":"2012","unstructured":"Garbett KA, Hsiao EY, K\u00e1lm\u00e1n S, et al. Effects of maternal immune activation on gene expression patterns in the fetal brain. Transl Psychiatry. 2012;24(2):e98\u2013e98. https:\/\/doi.org\/10.1038\/tp.2012.24.","journal-title":"Transl Psychiatry"},{"key":"42_CR142","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/J.SCHRES.2007.11.018","volume":"99","author":"SH Fatemi","year":"2008","unstructured":"Fatemi SH, Reutiman TJ, Folsom TD, et al. Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: Implications for genesis of neurodevelopmental disorders. Schizophr Res. 2008;99:56\u201370. https:\/\/doi.org\/10.1016\/J.SCHRES.2007.11.018.","journal-title":"Schizophr Res"},{"key":"42_CR143","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/J.BBI.2013.01.086","volume":"30","author":"B Tang","year":"2013","unstructured":"Tang B, Jia H, Kast RJ, Thomas EA. Epigenetic changes at gene promoters in response to immune activation in utero. Brain Behav Immun. 2013;30:168\u201375. https:\/\/doi.org\/10.1016\/J.BBI.2013.01.086.","journal-title":"Brain Behav Immun"},{"key":"42_CR144","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-018-37054-Z","author":"M Ronovsky","year":"2019","unstructured":"Ronovsky M, Zambon A, Cicvaric A, et al. A role for miR-132 in learned safety. Sci Rep. 2019. https:\/\/doi.org\/10.1038\/S41598-018-37054-Z.","journal-title":"Sci Rep"},{"key":"42_CR145","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1038\/ng.708","volume":"42","author":"J Borgel","year":"2010","unstructured":"Borgel J, Guibert S, Li Y, et al. Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet. 2010;42:1093\u2013100. https:\/\/doi.org\/10.1038\/ng.708.","journal-title":"Nat Genet"},{"issue":"9","key":"42_CR146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-017-02748-x","volume":"91","author":"TY Zhang","year":"2018","unstructured":"Zhang TY, Keown CL, Wen X, et al. Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus. Nat Commun. 2018;91(9):1\u201311. https:\/\/doi.org\/10.1038\/s41467-017-02748-x.","journal-title":"Nat Commun"},{"key":"42_CR147","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5402\/2012\/451865","volume":"2012","author":"VS Dalton","year":"2012","unstructured":"Dalton VS, Verdurand M, Walker A, et al. Synergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT 1A receptor binding in the hippocampus: testing the \u201ctwo hit\u201d hypothesis for the development of schizophrenia. ISRN Psychiatry. 2012;2012:1\u20139. https:\/\/doi.org\/10.5402\/2012\/451865.","journal-title":"ISRN Psychiatry"},{"key":"42_CR148","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/WCO.0b013e328336a01f","volume":"23","author":"MR Herbert","year":"2010","unstructured":"Herbert MR. Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr Opin Neurol. 2010;23:103\u201310. https:\/\/doi.org\/10.1097\/WCO.0b013e328336a01f.","journal-title":"Curr Opin Neurol"},{"key":"42_CR149","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.bbi.2018.06.004","volume":"73","author":"VF Labrousse","year":"2018","unstructured":"Labrousse VF, Leyrolle Q, Amadieu C, et al. Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation. Brain Behav Immun. 2018;73:427\u201340. https:\/\/doi.org\/10.1016\/j.bbi.2018.06.004.","journal-title":"Brain Behav Immun"},{"key":"42_CR150","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnins.2015.00194","volume":"9","author":"HM Rivera","year":"2015","unstructured":"Rivera HM, Christiansen KJ, Sullivan EL. The role of maternal obesity in the risk of neuropsychiatric disorders. Front Neurosci. 2015;9:1\u201316. https:\/\/doi.org\/10.3389\/fnins.2015.00194.","journal-title":"Front Neurosci"},{"key":"42_CR151","doi-asserted-by":"publisher","first-page":"e10967","DOI":"10.1371\/journal.pone.0010967","volume":"5","author":"A Aguilar-Valles","year":"2010","unstructured":"Aguilar-Valles A, Flores C, Luheshi GN. Prenatal inflammation-induced hypoferremia alters dopamine function in the adult offspring in rat: relevance for schizophrenia. PLoS ONE. 2010;5:e10967. https:\/\/doi.org\/10.1371\/journal.pone.0010967.","journal-title":"PLoS ONE"},{"key":"42_CR152","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41586-020-2745-3","volume":"586","author":"HE Vuong","year":"2020","unstructured":"Vuong HE, Pronovost GN, Williams DW, et al. The maternal microbiome modulates fetal neurodevelopment in mice. Nature. 2020;586:281\u20136. https:\/\/doi.org\/10.1038\/s41586-020-2745-3.","journal-title":"Nature"},{"key":"42_CR153","doi-asserted-by":"publisher","first-page":"104491","DOI":"10.1016\/j.ebiom.2023.104491","volume":"90","author":"Z Sun","year":"2023","unstructured":"Sun Z, Lee-Sarwar K, Kelly RS, et al. Revealing the importance of prenatal gut microbiome in offspring neurodevelopment in humans. eBioMedicine. 2023;90:104491. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104491.","journal-title":"eBioMedicine"},{"key":"42_CR154","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1126\/SCIENCE.277.5332.1659","volume":"277","author":"D Liu","year":"1997","unstructured":"Liu D, Diorio J, Tannenbaum B, et al. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science. 1997;277:1659\u201362. https:\/\/doi.org\/10.1126\/SCIENCE.277.5332.1659.","journal-title":"Science"},{"key":"42_CR155","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1126\/science.286.5442.1155","volume":"286","author":"D Francis","year":"1999","unstructured":"Francis D, Diorio J, Liu D, Meaney MJ. Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science. 1999;286:1155\u20138. https:\/\/doi.org\/10.1126\/science.286.5442.1155.","journal-title":"Science"},{"key":"42_CR156","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1002\/HIPO.20947","volume":"22","author":"B Leuner","year":"2012","unstructured":"Leuner B, Caponiti JM, Gould E. Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids. Hippocampus. 2012;22:861. https:\/\/doi.org\/10.1002\/HIPO.20947.","journal-title":"Hippocampus"},{"key":"42_CR157","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/OXFORDJOURNALS.SCHBUL.A006887","volume":"27","author":"TM Maynard","year":"2001","unstructured":"Maynard TM, Sikich L, Lieberman JA, LaMantia AS. Neural development, cell-cell signaling, and the \u201ctwo-hit\u201d hypothesis of schizophrenia. Schizophr Bull. 2001;27:457\u201376. https:\/\/doi.org\/10.1093\/OXFORDJOURNALS.SCHBUL.A006887.","journal-title":"Schizophr Bull"},{"issue":"Suppl","key":"42_CR158","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1289\/EHP.00108S3511","volume":"108","author":"D Rice","year":"2000","unstructured":"Rice D, Barone S. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect. 2000;108(Suppl):511\u201333. https:\/\/doi.org\/10.1289\/EHP.00108S3511.","journal-title":"Environ Health Perspect"},{"key":"42_CR159","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/NPP.2014.140","volume":"40","author":"M Kundakovic","year":"2015","unstructured":"Kundakovic M, Champagne FA. Early-life experience, epigenetics, and the developing brain. Neuropsychopharmacology. 2015;40:141. https:\/\/doi.org\/10.1038\/NPP.2014.140.","journal-title":"Neuropsychopharmacology"},{"key":"42_CR160","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1176\/appi.ajp.2009.08010031","volume":"166","author":"MC Clarke","year":"2009","unstructured":"Clarke MC, Tanskanen A, Huttunen M, et al. Evidence for an interaction between familial liability and prenatal exposure to infection in the causation of schizophrenia. Am J Psychiatry. 2009;166:1025\u201330. https:\/\/doi.org\/10.1176\/appi.ajp.2009.08010031.","journal-title":"Am J Psychiatry"},{"key":"42_CR161","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1017\/S0033291710000231","volume":"40","author":"HL Fisher","year":"2010","unstructured":"Fisher HL, Jones PB, Fearon P, et al. The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder. Psychol Med. 2010;40:1967\u201378. https:\/\/doi.org\/10.1017\/S0033291710000231.","journal-title":"Psychol Med"},{"issue":"9","key":"42_CR162","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/nrn2513","volume":"912","author":"T Paus","year":"2008","unstructured":"Paus T, Keshavan M, Giedd JN. Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci. 2008;912(9):947\u201357. https:\/\/doi.org\/10.1038\/nrn2513.","journal-title":"Nat Rev Neurosci"},{"issue":"12","key":"42_CR163","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-25220-3","volume":"121","author":"H Jacobsen","year":"2021","unstructured":"Jacobsen H, Walendy-Gnir\u00df K, Tekin-Bubenheim N, et al. Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life. Nat Commun. 2021;121(12):1\u201314. https:\/\/doi.org\/10.1038\/s41467-021-25220-3.","journal-title":"Nat Commun"},{"issue":"6","key":"42_CR164","doi-asserted-by":"publisher","first-page":"e772","DOI":"10.1038\/tp.2016.38","volume":"64","author":"S Giovanoli","year":"2016","unstructured":"Giovanoli S, Engler H, Engler A, et al. Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia. Transl Psychiatry. 2016;64(6):e772\u2013e772. https:\/\/doi.org\/10.1038\/tp.2016.38.","journal-title":"Transl Psychiatry"},{"key":"42_CR165","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/J.BBI.2020.05.076","volume":"89","author":"JY Goh","year":"2020","unstructured":"Goh JY, O\u2019Sullivan SE, Shortall SE, et al. Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat \u2018dual-hit\u2019 model for neurodevelopmental disorders. Brain Behav Immun. 2020;89:100\u201317. https:\/\/doi.org\/10.1016\/J.BBI.2020.05.076.","journal-title":"Brain Behav Immun"},{"key":"42_CR166","unstructured":"Lorenz K. \u00dcber tierisches und menschliches Verhalten Aus dem Werdegang der Verhaltenslehre Gesammelte Abhandlungen Band II. 1966."},{"key":"42_CR167","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/S10508-007-9277-X","volume":"37","author":"CH Kinsley","year":"2008","unstructured":"Kinsley CH, Bardi M, Karelina K, et al. Motherhood induces and maintains behavioral and neural plasticity across the lifespan in the rat. Arch Sex Behav. 2008;37:43\u201356. https:\/\/doi.org\/10.1007\/S10508-007-9277-X.","journal-title":"Arch Sex Behav"},{"key":"42_CR168","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022111648","author":"M Glat","year":"2022","unstructured":"Glat M, Gundacker A, Cuenca Rico L, et al. An accessory prefrontal cortex\u2013thalamus circuit sculpts maternal behavior in virgin female mice. EMBO J. 2022. https:\/\/doi.org\/10.15252\/embj.2022111648.","journal-title":"EMBO J"},{"issue":"9","key":"42_CR169","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrn2280","volume":"91","author":"PJ Brunton","year":"2007","unstructured":"Brunton PJ, Russell JA. The expectant brain: adapting for motherhood. Nat Rev Neurosci. 2007;91(9):11\u201325. https:\/\/doi.org\/10.1038\/nrn2280.","journal-title":"Nat Rev Neurosci"},{"key":"42_CR170","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/B978-0-12-809324-5.00400-4","volume-title":"Encyclopedia of behavioral neuroscience","author":"M Numan","year":"2017","unstructured":"Numan M. Parental behavior. In: Sala SD, editor. Encyclopedia of behavioral neuroscience. 2nd ed. Amsterdam: Elsevier; 2017. p. 459\u201373. https:\/\/doi.org\/10.1016\/B978-0-12-809324-5.00400-4.","edition":"2"},{"key":"42_CR171","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.neubiorev.2007.10.009","volume":"33","author":"FA Champagne","year":"2009","unstructured":"Champagne FA, Curley JP. Epigenetic mechanisms mediating the long-term effects of maternal care on development. Neurosci Biobehav Rev. 2009;33:593\u2013600.","journal-title":"Neurosci Biobehav Rev"},{"key":"42_CR172","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/j.1469-7610.2008.01973.x","volume":"50","author":"JF Paulson","year":"2009","unstructured":"Paulson JF, Keefe HA, Leiferman JA. Early parental depression and child language development. J Child Psychol Psychiatry Allied Discip. 2009;50:254\u201362. https:\/\/doi.org\/10.1111\/j.1469-7610.2008.01973.x.","journal-title":"J Child Psychol Psychiatry Allied Discip"},{"key":"42_CR173","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1676285","author":"CA Nelson","year":"2019","unstructured":"Nelson CA, Zeanah CH, Fox NA. How early experience shapes human development: the case of psychosocial deprivation. Neural Plast. 2019. https:\/\/doi.org\/10.1155\/2019\/1676285.","journal-title":"Neural Plast"},{"key":"42_CR174","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1017\/S0954579411000666","volume":"24","author":"MA Easterbrooks","year":"2012","unstructured":"Easterbrooks MA, Bureau J-FF, Lyons-Ruth K. Developmental correlates and predictors of emotional availability in mother-child interation: a longitudinal study from infancy to middle childhood. Dev Psychopathol. 2012;24:65\u201378. https:\/\/doi.org\/10.1017\/S0954579411000666.","journal-title":"Dev Psychopathol"},{"key":"42_CR175","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1136\/bmj.292.6529.1165","volume":"292","author":"SR Cogill","year":"1986","unstructured":"Cogill SR, Caplan HL, Alexandra H, et al. Impact of maternal postnatal depression on cognitive development of young children. Br Med J. 1986;292:1165\u20137. https:\/\/doi.org\/10.1136\/bmj.292.6529.1165.","journal-title":"Br Med J"},{"key":"42_CR176","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.bbr.2008.03.031","volume":"191","author":"S Macr\u00ec","year":"2008","unstructured":"Macr\u00ec S, Chiarotti F, W\u00fcrbel H. Maternal separation and maternal care act independently on the development of HPA responses in male rats. Behav Brain Res. 2008;191:227\u201334. https:\/\/doi.org\/10.1016\/j.bbr.2008.03.031.","journal-title":"Behav Brain Res"},{"key":"42_CR177","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804036-2.00016-9","author":"A Harker","year":"2018","unstructured":"Harker A. Social dysfunction: the effects of early trauma and adversity on socialization and brain development. Neurobiol Brain Behav Dev. 2018. https:\/\/doi.org\/10.1016\/B978-0-12-804036-2.00016-9.","journal-title":"Neurobiol Brain Behav Dev"},{"key":"42_CR178","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1126\/science.1252723","volume":"345","author":"JK Rilling","year":"2014","unstructured":"Rilling JK, Young LJ. The biology of mammalian parenting and its effect on offspring social development. Science. 2014;345:771\u20136. https:\/\/doi.org\/10.1126\/science.1252723.","journal-title":"Science"},{"key":"42_CR179","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1113\/jphysiol.2011.223305","volume":"590","author":"KL Connor","year":"2012","unstructured":"Connor KL, Vickers MH, Beltrand J, et al. Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring development and reproductive function. J Physiol. 2012;590:2167\u201380. https:\/\/doi.org\/10.1113\/jphysiol.2011.223305.","journal-title":"J Physiol"},{"key":"42_CR180","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1080\/14616730210167267","volume":"4","author":"J Belsky","year":"2002","unstructured":"Belsky J, Fearon RMP. Early attachment security, subsequent maternal sensitivity, and later child development: does continuity in development depend upon continuity of caregiving? Attach Hum Dev. 2002;4:361\u201387. https:\/\/doi.org\/10.1080\/14616730210167267.","journal-title":"Attach Hum Dev"},{"key":"42_CR181","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/j.pnpbp.2010.08.024","volume":"35","author":"K Mogi","year":"2011","unstructured":"Mogi K, Nagasawa M, Kikusui T. Developmental consequences and biological significance of mother-infant bonding. Prog Neuro-Psychopharmacol Biol Psychiatry. 2011;35:1232\u201341. https:\/\/doi.org\/10.1016\/j.pnpbp.2010.08.024.","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"42_CR182","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/s0149-7634(99)00011-1","volume":"23","author":"AS Fleming","year":"1999","unstructured":"Fleming AS, O\u2019Day DH, Kraemer GW. Neurobiology of mother-infant interactions: experience and central nervous system plasticity across development and generations. Neurosci Biobehav Rev. 1999;23:673\u201385. https:\/\/doi.org\/10.1016\/s0149-7634(99)00011-1.","journal-title":"Neurosci Biobehav Rev"},{"key":"42_CR183","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.yhbeh.2006.06.015","volume":"50","author":"S Macr\u00ec","year":"2006","unstructured":"Macr\u00ec S, W\u00fcrbel H. Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis. Horm Behav. 2006;50:667\u201380. https:\/\/doi.org\/10.1016\/j.yhbeh.2006.06.015.","journal-title":"Horm Behav"},{"key":"42_CR184","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/J.INFBEH.2012.04.005","volume":"35","author":"BM McManus","year":"2012","unstructured":"McManus BM, Poehlmann J. Parent\u2013child interaction, maternal depressive symptoms and preterm infant cognitive function. Infant Behav Dev. 2012;35:489\u201398. https:\/\/doi.org\/10.1016\/J.INFBEH.2012.04.005.","journal-title":"Infant Behav Dev"},{"key":"42_CR185","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1111\/JCPP.12413","volume":"56","author":"O Perra","year":"2015","unstructured":"Perra O, Phillips R, Fyfield R, et al. Does mothers\u2019 postnatal depression influence the development of imitation? J Child Psychol Psychiatry. 2015;56:1231\u20138. https:\/\/doi.org\/10.1111\/JCPP.12413.","journal-title":"J Child Psychol Psychiatry"},{"key":"42_CR186","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1006\/DREV.1995.1012","volume":"15","author":"PK Trickett","year":"1995","unstructured":"Trickett PK, McBride-Chang C. The developmental impact of different forms of child abuse and neglect. Dev Rev. 1995;15:311\u201337. https:\/\/doi.org\/10.1006\/DREV.1995.1012.","journal-title":"Dev Rev"},{"key":"42_CR187","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0272-7358(86)90003-6","volume":"6","author":"RT Ammerman","year":"1986","unstructured":"Ammerman RT, Cassisi JE, Hersen M, Van Hasselt VB. Consequences of physical abuse and neglect in children. Clin Psychol Rev. 1986;6:291\u2013310. https:\/\/doi.org\/10.1016\/0272-7358(86)90003-6.","journal-title":"Clin Psychol Rev"},{"key":"42_CR188","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","volume":"14","author":"VJ Felitti","year":"1998","unstructured":"Felitti VJ, Anda RF, Nordenberg D, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study. Am J Prev Med. 1998;14:245\u201358. https:\/\/doi.org\/10.1016\/S0749-3797(98)00017-8.","journal-title":"Am J Prev Med"},{"key":"42_CR189","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S0140-6736(08)61706-7","volume":"373","author":"R Gilbert","year":"2009","unstructured":"Gilbert R, Widom CS, Browne K, et al. Burden and consequences of child maltreatment in high-income countries. Lancet. 2009;373:68\u201381. https:\/\/doi.org\/10.1016\/S0140-6736(08)61706-7.","journal-title":"Lancet"},{"key":"42_CR190","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/mrdd.10074","volume":"9","author":"BS McEwen","year":"2003","unstructured":"McEwen BS. Early life influences on life-long patterns of behavior and health. Ment Retard Dev Disabil Res Rev. 2003;9:149\u201354. https:\/\/doi.org\/10.1002\/mrdd.10074.","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"42_CR191","doi-asserted-by":"publisher","first-page":"5335","DOI":"10.1073\/pnas.95.9.5335","volume":"95","author":"C Caldji","year":"1998","unstructured":"Caldji C, Tannenbaum B, Sharma S, et al. Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proc Natl Acad Sci. 1998;95:5335\u201340. https:\/\/doi.org\/10.1073\/pnas.95.9.5335.","journal-title":"Proc Natl Acad Sci"},{"key":"42_CR192","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0014-2999(00)00548-3","volume":"405","author":"S Levine","year":"2000","unstructured":"Levine S. Influence of psychological variables on the activity of the hypothalamic-pituitary-adrenal axis. Eur J Pharmacol. 2000;405:149\u201360. https:\/\/doi.org\/10.1016\/S0014-2999(00)00548-3.","journal-title":"Eur J Pharmacol"},{"key":"42_CR193","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1126\/SCIENCE.277.5332.1659\/ASSET\/F62129BF-CB05-4B6A-ABD3-5CC5D5F458EC\/ASSETS\/GRAPHIC\/SE3675687003.JPEG","volume":"277","author":"D Liu","year":"1997","unstructured":"Liu D, Diorio J, Tannenbaum B, et al. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic- pituitary-adrenal responses to stress. Science. 1997;277:1659\u201362. https:\/\/doi.org\/10.1126\/SCIENCE.277.5332.1659\/ASSET\/F62129BF-CB05-4B6A-ABD3-5CC5D5F458EC\/ASSETS\/GRAPHIC\/SE3675687003.JPEG.","journal-title":"Science"},{"issue":"7","key":"42_CR194","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/nn1276","volume":"78","author":"ICG Weaver","year":"2004","unstructured":"Weaver ICG, Cervoni N, Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci. 2004;78(7):847\u201354. https:\/\/doi.org\/10.1038\/nn1276.","journal-title":"Nat Neurosci"},{"issue":"3","key":"42_CR195","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/77702","volume":"38","author":"D Liu","year":"2000","unstructured":"Liu D, Diorio J, Day JC, et al. Maternal care, hippocampal synaptogenesis and cognitive development in rats. Nat Neurosci. 2000;38(3):799\u2013806. https:\/\/doi.org\/10.1038\/77702.","journal-title":"Nat Neurosci"},{"key":"42_CR196","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01602-x","author":"A Zambon","year":"2022","unstructured":"Zambon A, Rico LC, Herman M, et al. Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior. Mol Psychiatry. 2022. https:\/\/doi.org\/10.1038\/s41380-022-01602-x.","journal-title":"Mol Psychiatry"},{"key":"42_CR197","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.bbi.2016.12.008","volume":"63","author":"WR Crum","year":"2017","unstructured":"Crum WR, Sawiak SJ, Chege W, et al. Evolution of structural abnormalities in the rat brain following in utero exposure to maternal immune activation: a longitudinal in vivo MRI study. Brain Behav Immun. 2017;63:50\u20139. https:\/\/doi.org\/10.1016\/j.bbi.2016.12.008.","journal-title":"Brain Behav Immun"},{"key":"42_CR198","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.yhbeh.2015.08.008","volume":"77","author":"S Brummelte","year":"2016","unstructured":"Brummelte S, Galea LAM. Postpartum depression: etiology, treatment and consequences for maternal care. Horm Behav. 2016;77:153\u201366. https:\/\/doi.org\/10.1016\/j.yhbeh.2015.08.008.","journal-title":"Horm Behav"},{"key":"42_CR199","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3390\/ijerph18179307","volume":"83","author":"E Achytes","year":"2020","unstructured":"Achytes E, Keaton SA, Smart L, et al. Inflammation and kynurenine pathway dysregulation in post- partum women with severe and suicidal depression. Int J Environ Res Public Health. 2020;83:239\u201347. https:\/\/doi.org\/10.3390\/ijerph18179307.","journal-title":"Int J Environ Res Public Health"},{"key":"42_CR200","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/KI.1980.133","volume":"18","author":"NF Gant","year":"1980","unstructured":"Gant NF, Worley RJ, Everett RB, MacDonald PC. Control of vascular responsiveness during human pregnancy. Kidney Int. 1980;18:253\u20138. https:\/\/doi.org\/10.1038\/KI.1980.133.","journal-title":"Kidney Int"},{"key":"42_CR201","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S0889-8561(05)70175-2","volume":"20","author":"RA Wise","year":"2000","unstructured":"Wise RA, Polito AJ. Respiratory physiologic changes in pregnancy. Immunol Allergy Clin North Am. 2000;20:663\u201372. https:\/\/doi.org\/10.1016\/S0889-8561(05)70175-2.","journal-title":"Immunol Allergy Clin North Am"},{"key":"42_CR202","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1183\/20734735.008615","volume":"11","author":"A LoMauro","year":"2015","unstructured":"LoMauro A, Aliverti A. Respiratory physiology of pregnancy. Breathe. 2015;11:297\u2013301. https:\/\/doi.org\/10.1183\/20734735.008615.","journal-title":"Breathe"},{"key":"42_CR203","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0272-6386(12)81112-7","volume":"17","author":"MD Lindheimer","year":"1991","unstructured":"Lindheimer MD, Barron WM, Davison JM. Osmotic and volume control of vasopressin release in pregnancy. Am J Kidney Dis. 1991;17:105\u201311. https:\/\/doi.org\/10.1016\/S0272-6386(12)81112-7.","journal-title":"Am J Kidney Dis"},{"key":"42_CR204","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/S004040000104","volume":"264","author":"A Elsheikh","year":"2001","unstructured":"Elsheikh A, Creatsas G, Mastorakos G, et al. The renin-aldosterone system during normal and hypertensive pregnancy. Arch Gynecol Obstet. 2001;264:182\u20135. https:\/\/doi.org\/10.1007\/S004040000104.","journal-title":"Arch Gynecol Obstet"},{"key":"42_CR205","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1210\/JCEM-68-5-863","volume":"68","author":"HG D\u00f4rr","year":"1989","unstructured":"D\u00f4rr HG, Heller A, Versmold HT, et al. Longitudinal study of progestins, mineralocorticoids, and glucocorticoids throughout human pregnancy. J Clin Endocrinol Metab. 1989;68:863\u20138. https:\/\/doi.org\/10.1210\/JCEM-68-5-863.","journal-title":"J Clin Endocrinol Metab"},{"key":"42_CR206","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1210\/EDRV.18.3.0300","volume":"18","author":"D Glinoer","year":"1997","unstructured":"Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev. 1997;18:404\u201333. https:\/\/doi.org\/10.1210\/EDRV.18.3.0300.","journal-title":"Endocr Rev"},{"key":"42_CR207","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcell.2019.00138","volume":"7","author":"HM Hwang","year":"2019","unstructured":"Hwang HM, Ku RY, Hashimoto-Torii K. Prenatal environment that affects neuronal migration. Front Cell Dev Biol. 2019;7:1\u201311. https:\/\/doi.org\/10.3389\/fcell.2019.00138.","journal-title":"Front Cell Dev Biol"},{"key":"42_CR208","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.yfrne.2014.11.007","volume":"36","author":"RS Bridges","year":"2015","unstructured":"Bridges RS. Neuroendocrine regulation of maternal behavior. Front Neuroendocrinol. 2015;36:178\u201396. https:\/\/doi.org\/10.1016\/j.yfrne.2014.11.007.","journal-title":"Front Neuroendocrinol"},{"key":"42_CR209","doi-asserted-by":"publisher","first-page":"179","DOI":"10.4103\/0300-1652.107549","volume":"53","author":"N Magon","year":"2012","unstructured":"Magon N, Kumar P. Hormones in pregnancy. Niger Med J. 2012;53:179. https:\/\/doi.org\/10.4103\/0300-1652.107549.","journal-title":"Niger Med J"},{"key":"42_CR210","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/J.AJOG.2006.09.005","volume":"196","author":"T Zakar","year":"2007","unstructured":"Zakar T, Hertelendy F. Progesterone withdrawal: key to parturition. Am J Obstet Gynecol. 2007;196:289\u201396. https:\/\/doi.org\/10.1016\/J.AJOG.2006.09.005.","journal-title":"Am J Obstet Gynecol"},{"key":"42_CR211","doi-asserted-by":"publisher","DOI":"10.1095\/BIOLREPROD.113.107995","author":"VB Dorfman","year":"2013","unstructured":"Dorfman VB, Saucedo L, Di Giorgio NP, et al. Variation in progesterone receptors and GnRH expression in the hypothalamus of the pregnant South American plains vizcacha Lagostomus maximus (Mammalia, Rodentia). Biol Reprod. 2013. https:\/\/doi.org\/10.1095\/BIOLREPROD.113.107995.","journal-title":"Biol Reprod"},{"key":"42_CR212","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/J.MCE.2016.11.029","volume":"442","author":"GE Pennacchio","year":"2017","unstructured":"Pennacchio GE, Neira FJ, Soaje M, et al. Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat. Mol Cell Endocrinol. 2017;442:40\u201350. https:\/\/doi.org\/10.1016\/J.MCE.2016.11.029.","journal-title":"Mol Cell Endocrinol"},{"key":"42_CR213","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/J.IMLET.2014.06.013","volume":"162","author":"C La Rocca","year":"2014","unstructured":"La Rocca C, Carbone F, Longobardi S, Matarese G. The immunology of pregnancy: regulatory T cells control maternal immune tolerance toward the fetus. Immunol Lett. 2014;162:41\u20138. https:\/\/doi.org\/10.1016\/J.IMLET.2014.06.013.","journal-title":"Immunol Lett"},{"key":"42_CR214","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/CNE.903360210","volume":"336","author":"CS Woolley","year":"1993","unstructured":"Woolley CS, McEwen BS. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993;336:293\u2013306. https:\/\/doi.org\/10.1002\/CNE.903360210.","journal-title":"J Comp Neurol"},{"key":"42_CR215","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/1363849031000095279","volume":"6","author":"DG Stein","year":"2003","unstructured":"Stein DG, Hoffman SW. Estrogen and progesterone as neuroprotective agents in the treatment of acute brain injuries. Pediatr Rehabil. 2003;6:13\u201322. https:\/\/doi.org\/10.1080\/1363849031000095279.","journal-title":"Pediatr Rehabil"},{"key":"42_CR216","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.yhbeh.2005.05.017","volume":"49","author":"CH Kinsley","year":"2006","unstructured":"Kinsley CH, Trainer R, Stafisso-Sandoz G, et al. Motherhood and the hormones of pregnancy modify concentrations of hippocampal neuronal dendritic spines. Horm Behav. 2006;49:131\u201342. https:\/\/doi.org\/10.1016\/j.yhbeh.2005.05.017.","journal-title":"Horm Behav"},{"key":"42_CR217","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/0531-5565(94)90022-1","volume":"29","author":"BS McEwen","year":"1994","unstructured":"McEwen BS, Woolley CS. Estradiol and progesterone regulate neuronal structure and synaptic connectivity in adult as well as developing brain. Exp Gerontol. 1994;29:431\u20136. https:\/\/doi.org\/10.1016\/0531-5565(94)90022-1.","journal-title":"Exp Gerontol"},{"key":"42_CR218","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1073\/PNAS.051624598","volume":"98","author":"M Yankova","year":"2001","unstructured":"Yankova M, Hart SA, Woolley CS. Estrogen increases synaptic connectivity between single presynaptic inputs and multiple postsynaptic CA1 pyramidal cells: a serial electron-microscopic study. Proc Natl Acad Sci U S A. 2001;98:3525\u201330. https:\/\/doi.org\/10.1073\/PNAS.051624598.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"42_CR219","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1523\/JNEUROSCI.10-04-01286.1990","volume":"10","author":"E Gould","year":"1990","unstructured":"Gould E, Woolley CS, Frankfurt M, McEwen BS. Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci. 1990;10:1286\u201391. https:\/\/doi.org\/10.1523\/JNEUROSCI.10-04-01286.1990.","journal-title":"J Neurosci"},{"key":"42_CR220","doi-asserted-by":"publisher","first-page":"5792","DOI":"10.1523\/JNEUROSCI.19-14-05792.1999","volume":"19","author":"P Tanapat","year":"1999","unstructured":"Tanapat P, Hastings NB, Reeves AJ, Gould E. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J Neurosci. 1999;19:5792. https:\/\/doi.org\/10.1523\/JNEUROSCI.19-14-05792.1999.","journal-title":"J Neurosci"},{"key":"42_CR221","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/0006-8993(95)01059-9","volume":"703","author":"SG Warren","year":"1995","unstructured":"Warren SG, Humphreys AG, Juraska JM, Greenough WT. LTP varies across the estrous cycle: enhanced synaptic plasticity in proestrus rats. Brain Res. 1995;703:26\u201330. https:\/\/doi.org\/10.1016\/0006-8993(95)01059-9.","journal-title":"Brain Res"},{"key":"42_CR222","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1210\/ENDO-114-3-930","volume":"114","author":"RS Bridges","year":"1984","unstructured":"Bridges RS. A quantitative analysis of the roles of dosage, sequence, and duration of estradiol and progesterone exposure in the regulation of maternal behavior in the rat. Endocrinology. 1984;114:930\u201340. https:\/\/doi.org\/10.1210\/ENDO-114-3-930.","journal-title":"Endocrinology"},{"key":"42_CR223","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/S0361-9230(01)00554-8","volume":"55","author":"L Keyser-Marcus","year":"2001","unstructured":"Keyser-Marcus L, Stafisso-Sandoz G, Gerecke K, et al. Alterations of medial preoptic area neurons following pregnancy and pregnancy-like steroidal treatment in the rat. Brain Res Bull. 2001;55:737\u201345. https:\/\/doi.org\/10.1016\/S0361-9230(01)00554-8.","journal-title":"Brain Res Bull"},{"key":"42_CR224","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.neuroscience.2004.04.009","volume":"126","author":"AA Rasia-Filho","year":"2004","unstructured":"Rasia-Filho AA, Fabian C, Rigoti KM, Achaval M. Influence of sex, estrous cycle and motherhood on dendritic spine density in the rat medial amygdala revealed by the Golgi method. Neuroscience. 2004;126:839\u201347. https:\/\/doi.org\/10.1016\/j.neuroscience.2004.04.009.","journal-title":"Neuroscience"},{"key":"42_CR225","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1037\/0735-7044.110.3.567","volume":"110","author":"AS Fleming","year":"1996","unstructured":"Fleming AS, Korsmit M. Plasticity in the maternal circuit: effects of maternal experience on Fos-lir in hypothalamic, limbic, and cortical structures in the postpartum rat. Behav Neurosci. 1996;110:567\u201382. https:\/\/doi.org\/10.1037\/0735-7044.110.3.567.","journal-title":"Behav Neurosci"},{"issue":"Pt 1","key":"42_CR226","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1113\/JPHYSIOL.1994.SP020349","volume":"480","author":"MJ Freund-Mercier","year":"1994","unstructured":"Freund-Mercier MJ, Stoeckel ME, Klein MJ. Oxytocin receptors on oxytocin neurones: histoautoradiographic detection in the lactating rat. J Physiol. 1994;480(Pt 1):155\u201361. https:\/\/doi.org\/10.1113\/JPHYSIOL.1994.SP020349.","journal-title":"J Physiol"},{"key":"42_CR227","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1095\/BIOLREPROD35.5.1202","volume":"35","author":"AN Clancy","year":"1986","unstructured":"Clancy AN, Goldman BD, Bartke A, Macrides F. Reproductive effects of olfactory bulbectomy in the Syrian hamster. Biol Reprod. 1986;35:1202\u20139. https:\/\/doi.org\/10.1095\/BIOLREPROD35.5.1202.","journal-title":"Biol Reprod"},{"key":"42_CR228","doi-asserted-by":"publisher","DOI":"10.1038\/NCOMMS2336","author":"HX Liu","year":"2013","unstructured":"Liu HX, Lopatina O, Higashida C, et al. Displays of parental mouse pup retrieval following communicative interaction with maternal mates. Nat Commun. 2013. https:\/\/doi.org\/10.1038\/NCOMMS2336.","journal-title":"Nat Commun"},{"key":"42_CR229","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/J.ANDO.2016.04.002","volume":"77","author":"F L\u00e9vy","year":"2016","unstructured":"L\u00e9vy F. Neuroendocrine control of maternal behavior in non-human and human mammals. Ann Endocrinol. 2016;77:114\u201325. https:\/\/doi.org\/10.1016\/J.ANDO.2016.04.002.","journal-title":"Ann Endocrinol"},{"key":"42_CR230","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/nn0403-327","volume":"6","author":"DA Monks","year":"2003","unstructured":"Monks DA, Lonstein JS, Breedlove SM. Got milk? Oxytocin triggers hippocampal plasticity. Nat Neurosci. 2003;6:327\u20138. https:\/\/doi.org\/10.1038\/nn0403-327.","journal-title":"Nat Neurosci"},{"key":"42_CR231","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/NN1023","volume":"6","author":"K Tomizawa","year":"2003","unstructured":"Tomizawa K, Iga N, Lu YF, et al. Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade. Nat Neurosci. 2003;6:384\u201390. https:\/\/doi.org\/10.1038\/NN1023.","journal-title":"Nat Neurosci"},{"key":"42_CR232","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1126\/science.1076647","volume":"299","author":"T Shingo","year":"2003","unstructured":"Shingo T, Gregg C, Enwere E, et al. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science. 2003;299:117\u201320. https:\/\/doi.org\/10.1126\/science.1076647.","journal-title":"Science"},{"key":"42_CR233","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/J.YFRNE.2016.02.004","volume":"41","author":"B Leuner","year":"2016","unstructured":"Leuner B, Sabihi S. The birth of new neurons in the maternal brain: hormonal regulation and functional implications. Front Neuroendocrinol. 2016;41:99. https:\/\/doi.org\/10.1016\/J.YFRNE.2016.02.004.","journal-title":"Front Neuroendocrinol"},{"key":"42_CR234","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2016.00025","author":"L Torner","year":"2016","unstructured":"Torner L. Actions of prolactin in the brain: from physiological adaptations to stress and neurogenesis to psychopathology. Front Endocrinol. 2016. https:\/\/doi.org\/10.3389\/FENDO.2016.00025.","journal-title":"Front Endocrinol"},{"key":"42_CR235","doi-asserted-by":"publisher","first-page":"e0176910","DOI":"10.1371\/JOURNAL.PONE.0176910","volume":"12","author":"NA Rivero-Segura","year":"2017","unstructured":"Rivero-Segura NA, Flores-Soto E, De La Cadena SG, et al. Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-\u03baB activation. PLoS ONE. 2017;12:e0176910. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0176910.","journal-title":"PLoS ONE"},{"key":"42_CR236","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1176\/appi.ajp.2018.17121311","volume":"175","author":"AS Brown","year":"2018","unstructured":"Brown AS, Meyer U. maternal immune activation and neuropsychiatric illness: a translational research perspective. Am J Psychiatry. 2018;175:1073\u201383. https:\/\/doi.org\/10.1176\/appi.ajp.2018.17121311.","journal-title":"Am J Psychiatry"},{"key":"42_CR237","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/J.YFRNE.2012.08.006","volume":"33","author":"SD Bilbo","year":"2012","unstructured":"Bilbo SD, Schwarz JM. The immune system and developmental programming of brain and behavior. Front Neuroendocrinol. 2012;33:267. https:\/\/doi.org\/10.1016\/J.YFRNE.2012.08.006.","journal-title":"Front Neuroendocrinol"},{"key":"42_CR238","doi-asserted-by":"publisher","first-page":"10937","DOI":"10.1523\/JNEUROSCI.5302-10.2011","volume":"31","author":"C Lebel","year":"2011","unstructured":"Lebel C, Beaulieu C. Longitudinal development of human brain wiring continues from childhood into adulthood. J Neurosci. 2011;31:10937. https:\/\/doi.org\/10.1523\/JNEUROSCI.5302-10.2011.","journal-title":"J Neurosci"}],"container-title":["Discover Mental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44192-023-00042-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44192-023-00042-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44192-023-00042-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T14:02:17Z","timestamp":1700402537000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44192-023-00042-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,22]]},"references-count":238,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["42"],"URL":"https:\/\/doi.org\/10.1007\/s44192-023-00042-5","relation":{},"ISSN":["2731-4383"],"issn-type":[{"value":"2731-4383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,22]]},"assertion":[{"value":"23 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15"}}