{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:27:17Z","timestamp":1778599637396,"version":"3.51.4"},"reference-count":133,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR-389342"],"award-info":[{"award-number":["CIHR-389342"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR-451521"],"award-info":[{"award-number":["CIHR-451521"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Toronto Cannabis and Cannabinoid Research Consortium"},{"name":"Canada Research Chair in Endocannabinoid Imaging in Mental Illness"},{"name":"Labatt Family Innovation Fund in Brain Health"},{"DOI":"10.13039\/100015070","name":"Department of Psychiatry, University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Ment Health"],"DOI":"10.1007\/s44192-025-00155-z","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T11:56:42Z","timestamp":1744113402000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of pharmacological inhibition of fatty acid amide hydrolase on corticosterone release: a systematic review of preclinical studies"],"prefix":"10.1007","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-0338","authenticated-orcid":false,"given":"Christina F.","family":"Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-1484","authenticated-orcid":false,"given":"Isabelle","family":"Boileau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-4114","authenticated-orcid":false,"given":"Stefan","family":"Kloiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"issue":"3","key":"155_CR1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.31887\/DCNS.2015.17.3\/bbandelow","volume":"17","author":"B Bandelow","year":"2015","unstructured":"Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci. 2015;17(3):327\u201335.","journal-title":"Dialogues Clin Neurosci"},{"issue":"23","key":"155_CR2","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMcp1614701","volume":"376","author":"F Leichsenring","year":"2017","unstructured":"Leichsenring F, Leweke F. Social anxiety disorder. N Engl J Med. 2017;376(23):2255\u201364.","journal-title":"N Engl J Med"},{"issue":"1","key":"155_CR3","first-page":"30","volume":"38","author":"A Bystritsky","year":"2013","unstructured":"Bystritsky A, Khalsa SS, Cameron ME, Schiffman J. Current diagnosis and treatment of anxiety disorders. Pharm Ther. 2013;38(1):30\u201357.","journal-title":"Pharm Ther"},{"issue":"9","key":"155_CR4","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/sj.mp.4001852","volume":"11","author":"A Bystritsky","year":"2006","unstructured":"Bystritsky A. Treatment-resistant anxiety disorders. Mol Psychiatry. 2006;11(9):805\u201314.","journal-title":"Mol Psychiatry"},{"issue":"4","key":"155_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1518","volume":"13","author":"IP Androulakis","year":"2021","unstructured":"Androulakis IP. Circadian rhythms and the HPA axis: a systems view. WIREs Mech Dis. 2021;13(4): e1518.","journal-title":"WIREs Mech Dis"},{"issue":"1","key":"155_CR6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/nyas.12464","volume":"1318","author":"NC Nicolaides","year":"2014","unstructured":"Nicolaides NC, Charmandari E, Chrousos GP, Kino T. Circadian endocrine rhythms: the hypothalamic\u2013pituitary\u2013adrenal axis and its actions. Acad Sci. 2014;1318(1):71\u201380.","journal-title":"Acad Sci"},{"issue":"9","key":"155_CR7","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1001\/jama.1992.03480090092034","volume":"267","author":"GP Chrousos","year":"1992","unstructured":"Chrousos GP, Gold PW. The concepts of stress and stress system disorders: overview of physical and behavioral homeostasis. JAMA J Am Med Assoc. 1992;267(9):1244\u201352.","journal-title":"JAMA J Am Med Assoc"},{"key":"155_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/B978-0-08-045396-5.00230-X","volume-title":"Encyclopedia of behavioral neuroscience","author":"JP Herman","year":"2010","unstructured":"Herman JP. Regulation of the HPA axis by acute and chronic stress. In: Herman JP, editor. Encyclopedia of behavioral neuroscience. Amsterdam: Elsevier; 2010. p. 149\u201353."},{"issue":"4","key":"155_CR9","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3109\/10253890.2011.586446","volume":"14","author":"JG Tasker","year":"2011","unstructured":"Tasker JG, Herman JP. Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic\u2013pituitary\u2013adrenal axis. Stress. 2011;14(4):398\u2013406.","journal-title":"Stress"},{"key":"155_CR10","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3389\/fpsyt.2020.00443","volume":"11","author":"GE Tafet","year":"2020","unstructured":"Tafet GE, Nemeroff CB. Pharmacological treatment of anxiety disorders: the role of the HPA axis. Front Psychiatry. 2020;11:443.","journal-title":"Front Psychiatry"},{"issue":"1","key":"155_CR11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.pharmthera.2012.12.002","volume":"138","author":"V Micale","year":"2013","unstructured":"Micale V, Di Marzo V, Sulcova A, Wotjak CT, Drago F. Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacol Ther. 2013;138(1):18\u201337.","journal-title":"Pharmacol Ther"},{"key":"155_CR12","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/978-3-540-88955-7_12","volume-title":"Behavioral neurobiology of the endocannabinoid system","author":"BB Gorzalka","year":"2009","unstructured":"Gorzalka BB, Hill MN. Integration of endocannabinoid signaling into the neural network regulating stress-induced activation of the hypothalamic\u2013pituitary\u2013adrenal axis. In: Kendall D, Alexander S, editors. Behavioral neurobiology of the endocannabinoid system. Berlin: Springer; 2009. p. 289\u2013306. https:\/\/doi.org\/10.1007\/978-3-540-88955-7_12."},{"issue":"7","key":"155_CR13","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","volume":"79","author":"HC Lu","year":"2016","unstructured":"Lu HC, Mackie K. An introduction to the endogenous cannabinoid system. Biol Psychiatry. 2016;79(7):516\u201325.","journal-title":"Biol Psychiatry"},{"issue":"6507","key":"155_CR14","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/372686a0","volume":"372","author":"V Di Marzo","year":"1994","unstructured":"Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz JC, et al. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature. 1994;372(6507):686\u201391.","journal-title":"Nature"},{"issue":"5","key":"155_CR15","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1073\/pnas.87.5.1932","volume":"87","author":"M Herkenham","year":"1990","unstructured":"Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, de Costa BR, et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci. 1990;87(5):1932\u20136.","journal-title":"Proc Natl Acad Sci"},{"key":"155_CR16","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/3-540-26573-2_10","volume-title":"Cannabinoids","author":"K Mackie","year":"2005","unstructured":"Mackie K. Distribution of cannabinoid receptors in the central and peripheral nervous system. In: Pertwee RG, editor. Cannabinoids. Berlin: Springer; 2005. p. 299\u2013325. https:\/\/doi.org\/10.1007\/3-540-26573-2_10."},{"issue":"12","key":"155_CR17","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1111\/bph.13497","volume":"173","author":"SE O\u2019Sullivan","year":"2016","unstructured":"O\u2019Sullivan SE. An update on PPAR activation by cannabinoids. Br J Pharmacol. 2016;173(12):1899\u2013910.","journal-title":"Br J Pharmacol"},{"key":"155_CR18","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3389\/fnmol.2018.00487","volume":"11","author":"C Muller","year":"2018","unstructured":"Muller C, Morales P, Reggio PH. Cannabinoid ligands targeting TRP channels. Front Mol Neurosci. 2018;11:487\u2013487.","journal-title":"Front Mol Neurosci"},{"issue":"7","key":"155_CR19","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1038\/sj.bjp.0707460","volume":"152","author":"E Ryberg","year":"2007","unstructured":"Ryberg E, Larsson N, Sj\u00f6gren S, Hjorth S, Hermansson NO, Leonova J, et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007;152(7):1092\u2013101.","journal-title":"Br J Pharmacol"},{"key":"155_CR20","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.3389\/fphar.2018.01496","volume":"9","author":"R Guerrero-Alba","year":"2018","unstructured":"Guerrero-Alba R, Barrag\u00e1n-Iglesias P, Gonz\u00e1lez-Hern\u00e1ndez A, Valdez-Mor\u00e1les EE, Granados-Soto V, Cond\u00e9s-Lara M, et al. Some prospective alternatives for treating pain: the endocannabinoid system and its putative receptors GPR18 and GPR55. Front Pharmacol. 2018;9:1496.","journal-title":"Front Pharmacol"},{"issue":"2","key":"155_CR21","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1152\/jn.1995.73.2.907","volume":"73","author":"P Fan","year":"1995","unstructured":"Fan P. Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons. J Neurophysiol. 1995;73(2):907\u201310.","journal-title":"J Neurophysiol"},{"issue":"2","key":"155_CR22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1124\/pr.54.2.161","volume":"54","author":"AC Howlett","year":"2002","unstructured":"Howlett AC. International union of pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev. 2002;54(2):161\u2013202.","journal-title":"Pharmacol Rev"},{"issue":"16","key":"155_CR23","doi-asserted-by":"publisher","first-page":"10819","DOI":"10.1073\/pnas.152334899","volume":"99","author":"TP Dinh","year":"2002","unstructured":"Dinh TP, Carpenter D, Leslie FM, Freund TF, Katona I, Sensi SL, et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci. 2002;99(16):10819\u201324.","journal-title":"Proc Natl Acad Sci"},{"key":"155_CR24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/978-3-319-20825-1_2","volume-title":"endocannabinoids","author":"MG Cascio","year":"2015","unstructured":"Cascio MG, Marini P. Biosynthesis and fate of endocannabinoids. In: Pertwee RG, editor. endocannabinoids. Cham: Springer International Publishing; 2015. p. 39\u201358. https:\/\/doi.org\/10.1007\/978-3-319-20825-1_2."},{"issue":"11","key":"155_CR25","doi-asserted-by":"publisher","first-page":"4544","DOI":"10.1523\/JNEUROSCI.19-11-04544.1999","volume":"19","author":"I Katona","year":"1999","unstructured":"Katona I, Sperl\u00e1gh B, S\u0131\u0301k A, K\u00e4falvi A, Vizi ES, Mackie K, et al. Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J Neurosci. 1999;19(11):4544\u201358.","journal-title":"J Neurosci"},{"issue":"12","key":"155_CR26","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1046\/j.1460-9568.1999.00847.x","volume":"11","author":"G Marsicano","year":"1999","unstructured":"Marsicano G, Lutz B. Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain: CB1 expression in murine forebrain. Eur J Neurosci. 1999;11(12):4213\u201325.","journal-title":"Eur J Neurosci"},{"issue":"23","key":"155_CR27","doi-asserted-by":"publisher","first-page":"9506","DOI":"10.1523\/JNEUROSCI.21-23-09506.2001","volume":"21","author":"I Katona","year":"2001","unstructured":"Katona I, Rancz EA, Acsady L, Ledent C, Mackie K, Hajos N, et al. Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission. J Neurosci. 2001;21(23):9506\u201318.","journal-title":"J Neurosci"},{"issue":"5","key":"155_CR28","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.neuron.2014.01.012","volume":"81","author":"TS Ramikie","year":"2014","unstructured":"Ramikie TS, Nyilas R, Bluett RJ, Gamble-George JC, Hartley ND, Mackie K, et al. Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses. Neuron. 2014;81(5):1111\u201325.","journal-title":"Neuron"},{"issue":"8","key":"155_CR29","doi-asserted-by":"publisher","first-page":"e709","DOI":"10.1371\/journal.pone.0000709","volume":"2","author":"M Lafourcade","year":"2007","unstructured":"Lafourcade M, Elezgarai I, Mato S, Bakiri Y, Grandes P, Manzoni OJ. Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. PLoS ONE. 2007;2(8):e709\u2013e709.","journal-title":"PLoS ONE"},{"issue":"9","key":"155_CR30","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1038\/s41386-018-0064-2","volume":"43","author":"SF Lisboa","year":"2018","unstructured":"Lisboa SF, Niraula A, Resstel LB, Guimaraes FS, Godbout JP, Sheridan JF. Repeated social defeat-induced neuroinflammation, anxiety-like behavior and resistance to fear extinction were attenuated by the cannabinoid receptor agonist WIN55,212\u20132. Neuropsychopharmacol. 2018;43(9):1924\u201333.","journal-title":"Neuropsychopharmacol"},{"issue":"13","key":"155_CR31","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1038\/npp.2009.114","volume":"34","author":"MN Hill","year":"2009","unstructured":"Hill MN, McLaughlin RJ, Morrish AC, Viau V, Floresco SB, Hillard CJ, et al. Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis. Neuropsychopharmacology. 2009;34(13):2733\u201345.","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"155_CR32","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neuropharm.2007.06.012","volume":"54","author":"DJ Rademacher","year":"2008","unstructured":"Rademacher DJ, Meier SE, Shi L, Vanessa Ho WS, Jarrahian A, Hillard CJ. Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice. Neuropharmacology. 2008;54(1):108\u201316.","journal-title":"Neuropharmacology"},{"issue":"11","key":"155_CR33","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1038\/npp.2012.100","volume":"37","author":"A Dlugos","year":"2012","unstructured":"Dlugos A, Childs E, Stuhr KL, Hillard CJ, de Wit H. Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans. Neuropsychopharmacol. 2012;37(11):2416\u201327.","journal-title":"Neuropsychopharmacol"},{"issue":"2","key":"155_CR34","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1055\/s-2007-993211","volume":"41","author":"MN Hill","year":"2008","unstructured":"Hill MN, Miller GE, Ho WSV, Gorzalka BB, Hillard CJ. Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. Pharmacopsychiatry. 2008;41(2):48\u201353.","journal-title":"Pharmacopsychiatry"},{"key":"155_CR35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neuroscience.2011.12.030","volume":"204","author":"MN Hill","year":"2012","unstructured":"Hill MN, Tasker JG. Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis. Neuroscience. 2012;204:5\u201316.","journal-title":"Neuroscience"},{"issue":"9","key":"155_CR36","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1523\/JNEUROSCI.2737-14.2015","volume":"35","author":"JM Gray","year":"2015","unstructured":"Gray JM, Vecchiarelli HA, Morena M, Lee TTY, Hermanson DJ, Kim AB, et al. Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. J Neurosci. 2015;35(9):3879\u201392.","journal-title":"J Neurosci"},{"key":"155_CR37","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ejphar.2018.07.039","volume":"834","author":"V Micale","year":"2018","unstructured":"Micale V, Drago F. Endocannabinoid system, stress and HPA axis. Eur J Pharmacol. 2018;834:230\u20139.","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"155_CR38","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.yfrne.2005.08.001","volume":"26","author":"MF Dallman","year":"2005","unstructured":"Dallman MF. Fast glucocorticoid actions on brain: back to the future. Front Neuroendocrinol. 2005;26(3):103\u20138.","journal-title":"Front Neuroendocrinol"},{"key":"155_CR39","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/978-3-319-20825-1_11","volume-title":"Endocannabinoids","author":"CJ Hillard","year":"2015","unstructured":"Hillard CJ. Endocannabinoids and the endocrine system in health and disease. In: Pertwee RG, editor. Endocannabinoids. Cham: Springer International Publishing; 2015. p. 317\u201339. https:\/\/doi.org\/10.1007\/978-3-319-20825-1_11."},{"key":"155_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111953","volume":"188","author":"RKP Tripathi","year":"2020","unstructured":"Tripathi RKP. A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents. Eur J Med Chem. 2020;188: 111953.","journal-title":"Eur J Med Chem"},{"issue":"5","key":"155_CR41","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/s41386-020-00936-w","volume":"46","author":"MP Paulus","year":"2021","unstructured":"Paulus MP, Stein MB, Simmons AN, Risbrough VB, Halter R, Chaplan SR. The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial. Neuropsychopharmacology. 2021;46(5):1011\u20139.","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"155_CR42","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/s41386-020-00888-1","volume":"46","author":"ME Schmidt","year":"2021","unstructured":"Schmidt ME, Liebowitz MR, Stein MB, Grunfeld J, Van Hove I, Simmons WK, et al. The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study. Neuropsychopharmacology. 2021;46(5):1004\u201310.","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"155_CR43","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.biopsych.2019.07.034","volume":"87","author":"LM Mayo","year":"2020","unstructured":"Mayo LM, Asratian A, Lind\u00e9 J, Morena M, Haataja R, Hammar V, et al. Elevated anandamide, enhanced recall of fear extinction, and attenuated stress responses following inhibition of fatty acid amide hydrolase: a randomized, controlled experimental medicine trial. Biol Psychiatry. 2020;87(6):538\u201347.","journal-title":"Biol Psychiatry"},{"key":"155_CR44","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neubiorev.2016.12.033","volume":"76","author":"S Patel","year":"2017","unstructured":"Patel S, Hill MN, Cheer JF, Wotjak CT, Holmes A. The endocannabinoid system as a target for novel anxiolytic drugs. Neurosci Biobehav Rev. 2017;76:56\u201366.","journal-title":"Neurosci Biobehav Rev"},{"key":"155_CR45","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.euroneuro.2023.04.001","volume":"72","author":"CMB Kwee","year":"2023","unstructured":"Kwee CMB, Leen NA, Van Der Kamp RC, Van Lissa CJ, Cath DC, Groenink L, et al. Anxiolytic effects of endocannabinoid enhancing compounds: a systematic review and meta-analysis. Eur Neuropsychopharmacol. 2023;72:79\u201394.","journal-title":"Eur Neuropsychopharmacol"},{"key":"155_CR46","volume":"2021","author":"MJ Page","year":"2020","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, The PRISMA, et al. statement: an updated guideline for reporting systematic reviews. BMJ. 2020;2021: n71.","journal-title":"BMJ"},{"key":"155_CR47","volume":"2021","author":"MJ Page","year":"2020","unstructured":"Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, PRISMA, et al. explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2020;2021: n160.","journal-title":"BMJ"},{"key":"155_CR48","unstructured":"Pereira CF, Boileau I, Kloiber S. Effects of FAAH inhibition on corticosterone release: a systematic review of preclinical studies [preregistration]. OSF. 2024 Aug 2."},{"key":"155_CR49","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2288-14-43","volume":"14","author":"CR Hooijmans","year":"2014","unstructured":"Hooijmans CR, Rovers MM, de Vries RBM, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE\u2019s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14:43.","journal-title":"BMC Med Res Methodol"},{"key":"155_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.crneur.2021.100013","volume":"2","author":"F Atrooz","year":"2021","unstructured":"Atrooz F, Alkadhi KA, Salim S. Understanding stress: Insights from rodent models. Curr Res Neurobiol. 2021;2: 100013.","journal-title":"Curr Res Neurobiol"},{"issue":"8","key":"155_CR51","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1093\/ijnp\/pyy033","volume":"21","author":"HJC Chen","year":"2018","unstructured":"Chen HJC, Spiers JG, Sernia C, Lavidis NA. Inhibition of fatty acid amide hydrolase by PF-3845 alleviates the nitrergic and proinflammatory response in rat hippocampus following acute stress. Int J Neuropsychopharmacol. 2018;21(8):786\u201395.","journal-title":"Int J Neuropsychopharmacol"},{"key":"155_CR52","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.pbb.2013.11.026","volume":"117","author":"CJ Roberts","year":"2014","unstructured":"Roberts CJ, Stuhr KL, Hutz MJ, Raff H, Hillard CJ. Endocannabinoid signaling in hypothalamic\u2013pituitary\u2013adrenocortical axis recovery following stress: effects of indirect agonists and comparison of male and female mice. Pharmacol Biochem Behav. 2014;117:17\u201324.","journal-title":"Pharmacol Biochem Behav"},{"key":"155_CR53","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/B978-012373947-6.00216-6","volume-title":"Encyclopedia of stress","author":"R Kvetnansky","year":"2007","unstructured":"Kvetnansky R, McCarty R. Immobilization stress. In: Kvetnansky R, editor. Encyclopedia of stress. 2nd ed. New York: Academic Press; 2007. p. 445\u20139.","edition":"2"},{"issue":"1","key":"155_CR54","first-page":"114","volume":"19","author":"RJ McLaughlin","year":"2016","unstructured":"McLaughlin RJ, Verlezza S, Gray JM, Hill MN, Walker CD. Inhibition of anandamide hydrolysis dampens the neuroendocrine response to stress in neonatal rats subjected to suboptimal rearing conditions. Stress Amst Neth. 2016;19(1):114\u201324.","journal-title":"Stress Amst Neth"},{"key":"155_CR55","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.euroneuro.2019.12.119","volume":"32","author":"L Carnevali","year":"2020","unstructured":"Carnevali L, Statello R, Vacondio F, Ferlenghi F, Spadoni G, Rivara S, et al. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. Eur Neuropsychopharmacol. 2020;32:77\u201387.","journal-title":"Eur Neuropsychopharmacol"},{"key":"155_CR56","first-page":"1","volume":"1","author":"L Carnevali","year":"2023","unstructured":"Carnevali L, Barbetti M, Fotio Y, Ferlenghi F, Vacondio F, Mor M, et al. Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress-induced social avoidance and anxiety-like behaviors in male rats. Psychopharmacology (Berlin). 2023;1:1\u201313.","journal-title":"Psychopharmacology (Berlin)"},{"issue":"11","key":"155_CR57","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1016\/j.euroneuro.2015.07.015","volume":"25","author":"L Carnevali","year":"2015","unstructured":"Carnevali L, Vacondio F, Rossi S, Callegari S, Macchi E, Spadoni G, et al. Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats. Eur Neuropsychopharmacol. 2015;25(11):2157\u201369.","journal-title":"Eur Neuropsychopharmacol"},{"key":"155_CR58","first-page":"4367","volume":"77","author":"JM Koolhaas","year":"2013","unstructured":"Koolhaas JM, Coppens CM, de Boer SF, Buwalda B, Meerlo P, Timmermans PJA. The Resident-intruder paradigm: a standardized test for aggression, violence and social stress. J Vis Exp JoVE. 2013;77:4367.","journal-title":"J Vis Exp JoVE"},{"issue":"11","key":"155_CR59","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1002\/dneu.20666","volume":"68","author":"R Llorente","year":"2008","unstructured":"Llorente R, Llorente-Berzal A, Petrosino S, Marco EM, Guaza C, Prada C, et al. Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system. Dev Neurobiol. 2008;68(11):1334\u201347.","journal-title":"Dev Neurobiol"},{"issue":"2","key":"155_CR60","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/0887-8994(96)00153-1","volume":"15","author":"EE Gilles","year":"1996","unstructured":"Gilles EE, Schultz L, Baram TZ. Abnormal corticosterone regulation in an immature rat model of continuous chronic stress. Pediatr Neurol. 1996;15(2):114\u20139.","journal-title":"Pediatr Neurol"},{"issue":"4","key":"155_CR61","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","volume":"47","author":"RD Porsolt","year":"1978","unstructured":"Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol. 1978;47(4):379\u201391.","journal-title":"Eur J Pharmacol"},{"issue":"9","key":"155_CR62","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/j.euroneuro.2014.07.005","volume":"24","author":"G Bedse","year":"2014","unstructured":"Bedse G, Colangeli R, Lavecchia AM, Romano A, Altieri F, Cifani C, et al. Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress. Eur Neuropsychopharmacol. 2014;24(9):1511\u201323.","journal-title":"Eur Neuropsychopharmacol"},{"issue":"5","key":"155_CR63","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.999","volume":"10","author":"W Zada","year":"2022","unstructured":"Zada W, VanRyzin JW, Perez-Pouchoulen M, Baglot SL, Hill MN, Abbas G, et al. Fatty acid amide hydrolase inhibition and N-arachidonoylethanolamine modulation by isoflavonoids: a novel target for upcoming antidepressants. Pharmacol Res Perspect. 2022;10(5): e00999.","journal-title":"Pharmacol Res Perspect"},{"issue":"7","key":"155_CR64","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.neubiorev.2004.09.004","volume":"28","author":"JW Rudy","year":"2004","unstructured":"Rudy JW, Huff NC, Matus-Amat P. Understanding contextual fear conditioning: insights from a two-process model. Neurosci Biobehav Rev. 2004;28(7):675\u201385.","journal-title":"Neurosci Biobehav Rev"},{"issue":"20","key":"155_CR65","doi-asserted-by":"publisher","first-page":"4683","DOI":"10.3390\/molecules25204683","volume":"25","author":"H Ahmad","year":"2020","unstructured":"Ahmad H, Rauf K, Zada W, McCarthy M, Abbas G, Anwar F, et al. Kaempferol facilitated extinction learning in contextual fear conditioned rats via inhibition of fatty-acid amide hydrolase. Molecules. 2020;25(20):4683.","journal-title":"Molecules"},{"issue":"6","key":"155_CR66","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0306-4530(97)00044-9","volume":"22","author":"I Liberzon","year":"1997","unstructured":"Liberzon I, Krstov M, Young EA. Stress-restress: effects on ACTH and fast feedback. Psychoneuroendocrinology. 1997;22(6):443\u201353.","journal-title":"Psychoneuroendocrinology"},{"key":"155_CR67","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neuropharm.2016.10.007","volume":"113","author":"A Simonnet","year":"2017","unstructured":"Simonnet A, Zamberletti E, Cador M, Rubino T, Caill\u00e9 S. Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors. Neuropharmacol. 2017;113:252\u20139.","journal-title":"Neuropharmacol"},{"key":"155_CR68","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1016\/B978-012515400-0\/50043-9","volume-title":"Knobil and Neill\u2019s physiology of reproduction","author":"SR Ojeda","year":"2006","unstructured":"Ojeda SR, Skinner MK. Chapter 38-puberty in the rat. In: Neill JD, editor. Knobil and Neill\u2019s physiology of reproduction. 3rd ed. St Louis: Academic Press; 2006. p. 2061\u2013126.","edition":"3"},{"issue":"6","key":"155_CR69","first-page":"624","volume":"4","author":"P Sengupta","year":"2013","unstructured":"Sengupta P. The laboratory rat: relating its age with human\u2019s. Int J Prev Med. 2013;4(6):624\u201330.","journal-title":"Int J Prev Med"},{"issue":"1","key":"155_CR70","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0149-7634(03)00018-6","volume":"27","author":"E Tirelli","year":"2003","unstructured":"Tirelli E, Laviola G, Adriani W. Ontogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents. Neurosci Biobehav Rev. 2003;27(1):163\u201378.","journal-title":"Neurosci Biobehav Rev"},{"key":"155_CR71","unstructured":"Charles river. Wistar Han IGS rat. https:\/\/www.criver.com\/products-services\/find-model\/wistar-han-igs-rat. Accessed 8 Apr 2024."},{"issue":"1","key":"155_CR72","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1186\/1742-9994-12-S1-S17","volume":"12","author":"V Brust","year":"2015","unstructured":"Brust V, Schindler PM, Lewejohann L. Lifetime development of behavioural phenotype in the house mouse (Mus musculus). Front Zool. 2015;12(1):S17.","journal-title":"Front Zool"},{"key":"155_CR73","unstructured":"The Jackson Laboratory. Body weight information for C57BL\/6J (000664). https:\/\/www.jax.org\/jax-mice-and-services\/strain-data-sheet-pages\/body-weight-chart-000664. Accessed 8 Apr 2024."},{"issue":"4","key":"155_CR74","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s12263-009-0136-3","volume":"4","author":"JPE Spencer","year":"2009","unstructured":"Spencer JPE. Flavonoids and brain health: multiple effects underpinned by common mechanisms. Genes Nutr. 2009;4(4):243.","journal-title":"Genes Nutr"},{"issue":"10","key":"155_CR75","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1111\/1440-1681.12155","volume":"40","author":"SG Ruginsk","year":"2013","unstructured":"Ruginsk SG, Uchoa ET, Elias LL, Antunes-Rodrigues J. Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion. Clin Exp Pharmacol Physiol. 2013;40(10):698\u2013705.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"155_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.104808","volume":"121","author":"L Markey","year":"2020","unstructured":"Markey L, Hooper A, Melon LC, Baglot S, Hill MN, Maguire J, et al. Colonization with the commensal fungus Candida albicans perturbs the gut-brain axis through dysregulation of endocannabinoid signaling. Psychoneuroendocrinology. 2020;121: 104808.","journal-title":"Psychoneuroendocrinology"},{"key":"155_CR77","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.neuroscience.2011.09.032","volume":"204","author":"DM Kerr","year":"2012","unstructured":"Kerr DM, Burke NN, Ford GK, Connor TJ, Harhen B, Egan LJ, et al. Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor. Neuroscience. 2012;204:53\u201363.","journal-title":"Neuroscience"},{"key":"155_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2024.110963","volume":"131","author":"M Barbetti","year":"2024","unstructured":"Barbetti M, Mancabelli L, Vacondio F, Longhi G, Ferlenghi F, Viglioli M, et al. Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats. Prog Neuropsychopharmacol Biol Psychiatry. 2024;131: 110963.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"155_CR79","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.phrs.2014.04.014","volume":"87","author":"A Navarria","year":"2014","unstructured":"Navarria A, Tamburella A, Iannotti FA, Micale V, Camillieri G, Gozzo L, et al. The dual blocker of FAAH\/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. Pharmacol Res. 2014;87:151\u20139.","journal-title":"Pharmacol Res"},{"issue":"6","key":"155_CR80","doi-asserted-by":"publisher","first-page":"588","DOI":"10.2174\/0113895575262104230928042150","volume":"24","author":"VK Patel","year":"2024","unstructured":"Patel VK, Vaishnaw A, Shirbhate E, Kore R, Singh V, Veerasamy R, et al. Cortisol as a target for treating mental disorders: a promising avenue for therapy. Mini Rev Med Chem. 2024;24(6):588\u2013600.","journal-title":"Mini Rev Med Chem"},{"issue":"20","key":"155_CR81","doi-asserted-by":"publisher","first-page":"9406","DOI":"10.1073\/pnas.0914661107","volume":"107","author":"MN Hill","year":"2010","unstructured":"Hill MN, McLaughlin RJ, Bingham B, Shrestha L, Lee TTY, Gray JM, et al. Endogenous cannabinoid signaling is essential for stress adaptation. Proc Natl Acad Sci USA. 2010;107(20):9406\u201311.","journal-title":"Proc Natl Acad Sci USA"},{"key":"155_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.lmot.2023.101872","volume":"81","author":"M Dargahi","year":"2023","unstructured":"Dargahi M, Karimi G, Etemad L, Alavi MS, Roohbakhsh A. Fatty acid amide hydrolase inhibitor URB597 suppressed conditioned and sensitized fear responses in a rat model of post-traumatic stress disorder. Learn Motiv. 2023;81: 101872.","journal-title":"Learn Motiv"},{"issue":"2","key":"155_CR83","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.pbb.2005.01.029","volume":"81","author":"MP Viveros","year":"2005","unstructured":"Viveros MP, Marco EM, File SE. Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav. 2005;81(2):331\u201342.","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"155_CR84","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0163-7258(02)00254-1","volume":"95","author":"R Maldonado","year":"2002","unstructured":"Maldonado R. Study of cannabinoid dependence in animals. Pharmacol Ther. 2002;95(2):153\u201364.","journal-title":"Pharmacol Ther"},{"issue":"3","key":"155_CR85","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/sj.bjp.0706157","volume":"145","author":"JL Wiley","year":"2005","unstructured":"Wiley JL, Burston JJ, Leggett DC, Alekseeva OO, Razdan RK, Mahadevan A, et al. CB1 cannabinoid receptor-mediated modulation of food intake in mice. Br J Pharmacol. 2005;145(3):293\u2013300.","journal-title":"Br J Pharmacol"},{"issue":"11","key":"155_CR86","doi-asserted-by":"publisher","first-page":"e26617","DOI":"10.1371\/journal.pone.0026617","volume":"6","author":"M H\u00e4ring","year":"2011","unstructured":"H\u00e4ring M, Kaiser N, Monory K, Lutz B. Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration. PLoS ONE. 2011;6(11):e26617\u2013e26617.","journal-title":"PLoS ONE"},{"issue":"12","key":"155_CR87","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.1038\/npp.2012.123","volume":"37","author":"AA Rey","year":"2012","unstructured":"Rey AA, Purrio M, Viveros MP, Lutz B. Biphasic effects of cannabinoids in anxiety responses: CB1 and GABAB receptors in the balance of GABAergic and glutamatergic neurotransmission. Neuropsychopharmacol. 2012;37(12):2624\u201334.","journal-title":"Neuropsychopharmacol"},{"issue":"6743","key":"155_CR88","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/22761","volume":"400","author":"PM Zygmunt","year":"1999","unstructured":"Zygmunt PM, Petersson J, Andersson DA, Chuang H, S\u00f8rg\u00e5rd M, Di Marzo V, et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature. 1999;400(6743):452\u20137.","journal-title":"Nature"},{"key":"155_CR89","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18247","volume":"6","author":"JG McCall","year":"2017","unstructured":"McCall JG, Siuda ER, Bhatti DL, Lawson LA, McElligott ZA, Stuber GD, et al. Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior. Elife. 2017;6: e18247.","journal-title":"Elife"},{"issue":"4","key":"155_CR90","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13084","volume":"34","author":"BB Jamieson","year":"2022","unstructured":"Jamieson BB, Kim JS, Iremonger KJ. Cannabinoid and vanilloid pathways mediate opposing forms of synaptic plasticity in corticotropin-releasing hormone neurons. J Neuroendocrinol. 2022;34(4): e13084.","journal-title":"J Neuroendocrinol"},{"issue":"2","key":"155_CR91","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.celrep.2017.03.050","volume":"19","author":"SE Wang","year":"2017","unstructured":"Wang SE, Ko SY, Jo S, Choi M, Lee SH, Jo HR, et al. TRPV1 regulates stress responses through HDAC2. Cell Rep. 2017;19(2):401\u201312.","journal-title":"Cell Rep"},{"key":"155_CR92","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bbr.2019.01.010","volume":"362","author":"TG Freels","year":"2019","unstructured":"Freels TG, Lester DB, Cook MN. Arachidonoyl serotonin (AA-5-HT) modulates general fear-like behavior and inhibits mesolimbic dopamine release. Behav Brain Res. 2019;362:140\u201351.","journal-title":"Behav Brain Res"},{"issue":"9","key":"155_CR93","first-page":"591","volume":"18","author":"MR Zarrindast","year":"2015","unstructured":"Zarrindast MR, Khakpai F. The modulatory role of dopamine in anxiety-like behavior. Arch Iran Med. 2015;18(9):591\u2013603.","journal-title":"Arch Iran Med"},{"issue":"1","key":"155_CR94","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.brainres.2005.12.100","volume":"1076","author":"RM Sullivan","year":"2006","unstructured":"Sullivan RM, Dufresne MM. Mesocortical dopamine and HPA axis regulation: role of laterality and early environment. Brain Res. 2006;1076(1):49\u201359.","journal-title":"Brain Res"},{"issue":"10","key":"155_CR95","doi-asserted-by":"publisher","first-page":"854","DOI":"10.7326\/0003-4819-117-10-854","volume":"117","author":"EM Sternberg","year":"1992","unstructured":"Sternberg EM, Chrousos GP, Wilder RL, Gold PW. The stress response and the regulation of inflammatory disease. Ann Intern Med. 1992;117(10):854\u201366.","journal-title":"Ann Intern Med"},{"key":"155_CR96","first-page":"49","volume-title":"International review of neurobiology","author":"TTY Lee","year":"2015","unstructured":"Lee TTY, Gorzalka BB. Evidence for a role of adolescent endocannabinoid signaling in regulating HPA axis stress responsivity and emotional behavior development. In: Lee TT, editor. International review of neurobiology. Amsterdam: Elsevier; 2015. p. 49\u201384."},{"issue":"5828","key":"155_CR97","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1126\/science.1137406","volume":"316","author":"P Berghuis","year":"2007","unstructured":"Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Urb\u00e1n GM, et al. Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science. 2007;316(5828):1212\u20136.","journal-title":"Science"},{"issue":"25","key":"155_CR98","doi-asserted-by":"publisher","first-page":"8760","DOI":"10.1073\/pnas.0803545105","volume":"105","author":"J Mulder","year":"2008","unstructured":"Mulder J, Aguado T, Keimpema E, Barab\u00e1s K, Ballester Rosado CJ, Nguyen L, et al. Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc Natl Acad Sci. 2008;105(25):8760\u20135.","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"155_CR99","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/gbb.12253","volume":"15","author":"TTY Lee","year":"2016","unstructured":"Lee TTY, Hill MN, Lee FS. Developmental regulation of fear learning and anxiety behavior by endocannabinoids. Genes Brain Behav. 2016;15(1):108\u201324.","journal-title":"Genes Brain Behav"},{"key":"155_CR100","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.neuroscience.2012.10.048","volume":"249","author":"L Eiland","year":"2013","unstructured":"Eiland L, Romeo RD. Stress and the developing adolescent brain. Neuroscience. 2013;249:162\u201371.","journal-title":"Neuroscience"},{"issue":"1","key":"155_CR101","first-page":"4","volume":"67","author":"TTY Lee","year":"2013","unstructured":"Lee TTY, Hill MN, Hillard CJ, Gorzalka BB. Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period. Synap N Y N. 2013;67(1):4\u201310.","journal-title":"Synap N Y N"},{"key":"155_CR102","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.psyneuen.2014.01.016","volume":"42","author":"RD Romeo","year":"2014","unstructured":"Romeo RD, Minhas S, Svirsky SE, Hall BS, Savenkova M, Karatsoreos IN. Pubertal shifts in adrenal responsiveness to stress and adrenocorticotropic hormone in male rats. Psychoneuroendocrinology. 2014;42:146\u201352.","journal-title":"Psychoneuroendocrinology"},{"key":"155_CR103","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuroscience.2011.10.006","volume":"204","author":"TTY Lee","year":"2012","unstructured":"Lee TTY, Gorzalka BB. Timing is everything: evidence for a role of corticolimbic endocannabinoids in modulating hypothalamic\u2013pituitary\u2013adrenal axis activity across developmental periods. Neuroscience. 2012;204:17\u201330.","journal-title":"Neuroscience"},{"issue":"7","key":"155_CR104","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1101\/lm.041608.116","volume":"23","author":"S Alteba","year":"2016","unstructured":"Alteba S, Korem N, Akirav I. Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood. Learn Mem Cold Spring Harb N. 2016;23(7):349\u201358.","journal-title":"Learn Mem Cold Spring Harb N"},{"key":"155_CR105","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105938","volume":"174","author":"T Stark","year":"2021","unstructured":"Stark T, Di Martino S, Drago F, Wotjak CT, Micale V. Phytocannabinoids and schizophrenia: Focus on adolescence as a critical window of enhanced vulnerability and opportunity for treatment. Pharmacol Res. 2021;174: 105938.","journal-title":"Pharmacol Res"},{"issue":"3","key":"155_CR106","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0024-3205(94)00585-0","volume":"54","author":"F Rodr\u00edguez de Fonseca","year":"1994","unstructured":"Rodr\u00edguez de Fonseca F, Cebeira M, Ramos JA, Mart\u00edn M, Fern\u00e1ndez-Ruiz JJ. Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement. Life Sci. 1994;54(3):159\u201370.","journal-title":"Life Sci"},{"issue":"3","key":"155_CR107","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1002\/j.2040-4603.2014.tb00575.x","volume":"4","author":"N Goel","year":"2014","unstructured":"Goel N, Workman JL, Lee TT, Innala L, Viau V. Sex differences in the HPA axis. Compr Physiol. 2014;4(3):1121\u201355.","journal-title":"Compr Physiol"},{"issue":"5","key":"155_CR108","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1210\/endo-68-5-818","volume":"68","author":"JI Kitay","year":"1961","unstructured":"Kitay JI. Sex differences in adrenal cortical secretion in the rat S. Endocrinology. 1961;68(5):818\u201324.","journal-title":"Endocrinology"},{"key":"155_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2020.106893","volume":"80","author":"D Dow-Edwards","year":"2020","unstructured":"Dow-Edwards D. Sex differences in the interactive effects of early life stress and the endocannabinoid system. Neurotoxicol Teratol. 2020;80: 106893.","journal-title":"Neurotoxicol Teratol"},{"issue":"47","key":"155_CR110","doi-asserted-by":"publisher","first-page":"20535","DOI":"10.1073\/pnas.1005003107","volume":"107","author":"DL Krebs-Kraft","year":"2010","unstructured":"Krebs-Kraft DL, Hill MN, Hillard CJ, McCarthy MM. Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior. Proc Natl Acad Sci USA. 2010;107(47):20535\u201340.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"155_CR111","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1111\/bph.15341","volume":"178","author":"M Morena","year":"2021","unstructured":"Morena M, Nastase AS, Santori A, Cravatt BF, Shansky RM, Hill MN. Sex-dependent effects of endocannabinoid modulation of conditioned fear extinction in rats. Br J Pharmacol. 2021;178(4):983\u201396.","journal-title":"Br J Pharmacol"},{"key":"155_CR112","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2021.110438","volume":"113","author":"JJ Simone","year":"2022","unstructured":"Simone JJ, Green MR, McCormick CM. Endocannabinoid system contributions to sex-specific adolescent neurodevelopment. Prog Neuropsychopharmacol Biol Psychiatry. 2022;113: 110438.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"155_CR113","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2019.100155","volume":"10","author":"M Rinc\u00f3n-Cort\u00e9s","year":"2019","unstructured":"Rinc\u00f3n-Cort\u00e9s M, Herman JP, Lupien S, Maguire J, Shansky RM. Stress: influence of sex, reproductive status and gender. Neurobiol Stress. 2019;10: 100155.","journal-title":"Neurobiol Stress"},{"key":"155_CR114","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2022.100470","volume":"20","author":"HA Vecchiarelli","year":"2022","unstructured":"Vecchiarelli HA, Morena M, Lee TTY, Nastase AS, Aukema RJ, Leitl KD, et al. Sex and stressor modality influence acute stress-induced dynamic changes in corticolimbic endocannabinoid levels in adult Sprague Dawley rats. Neurobiol Stress. 2022;20: 100470.","journal-title":"Neurobiol Stress"},{"issue":"5\u20136","key":"155_CR115","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1097\/FBP.0000000000000068","volume":"25","author":"EM Marco","year":"2014","unstructured":"Marco EM, Echeverry-Alzate V, L\u00f3pez-Moreno JA, Gin\u00e9 E, Pe\u00f1asco S, Viveros MP. Consequences of early life stress on the expression of endocannabinoid-related genes in the rat brain. Behav Pharmacol. 2014;25(5\u20136):547\u201356.","journal-title":"Behav Pharmacol"},{"issue":"3","key":"155_CR116","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1210\/en.2011-1643","volume":"153","author":"BB Gorzalka","year":"2012","unstructured":"Gorzalka BB, Dang SS. Minireview: Endocannabinoids and gonadal hormones: bidirectional interactions in physiology and behavior. Endocrinol Phila. 2012;153(3):1016\u201324.","journal-title":"Endocrinol Phila"},{"issue":"4","key":"155_CR117","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00213-009-1494-7","volume":"204","author":"J Haller","year":"2009","unstructured":"Haller J, Barna I, Barsvari B, Gyimesi Pelczer K, Yasar S, Panlilio LV, et al. Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats. Psychopharmacology. 2009;204(4):607\u201316.","journal-title":"Psychopharmacology"},{"key":"155_CR118","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104680","volume":"138","author":"M Ahmed","year":"2022","unstructured":"Ahmed M, Best LM, Pereira CF, Boileau I, Kloiber S. Effects of endocannabinoid system modulation on social behaviour: a systematic review of animal studies. Neurosci Biobehav Rev. 2022;138: 104680.","journal-title":"Neurosci Biobehav Rev"},{"issue":"7","key":"155_CR119","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.tins.2017.04.005","volume":"40","author":"D Wei","year":"2017","unstructured":"Wei D, Allsop S, Tye K, Piomelli D. Endocannabinoid signaling in the control of social behavior. Trends Neurosci. 2017;40(7):385\u201396.","journal-title":"Trends Neurosci"},{"key":"155_CR120","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/9781118083222.ch2","volume-title":"The handbook of stress","author":"JP Herman","year":"2011","unstructured":"Herman JP. Central nervous system regulation of the hypothalamic\u2013pituitary\u2013adrenal axis stress response. In: Conrad CD, editor. The handbook of stress. Blackwell: Wiley; 2011. p. 29\u201346."},{"issue":"1","key":"155_CR121","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neuropharm.2007.07.005","volume":"54","author":"F Moreira","year":"2008","unstructured":"Moreira F, Kaiser N, Monory K, Lutz B. Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. Neuropharmacology. 2008;54(1):141\u201350.","journal-title":"Neuropharmacology"},{"issue":"12","key":"155_CR122","doi-asserted-by":"publisher","first-page":"4850","DOI":"10.1523\/JNEUROSCI.23-12-04850.2003","volume":"23","author":"S Di","year":"2003","unstructured":"Di S, Malcher-Lopes R, Halmos KC, Tasker JG. Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J Neurosci. 2003;23(12):4850\u20137.","journal-title":"J Neurosci"},{"issue":"29","key":"155_CR123","doi-asserted-by":"publisher","first-page":"10506","DOI":"10.1523\/JNEUROSCI.0496-11.2011","volume":"31","author":"MN Hill","year":"2011","unstructured":"Hill MN, McLaughlin RJ, Pan B, Fitzgerald ML, Roberts CJ, Lee TTY, et al. Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. J Neurosci. 2011;31(29):10506\u201315.","journal-title":"J Neurosci"},{"issue":"1","key":"155_CR124","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1177\/0269881111409606","volume":"26","author":"M Wang","year":"2012","unstructured":"Wang M, Hill MN, Zhang L, Gorzalka BB, Hillard CJ, Alger BE. Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation. J Psychopharmacol Oxf Engl. 2012;26(1):56\u201370.","journal-title":"J Psychopharmacol Oxf Engl"},{"issue":"1","key":"155_CR125","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/j.2040-4603.2017.tb00740.x","volume":"7","author":"CJ Hillard","year":"2016","unstructured":"Hillard CJ, Beatka M, Sarvaideo J. Endocannabinoid signaling and the hypothalamic-pituitary-adrenal axis. Compr Physiol. 2016;7(1):1\u201315.","journal-title":"Compr Physiol"},{"issue":"8","key":"155_CR126","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.psyneuen.2009.03.013","volume":"34","author":"MN Hill","year":"2009","unstructured":"Hill MN, Miller GE, Carrier EJ, Gorzalka BB, Hillard CJ. Circulating endocannabinoids and N -acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. Psychoneuroendocrinology. 2009;34(8):1257\u201362.","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"155_CR127","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/mp.2013.61","volume":"18","author":"A Neumeister","year":"2013","unstructured":"Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, et al. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Mol Psychiatry. 2013;18(9):1034\u201340.","journal-title":"Mol Psychiatry"},{"issue":"5","key":"155_CR128","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062741","volume":"8","author":"D Hauer","year":"2013","unstructured":"Hauer D, Schelling G, Gola H, Campolongo P, Morath J, Roozendaal B, et al. Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder. PLoS ONE. 2013;8(5): e62741.","journal-title":"PLoS ONE"},{"issue":"12","key":"155_CR129","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1016\/j.psyneuen.2013.08.004","volume":"38","author":"MN Hill","year":"2013","unstructured":"Hill MN, Bierer LM, Makotkine I, Golier JA, Galea S, McEwen BS, et al. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks. Psychoneuroendocrinology. 2013;38(12):2952\u201361.","journal-title":"Psychoneuroendocrinology"},{"issue":"24","key":"155_CR130","doi-asserted-by":"publisher","first-page":"17452","DOI":"10.3390\/ijms242417452","volume":"24","author":"J Spohrs","year":"2023","unstructured":"Spohrs J, K\u00fchnle V, Mikusky D, Sanh\u00fcter N, Macchia A, Nickel S, et al. Plasma endocannabinoid levels in patients with borderline personality disorder and healthy controls. Int J Mol Sci. 2023;24(24):17452.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"155_CR131","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00406-013-0470-8","volume":"264","author":"C Schaefer","year":"2014","unstructured":"Schaefer C, Enning F, Mueller JK, Bumb JM, Rohleder C, Odorfer TM, et al. Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders. Eur Arch Psychiatry Clin Neurosci. 2014;264(5):459\u201363.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"11","key":"155_CR132","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1038\/s41386-020-0731-y","volume":"45","author":"NJ Kolla","year":"2020","unstructured":"Kolla NJ, Mizrahi R, Karas K, Wang C, Bagby RM, McMain S, et al. Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [11C]CURB positron emission tomography study. Neuropsychopharmacology. 2020;45(11):1834\u201341.","journal-title":"Neuropsychopharmacology"},{"key":"155_CR133","first-page":"397","volume-title":"Progress in brain research","author":"MA Steiner","year":"2008","unstructured":"Steiner MA, Wotjak CT. Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis. In: Neumann ID, Landgraf R, editors. Progress in brain research. Amsterdam: Elsevier; 2008. p. 397\u2013432."}],"container-title":["Discover Mental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44192-025-00155-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44192-025-00155-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44192-025-00155-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T16:41:38Z","timestamp":1744216898000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44192-025-00155-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":133,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["155"],"URL":"https:\/\/doi.org\/10.1007\/s44192-025-00155-z","relation":{},"ISSN":["2731-4383"],"issn-type":[{"value":"2731-4383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"assertion":[{"value":"31 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"51"}}