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Bacterial production of an enzyme called extended-spectrum beta-lactamase (ESBL) can generate resistance to antimicrobial therapeutics. Therefore, between 2012 and 2013, we investigated <jats:italic>K. pneumoniae<\/jats:italic> that produce ESBLs with the prevalence of individual genes including <jats:italic>bla<\/jats:italic><jats:sub>SHV<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>TEM<\/jats:sub>, and <jats:italic>bla<\/jats:italic><jats:sub>OXA<\/jats:sub> isolated from clinical samples. A total of 99 variable diagnostic samples including blood from hematological malignancies (<jats:italic>n<\/jats:italic>\u2009=\u200914) or other clinical sources including sputum, pus, urine, and wound (<jats:italic>n<\/jats:italic>\u2009=\u200985) were analyzed. All samples' bacterial type was confirmed and their susceptibility to antimicrobial agents was established. Polymerase chain reaction (PCR) amplification was carried out to ascertain presence of specific genes that included <jats:italic>bla<\/jats:italic><jats:sub>SHV<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>TEM<\/jats:sub>, and <jats:italic>bla<\/jats:italic><jats:sub>OXA.<\/jats:sub> Plasmid DNA profiles were determined to assess significance between resistance to antimicrobial agents and plasmid number. It was found that among non-hematologic malignancy isolates, the highest rate of resistance was 87.9% to imipenem, with lowest rate being 2% to ampicillin. However, in hematologic malignancy isolates, the highest microbial resistance was 92.9% to ampicillin with the lowest rate of resistance at 28.6% to imipenem. Among collected isolates, 45% were ESBL-producers with 50% occurrence in hematologic malignancy individuals that were ESBL-producers. Within ESBL-producing isolates from hematologic malignancy individuals<jats:italic>, bla<\/jats:italic><jats:sub>SHV<\/jats:sub> was detected in 100%, <jats:italic>bla<\/jats:italic><jats:sub><jats:italic>CTX<\/jats:italic>-M<\/jats:sub> in 85.7%, and <jats:italic>bla<\/jats:italic><jats:sub>TEM<\/jats:sub> and <jats:italic>bla<\/jats:italic><jats:sub>OXA-1<\/jats:sub> at 57.1% and 27.1%, respectively. In addition, <jats:italic>bla<\/jats:italic><jats:sub>SHV,<\/jats:sub><jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub>, and <jats:italic>bla<\/jats:italic><jats:sub>OXA<\/jats:sub> were found in all non-hematological malignancy individuals with <jats:italic>bla<\/jats:italic><jats:sub>TEM<\/jats:sub> detected in 55.5% of samples. Our findings indicate that ESBLs expressing <jats:italic>bla<\/jats:italic><jats:sub>SHV<\/jats:sub> and <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub> genes are significantly prevalent in <jats:italic>K. pneumoniae<\/jats:italic> isolates from hematologic malignancy individuals. Plasmid analysis indicated plasmids in isolates collected from hematological malignancy individuals. Furthermore, there was a correlation between resistance to antimicrobial agents and plasmids within two groups analyzed. This study indicates an increase in incidence of <jats:italic>K. pneumoniae<\/jats:italic> infections displaying ESBL phenotypes in Jordan.<\/jats:p>","DOI":"10.1007\/s44197-023-00096-2","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T18:03:03Z","timestamp":1682359383000},"page":"180-190","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence of Extended-Spectrum \u03b2-Lactamases in Multidrug-Resistant Klebsiella pneumoniae Isolates in Jordanian Hospitals"],"prefix":"10.1007","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-3232","authenticated-orcid":false,"given":"Suhaila A.","family":"Al-Sheboul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghina S.","family":"Al-Madi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-6943","authenticated-orcid":false,"given":"Brent","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1816-9018","authenticated-orcid":false,"given":"Wail A.","family":"Hayajneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"issue":"2","key":"96_CR1","doi-asserted-by":"publisher","DOI":"10.5812\/jkums.106135","volume":"24","author":"IA Naqid","year":"2020","unstructured":"Naqid IA, Hussein NR, Balatay AA, Saeed KA, Ahmed HA. 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