{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:35:32Z","timestamp":1790422532447,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Joint project of Chongqing Health Commission and Science and Technology Bureau","award":["2023GDRC008"],"award-info":[{"award-number":["2023GDRC008"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["ANAL. SCI."],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s44211-026-00926-w","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:11:57Z","timestamp":1779171117000},"page":"701-710","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Uniform shear-induced platelet aggregation analysis via microfluidics fabricated from 3D-printed mold: a rapid platform for antiplatelet drug assessment"],"prefix":"10.1007","volume":"42","author":[{"given":"Xuemei","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanrong","family":"Huan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-796X","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"issue":"5","key":"926_CR1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/eurheartj\/ehae776","volume":"46","author":"G Vilahur","year":"2025","unstructured":"G. Vilahur, V. Fuster, Interplay between platelets and coagulation: from protective haemostasis to pathological arterial thrombosis. Eur. Heart J. 46(5), 413\u2013423 (2025). https:\/\/doi.org\/10.1093\/eurheartj\/ehae776","journal-title":"Eur. Heart J."},{"issue":"3","key":"926_CR2","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s10238-022-00829-w","volume":"23","author":"S Navarrete","year":"2022","unstructured":"S. Navarrete, C. Solar, R. Tapia, J. Pereira, E. Fuentes, I. Palomo, Pathophysiology of deep vein thrombosis. Clin. Exp. Med. 23(3), 645\u2013654 (2022). https:\/\/doi.org\/10.1007\/s10238-022-00829-w","journal-title":"Clin. Exp. Med."},{"key":"926_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111447","author":"S Schulman","year":"2024","unstructured":"S. Schulman, A. Makatsariya, J. Khizroeva, V. Bitsadze, D. Kapanadze, The basic principles of pathophysiology of venous thrombosis. Int. J. Mol. Sci. (2024). https:\/\/doi.org\/10.3390\/ijms252111447","journal-title":"Int. J. Mol. Sci."},{"key":"926_CR4","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13866","author":"A Bourguignon","year":"2022","unstructured":"A. Bourguignon, S. Tasneem, C.P.M. Hayward, Update on platelet procoagulant mechanisms in health and in bleeding disorders. Int. J. Lab. Hematol. (2022). https:\/\/doi.org\/10.1111\/ijlh.13866","journal-title":"Int. J. Lab. Hematol."},{"issue":"1","key":"926_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06891-8","volume":"23","author":"L Sun","year":"2025","unstructured":"L. Sun, H. Li, Y. Li, X. Li, H. Tian, J. Liu, M. Liu, J. Wang, Q. Huang, Z. Zhang, X. Ji, L. Xi, K. Li, Y. Li, X. Niu, M. Duo, B. Zou, J. Wen, J. Li, R. Miao, W. Xie, S. Xu, P. Yang, Z. Zhai, Proteomic insights into platelet dysregulation and pathogenic mechanisms of chronic thromboembolic pulmonary hypertension. J. Transl. Med. 23(1), 1074 (2025). https:\/\/doi.org\/10.1186\/s12967-025-06891-8","journal-title":"J. Transl. Med."},{"issue":"1","key":"926_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91416-8","volume":"11","author":"AJ Velasquez-Mao","year":"2021","unstructured":"A.J. Velasquez-Mao, M.A. Velasquez, Z. Hui, D. Armas-Ayon, J. Wang, M.H. Vandsburger, Hemodialysis exacerbates proteolytic imbalance and pro-fibrotic platelet dysfunction. Sci. Rep. 11(1), 11764 (2021). https:\/\/doi.org\/10.1038\/s41598-021-91416-8","journal-title":"Sci. Rep."},{"issue":"3","key":"926_CR7","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","volume":"16","author":"PEJvd Meijden","year":"2019","unstructured":"PEJvd. Meijden, J.W.M. Heemskerk, Platelet biology and functions: new concepts and clinical perspectives. Nat. Rev. Cardiol. 16(3), 166\u2013179 (2019). https:\/\/doi.org\/10.1038\/s41569-018-0110-0","journal-title":"Nat. Rev. Cardiol."},{"issue":"9","key":"926_CR8","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41569-023-00854-6","volume":"20","author":"M Gawaz","year":"2023","unstructured":"M. Gawaz, T. Geisler, O. Borst, Current concepts and novel targets for antiplatelet therapy. Nat. Rev. Cardiol. 20(9), 583\u2013599 (2023). https:\/\/doi.org\/10.1038\/s41569-023-00854-6","journal-title":"Nat. Rev. Cardiol."},{"key":"926_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154463","author":"Y Zhou","year":"2022","unstructured":"Y. Zhou, D. Zhang, P. Tan, B. Xian, H. Jiang, Q. Wu, X. Huang, P. Zhang, X. Xiao, J. Pei, Mechanism of platelet activation and potential therapeutic effects of natural drugs. Phytomed. Int. J. Phytother. Phytopharmacol. (2022). https:\/\/doi.org\/10.1016\/j.phymed.2022.154463","journal-title":"Phytomed. Int. J. Phytother. Phytopharmacol."},{"issue":"24","key":"926_CR10","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1182\/blood.2024025476","volume":"144","author":"R Kaiser","year":"2024","unstructured":"R. Kaiser, R. Dewender, M. Mulkers, J. Stermann, D. Rossaro, L. Di Fina, L. Li, C. Gold, M. Schmid, L. K\u00e4\u00e4b, L. Eivers, S. Akg\u00f6l, K. Yue, L. Kammerer, Q. Loew, A. Anjum, R. Escaig, A. Akhalkatsi, L. Laun, J. Kranich, T. Brocker, T.T. Mueller, A. Kr\u00e4chan, J. Gmeiner, K. Pekayvaz, M. Thienel, S. Massberg, K. Stark, B. Kilani, L. Nicolai, Procoagulant platelet activation promotes venous thrombosis. Blood 144(24), 2546\u20132553 (2024). https:\/\/doi.org\/10.1182\/blood.2024025476","journal-title":"Blood"},{"issue":"7","key":"926_CR11","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1016\/j.jtha.2025.01.011","volume":"23","author":"D Mehic","year":"2025","unstructured":"D. Mehic, B. Eichinger, T. Dreier, A. Tolios, B. Eichelberger, A. Kaider, C. Ay, I. Pabinger, J. Gebhart, Platelet function analyzer (PFA-100) in patients with mild-to-moderate bleeding disorders and bleeding disorder of unknown cause. J. Thromb. Haemost. 23(7), 2335\u20132341 (2025). https:\/\/doi.org\/10.1016\/j.jtha.2025.01.011","journal-title":"J. Thromb. Haemost."},{"issue":"6","key":"926_CR12","doi-asserted-by":"publisher","first-page":"572","DOI":"10.3343\/alm.2024.0003","volume":"44","author":"S Woo","year":"2024","unstructured":"S. Woo, B. Kim, N.H. Heo, M.-S. Kim, Y.A. Yoon, Y.-J. Choi, Reliability of the DI-60 digital image analyzer for detecting platelet clumping and obtaining accurate platelet counts. Ann. Lab. Med. 44(6), 572\u2013575 (2024). https:\/\/doi.org\/10.3343\/alm.2024.0003","journal-title":"Ann. Lab. Med."},{"issue":"2","key":"926_CR13","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1055\/s-0043-1777308","volume":"50","author":"SK Kundu","year":"2023","unstructured":"S.K. Kundu, E.J. Heilmann, R. Sio, C. Garcia, R.M. Davidson, R.A. Ostgaard, Description of an in vitro platelet function analyzer-PFA-100\u2122. Semin. Thromb. Hemost. 50(2), 314\u2013319 (2023). https:\/\/doi.org\/10.1055\/s-0043-1777308","journal-title":"Semin. Thromb. Hemost."},{"issue":"10","key":"926_CR14","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1111\/j.1365-2044.2012.07231.x","volume":"67","author":"NS Weitzel","year":"2012","unstructured":"N.S. Weitzel, L.B. Weitzel, L.E. Epperson, A. Karimpour-Ford, Z.V. Tran, T. Seres, Platelet mapping as part of modified thromboelastography (TEG\u00ae) in patients undergoing cardiac surgery and cardiopulmonary bypass. Anaesthesia 67(10), 1158\u20131165 (2012). https:\/\/doi.org\/10.1111\/j.1365-2044.2012.07231.x","journal-title":"Anaesthesia"},{"issue":"7","key":"926_CR15","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/MBC.0000000000000941","volume":"31","author":"H Mansouritorghabeh","year":"2020","unstructured":"H. Mansouritorghabeh, B. De Laat, M. Roest, Current methods of measuring platelet activity: pros and cons. Blood Coagul. Fibrinolysis 31(7), 426\u2013433 (2020). https:\/\/doi.org\/10.1097\/MBC.0000000000000941","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"926_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2025.123540","volume":"475","author":"ST Lim","year":"2025","unstructured":"S.T. Lim, S.J.X. Murphy, D.R. Smith, D.R. Collins, T. Coughlan, S.M. Murphy, A.J. Mccarthy, B. Egan, S.Y. Lim, D. Cox, D.J.H. Mccabe, Pilot study of on-treatment platelet reactivity at low shear stress and platelet activation status on aspirin or clopidogrel monotherapy in patients with TIA or ischaemic stroke. J. Neurol. Sci. 475, 123540 (2025). https:\/\/doi.org\/10.1016\/j.jns.2025.123540","journal-title":"J. Neurol. Sci."},{"issue":"5","key":"926_CR17","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1080\/09537104.2017.1319047","volume":"28","author":"C Zhang","year":"2017","unstructured":"C. Zhang, S. Neelamegham, Application of microfluidic devices in studies of thrombosis and hemostasis. Platelets 28(5), 434\u2013440 (2017). https:\/\/doi.org\/10.1080\/09537104.2017.1319047","journal-title":"Platelets"},{"issue":"6","key":"926_CR18","doi-asserted-by":"publisher","DOI":"10.1063\/1.4989386","volume":"11","author":"NZ Alsmadi","year":"2017","unstructured":"N.Z. Alsmadi, S.J. Shapiro, C.S. Lewis, V.M. Sheth, T.A. Snyder, D.W. Schmidtke, Constricted microfluidic devices to study the effects of transient high shear exposure on platelets. Biomicrofluidics 11(6), 064105 (2017). https:\/\/doi.org\/10.1063\/1.4989386","journal-title":"Biomicrofluidics"},{"issue":"5","key":"926_CR19","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1515\/cclm-2022-0666","volume":"61","author":"EJ Favaloro","year":"2022","unstructured":"E.J. Favaloro, L. Pasalic, G. Lippi, Towards 50 years of platelet function analyser (PFA) testing. Clin. Chem. Lab. Med. 61(5), 851\u2013860 (2022). https:\/\/doi.org\/10.1515\/cclm-2022-0666","journal-title":"Clin. Chem. Lab. Med."},{"issue":"6","key":"926_CR20","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/nm.1955","volume":"15","author":"WS Nesbitt","year":"2009","unstructured":"W.S. Nesbitt, E. Westein, F.J. Tovar-Lopez, E. Tolouei, A. Mitchell, J. Fu, J. Carberry, A. Fouras, S.P. Jackson, A shear gradient\u2013dependent platelet aggregation mechanism drives thrombus formation. Nat. Med. 15(6), 665\u2013673 (2009). https:\/\/doi.org\/10.1038\/nm.1955","journal-title":"Nat. Med."},{"issue":"3","key":"926_CR21","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1039\/b916757a","volume":"10","author":"FJ Tovar-Lopez","year":"2010","unstructured":"F.J. Tovar-Lopez, G. Rosengarten, E. Westein, K. Khoshmanesh, S.P. Jackson, A. Mitchell, W.S. Nesbitt, A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood. Lab Chip 10(3), 291\u2013302 (2010). https:\/\/doi.org\/10.1039\/b916757a","journal-title":"Lab Chip"},{"issue":"4","key":"926_CR22","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1073\/pnas.1209905110","volume":"110","author":"E Westein","year":"2013","unstructured":"E. Westein, A.D. Van Der Meer, M.J. Kuijpers, J.P. Frimat, A. Van Den Berg, J.W. Heemskerk, Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner. Proc. Natl. Acad. Sci. U. S. A. 110(4), 1357\u20131362 (2013). https:\/\/doi.org\/10.1073\/pnas.1209905110","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"926_CR23","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3195","volume":"9","author":"A Dupuy","year":"2019","unstructured":"A. Dupuy, L.A. Ju, F.H. Passam, Straight channel microfluidic chips for the study of platelet adhesion under flow. Bio-Protoc. 9(6), e3195 (2019). https:\/\/doi.org\/10.21769\/BioProtoc.3195","journal-title":"Bio-Protoc."},{"key":"926_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/mi10110787","author":"I Provenzale","year":"2019","unstructured":"I. Provenzale, S.L.N. Brouns, P.E.J. Van Der Meijden, F. Swieringa, J.W.M. Heemskerk, Whole blood based multiparameter assessment of thrombus formation in standard microfluidic devices to proxy in vivo haemostasis and thrombosis. Micromachines (2019). https:\/\/doi.org\/10.3390\/mi10110787","journal-title":"Micromachines"},{"issue":"1","key":"926_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.thromres.2015.05.012","volume":"136","author":"BR Branchford","year":"2015","unstructured":"B.R. Branchford, C.J. Ng, K.B. Neeves, J. Di Paola, Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis. Thromb. Res. 136(1), 13\u201319 (2015). https:\/\/doi.org\/10.1016\/j.thromres.2015.05.012","journal-title":"Thromb. Res."},{"issue":"1","key":"926_CR26","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/jth.13881","volume":"16","author":"M Lehmann","year":"2017","unstructured":"M. Lehmann, K. Ashworth, M. Manco-Johnson, J. Di Paola, K.B. Neeves, C.J. Ng, Evaluation of a microfluidic flow assay to screen for von Willebrand disease and low von Willebrand factor levels. J. Thromb. Haemost. 16(1), 104\u2013115 (2017). https:\/\/doi.org\/10.1111\/jth.13881","journal-title":"J. Thromb. Haemost."},{"key":"926_CR27","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14653","author":"X Gao","year":"2023","unstructured":"X. Gao, T. Zhang, X. Huang, X. Huan, Y. Li, Evaluating the impact of transient shear stress on platelet activation, adhesion, and aggregation with microfluidic chip technique. Artif. Organs (2023). https:\/\/doi.org\/10.1111\/aor.14653","journal-title":"Artif. Organs"},{"key":"926_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semcdb.2020.06.002","volume":"112","author":"BM Trevisan","year":"2021","unstructured":"B.M. Trevisan, C.D. Porada, A. Atala, G. Almeida-Porada, Microfluidic devices for studying coagulation biology. Semin. Cell Dev. Biol. 112, 1\u20137 (2021). https:\/\/doi.org\/10.1016\/j.semcdb.2020.06.002","journal-title":"Semin. Cell Dev. Biol."},{"key":"926_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijengsci.2019.103206","author":"W-T Wu","year":"2019","unstructured":"W.-T. Wu, M. Zhussupbekov, N. Aubry, J.F. Antaki, M. Massoudi, Simulation of thrombosis in a stenotic microchannel: the effects of vWF-enhanced shear activation of platelets. Int. J. Eng. Sci. (2019). https:\/\/doi.org\/10.1016\/j.ijengsci.2019.103206","journal-title":"Int. J. Eng. Sci."},{"issue":"5","key":"926_CR30","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1007\/s10439-023-03193-2","volume":"51","author":"P Wang","year":"2023","unstructured":"P. Wang, J. Sheriff, P. Zhang, Y. Deng, D. Bluestein, A multiscale model for shear-mediated platelet adhesion dynamics: correlating in silico with in vitro results. Ann. Biomed. Eng. 51(5), 1094\u20131105 (2023). https:\/\/doi.org\/10.1007\/s10439-023-03193-2","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"926_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-020-00309-7","volume":"21","author":"MF Schneider","year":"2020","unstructured":"M.F. Schneider, M.A. Fallah, C. Mess, T. Obser, R. Schneppenheim, A. Alexander-Katz, S.W. Schneider, V. Huck, Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF. BMC Mol. Cell Biol. 21(1), 64 (2020). https:\/\/doi.org\/10.1186\/s12860-020-00309-7","journal-title":"BMC Mol. Cell Biol."},{"issue":"19","key":"926_CR32","doi-asserted-by":"publisher","first-page":"7899","DOI":"10.1073\/pnas.0608422104","volume":"104","author":"SW Schneider","year":"2007","unstructured":"S.W. Schneider, S. Nuschele, A. Wixforth, C. Gorzelanny, A. Alexander-Katz, R.R. Netz, M.F. Schneider, Shear-induced unfolding triggers adhesion of von Willebrand factor fibers. Proc. Natl. Acad. Sci. U. S. A. 104(19), 7899\u20137903 (2007). https:\/\/doi.org\/10.1073\/pnas.0608422104","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"926_CR33","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1182\/blood-2017-05-785253","volume":"132","author":"A Pang","year":"2018","unstructured":"A. Pang, Y. Cui, Y. Chen, N. Cheng, M.K. Delaney, M. Gu, A. Stojanovic-Terpo, C. Zhu, X. Du, Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation. Blood 132(5), 533\u2013543 (2018). https:\/\/doi.org\/10.1182\/blood-2017-05-785253","journal-title":"Blood"},{"issue":"10","key":"926_CR34","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1002\/jbm.a.36460","volume":"106","author":"TA Horbett","year":"2018","unstructured":"T.A. Horbett, Fibrinogen adsorption to biomaterials. J. Biomed. Mater. Res. A 106(10), 2777\u20132788 (2018). https:\/\/doi.org\/10.1002\/jbm.a.36460","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"3","key":"926_CR35","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1177\/17474930241299666","volume":"20","author":"C Tao","year":"2024","unstructured":"C. Tao, T. Liu, J. Sun, Y. Zhu, R. Li, L. Wang, C. Zhang, J. Song, X. Jing, T.N. Nguyen, R.G. Nogueira, J.L. Saver, W. Hu, Advancing stroke safety and efficacy through early tirofiban administration after intravenous thrombolysis: the multicenter, randomized, placebo-controlled, double-blind ASSET IT trial protocol. Int. J. Stroke 20(3), 373\u2013377 (2024). https:\/\/doi.org\/10.1177\/17474930241299666","journal-title":"Int. J. Stroke"},{"issue":"2","key":"926_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1159\/000512601","volume":"50","author":"L Tang","year":"2021","unstructured":"L. Tang, X. Tang, Q. Yang, The application of tirofiban in the endovascular treatment of acute ischemic stroke: a meta-analysis. Cerebrovasc. Dis. 50(2), 121\u2013131 (2021). https:\/\/doi.org\/10.1159\/000512601","journal-title":"Cerebrovasc. Dis."},{"issue":"5","key":"926_CR37","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s40265-019-01078-0","volume":"79","author":"M Yang","year":"2019","unstructured":"M. Yang, X. Huo, Z. Miao, Y. Wang, Platelet glycoprotein IIb\/IIIa receptor inhibitor tirofiban in acute ischemic stroke. Drugs 79(5), 515\u2013529 (2019). https:\/\/doi.org\/10.1007\/s40265-019-01078-0","journal-title":"Drugs"},{"issue":"6","key":"926_CR38","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s10557-024-07624-7","volume":"38","author":"B Rocca","year":"2024","unstructured":"B. Rocca, E. Bigagli, E. Cerbai, Ticagrelor and statins: dangerous liaisons? Cardiovasc. Drugs Ther. 38(6), 1103\u20131109 (2024). https:\/\/doi.org\/10.1007\/s10557-024-07624-7","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"Suppl 1","key":"926_CR39","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1111\/jth.12952","volume":"13","author":"M Cattaneo","year":"2015","unstructured":"M. Cattaneo, P2Y12 receptors: structure and function. J. Thromb. Haemost. 13(Suppl 1), S10\u2013S16 (2015). https:\/\/doi.org\/10.1111\/jth.12952","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"926_CR40","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s10555-017-9675-z","volume":"36","author":"A Ornelas","year":"2017","unstructured":"A. Ornelas, N. Zacharias-Millward, D.G. Menter, J.S. Davis, L. Lichtenberger, D. Hawke, E. Hawk, E. Vilar, P. Bhattacharya, S. Millward, Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention. Cancer Metastasis Rev. 36(2), 289\u2013303 (2017). https:\/\/doi.org\/10.1007\/s10555-017-9675-z","journal-title":"Cancer Metastasis Rev."},{"issue":"4","key":"926_CR41","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.3324\/haematol.2022.281006","volume":"108","author":"P Simeone","year":"2023","unstructured":"P. Simeone, R. Liani, R. Tripaldi, S. Ciotti, A. Recchiuti, V. Abbonante, B. Porro, P. Del Boccio, A. Di Castelnuovo, P. Lanuti, M. Camera, D. Pieragostino, M. Lee-Sundlov, M. Luongo, R. Auciello, G. Bologna, M.C. Cufaro, E. Tremoli, K.M. Hoffmeister, F. Cipollone, A. Balduini, F. Santilli, Reduced platelet glycoprotein Ib\u03b1 shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen. Haematologica 108(4), 1141\u20131157 (2023). https:\/\/doi.org\/10.3324\/haematol.2022.281006","journal-title":"Haematologica"}],"container-title":["Analytical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44211-026-00926-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44211-026-00926-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44211-026-00926-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:03:24Z","timestamp":1784883804000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44211-026-00926-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["926"],"URL":"https:\/\/doi.org\/10.1007\/s44211-026-00926-w","relation":{},"ISSN":["0910-6340","1348-2246"],"issn-type":[{"value":"0910-6340","type":"print"},{"value":"1348-2246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"15 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":1,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}