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However, their roles in B-cell progression and tumorigenesis remain poorly understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed gene expression profiles and overall survival data of 123 patients with mantle cell lymphoma (MCL). The LSM index was developed to assess its potential as a prognostic marker of MCL survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five of the eight\n                      <jats:italic>LSM<\/jats:italic>\n                      genes were identified as potential prognostic markers for survival in MCL, with particular emphasis on the\n                      <jats:italic>LSM<\/jats:italic>\n                      .index. The expression levels of these\n                      <jats:italic>LSM<\/jats:italic>\n                      genes demonstrated their potential utility as classifiers of MCL. The\n                      <jats:italic>LSM<\/jats:italic>\n                      .index-high group exhibited both poorer survival rates and lower RNA levels than did the overall transcript profile. Notably,\n                      <jats:italic>LSM1<\/jats:italic>\n                      and\n                      <jats:italic>LSM8<\/jats:italic>\n                      were overexpressed in the\n                      <jats:italic>LSM<\/jats:italic>\n                      .index-high group, with\n                      <jats:italic>LSM1<\/jats:italic>\n                      showing 2.5-fold increase (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and\n                      <jats:italic>LSM8<\/jats:italic>\n                      depicting 1.8-fold increase (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) than those in the\n                      <jats:italic>LSM<\/jats:italic>\n                      .index-low group. Furthermore, elevated\n                      <jats:italic>LSM<\/jats:italic>\n                      gene expression was associated with increased cell division and RNA splicing pathway activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>LSM<\/jats:italic>\n                      .index demonstrates potential as a prognostic marker for survival in patients with MCL. Elevated expression of\n                      <jats:italic>LSM<\/jats:italic>\n                      genes, particularly\n                      <jats:italic>LSM1<\/jats:italic>\n                      and\n                      <jats:italic>LSM8<\/jats:italic>\n                      , may be linked to poor survival outcomes through their involvement in cell division and RNA splicing pathways. These findings suggest that\n                      <jats:italic>LSM<\/jats:italic>\n                      genes may contribute to the aggressive behavior of MCL and represent potential targets for therapeutic interventions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s44313-024-00037-3","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T05:03:37Z","timestamp":1729141417000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic significance and biological implications of SM-like genes in mantle cell lymphoma"],"prefix":"10.1007","volume":"59","author":[{"given":"Xue","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjian","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoni","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuansheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"issue":"4","key":"37_CR1","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.cell.2009.01.019","volume":"136","author":"J Houseley","year":"2009","unstructured":"Houseley J, Tollervey D. 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