{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:47:51Z","timestamp":1757609271068,"version":"3.44.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Blood Res."],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Prevention of vascular events is the main objective in patients with polycythemia vera (PV) or essential thrombocythemia (ET). Carotid ultrasonography (USG) is a safe and noninvasive diagnostic tool that can be used to stratify cardiovascular and stroke risks. In our previous study, carotid plaque burden was significantly higher in patients with PV\/ET than in the general population. This study aimed to determine changes in carotid plaques in patients with PV\/ET.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We retrospectively evaluated the medical records of patients with ET\/PV who had undergone carotid USG at least twice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Of the 56 patients, 30 had PV and 26 had ET. The carotid plaque score was increased in the follow-up carotid USG compared with that in the initial carotid USG (3.38\u2009\u00b1\u20091.47 vs. 3.73\u2009\u00b1\u20091.46, <jats:italic>p<\/jats:italic>\u2009=\u20090.0139). The carotid plaque burden at the time of follow-up carotid USG showed no significant differences in patients with a complete hematologic response (CHR); however, it significantly worsened in patients who failed to achieve CHR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We confirmed that the carotid plaque burden persisted during follow-up in patients with PV\/ET. A CHR may prevent an increase in carotid plaque burden.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s44313-025-00098-y","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T07:32:59Z","timestamp":1756711979000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progression of carotid plaque burden in patients with polycythemia vera and essential thrombocythemia"],"prefix":"10.1007","volume":"60","author":[{"given":"Seong Soon","family":"Kwon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Young","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Ha","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namsu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Ho","family":"Won","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seug Yun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"issue":"8","key":"98_CR1","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1016\/j.numecd.2022.04.013","volume":"32","author":"SS Kwon","year":"2022","unstructured":"Kwon SS, Yoon SY, Jeong SY, Lee MY, Kim KH, Lee N, et al. Neutrophil-lymphocyte ratio and carotid plaque burden in patients with essential thrombocythemia and polycythemia vera. Nutr Metab Cardiovasc Dis. 2022;32(8):1913\u20136. https:\/\/doi.org\/10.1016\/j.numecd.2022.04.013.","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"23","key":"98_CR2","doi-asserted-by":"publisher","first-page":"4778","DOI":"10.1182\/blood-2013-01-478891","volume":"121","author":"G Barosi","year":"2013","unstructured":"Barosi G, Mesa R, Finazzi G, Harrison C, Kiladjian J-J, Lengfelder E, et al. Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project. Blood. 2013;121(23):4778\u201381. https:\/\/doi.org\/10.1182\/blood-2013-01-478891.","journal-title":"Blood"},{"issue":"14","key":"98_CR3","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.1182\/bloodadvances.2023009784","volume":"7","author":"D Tuyet Kristensen","year":"2023","unstructured":"Tuyet Kristensen D, Kisbye \u00d8vlisen A, Hjort Kyneb Jakobsen L, Tang Severinsen M, Hannig LH, Starklint J, et al. Use of statins and risk of myeloproliferative neoplasms: a Danish nationwide case-control study. Blood Adv. 2023;7(14):3450\u20137. https:\/\/doi.org\/10.1182\/bloodadvances.2023009784.","journal-title":"Blood Adv"},{"issue":"1","key":"98_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1056\/NEJMoa1208500","volume":"368","author":"R Marchioli","year":"2013","unstructured":"Marchioli R, Finazzi G, Specchia G, Cacciola R, Cavazzina R, Cilloni D, et al. Cardiovascular events and intensity of treatment in polycythemia vera. N Engl J Med. 2013;368(1):22\u201333. https:\/\/doi.org\/10.1056\/NEJMoa1208500.","journal-title":"N Engl J Med"},{"key":"98_CR5","doi-asserted-by":"publisher","first-page":"S326","DOI":"10.1016\/S2152-2650(22)01437-9","volume":"22","author":"AT Gerds","year":"2022","unstructured":"Gerds AT, Mesa R, Burke JM, Grunwald MR, Scherber R, Yu J, et al. MPN-103 a real-world evaluation of the association between elevated blood counts and thrombotic events in polycythemia vera: analysis of data from the REVEAL study. Clin Lymphoma Myeloma Leuk. 2022;22:S326. https:\/\/doi.org\/10.1016\/S2152-2650(22)01437-9.","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"19","key":"98_CR6","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1182\/blood.2019003347","volume":"135","author":"L Ronner","year":"2020","unstructured":"Ronner L, Podoltsev N, Gotlib J, Heaney ML, Kuykendall AT, O\u2019Connell C, et al. Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis. Blood. 2020;135(19):1696\u2013703. https:\/\/doi.org\/10.1182\/blood.2019003347.","journal-title":"Blood"},{"issue":"11","key":"98_CR7","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1182\/bloodadvances.2019000211","volume":"3","author":"A Carobbio","year":"2019","unstructured":"Carobbio A, Ferrari A, Masciulli A, Ghirardi A, Barosi G, Barbui T. Leukocytosis and thrombosis in essential thrombocythemia and polycythemia vera: a systematic review and meta-analysis. Blood Adv. 2019;3(11):1729\u201337. https:\/\/doi.org\/10.1182\/bloodadvances.2019000211.","journal-title":"Blood Adv"}],"container-title":["Blood Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44313-025-00098-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44313-025-00098-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44313-025-00098-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T09:22:19Z","timestamp":1756891339000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44313-025-00098-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["98"],"URL":"https:\/\/doi.org\/10.1007\/s44313-025-00098-y","relation":{},"ISSN":["2287-979X","2288-0011"],"issn-type":[{"type":"print","value":"2287-979X"},{"type":"electronic","value":"2288-0011"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"assertion":[{"value":"8 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"48"}}