{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:03:22Z","timestamp":1780995802713,"version":"3.54.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program","doi-asserted-by":"crossref","award":["2021-76"],"award-info":[{"award-number":["2021-76"]}],"id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fujian Provincial Clinical Research Center for Hematological Malignancies","award":["2020Y2006"],"award-info":[{"award-number":["2020Y2006"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Blood Res."],"published-print":{"date-parts":[[2026,12]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n The spleen plays a significant role in innate and adaptive immunity. We aimed to evaluate the prognostic significance of the splenic volume in patients with diffuse large B-cell lymphoma (DLBCL), research on which is limited.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively analyzed 175 patients diagnosed with DLBCL. Based on optimal thresholds, patients were stratified into small (<\u2009185 cm\n 3<\/jats:sup>\n ), medium (185\u2013315 cm\n 3<\/jats:sup>\n ), and large (\u2265\u2009315 cm\n 3<\/jats:sup>\n ) splenic volume groups. Survival analysis was performed using Kaplan\u2013Meier and Cox proportional hazards model.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A significant decrease in progression-free survival (PFS) (\n P<\/jats:italic>\n \u2009<\u20090.0001) and overall survival (OS) (\n P<\/jats:italic>\n \u2009<\u20090.0001) was observed in the large group that received cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone (CHOP) without or with rituximab (R-CHOP) treatment. Among the 139 patients who received R-CHOP, significant adverse effects on PFS (\n P<\/jats:italic>\n \u2009<\u20090.0036) and OS (\n P<\/jats:italic>\n \u2009<\u20090.0035) were observed in the large group. Univariate and multivariate analyses demonstrated that enlarged splenic volume (\u2265\u2009315 cm\n 3<\/jats:sup>\n ) was associated with decreased PFS (\n P<\/jats:italic>\n \u2009<\u20090.0001,\n P<\/jats:italic>\n \u2009<\u20090.01, respectively) and OS (\n P<\/jats:italic>\n \u2009<\u20090.001,\n P<\/jats:italic>\n \u2009<\u20090.01, respectively). In terms of peripheral blood inflammatory markers, patients with enlarged splenic volume (\u2265\u2009315 cm\n 3<\/jats:sup>\n ) exhibited lymphocytopenia, increased monocyte-to-lymphocyte ratio (MLR), increased neutrophil-to-lymphocyte ratio (NLR), and higher red blood cell distribution width (RDW) compared to that in those with smaller splenic volumes (\n P<\/jats:italic>\n \u2009<\u20090.001,\n P<\/jats:italic>\n \u2009<\u20090.001,\n P<\/jats:italic>\n \u2009=\u20090.01, and\n P<\/jats:italic>\n \u2009<\u20090.005, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Splenic volume exceeding 315 cm\n 3<\/jats:sup>\n is a poor prognostic factor for PFS and OS in patients with DLBCL. An enlarged splenic volume may be associated with compromised anti-cancer immune responses and aberrant inflammatory conditions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s44313-026-00138-1","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T02:34:59Z","timestamp":1778207699000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enlarged splenic volume predicts poor survival and is associated with inflammatory imbalance in patients with diffuse large B-cell lymphoma"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3298-2714","authenticated-orcid":false,"given":"Zongjian","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunquan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4276-7026","authenticated-orcid":false,"given":"Xiaomei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7428-8682","authenticated-orcid":false,"given":"Shaoyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"issue":"9","key":"138_CR1","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1056\/NEJMra2027612","volume":"384","author":"LH Sehn","year":"2021","unstructured":"Sehn LH, Salles G. Diffuse large B-cell lymphoma. N Engl J Med. 2021;384(9):842\u201358. https:\/\/doi.org\/10.1056\/NEJMra2027612.","journal-title":"N Engl J Med"},{"issue":"8","key":"138_CR2","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1038\/s41375-021-01285-3","volume":"35","author":"MY He","year":"2021","unstructured":"He MY, Kridel R. Treatment resistance in diffuse large B-cell lymphoma. Leukemia. 2021;35(8):2151\u201365. https:\/\/doi.org\/10.1038\/s41375-021-01285-3.","journal-title":"Leukemia"},{"issue":"1","key":"138_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1158\/0008-5472.Can-20-2339","volume":"81","author":"J Steenbrugge","year":"2021","unstructured":"Steenbrugge J, De Jaeghere EA, Meyer E, Denys H, De Wever O. Splenic hematopoietic and stromal cells in cancer progression. 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Cancer. 2012;118(17):4166\u201372. https:\/\/doi.org\/10.1002\/cncr.27381.","journal-title":"Cancer"}],"container-title":["Blood Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44313-026-00138-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44313-026-00138-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44313-026-00138-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:45:49Z","timestamp":1780994749000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44313-026-00138-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["138"],"URL":"https:\/\/doi.org\/10.1007\/s44313-026-00138-1","relation":{},"ISSN":["2287-979X","2288-0011"],"issn-type":[{"value":"2287-979X","type":"print"},{"value":"2288-0011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"15 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study involving human participants adhered to the ethical standards of the 1964 Declaration of Helsinki and was approved by the Ethics Committee of Fujian Medical University Union Hospital. The data were anonymized and maintained confidentially.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"28"}}