{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:04:21Z","timestamp":1784811861645,"version":"3.55.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmic Physiol. Opt."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the changes in corneal endothelial morphology and central corneal thickness following short-term scleral lens wear in eyes that had undergone penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK), and to examine the association between baseline endothelial characteristics and the magnitude of scleral lens\u2013induced corneal oedema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve eyes were fitted with non-fenestrated scleral lenses (oxygen permeability [Dk] 100; centre thickness \u2248 250\u2009\u00b5m). Endothelial cell density (ECD), coefficient of variation in cell size (CoV), percentage of hexagonal cells (% Hex) and central corneal thickness (CCT) were measured before and immediately after 8\u2009h of scleral lens wear using specular microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following lens wear,\u00a0ECD (2041\u2009\u00b1\u2009557 vs 1827\u2009\u00b1\u2009481 cells\/mm\u00b2) and\u00a0% Hex (44.4\u2009\u00b1\u200912.0% vs 38.2\u2009\u00b1\u200910.0%) decreased, while\u00a0CoV (37.3\u2009\u00b1\u200910.3% vs 42.4\u2009\u00b1\u20099.4%) and\u00a0CCT (485.3\u2009\u00b1\u200947.1 vs 520.4\u2009\u00b1\u200951.3\u2009\u00b5m, 7.2\u2009\u00b1\u20093.1% oedema) increased (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001). These short\u2011term specular microscopy-derived changes in ECD and\u00a0endothelial morphology may be an imaging artefact associated with transient corneal swelling rather than true endothelial cell loss. The magnitude of corneal oedema was not associated with any baseline corneal endothelial parameters (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.20) but correlated with graft age (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.80). Corneal oedema was greater in PK than DALK eyes (11.38% vs 5.23%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), and PK grafts were older on average (7 vs 5 years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Short-term scleral lens wear induced significant corneal swelling in post-keratoplasty eyes but was not associated with baseline endothelial parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s44402-026-00111-6","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:47:40Z","timestamp":1781185660000},"page":"779-785","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Corneal and Endothelial Parameters Following Scleral Lens Wear in Post-Keratoplasty Eyes"],"prefix":"10.1007","volume":"46","author":[{"given":"Ankit","family":"Raj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth","family":"Dumpati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Willcox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"111_CR1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.74187","volume":"16","author":"RF Mutwaly Sr","year":"2024","unstructured":"Mutwaly RF Sr. Corneal endothelial polymegathism and pleomorphism induced by daily-wear soft contact lenses. 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