{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:25:33Z","timestamp":1788452733567,"version":"build-2803163510"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Gilbert Memorial Fund Research Grant"},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["NEI- R01EY023261"],"award-info":[{"award-number":["NEI- R01EY023261"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmic Physiol. Opt."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare an objective assessment of intermittent exotropia (IXT) control and deviation size using the binocular eye alignment monitor (BEAM) to standard clinical assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>IXT control and deviation size were evaluated in 15 participants aged 8\u201335 years. Participants completed two visits that included a 90-min BEAM eye movement recording at a distance (6\u2009m) to evaluate distance IXT size and control of the deviation objectively. IXT control was assessed using the mean of three measurements of the IXT Office Control Scale, and the deviation size was measured with the prism alternate cover test (PACT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean IXT control score in the IXT participants was 2.2\u2009\u00b1\u20091 points, which was weakly correlated with the percentage of time strabismic as measured by the BEAM (Spearman\u2019s correlation coefficient\u2009=\u20090.29;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.30). Distance PACT and mean BEAM deviation size demonstrated a moderate, non-significant association (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08). BEAM measurements were consistently smaller than PACT measurements. IXT distance control (0.44; 95% CI: 0.04\u20130.80;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and the median deviation size measured by the BEAM (\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u2009\u22122.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) were significantly different between visits 1 and 2 (\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u2009\u22122.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03); however, the percentage of time deviated (BEAM) was not significantly different between the two study visits (\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u2009\u22120.63;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.50).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The notable differences in control observed with the BEAM compared to current clinical measures suggest that office control scores and prolonged objective monitoring may capture different aspects of IXT control. Objective monitoring over extended periods may be a valuable complement to traditional clinical assessment in both research and clinical care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s44402-026-00179-0","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:04:07Z","timestamp":1788451447000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Objective Assessment of Intermittent Exotropia Magnitude and Control Using the Binocular Eye Alignment Monitor"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4683-2796","authenticated-orcid":false,"given":"Erin C.","family":"Jenewein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Scheiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara L.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"179_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1080\/09273970600894716","volume":"14","author":"BG Mohney","year":"2006","unstructured":"Mohney BG, Holmes JM. An office-based scale for assessing control in intermittent exotropia. Strabismus. 2006;14:147\u201350. https:\/\/doi.org\/10.1080\/09273970600894716.","journal-title":"Strabismus"},{"key":"179_CR2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jcjo.2016.08.017","volume":"52","author":"H Kim","year":"2017","unstructured":"Kim H, Kim DH, Ahn H, Lim HT. Proposing a new scoring system in intermittent exotropia: towards a better assessment of control. Can J Ophthalmol. 2017;52:235\u20139. https:\/\/doi.org\/10.1016\/j.jcjo.2016.08.017.","journal-title":"Can J Ophthalmol"},{"key":"179_CR3","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1136\/bjo.2007.120287","volume":"92","author":"D Buck","year":"2008","unstructured":"Buck D, Clarke MP, Haggerty H, Hrisos S, Powell C, Sloper J, et al. Grading the severity of intermittent distance exotropia: the revised Newcastle Control Score. Br J Ophthalmol. 2008;92:577. https:\/\/doi.org\/10.1136\/bjo.2007.120287.","journal-title":"Br J Ophthalmol"},{"key":"179_CR4","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ajo.2023.01.014","volume":"250","author":"JR Economides","year":"2023","unstructured":"Economides JR, Dilbeck MD, Gentry TN, Horton JC. Ambulatory monitoring with eye tracking glasses to assess the severity of intermittent exotropia. Am J Ophthalmol. 2023;250:120\u20139. https:\/\/doi.org\/10.1016\/j.ajo.2023.01.014.","journal-title":"Am J Ophthalmol"},{"key":"179_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1167\/tvst.14.8.17","volume":"14","author":"CJ Morris","year":"2025","unstructured":"Morris CJ, Jenewein E, Scheiman M, Alvarez TL. Binocular Eye Alignment Monitor (BEAM): home monitoring proof-of-concept device to quantify binocular alignment for intermittent exotropia. Transl Vis Sci Technol. 2025;14:17. https:\/\/doi.org\/10.1167\/tvst.14.8.17.","journal-title":"Transl Vis Sci Technol"},{"key":"179_CR6","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.ophtha.2007.03.084","volume":"115","author":"SR Hatt","year":"2008","unstructured":"Hatt SR, Mohney BG, Leske DA, Holmes JM. Variability of control in intermittent exotropia. Ophthalmology. 2008;115:371\u20136.e2. https:\/\/doi.org\/10.1016\/j.ophtha.2007.03.084.","journal-title":"Ophthalmology"},{"key":"179_CR7","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3928\/01913913-20200825-02","volume":"57","author":"SM Prile","year":"2020","unstructured":"Prile SM, Kim J, Moon Y, Lim HT. Assessing variability of control within a single day in intermittent exotropia. J Pediatr Ophthalmol Strabismus. 2020;57:378\u201383. https:\/\/doi.org\/10.3928\/01913913-20200825-02.","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"179_CR8","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jaapos.2017.05.006","volume":"21","author":"WJ Kim","year":"2017","unstructured":"Kim WJ, Kim MM. Variability of preoperative measurements in intermittent exotropia and its effect on surgical outcome. J AAPOS. 2017;21:210\u20134. https:\/\/doi.org\/10.1016\/j.jaapos.2017.05.006.","journal-title":"J AAPOS"},{"key":"179_CR9","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jaapos.2017.04.005","volume":"21","author":"R Superstein","year":"2017","unstructured":"Superstein R, Dean TW, Holmes JM, Chandler DL, Cotter SA, Wallace DK, et al. Relationship among clinical factors in childhood intermittent exotropia. J Am Assoc Pediatr Ophthalmol Strabismus. 2017;21:268\u201373. https:\/\/doi.org\/10.1016\/j.jaapos.2017.04.005.","journal-title":"J Am Assoc Pediatr Ophthalmol Strabismus"},{"key":"179_CR10","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1007\/s00417-025-06758-0","volume":"263","author":"DH Kim","year":"2025","unstructured":"Kim DH, Lew H, Rah SH, Yoo Y-J, Ahn H, Kim US, et al. Clinical characteristics of intermittent exotropia according to fusional control: findings from the Korean Intermittent Exotropia Study (KIEMS). Graefe\u2019s Arch Clin Exp Ophthalmol. 2025;263:2663\u201370. https:\/\/doi.org\/10.1007\/s00417-025-06758-0.","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol"}],"container-title":["Ophthalmic and Physiological Optics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44402-026-00179-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44402-026-00179-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44402-026-00179-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:04:09Z","timestamp":1788451449000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44402-026-00179-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":10,"alternative-id":["179"],"URL":"https:\/\/doi.org\/10.1007\/s44402-026-00179-0","relation":{},"ISSN":["0275-5408","1475-1313"],"issn-type":[{"value":"0275-5408","type":"print"},{"value":"1475-1313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"13 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all participants 18 years of age and older and from the parent or guardian of participants under the age of 18 years. Assent was obtained from all participants under the age of 18 years.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Consent to publish declaration is not applicable.","order":3,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}}]}}