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Opt."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aims to investigate the long-term impact of soft contact lens (SCL) wear on the cornea in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-one participants who had worn daily disposable hydrogel SCLs for over 10 years (\u226510\u2009h\/day, 6 days\/week) since ages 8\u201312 years were recruited, together with age-matched controls without contact lens wear. Corneal epithelial (CET) and stromal thickness (CST) were measured using anterior segment optical coherence tomography in central (2\u2009mm), mid-peripheral (2\u20135\u2009mm) and peripheral (5\u20136\u2009mm) annular regions. Corneal endothelium was imaged with a non-contact specular microscope to calculate corneal endothelial cell density (ECD), coefficients of variation of cell size (polymegethism, CV,%) and percentage of hexagonal cells (pleomorphism, HEX,%) in the central and six peripheral regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants\u2019 mean age was 21.3\u2009\u00b1\u20091.2 years in the control group (12 females) and 21.6\u2009\u00b1\u20091.5 years in the SCL group (10 females). Mean central 2-mm CET and CST were similar between groups (CET: Control vs SCL: 52.4\u2009\u00b1\u20093.4 vs 52.2\u2009\u00b1\u20092.5\u2009\u03bcm, CST: 478.3\u2009\u00b1\u200930.8 vs 487.6\u2009\u00b1\u200923.4, both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.20), with no significant differences in peripheral regions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.10). Neither central ECD (3064\u2009\u00b1\u2009249 vs 3076\u2009\u00b1\u2009203\u2009cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ), HEX (67.3\u2009\u00b1\u20096.8 vs 65.9\u2009\u00b1\u20097.4%) nor CV (28.0\u2009\u00b1\u20093.8 vs 29.8\u2009\u00b1\u20093.8%) differed significantly between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.10). The SCL group showed significantly higher CV in the superior and superonasal regions only (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), while peripheral ECD and HEX were similar between groups (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long-term wear of daily disposable hydrogel SCLs in children did not alter CET and CST significantly over a minimum 10-year period. Corneal endothelial integrity and pleomorphism were maintained, with higher polymegethism observed only in two peripheral regions. These findings support daily disposable hydrogel SCLs as a safe and suitable choice for children over a typical myopia control treatment period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s44402-026-00211-3","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:11:33Z","timestamp":1792577493000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Corneal Epithelium to Endothelium: Long-Term Corneal Changes in Myopic Children Wearing Daily Disposable Hydrogel Soft Contact Lenses"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0640-3327","authenticated-orcid":false,"given":"Hiu Yan","family":"Lam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0855-8554","authenticated-orcid":false,"given":"Raquel","family":"Gil-Cazorla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-9516","authenticated-orcid":false,"given":"Nicola S.","family":"Logan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"211_CR1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/j.1475-1313.2005.00298.x","volume":"25","author":"SM Saw","year":"2005","unstructured":"Saw SM, Gazzard G, Shih-Yen EC, Chua WH. 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RGC has received research support from CooperVision, Inc.; however, it is unrelated to the work presented in this article. SJ declares no competing interests. NSL is an editorial board member of OPO; however, she played no role in the management or peer-review of this paper. NSL has received research funding from CooperVision, Inc., EssilorLuxottica, Hoya VisionCare, Ocumension, Ocus Innovation and Sightglass Vision. NSL has received consultancy from CooperVision Inc., EssilorLuxottica, Sightglass Vision and ZEISS Vision Care.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study adhered to the tenets of the Declaration of Helsinki and was given a favourable opinion by the Health and Life Sciences Research Ethics Committee of Aston University (REC ID:HLS21205\/1473). Written informed consent was obtained from all participants prior to data collection.","order":2,"name":"Ethics","label":"Ethics Approval and Consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}