{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:34:17Z","timestamp":1767807257351,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"10-12","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["340296"],"award-info":[{"award-number":["340296"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Saudi Dent. J."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s44445-025-00089-w","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:58:10Z","timestamp":1762552690000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between maternal serum levels of Alpha-Fetoprotein and eruption timing of the first central deciduous tooth: a cross-sectional study"],"prefix":"10.1007","volume":"37","author":[{"given":"Elham","family":"Faghihian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamin","family":"Ghobadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasool","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Saberi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"89_CR1","volume-title":"Alpha Fetoprotein","author":"OO Adigun","year":"2023","unstructured":"Adigun OO, Yarrarapu SNS, Zubair M et al (2023) Alpha Fetoprotein. StatPearls Publishing, Treasure Island (FL)"},{"key":"89_CR2","first-page":"52","volume":"27","author":"O Aktoren","year":"2010","unstructured":"Aktoren O, Tuna E, Guven Y et al (2010) A Study on Neonatal Factors and Eruption Time of Primary Teeth. Community Dent Healt 27:52","journal-title":"Community Dent Healt"},{"key":"89_CR3","first-page":"67","volume":"12","author":"R Almonaitiene","year":"2010","unstructured":"Almonaitiene R, Balciuniene I, Tutkuviene JJS (2010) Factors influencing permanent teeth eruption. Part one\u2013general factors. Stomatologija 12:67\u201372","journal-title":"Stomatologija"},{"key":"89_CR4","first-page":"93","volume":"14","author":"R Almonaitiene","year":"2012","unstructured":"Almonaitiene R, Balciuniene I, Tutkuviene JJS (2012) Standards for permanent teeth emergence time and sequence in Lithuanian children, residents of Vilnius city. Stomatologija 14:93\u2013100","journal-title":"Stomatologija"},{"key":"89_CR5","doi-asserted-by":"publisher","first-page":"e018621","DOI":"10.1136\/bmjopen-2017-018621","volume":"7","author":"KA Alnemer","year":"2017","unstructured":"Alnemer KA, Pani SC, Althubaiti AM et al (2017) Impact of birth characteristics, breast feeding and vital statistics on the eruption of primary teeth among healthy infants in Saudi Arabia: an observational study. BMJ Open 7:e018621","journal-title":"BMJ Open"},{"key":"89_CR6","doi-asserted-by":"crossref","unstructured":"Baschat AA, Magder LS, Doyle LE et al (2014) Prediction of preeclampsia utilizing the first trimester screening examination. Am J Obstet Gynecol 211: 514. e511\u2013514. e517","DOI":"10.1016\/j.ajog.2014.04.018"},{"key":"89_CR7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ejogrb.2014.07.018","volume":"181","author":"JL Cohen","year":"2014","unstructured":"Cohen JL, Smilen KE, Bianco AT et al (2014) Predictive value of combined serum biomarkers for adverse pregnancy outcomes. Eur J Obstet Gynecol Reprod Biol 181:89\u201394","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"89_CR8","doi-asserted-by":"publisher","first-page":"nzy100","DOI":"10.1093\/cdn\/nzy100","volume":"3","author":"B Dhamo","year":"2019","unstructured":"Dhamo B, Miliku K, Voortman T et al (2019) The associations of maternal and neonatal vitamin D with dental development in childhood. Curr Dev Nutr 3:nzy100. https:\/\/doi.org\/10.1093\/cdn\/nzy100","journal-title":"Curr Dev Nutr"},{"key":"89_CR9","doi-asserted-by":"publisher","unstructured":"Dinglas C, Afsar N, Cochrane E et al (2020) First-trimester maternal serum alpha fetoprotein is associated with ischemic placental disease. Am J Obstet Gynecol. 222:499.e491\u2013499.e496. https:\/\/doi.org\/10.1016\/j.ajog.2019.11.1264","DOI":"10.1016\/j.ajog.2019.11.1264"},{"key":"89_CR10","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1080\/10408444.2019.1629873","volume":"49","author":"J Gomes","year":"2019","unstructured":"Gomes J, Au F, Basak A et al (2019) Maternal blood biomarkers and adverse pregnancy outcomes: a systematic review and meta-analysis. Crit Rev Toxicol 49:461\u2013478","journal-title":"Crit Rev Toxicol"},{"key":"89_CR11","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1152\/physrev.00029.2013","volume":"94","author":"MA Hanson","year":"2014","unstructured":"Hanson MA, Gluckman PD (2014) Early developmental conditioning of later health and disease: physiology or pathophysiology? Physiol Rev 94:1027\u20131076. https:\/\/doi.org\/10.1152\/physrev.00029.2013","journal-title":"Physiol Rev"},{"key":"89_CR12","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1111\/j.1471-0528.1976.tb00881.x","volume":"83","author":"D Hay","year":"1976","unstructured":"Hay D, Forrester P, Hancock R et al (1976) Maternal serum alpha-fetoprotein in normal pregnancy. BJOG 83:534\u2013538","journal-title":"BJOG"},{"key":"89_CR13","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/ajpa.10239","volume":"122","author":"DJ Holman","year":"2003","unstructured":"Holman DJ, Jones RE (2003) Longitudinal analysis of deciduous tooth emergence: III. Sexual dimorphism in Bangladeshi, Guatemalan, Japanese, and Javanese children. Am J Phys Anthropol 122:269\u2013278","journal-title":"Am J Phys Anthropol"},{"key":"89_CR14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.tjog.2019.11.011","volume":"59","author":"J-L Hu","year":"2020","unstructured":"Hu J-L, Zhang Y-J, Zhang J-M et al (2020) Pregnancy outcomes of women with elevated second-trimester maternal serum alpha-fetoprotein. Taiwan J Obstet Gynecol 59:73\u201378. https:\/\/doi.org\/10.1016\/j.tjog.2019.11.011","journal-title":"Taiwan J Obstet Gynecol"},{"key":"89_CR15","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1177\/154405910708601204","volume":"86","author":"TE Hughes","year":"2007","unstructured":"Hughes TE, Bockmann MR, Seow K et al (2007) Strong genetic control of emergence of human primary incisors. J Dent Res 86:1160\u20131165","journal-title":"J Dent Res"},{"key":"89_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/wdev.63","volume":"2","author":"AH Jheon","year":"2013","unstructured":"Jheon AH, Seidel K, Biehs B et al (2013) From molecules to mastication: the development and evolution of teeth. Wires Dev Biol 2:165\u2013182","journal-title":"Wires Dev Biol"},{"key":"89_CR17","unstructured":"Kanagaratnam S, Schluter PJ (2012) The age of permanent tooth emergence in children of different ethnic origin in the Auckland region: a cross-sectional study. N Z Dent J 108(2):55\u201361"},{"key":"89_CR18","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1017\/s2040174415001130","volume":"6","author":"G Ntani","year":"2015","unstructured":"Ntani G, Day PF, Baird J et al (2015) Maternal and early life factors of tooth emergence patterns and number of teeth at 1 and 2 years of age. J Dev Orig Health Dis 6:299\u2013307. https:\/\/doi.org\/10.1017\/s2040174415001130","journal-title":"J Dev Orig Health Dis"},{"key":"89_CR19","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1740-8709.2008.00156.x","volume":"5","author":"EO Oziegbe","year":"2009","unstructured":"Oziegbe EO, Adekoya-Sofowora C, Folayan MO et al (2009) Relationship between Socio-Demographic and Anthropometric Variables and Number of Erupted Primary Teeth in Suburban Nigerian Children. Matern Child Nutr 5:86\u201392","journal-title":"Matern Child Nutr"},{"key":"89_CR20","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.aanat.2015.05.004","volume":"203","author":"IS Pavi\u010din","year":"2016","unstructured":"Pavi\u010din IS, Duman\u010di\u0107 J, Badel T et al (2016) Timing of emergence of the first primary tooth in preterm and full-term infants. Ann Anat 203:19\u201323","journal-title":"Ann Anat"},{"key":"89_CR21","doi-asserted-by":"publisher","first-page":"79","DOI":"10.15171\/joddd.2015.0016","volume":"9","author":"H Poureslami","year":"2015","unstructured":"Poureslami H, Asl Aminabadi N, Sighari Deljavan A et al (2015) Does timing of eruption in first primary tooth correlate with that of first permanent tooth? A 9-years cohort study. J Dent Res Dent Clin Dent Prospect 9:79\u201385. https:\/\/doi.org\/10.15171\/joddd.2015.0016","journal-title":"J Dent Res Dent Clin Dent Prospect"},{"key":"89_CR22","first-page":"122","volume":"47","author":"P Rantakallio","year":"1983","unstructured":"Rantakallio P, M\u00e4kinen HJG (1983) The effect of maternal smoking on the timing of deciduous tooth eruption. Growth 47:122\u2013128","journal-title":"Growth"},{"key":"89_CR23","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S1875-9572(10)60044-7","volume":"51","author":"N Sajjadian","year":"2010","unstructured":"Sajjadian N, Shajari H, Jahadi R et al (2010) Relationship between birth weight and time of first deciduous tooth eruption in 143 consecutively born infants. Pediatr Neonatol 51:235\u2013237","journal-title":"Pediatr Neonatol"},{"key":"89_CR24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1097\/01.AOG.0000191302.79560.d8","volume":"107","author":"GC Smith","year":"2006","unstructured":"Smith GC, Shah I, Crossley JA et al (2006) Pregnancy-associated plasma protein A and alpha-fetoprotein and prediction of adverse perinatal outcome. Obstet Gynecol 107:161\u2013166","journal-title":"Obstet Gynecol"},{"key":"89_CR25","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/uog.5163","volume":"31","author":"K Spencer","year":"2008","unstructured":"Spencer K, Cowans N, Molina F et al (2008) First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of preterm or early preterm delivery. Ultrasound Obstet Gynecol 31:147\u2013152","journal-title":"Ultrasound Obstet Gynecol"},{"key":"89_CR26","unstructured":"Tafti A, Clark P (2025) Anatomy, head and neck, primary dentition. In: StatPearls [Internet].\u00a0StatPearls Publishing, Treasure Island (FL)"},{"key":"89_CR27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12916-024-03278-2","volume":"22","author":"S Tong","year":"2024","unstructured":"Tong S, Benhalima K, Muglia L et al (2024) Novel insights from our special issue on maternal factors during pregnancy that influence maternal, fetal and childhood outcomes. BMC Med 22:79. https:\/\/doi.org\/10.1186\/s12916-024-03278-2","journal-title":"BMC Med"},{"key":"89_CR28","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrg1380","volume":"5","author":"A Tucker","year":"2004","unstructured":"Tucker A, Sharpe P (2004) The cutting-edge of mammalian development; how the embryo makes teeth. Nat Rev Genet 5:499\u2013508","journal-title":"Nat Rev Genet"},{"key":"89_CR29","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1007\/s00784-015-1670-6","volume":"20","author":"C Un Lam","year":"2016","unstructured":"Un Lam C, Hsu C-YS, Yee R et al (2016) Influence of metabolic-linked early life factors on the eruption timing of the first primary tooth. Clin Oral Invest 20:1871\u20131879","journal-title":"Clin Oral Invest"},{"key":"89_CR30","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1038\/s41598-019-39572-w","volume":"9","author":"H Wu","year":"2019","unstructured":"Wu H, Chen T, Ma Q et al (2019) Associations of maternal, perinatal and postnatal factors with the eruption timing of the first primary tooth. Sci Rep 9:2645","journal-title":"Sci Rep"},{"key":"89_CR31","doi-asserted-by":"publisher","first-page":"138107","DOI":"10.1016\/j.scitotenv.2020.138107","volume":"723","author":"H Wu","year":"2020","unstructured":"Wu H, Xu B, Guan Y et al (2020) A metabolomic study on the association of exposure to heavy metals in the first trimester with primary tooth eruption. Sci Total Environ 723:138107. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.138107","journal-title":"Sci Total Environ"},{"key":"89_CR32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3109\/03014460.2015.1006140","volume":"43","author":"E \u017b\u0105dzi\u0144ska","year":"2016","unstructured":"\u017b\u0105dzi\u0144ska E, Sitek A, Rosset I (2016) Relationship between pre-natal factors, the perinatal environment, motor development in the first year of life and the timing of first deciduous tooth emergence. Ann Hum Biol 43:25\u201333","journal-title":"Ann Hum Biol"}],"container-title":["The Saudi Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44445-025-00089-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44445-025-00089-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44445-025-00089-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T16:27:05Z","timestamp":1767803225000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44445-025-00089-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":32,"journal-issue":{"issue":"10-12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["89"],"URL":"https:\/\/doi.org\/10.1007\/s44445-025-00089-w","relation":{},"ISSN":["1013-9052","2524-1702"],"issn-type":[{"value":"1013-9052","type":"print"},{"value":"2524-1702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,7]]},"assertion":[{"value":"6 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the ethics committee of Isfahan University of Medical Sciences (ethics code: IR.MUI.RESEARCH.REC.1402.139). An informed consent form was obtained from each mother before study initiation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The is no conflict of interests to be declared.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"77"}}